scholarly journals Synthesis of Flavonoids or Other Nature-Inspired Small Molecules

Molbank ◽  
10.3390/m1313 ◽  
2022 ◽  
Vol 2022 (1) ◽  
pp. M1313
Author(s):  
Giovanni Ribaudo
Keyword(s):  
Small Molecules ◽  
Functional Groups ◽  
Natural Compounds ◽  
Stereochemical Properties

Natural compounds are endowed with an intriguing variety of scaffolds, functional groups and stereochemical properties [...]

Broad Assessment of Bioactivity of a Collection of Spiroindane Pyrrolidines Through “Cell Painting”

2020 ◽  
Author(s):  
Zarko Boskovic ◽  
Manvendra Singh ◽  
Zachary Pearson ◽  
Nathan Garza
Keyword(s):  
Biological Activity ◽  
Small Molecules ◽  
Functional Groups ◽  
Organelle Morphology

A collection of small molecules has been synthesized by composing photo-cycloaddition, C-H functionalization, and N-capping strategies. Multidimensional biological fingerprints of molecules comprising this collection have been recorded as changes in cell and organelle morphology. This untargeted, phenotypic approach allowed for a broad assessment of biological activity to be determined. Reproducibility and the magnitude of measured fingerprints revealed activity of several treatments. Reactive functional groups, such as imines, dominated the observed activity. Two non-reactive candidate compounds with distinct bioactivity fingerprints were identified, as well.

Natural Compounds (Small Molecules) as Potential and Real Drugs of Alzheimer's Disease

2014 ◽  
pp. 153-194 ◽  
Author(s):  
Lucie Cahlíková ◽  
Kateřina Macáková ◽  
Nina Benešová ◽  
Jakub Chlebek ◽  
Anna Hošťálková ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Small Molecules ◽  
Natural Compounds

Targeting the phosphoinositide 3-kinase/AKT pathways by small molecules and natural compounds as a therapeutic approach for breast cancer cells

2019 ◽  
Vol 46 (5) ◽  
pp. 4809-4816 ◽  
Author(s):  
Amin Soltani ◽  
Samira Torki ◽  
Milad Sabzevary Ghahfarokhi ◽  
Mohammad Saied Jami ◽  
Mahdi Ghatrehsamani
Keyword(s):  
Breast Cancer ◽  
Small Molecules ◽  
Cancer Cells ◽  
Therapeutic Approach ◽  
Breast Cancer Cells ◽  
Natural Compounds ◽  
Phosphoinositide 3 Kinase

scholarly journals Reactivity of Copper Electrodes towards Functional Groups and Small Molecules in the Context of CO2 Electro-Reductions

Catalysts ◽  
2017 ◽  
Vol 7 (5) ◽  
pp. 161 ◽  
Author(s):  
Bernhard Schmid ◽  
Christian Reller ◽  
Sebastian Neubauer ◽  
Maximilian Fleischer ◽  
Romano Dorta ◽  
...  
Keyword(s):  
Small Molecules ◽  
Functional Groups ◽  
Copper Electrodes

Broad Assessment of Bioactivity of a Collection of Spiroindane Pyrrolidines Through “Cell Painting”

2020 ◽  
Author(s):  
Zarko Boskovic ◽  
Manvendra Singh ◽  
Zachary Pearson ◽  
Nathan Garza
Keyword(s):  
Biological Activity ◽  
Small Molecules ◽  
Functional Groups ◽  
Organelle Morphology

A collection of small molecules has been synthesized by composing photo-cycloaddition, C-H functionalization, and N-capping strategies. Multidimensional biological fingerprints of molecules comprising this collection have been recorded as changes in cell and organelle morphology. This untargeted, phenotypic approach allowed for a broad assessment of biological activity to be determined. Reproducibility and the magnitude of measured fingerprints revealed activity of several treatments. Reactive functional groups, such as imines, dominated the observed activity. Two non-reactive candidate compounds with distinct bioactivity fingerprints were identified, as well.

