scholarly journals (R)-7-(Azepan-3-ylamino)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid Hydrochloride

Molbank ◽  
10.3390/m801 ◽  
2013 ◽  
Vol 2013 (2) ◽  
pp. M801
Author(s):  
Zhengjun Xia ◽  
Zaixin Chen ◽  
Shuitao Yu
Keyword(s):  
Carboxylic Acid ◽  
Acid Hydrochloride

SYNTHESIS OF AMINO ACIDS FROM SUBSTITUTED CYANOACETIC ESTERS

1948 ◽  
Vol 26b (7) ◽  
pp. 503-510 ◽  
Author(s):  
Paul E. Gagnon ◽  
Jean L. Boivin
Keyword(s):  
Amino Acids ◽  
Carboxylic Acid ◽  
Hydrochloric Acid ◽  
Aminobutyric Acid ◽  
Acid Hydrochloride ◽  
First Time ◽  
Hydrolysis Of

Nine α-amino acids, namely, dl-alanine, dl-α-aminobutyric acid, dl-α-ammoenanthic acid, dl-α-amino-γ-phenoxybutyric acid, dl-C-phenylglycine, dl-proline, dl-ornithine, dl-lysine and 2-aminoindane-2-carboxylic acid have been prepared from α-substituted cyanoacetic esters. Pyrrolidine or piperidine was isolated when it was attempted to prepare ornithine or lysine by hydrolysis of diurethanes with hydrochloric acid. When a mixture of formic and hydrochloric acids and water was used as hydrolyzing agent, ornithine or lysine was obtained in low yield in addition to traces of pyrrolidine or piperidine. The following compounds, as far as the authors are aware, have been prepared for the first time: α-cyanopropionhydrazide, benzal α-cyanopropionhydrazide, α-cyanopropionic azide, α-carbethoxyaminopropiononitrile, α-cyanobutyrhydrazide, benzal α-cyanobutyrhydrazide, α-cyanobutyric azide, α-carbethoxyaminobutyronitrile, ethyl α-cyanoenanthate, α-cyanoenanthic hydrazide, benzal α-cyanoenanthic hydrazide, α-cyanoenanthic azide, α-carbethoxyaminoenanthonitrile, 5-(n-amyl)-hydantoin, ethyl α-cyano-γ-phenoxybutyrate, ethyl bis-β-phenoxyethylmalonate mononitrile, α-cyano-γ-phenoxybutyrhydrazide, benzal α-cyano-γ-phenoxybutyrhydrazide, α-cyano-γ-phenoxybutyric azide, α-carbethoxyamino-γ-phenoxybutyronitrile, 5-(β-phenoxyethyl)-hydantoin, α-cyano-α-phenylacethydrazide, benzal α-cyano-α-phenylacethydrazide, α-cyano-α-phenylacetic azide, ethyl δ-bromo-α-cyanovalerate, δ-bromo-α-cyanovalerhydrazide, benzal δ-bromo-α-cyanovalerhydrazide, δ-bromo-α-cyanovaleric azide, δ-bromo-α-carbethoxyaminovaleronitrile, dibenzal α-cyanoadipic dihydrazide, α-cyanoadipic diazide, α,δ-dicarbethoxyaminoadiponitrile, dibenzal α-cyanopimelic dihydrazide, α-cyanopimelic diazide, α, ε-dicarbethoxyaminocapronitrile, 2-cyano-2-carbethoxyindane, 2-cyano-2-carboxylindane hydrazide, benzal 2-cyano-2-carboxylindane hydrazide, 2-cyano-2-carboxylindane azide, 2-cyano-2-carbethoxyaminoindane, 2-aminoindane-2-carboxylic acid, 2-aminoindane-2-carboxylic acid hydrochloride.

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