scholarly journals Smart Injectable Self-Setting Monetite Based Bioceramics for Orthopedic Applications

Materials ◽  
2018 ◽  
Vol 11 (7) ◽  
pp. 1258 ◽  
Author(s):  
Naresh Koju ◽  
Prabaha Sikder ◽  
Bipin Gaihre ◽  
Sarit B. Bhaduri
Keyword(s):  
Bone Cement ◽  
Vital Role ◽  
Fracture Site ◽  
Bone Cements ◽  
Defect Site ◽  
Calcium Phosphate Bone Cement ◽  
Fusion Applications ◽  
Bone Integration ◽  
Orthopedic Applications

The present study is the first of its kind dealing with the development of a specific bioceramic which qualifies as a potential material in hard-tissue replacements. Specifically, we report the synthesis and evaluation of smart injectable calcium phosphate bone cement (CPC) which we believe will be suitable for various kinds of orthopedic and spinal-fusion applications. The smart nature of this next generation orthopedic implant is attained by incorporating piezoelectric barium titanate (BT) particles into monetite-based (dicalcium phosphate anhydrous, DCPA) CPC composition. The main goal is to take advantage of the piezoelectric properties of BT, as electromechanical effect plays a vital role in fracture healing at the defect site and bone integration with the implant. Furthermore, radiopacity of BT would help in easy detection of the CPC presence at the fracture site during surgery. Results reveal that BT addition favors important properties of bone cement such as good compressive strength, injectability, bioactivity, biocompatibility, and even washout resistance. Most importantly, the self-setting nature of the bone cements are not compromised with BT incorporation. The in vitro results confirm that the developed bone-cement abides by the standard orthopedic requirements making it apt for real-time prosthetic materials.

Influence of Antibiotics Addition in Bone Cements for Hip Arthroplasty on their Mechanical Properties: Clinical Perspective and In Vitro Tests

2016 ◽  
Vol 695 ◽  
pp. 123-127
Author(s):  
Razvan Ene ◽  
Zsombor Panti ◽  
Mihai Nica ◽  
Marian Pleniceanu ◽  
Patricia Ene ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Cement ◽  
Hip Arthroplasty ◽  
Revision Surgery ◽  
Bone Cements ◽  
Artificial Joints ◽  
The One ◽  
Prophylactic Method ◽  
Active Substances

Bone cement has been used for over half a century, to successfully anchor artificial joints. From its emergence there have appeared a number of types of bone cement, with the 2 major classes being bone cement with or without active substances. The one with the added antibiotics is used primarily in the treatment and revision surgery of infected total hip arthroplasty (THA), as well as a prophylactic method in primary THA in patients with high risks for this complication. The purpose of this study is to determine the mechanical properties of bone cement with added antibiotics. Over a period of 2 years, a number of 41 cases were chosen for this study: 25 with revision surgery for THA, where bone cement with antibiotics was used, and 16 with primary THA, where regular bone cement was used. A number of studies have been performed on the mechanical properties of the 2 types of cement, which determined that the cement with antibiotics presents a slightly lower compressive strength, tensile strength, elastic modulus and fatigue strength compared with regular cement. These variations, however, become more pronounced as the quantity of the antibiotic goes up. The mechanical properties of the cement with antibiotics are similar with those of the regular cement, when low doses of antibiotics are used and become more evident as the doses go up. In conclusion, the antibiotic bone cement is a trustworthy tool in the surgeon’s arsenal against infection, with minimal detriments from the mechanical view.

Mechanical Strength and In Vitro Antibiotic Release Profile of Antibiotic-Loaded Calcium Phosphate Bone Cement

2013 ◽  
Vol 24 (4) ◽  
pp. 1447-1450 ◽  
Author(s):  
Yoshiaki Sakamoto ◽  
Hiroko Ochiai ◽  
Ikuko Ohsugi ◽  
Yoshikazu Inoue ◽  
Yohko Yoshimura ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Mechanical Strength ◽  
Bone Cement ◽  
Release Profile ◽  
Calcium Phosphate Bone Cement ◽  
Antibiotic Release

Development of injectable chitosan/biphasic calcium phosphate bone cement and in vitro and in vivo evaluation

2020 ◽  
Vol 15 (5) ◽  
pp. 055038
Author(s):  
Sirirat T. Rattanachan ◽  
Nuan La-ong Srakaew ◽  
Paritat Thaitalay ◽  
Oranich Thongsri ◽  
Rawee Dangviriyakul ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Biphasic Calcium Phosphate ◽  
In Vivo Evaluation ◽  
Calcium Phosphate Bone Cement

scholarly journals FABRICATION OF POLY(LACTIC-CO-GLYCOLIC ACID)/CALCIUM PHOSPHATE BONE CEMENT COMPOSITE: SYNTHESIZATION OF CALCIUM PHOSPHATE FROM CRAB SHELLS

