scholarly journals (R,S)-2-{[4-(4-Methylphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl]thio}-1-phenyl-1-ethanol

Molbank ◽  
10.3390/m1241 ◽  
2021 ◽  
Vol 2021 (3) ◽  
pp. M1241
Author(s):  
Vladislav-Silvestru Valicsek ◽  
Valentin Badea

4-(4-Methylphenyl)-5-phenyl-4H-1,2,4-triazol-3-thiol (4) was alkylated to 2-{[4-(4-methylphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl]thio}-1-phenylethan-1-one (5) in alkaline conditions using 2-bromo-1-phenylethanone. The alkylated compound (5) was reduced at the carbonyl group to the corresponding racemic secondary alcohol with an asymmetric carbon, (R,S)-2-{[4-(4-methylphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl]thio}-1-phenyl-1-ethanol (6). Both synthesized compounds, ketone (5) and secondary alcohol (6), are new and have not yet been reported in the literature. All the synthesized compounds were characterized by IR, 1D and 2D 1H-1H, 1H-13C and 1H-15N NMR spectroscopy and by elemental analysis.

Molbank ◽  
10.3390/m1231 ◽  
2021 ◽  
Vol 2021 (2) ◽  
pp. M1231
Author(s):  
Flavius-Gabriel Wurfer ◽  
Valentin Badea

4-(4-Methoxyphenyl)-5-phenyl--4H-1,2,4-triazole-3-thiol (4) was alkylated to 2-{[4-(-4-methoxyphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl]thio}-1-phenylethan-1-one (5) in alkaline conditions using 2-bromo-1-phenylethanone. The alkylated compound (5) was reduced at the carbonyl group to the corresponding racemic secondary alcohol with an asymmetric carbon, (R,S)-2-{[4-(4-methoxyphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl]thio}-1-phenyl-1-ethanol (6). Both synthesized compounds, ketone (5) and secondary alcohol (6), are new and have not been reported yet in the literature. All the synthesized compounds were characterized by IR, 1D and 2D NMR 1H-1H, 1H-13C and 1H-15N-NMR spectroscopy and by elemental analysis.


Molbank ◽  
10.3390/m1268 ◽  
2021 ◽  
Vol 2021 (3) ◽  
pp. M1268
Author(s):  
Milenca Mariana Vorga ◽  
Valentin Badea

The novel racemic secondary alcohol (±)-2-{[4-(4-bromophenyl)-5-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}-1-phenyl-1-ethanol (12) has been successfully synthesized through S-alkylation of 4-(4-bromophenyl)-5-phenyl-4H-1,2,4-triazole-3-thiol (10) in alkaline medium with 2-bromo-1-phenylethanone followed by reduction of the corresponding ketone 11. All the synthesized compounds were characterized by IR, 1D (1H, 13C, DEPT135) and 2D (1H-1H, 1H-13C and 1H-15N) NMR spectroscopy, elemental analysis and HRMS spectrometry.


Polyhedron ◽  
2002 ◽  
Vol 21 (21) ◽  
pp. 2099-2105 ◽  
Author(s):  
Saeed Ahmad ◽  
Anvarhusein A. Isab ◽  
Abdul Rahman Al-Arfaj ◽  
Alan P. Arnold

ChemInform ◽  
2010 ◽  
Vol 33 (31) ◽  
pp. no-no
Author(s):  
Radek Marek ◽  
Antonin Lycka

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