scholarly journals Biological Evaluation of Flexible Polyurethane/Poly l-Lactic Acid Composite Scaffold as a Potential Filler for Bone Regeneration

Materials ◽  
2017 ◽  
Vol 10 (9) ◽  
pp. 1042 ◽  
Author(s):  
◽  
Keyword(s):  
Lactic Acid ◽  
Bone Regeneration ◽  
Composite Scaffold ◽  
Biological Evaluation ◽  
Flexible Polyurethane

Enhanced Bone Regeneration Using a ZIF‐8‐loaded Fibrin Composite Scaffold

2021 ◽  
pp. 2100416
Author(s):  
Wentao Shi ◽  
Lu Bian ◽  
Yiqing Wu ◽  
Zhe Wang ◽  
Yao Dai ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Composite Scaffold

scholarly journals Angiogenin-loaded fibrin/bone powder composite scaffold for vascularized bone regeneration

2015 ◽  
Vol 19 (1) ◽  
Author(s):  
Beom-Su Kim ◽  
Jin-Seong Kim ◽  
Sun-Sik Yang ◽  
Hyung-Woo Kim ◽  
Hun Jun Lim ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Composite Scaffold ◽  
Powder Composite ◽  
Bone Powder ◽  
Vascularized Bone

Biological Evaluation of Chitosan Nanofiber Membrane for Guided Bone Regeneration

2005 ◽  
Vol 76 (10) ◽  
pp. 1778-1784 ◽  
Author(s):  
Seung-Yun Shin ◽  
Ho-Nam Park ◽  
Kyoung-Hwa Kim ◽  
Myung-Hee Lee ◽  
Young Suk Choi ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Biological Evaluation ◽  
Guided Bone Regeneration ◽  
Nanofiber Membrane ◽  
Chitosan Nanofiber

Preparation of Nano-Fibrous Poly(L-lactic acid) Scaffold with Hierarchical Pores

2011 ◽  
Vol 418-420 ◽  
pp. 303-306
Author(s):  
Xue Jun Wang ◽  
Tao Lou ◽  
Guo Jun Song
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Pore Size ◽  
Composite Scaffold ◽  
Compressive Modulus ◽  
High Porosity ◽  
Nano Composite ◽  
Hierarchical Pores ◽  
Fiber Size ◽  
Hierarchical Pore

In this study, a nano-fibrous PLLA scaffold with hierarchical pore was sucessfully fabricated using combined TIPS and particle leaching method.The scaffold had a nano-fibrous PLLA matrix (fiber size 100-800 nm), an interconnective hierarchical pores (1.0- 425 μm), high porosity (>96%). The compressive modulus of scaffold with different pore size was between 0.16 MPa to 0.2 Mpa and it decreased with the increased salt size embedded in. The new nano composite scaffold is potentially a very promising scaffold for tissue engineering.

scholarly journals A Comparative Study of Bioartificial Bone Tissue Poly-L-lactic Acid/Polycaprolactone and PLLA Scaffolds Applied in Bone Regeneration

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Weizong Weng ◽  
Shaojun Song ◽  
Liehu Cao ◽  
Xiao Chen ◽  
Yuanqi Cai ◽  
...  
Keyword(s):  
Lactic Acid ◽  
New Zealand ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Bone Defect ◽  
Mineral Density ◽  
Group A ◽  
Repair Bone Defect ◽  
Group B ◽  
New Zealand Rabbits

Bioartificial bone tissue engineering is an increasingly popular technique to repair bone defect caused by injury or disease. This study aimed to investigate the feasibility of PLLA/PCL (poly-L-lactic acid/polycaprolactone) by a comparison study of PLLA/PCL and PLLA scaffolds applied in bone regeneration. Thirty healthy mature New Zealand rabbits on which 15 mm distal ulna defect model had been established were selected and then were divided into three groups randomly: group A (repaired with PLLA scaffold), group B (repaired with PLLA/PCL scaffold), and group C (no scaffold) to evaluate the bone-remodeling ability of the implants. Micro-CT examination revealed the prime bone regeneration ability of group B in three groups. Bone mineral density of surgical site in group B was higher than group A but lower than group C. Meanwhile, the bone regeneration in both groups A and B proceeded with signs of inflammation for the initial fast degradation of scaffolds. As a whole, PLLA/PCL scaffoldsin vivoinitially degrade fast and were better suited to repair bone defect than PLLA in New Zealand rabbits. Furthermore, for the low mineral density of new bone and rapid degradation of the scaffolds, more researches were necessary to optimize the composite for bone regeneration.

scholarly journals Injectable Alginate-Peptide Composite Hydrogel as a Scaffold for Bone Tissue Regeneration