2018 ◽  
Vol 80 (4) ◽  
Author(s):  
Mohammad Redzuan Abdul Hanan ◽  
Ahmad Kafrawi Nasution ◽  
Rafaqat Hussain ◽  
Syafiqah Saidin
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Glycolic Acid ◽  
Waste Product ◽  
Cement Composite ◽  
Chemical Route ◽  
Calcium Phosphate Bone Cement ◽  
Calcium Compound ◽  
Dsc Analyses

Crab shells are waste product, rich with calcium compound. Calcium element is often used as a material for bone scaffold due to its bioactive and biodegradation properties. In this study, calcium phosphate (CaP) nanoparticles were synthesized from crab shells through a wet chemical route. The CaP nanoparticles were then sintered and mixed with poly(lactic-co-glycolic acid) (PLGA) to form a bone cement composite. The mixture was casted in a cylinder shape and it was characterized through ATR-FTIR, XRD, FESEM, contact angle and DSC analyses. The CaP pellet and the CaP/PLGA bone cement composite were then subjected to in vitro simulated body fluid (SBF) bioactivity test. The CaP/PLGA bone cement composite was found to have a composition of crystal CaP and PLGA with a tolerable glass transition state, suitable to be used in a physiological environment. The CaP nanoparticles were agglomerated on the 3D interconnected surface of PLGA. The hydrophobicity of the CaP was increased (66.94%) with the addition of PLGA as a binder matrix where this composite has induced the formation of apatite layer. This bioactive property is crucial in fabricating a bone substitute material as it can promotes cell penetration, attachment and proliferation..

In Vivo and In Vitro Response to a Gelatin/α-Tricalcium Phosphate Bone Cement

2007 ◽  
Vol 361-363 ◽  
pp. 1001-1004 ◽  
Author(s):  
Barbara Bracci ◽  
Milena Fini ◽  
Silvia Panzavolta ◽  
Paola Torricelli ◽  
Adriana Bigi
Keyword(s):  
Bone Cement ◽  
Critical Size ◽  
Control Cell ◽  
Critical Size Defects ◽  
Calcium Phosphate Bone Cement ◽  
Proliferation And Differentiation ◽  
In Vivo Tests ◽  
In Vitro Response

We recently developed a new biomimetic calcium phosphate bone cement enriched with gelatin (GEL-CP) which exhibits improved mechanical properties with respect to the control cement (C-CP) and a good response to osteoblast-like cells. In this work, we have extended the investigation to primary culture of osteoblasts derived from normal (N-OB) and osteopenic (O-OB) sheep bones cultured on samples of GEL-CP, and their behavior was compared to that of cells cultured on C-CP as control. Cell morphology, proliferation, and differentiation were evaluated at 3 and 7 days. Preliminary in vivo tests were carried out onto critical size defects in the radius diaphysis of rats.

Preliminary Study on the Biocompatibility of Calcium Phosphate Bone Cement Containing N,O-Carboxymethyl Chitosan

2007 ◽  
Vol 330-332 ◽  
pp. 807-810
Author(s):  
Qi Huang ◽  
Feng Cao ◽  
Dong Xu Li
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Normal Saline ◽  
Carboxymethyl Chitosan ◽  
In Vitro Tests ◽  
Calcium Phosphate Bone Cement ◽  
Biological Reaction ◽  
Good Biocompatibility ◽  
Preliminary Study

N,O-carboxymethyl chitosan (CMCTS) was added in Calcium phosphate bone cement (CPC). A preliminary study was carried out in order to evaluate the biocompatibility of CPC containing CMCTS. In vitro tests were done using extract liquid from normal saline. The result showed that the biological reaction complied with standards of GB/16886 and the composite might have good biocompatibility.

In vitro and in vivo effectiveness of a novel injectable calcitonin-loaded collagen/ceramic bone substitute

2021 ◽  
pp. 088532822198998
Author(s):  
Karl Wu ◽  
Yu-Chun Chen ◽  
Shang M Lin ◽  
Chih-Hung Chang
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Degradation Rate ◽  
Rabbit Model ◽  
Type I ◽  
Calcium Phosphate Bone Cement ◽  
Osteogenic Effect ◽  
Composite Bone

This study aimed to evaluate the effectiveness of a novel calcitonin-loaded calcium phosphate composite bone cement in vitro and in vivo. The novel composite bone cements were composed of NuROs injectable bone graft substitute, type I collagen, and/or salmon calcitonin. The setting time, porosity, wettability, compressive strength, compressive modulus, and crystallographic structures of cement specimens were determined. Degradation rate, calcitonin release rate, and osteoinductivity were assessed in vitro. In addition, osteogenic effect was examined in a rabbit model of femoral defect. The results revealed that addition of collagen/calcitonin did not substantially alter physical properties and degradation rate of bone cement specimens. Calcitonin was released into culture medium in a two-phase manner. Osteogenic effect of conditioned medium derived from calcitonin containing bone cement was observed. Finally, de novo bone growth and bone mineralization across the bone defect area were observed in rabbits after implantation of composite bone cement specimens. In conclusion, this novel calcitonin-loaded composite calcium phosphate bone cement exhibits biocompatibility, bioresorbability, osteoinductivity, and osteoconductivity, which may be suitable for clinical use.

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