scholarly journals Fungi-Mediated Biotransformation of the Isomeric Forms of the Apocarotenoids Ionone, Damascone and Theaspirane

Molecules ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 19 ◽  
Author(s):  
Stefano Serra ◽  
Davide De Simeis
Keyword(s):  
Double Bond ◽  
Functional Groups ◽  
Chemical Compound ◽  
Natural Compounds ◽  
Fungal Species ◽  
Minor Amount ◽  
Natural Form ◽  
Active Compounds ◽  
Reduced Products ◽  
Oxidized Products

In this work, we describe a study on the biotransformation of seven natural occurring apocarotenoids by means of eleven selected fungal species. The substrates, namely ionone (α-, β- and γ-isomers), 3,4-dehydroionone, damascone (α- and β-isomers) and theaspirane are relevant flavour and fragrances components. We found that most of the investigated biotransformation reactions afforded oxidized products such as hydroxy- keto- or epoxy-derivatives. On the contrary, the reduction of the keto groups or the reduction of the double bond functional groups were observed only for few substrates, where the reduced products are however formed in minor amount. When starting apocarotenoids are isomers of the same chemical compound (e.g., ionone isomers) their biotransformation can give products very different from each other, depending both on the starting substrate and on the fungal species used. Since the majority of the starting apocarotenoids are often available in natural form and the described products are natural compounds, identified in flavours or fragrances, our biotransformation procedures can be regarded as prospective processes for the preparation of high value olfactory active compounds.

scholarly journals Harnessing the Intrinsic Photochemistry of Isoxazoles for the Development of Chemoproteomic Crosslinking Methods

2021 ◽  
Author(s):  
Marshall G. Lougee ◽  
Vinayak Vishnu Pagar ◽  
Hee Jong Kim ◽  
Samantha X. Pancoe ◽  
Robert H. Mach ◽  
...  
Keyword(s):  
Protein Binding ◽  
Small Molecules ◽  
Functional Groups ◽  
Ex Vivo ◽  
Initial Report ◽  
Biologically Relevant ◽  
Fine Grained ◽  
Wide Range ◽  
Unique Method

Photo-crosslinking is a powerful technique for identifying both coarse- and fine-grained information on protein binding by small molecules. However, the scope of useful functional groups remains limited, with most studies focusing on diazirine, aryl azide, or benzophenone-containing molecules. Here, we report a unique method for photo-crosslinking, employing the intrinsic photochemistry of the isoxazole, a common heterocycle in medicinal chemistry, to offer an alternative to existing strategies using more perturbing, extrinsic crosslinkers. In this initial report, this technique is applied both in vitro and ex vivo, used in a variety of common chemoproteomic workflows, and validated across multiple proteins, demonstrating the utility of isoxazole photo-crosslinking in a wide range of biologically relevant experiments.

Silver-Promoted Versatile Cross-Dehydrogenative Coupling of Quinaldine with Usual Ethers

Synlett ◽  
2019 ◽  
Vol 30 (18) ◽  
pp. 2096-2100 ◽  
Author(s):  
Shoufeng Wang ◽  
Yafei Fan ◽  
Huaiqing Zhao ◽  
Jianfeng Wang ◽  
Shuxiang Zhang ◽  
...  
Keyword(s):  
Small Molecules ◽  
Functional Groups ◽  
Dehydrogenative Coupling ◽  
Convenient Route

The application of small molecules as synthetic blocks is a field of great meaning and full of challenges, especially the use of inert ether molecules, such as THF as starting materials. A versatile and easily handled cross-dehydrogenative coupling between ethers and quinaldine is reported here. Compared to the developed reaction, Selectfluor is used as a mild oxidant, and a variety of functional groups are tolerated. Nitrogen protection, anhydrous systems, and external base are not needed, making this method a convenient route to functional heterocycles.

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