scholarly journals Bilayer Poly(Lactic-co-glycolic acid)/Nano-Hydroxyapatite Membrane with Barrier Function and Osteogenesis Promotion for Guided Bone Regeneration

Materials ◽  
2017 ◽  
Vol 10 (3) ◽  
pp. 257 ◽  
Author(s):  
Li Fu ◽  
Zhanfeng Wang ◽  
Shujun Dong ◽  
Yan Cai ◽  
Yuxin Ni ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Barrier Function ◽  
Glycolic Acid ◽  
Guided Bone Regeneration

scholarly journals Comparative In Vivo Analysis of the Integration Behavior and Immune Response of Collagen-Based Dental Barrier Membranes for Guided Bone Regeneration (GBR)

Membranes ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 712
Author(s):  
Milena Radenković ◽  
Said Alkildani ◽  
Ignacio Stoewe ◽  
James Bielenstein ◽  
Bernd Sundag ◽  
...  
Keyword(s):  
Wound Healing ◽  
Bone Regeneration ◽  
Barrier Function ◽  
Guided Bone Regeneration ◽  
Collagen Membrane ◽  
Cellular Infiltration ◽  
Barrier Membranes ◽  
Tissue Integration ◽  
Tissue Reactions

Collagen-based resorbable barrier membranes have been increasingly utilized for Guided Bone Regeneration (GBR), as an alternative to non-resorbable synthetic membranes that require a second surgical intervention for removal. One of the most important characteristics of a resorbable barrier membrane is its mechanical integrity that is required for space maintenance and its tissue integration that plays a crucial role in wound healing and bone augmentation. This study compares a commercially available porcine-derived sugar-crosslinked collagen membrane with two non-crosslinked collagen barrier membranes. The material analysis provides an insight into the influence of manufacturing on the microstructure. In vivo subcutaneous implantation model provides further information on the host tissue reaction of the barrier membranes, as well as their tissue integration patterns that involve cellular infiltration, vascularization, and degradation. The obtained histochemical and immunohistochemical results over three time points (10, 30, and 60 days) showed that the tissue response to the sugar crosslinked collagen membrane involves inflammatory macrophages in a comparable manner to the macrophages observed in the surrounding tissue of the control collagen-based membranes, which were proven as biocompatible. The tissue reactions to the barrier membranes were additionally compared to wounds from a sham operation. Results suggest wound healing properties of all the investigated barrier membranes. However, the sugar-crosslinked membrane lacked in cellular infiltration and transmembraneous vascularization, providing an exclusive barrier function in GBR. Moreover, this membrane maintained a similar swelling ratio over examined timepoints, which suggests a very slow degradation pattern and supports its barrier function. Based on the study results, which showed biocompatibility of the sugar crosslinked membrane and its stability up to 60 days post-implantation, it can be concluded that this membrane may be suitable for application in GBR as a biomaterial with exclusive barrier functionality, similar to non-resorbable options.

Influence of calcium phosphates incorporation into poly(lactic-co-glycolic acid) electrospun membranes for guided bone regeneration

2020 ◽  
Vol 179 ◽  
pp. 109253
Author(s):  
Vivian Inês dos Santos ◽  
Claudia Merlini ◽  
Águedo Aragones ◽  
Karina Cesca ◽  
Márcio Celso Fredel
Keyword(s):  
Bone Regeneration ◽  
Glycolic Acid ◽  
Calcium Phosphates ◽  
Guided Bone Regeneration ◽  
Electrospun Membranes

scholarly journals Examination of Optimal Concentrations of Poly (Lactic-co-glycolic Acid) in Hexafluoroisopropyl Alcohol for Guided Bone Regeneration Membrane Prepared by Electrospinning

2020 ◽  
Vol 18 (3-4) ◽  
pp. 239-247
Author(s):  
Daisuke Isaji ◽  
Takehiro Watanabe ◽  
Takahiro Takahashi ◽  
Hiroki Sato ◽  
Hiroshi Nakada ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Glycolic Acid ◽  
Guided Bone Regeneration

Guided bone regeneration by poly(lactic-co-glycolic acid) grafted hyaluronic acid bi-layer films for periodontal barrier applications

2009 ◽  
Vol 5 (9) ◽  
pp. 3394-3403 ◽  
Author(s):  
Jung Kyu Park ◽  
Junseok Yeom ◽  
Eun Ju Oh ◽  
Mallikarjuna Reddy ◽  
Jong Young Kim ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Bone Regeneration ◽  
Glycolic Acid ◽  
Guided Bone Regeneration

Importance of Poly(lactic-co-glycolic acid) in Scaffolds for Guided Bone Regeneration: A Focused Review

2015 ◽  
Vol 41 (4) ◽  
pp. e152-e157 ◽  
Author(s):  
Gabriel Castillo-Dalí ◽  
Rocío Velázquez-Cayón ◽  
M. Angeles Serrera-Figallo ◽  
Agustín Rodríguez-González-Elipe ◽  
José-Luis Gutierrez-Pérez ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Bone Repair ◽  
Glycolic Acid ◽  
Guided Bone Regeneration ◽  
Future Research ◽  
Loss Of Function ◽  
Important Health

Total or partial tissue damage and loss of function in an organ are two of the most serious and costly issues in human health. Initially, these problems were approached through organ and allogenic tissue transplantation, but this option is limited by the scarce availability of donors. In this manner, new bone for restoring or replacing lost and damaged bone tissue is an important health and socioeconomic necessity. Tissue engineering has been used as a strategy during the 21st century for mitigating this need through the development of guided bone regeneration scaffold and composites. In this manner, compared with other traditional methods, bone tissue engineering offers a new and interesting approach to bone repair. The poly-α-hydroxy acids, which include the copolymers of lactic acid and glycolic acid, have been used commonly in the fabrication of these scaffolds. The objective of our article was to review the characteristics and functions of scaffold with biomedical applications, with special interest in scaffold construction using poly(lactic-co-glycolic acid) polymers, in order to update the current methods used for fabrication and to improve the quality of these scaffolds, integrating this information into the context of advancements made in tissue engineering based on these structures. In the future, research into bone regeneration should be oriented toward a fruitful exchange between disciplines involved in tissue engineering, which is coming very close to filling the gaps in our ability to provide implants and restoration of functionality in bone tissue. Overcoming this challenge will provide benefits to a major portion of the population and facilitate substantial improvements to quality of life.

scholarly journals Effect of Attapulgite-Doped Electrospun Fibrous PLGA Scaffold on Pro-Osteogenesis and Barrier Function in the Application of Guided Bone Regeneration

2020 ◽  
Vol Volume 15 ◽  
pp. 6761-6777
Author(s):  
XinRu Xie ◽  
Xiangyang Shi ◽  
Shaoyi Wang ◽  
Lingyan Cao ◽  
Chi Yang ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Barrier Function ◽  
Guided Bone Regeneration ◽  
Plga Scaffold

Development and structure of a novel barrier membrane composed of drug-loaded poly(lactic-co-glycolic acid) particles for guided bone regeneration

2011 ◽  
Vol 34 (4) ◽  
pp. 779-787 ◽  
Author(s):  
Jun-Sik Son ◽  
Su-Gwan Kim ◽  
Seung-Chan Jin ◽  
Zheng-Gang Piao ◽  
Sook-Young Lee ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Glycolic Acid ◽  
Guided Bone Regeneration ◽  
Barrier Membrane
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