Asymmetric Synthesis of a New Monocyclic β-Lactam as a potential biological active compound

Molbank ◽  
10.3390/m439 ◽  
2005 ◽  
Vol 2005 (4) ◽  
pp. M439 ◽  
Author(s):  
A. A. Jarrahpour ◽  
A. R. Jahaniani
Keyword(s):  
Asymmetric Synthesis ◽  
Active Compound ◽  
Biological Active Compound

scholarly journals An Alternative Enzymatic Route to the Ergogenic Ketone Body Ester (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate

Catalysts ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 140
Author(s):  
Ferdinando Zaccone ◽  
Valentina Venturi ◽  
Pier Paolo Giovannini ◽  
Claudio Trapella ◽  
Marco Narducci ◽  
...  
Keyword(s):  
Vinyl Acetate ◽  
Active Compound ◽  
Enzymatic Synthesis ◽  
Ketone Body ◽  
Kinetic Resolution ◽  
Candida Antarctica Lipase B ◽  
Candida Antarctica Lipase ◽  
Synthetic Pathway ◽  
Enzymatic Route ◽  
Biological Active Compound

Recent studies have highlighted the therapeutic and ergogenic potential of the ketone body ester, (R)-3-hydroxybutyl-(R)-3-hydroxybutyrate. In the present work, the enzymatic synthesis of this biological active compound is reported. The (R)-3-hydroxybutyl-(R)-3-hydroxybutyrate has been produced through the transesterification of racemic ethyl 3-hydroxybutyrate with (R)-1,3-butanediol by exploiting the selectivity of Candida antarctica lipase B (CAL-B). The needed (R)-1,3-butanediol was in turn obtained from the kinetic resolution of the racemate achieved by acetylation with vinyl acetate, also in this case, thanks to the enantioselectivity of the CAL-B used as catalyst. Finally, the stereochemical inversion of the unreacted (S) enantiomers of the ethyl 3-hydroxybutyate and 1,3-butanediol accomplished by known procedure allowed to increase the overall yield of the synthetic pathway by incorporating up to 70% of the starting racemic reagents into the final product.

scholarly journals Asymmetric Synthesis and Cytotoxicity Evaluation of Right-Half Models of Antitumor Renieramycin Marine Natural Products

Marine Drugs ◽  
2018 ◽  
Vol 17 (1) ◽  
pp. 3 ◽  
Author(s):  
Takehiro Matsubara ◽  
Masashi Yokoya ◽  
Natchanun Sirimangkalakitti ◽  
Naoki Saito
Keyword(s):  
Prostate Cancer ◽  
Colorectal Cancer ◽  
Natural Products ◽  
Asymmetric Synthesis ◽  
Active Compound ◽  
Hct116 Cell ◽  
Human Prostate Cancer ◽  
Model Compounds ◽  
Structure Activity ◽  
Sar Study

A general protocol for the asymmetric synthesis of 3-N-arylmethylated right-half model compounds of renieramycins was developed, which enabled structure–activity relationship (SAR) study of several 3-N-arylmethyl derivatives. The most active compound (6a) showed significant cytotoxic activity against human prostate cancer DU145 and colorectal cancer HCT116 cell lines (IC50 = 11.9, and 12.5 nM, respectively).

Pd/C-catalyzed synthesis of oxamates by oxidative cross double carbonylation of alcohols and tertiary amines through C–N bond cleavage

2019 ◽  
Vol 43 (46) ◽  
pp. 18072-18078 ◽  
Author(s):  
Yuvraj A. Kolekar ◽  
Bhalchandra M. Bhanage
Keyword(s):  
Active Compound ◽  
Bond Cleavage ◽  
Tertiary Amines ◽  
Carbonylation Reaction ◽  
Palladium Catalyzed ◽  
Biological Active Compound

Palladium-catalyzed oxidative cross double carbonylation reaction between tertiary amines and alcohols using oxidant O2 and KI as the additive affords oxamates. Oxamate are as a intermediate in biological active compound and glycol synthesis.

TLC-bioautography linked with guess: A truely targeted active compound isolation process

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
EM Grzelak ◽  
Y Liu ◽  
JW Nam ◽  
JB Friesen ◽  
SN Chen ◽  
...  
Keyword(s):  
Active Compound ◽  
Tlc Bioautography

Hepatoprotective effects of Artemisia princeps and its active compound eupatilin against oxidative stress

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
KH Jegal ◽  
EH Jung ◽  
SM Park ◽  
IJ Cho ◽  
SC Kim
Keyword(s):  
Oxidative Stress ◽  
Active Compound ◽  
Artemisia Princeps ◽  
Hepatoprotective Effects
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