Nanomaterials ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 497 ◽  
Author(s):  
Moumita Ghosh ◽  
Michal Halperin-Sternfeld ◽  
Itzhak Grinberg ◽  
Lihi Adler-Abramovich
Keyword(s):  
Extracellular Matrix ◽  
Bone Regeneration ◽  
Composite Scaffold ◽  
Three Dimensional ◽  
Composite Hydrogel ◽  
Bone Tissue Regeneration ◽  
Pcr Analysis ◽  
Alizarin Red ◽  
In Vitro Biocompatibility

The high demand for tissue engineering scaffolds capable of inducing bone regeneration using minimally invasive techniques prompts the need for the development of new biomaterials. Herein, we investigate the ability of Alginate incorporated with the fluorenylmethoxycarbonyl-diphenylalanine (FmocFF) peptide composite hydrogel to serve as a potential biomaterial for bone regeneration. We demonstrate that the incorporation of the self-assembling peptide, FmocFF, in sodium alginate leads to the production of a rigid, yet injectable, hydrogel without the addition of cross-linking agents. Scanning electron microscopy reveals a nanofibrous structure which mimics the natural bone extracellular matrix. The formed composite hydrogel exhibits thixotropic behavior and a high storage modulus of approximately 10 kPA, as observed in rheological measurements. The in vitro biocompatibility tests carried out with MC3T3-E1 preosteoblast cells demonstrate good cell viability and adhesion to the hydrogel fibers. This composite scaffold can induce osteogenic differentiation and facilitate calcium mineralization, as shown by Alizarin red staining, alkaline phosphatase activity and RT-PCR analysis. The high biocompatibility, excellent mechanical properties and similarity to the native extracellular matrix suggest the utilization of this hydrogel as a temporary three-dimensional cellular microenvironment promoting bone regeneration.

scholarly journals Biomimetic and osteogenic 3D silk fibroin composite scaffolds with nano MgO and mineralized hydroxyapatite for bone regeneration

2020 ◽  
Vol 11 ◽  
pp. 204173142096779
Author(s):  
Ziquan Wu ◽  
Zhulong Meng ◽  
Qianjin Wu ◽  
Delu Zeng ◽  
Zhengdong Guo ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Bone Repair ◽  
Composite Scaffold ◽  
Bone Tissue Regeneration ◽  
Bone Mesenchymal Stem Cells ◽  
Differentiation Potential ◽  
Composite Effect ◽  
Sd Rat

Artificial bioactive materials have received increasing attention worldwide in clinical orthopedics to repair bone defects that are caused by trauma, infections or tumors, especially dedicated to the multifunctional composite effect of materials. In this study, a weakly alkaline, biomimetic and osteogenic, three-dimensional composite scaffold (3DS) with hydroxyapatite (HAp) and nano magnesium oxide (MgO) embedded in fiber (F) of silkworm cocoon and silk fibroin (SF) is evaluated comprehensively for its bone repair potential in vivo and in vitro experiments, particularly focusing on the combined effect between HAp and MgO. Magnesium ions (Mg2+) has long been proven to promote bone tissue regeneration, and HAp is provided with osteoconductive properties. Interestingly, the weak alkaline microenvironment from MgO may also be crucial to promote Sprague-Dawley (SD) rat bone mesenchymal stem cells (BMSCs) proliferation, osteogenic differentiation and alkaline phosphatase (ALP) activities. This SF/F/HAp/nano MgO (SFFHM) 3DS with superior biocompatibility and biodegradability has better mechanical properties, BMSCs proliferation ability, osteogenic activity and differentiation potential compared with the scaffolds adding HAp or MgO alone or neither. Similarly, corresponding meaningful results are also demonstrated in a model of distal lateral femoral defect in SD rat. Therefore, we provide a promising 3D composite scaffold for promoting bone regeneration applications in bone tissue engineering.

In-vitro and in-vivo studies of PLA / PCL / gelatin composite scaffold containing ascorbic acid for bone regeneration

2020 ◽  
pp. 102077 ◽  
Author(s):  
Seyedeh Fatemeh Hashemi ◽  
Mohsen Mehrabi ◽  
Arian Ehterami ◽  
Anneh Mohammad Gharravi ◽  
Fateme Sadat Bitaraf ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Bone Regeneration ◽  
Composite Scaffold ◽  
In Vivo Studies

Mineralization of nanohydroxyapatite on electrospun poly(l-lactic acid)/gelatin by an alternate soaking process: A biomimetic scaffold for bone regeneration

2012 ◽  
Vol 27 (4) ◽  
pp. 356-374 ◽  
Author(s):  
Amit Kumar Jaiswal ◽  
Vikash Chandra ◽  
Ramesh R Bhonde ◽  
Vivek Prithviraj Soni ◽  
Jayesh Ramesh Bellare
Keyword(s):  
Lactic Acid ◽  
Bone Regeneration ◽  
Biomimetic Scaffold
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