scholarly journals 4′-(N-(Propan-1,2-dienyl)pyrrol-2-yl)-2,2′:6′,2″-terpyridine

Molbank ◽  
10.3390/m1142 ◽  
2020 ◽  
Vol 2020 (2) ◽  
pp. M1142 ◽  
Author(s):  
Jérôme Husson ◽  
Laurent Guyard
Keyword(s):  
Propargyl Bromide ◽  
Sole Product

A new pyrrole-substituted terpyridine derivative that possesses an allene moiety was obtained as an “unexpected” sole product during an attempt to alkylate the N-atom of pyrrole with propargyl bromide in order to obtain an alkyne-functionalized terpyridine.

Enzymatic Iodination of Maleic and Fumaric Acids Diethyl Esters

2009 ◽  
Vol 59 (12) ◽  
pp. 1400-1404
Author(s):  
Marius Tudorascu ◽  
Spiridon Oprea ◽  
Afrodita Doina Marculescu ◽  
Stefania Tudorascu
Keyword(s):  
Hydrogen Peroxide ◽  
Tartaric Acid ◽  
Disperse System ◽  
Hydrogen Peroxide Solution ◽  
Ultrasonic Pretreatment ◽  
Tartaric Acids ◽  
Inactive Form ◽  
Generating System ◽  
Sole Product

The mechanism of the enzymatic iodination process of diethylmaleate and diethylfumarate (which present no miscibility with water) in the presence of lactoperoxidase, both in diluted hydrogen peroxide solution and in a generating system of hydrogen peroxide using ammonium and calcium iodides as halide sources in disperse system (after an ultrasonic pretreatment) was studied. The obtained sole product (diethyl-2, 3-diiodosuccinate) after the enzymatic iodination process was directly hydrolyzed to a tartaric acid present in an optically inactive form. The mechanism of obtaining the intermediate and final products and respectively, the existence of both D, L-tartaric acid and meso-tartaric acids (as lithium bitartrates) were also investigated.

One-Pot, Regioselective Synthesis of Homopropargyl Alcohols using Propargyl Bromide and Carbonyl Compound by the Mg-mediated Reaction under Solvent-free Conditions

2020 ◽  
Vol 17 (6) ◽  
pp. 438-442
Author(s):  
Xiaofang Ma ◽  
Shunxi Li ◽  
Samrat Devaramani ◽  
Guohu Zhao ◽  
Daqian Xu
Keyword(s):  
Reaction Time ◽  
Organic Synthesis ◽  
Carbonyl Compounds ◽  
Solvent Free ◽  
Propargyl Bromide ◽  
Important Goal ◽  
One Pot ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
Volatile Organic

The elimination of volatile organic solvents in organic synthesis is the most important goal in “Green” chemistry. We report a simple, efficient and facile method for the addition of progargyl bromide to carbonyl compounds using Mg metal as a mediator under solvent-free conditions which could regioselectively generate homopropargyl alcohols efficiently in good to excellent yields. The procedure has advantages such as short reaction time, operationally simple, excellent product yields, high regioselectivity and organic solvent-free.

Mechanism of Degradation of Methyl Bromide and Propargyl Bromide in Soil

2000 ◽  
Vol 29 (4) ◽  
pp. 1322-1328 ◽  
Author(s):  
Sharon K. Papiernik ◽  
Jianying Gan ◽  
Scott R. Yates
Keyword(s):  
Methyl Bromide ◽  
Propargyl Bromide ◽  
Mechanism Of Degradation

Trimethylsilylation of Propargyl Chloride and Propargyl Bromide

1990 ◽  
Vol 20 (21) ◽  
pp. 3375-3378 ◽  
Author(s):  
H. D. Verkruijsse ◽  
L. Brandsma
Keyword(s):  
Propargyl Bromide

scholarly journals Identification and Elimination of the Competing N-Acetyldiaminopentane Pathway for Improved Production of Diaminopentane by Corynebacterium glutamicum

2010 ◽  
Vol 76 (15) ◽  
pp. 5175-5180 ◽  
Author(s):  
Stefanie Kind ◽  
Weol Kyu Jeong ◽  
Hartwig Schr�der ◽  
Oskar Zelder ◽  
Christoph Wittmann
Keyword(s):  
Corynebacterium Glutamicum ◽  
Parent Strain ◽  
Specific Growth ◽  
Comparative Transcriptome ◽  
Carbon Yield ◽  
Glucose Uptake Rate ◽  
Acetyl Coenzyme A ◽  
Single Deletion ◽  
Negative Growth ◽  
Sole Product

ABSTRACT The present work describes the development of a superior strain of Corynebacterium glutamicum for diaminopentane (cadaverine) production aimed at the identification and deletion of the underlying unknown N-acetyldiaminopentane pathway. This acetylated product variant, recently discovered, is a highly undesired by-product with respect to carbon yield and product purity. Initial studies with C. glutamicum DAP-3c, a previously derived tailor-made diaminopentane producer, showed that up to 20% of the product occurs in the unfavorable acetylated form. The strain revealed enzymatic activity for diaminopentane acetylation, requiring acetyl-coenzyme A (CoA) as a donor. Comparative transcriptome analysis of DAP-3c and its parent strain did not reveal significant differences in the expression levels of 17 potential candidates annotated as N-acetyltransferases. Targeted single deletion of several of the candidate genes showed NCgl1469 to be the responsible enzyme. NCgl1469 was functionally assigned as diaminopentane acetyltransferase. The deletion strain, designated C. glutamicum DAP-4, exhibited a complete lack of N-acetyldiaminopentane accumulation in medium. Hereby, the yield for diaminopentane increased by 11%. The mutant strain allowed the production of diaminopentane as the sole product. The deletion did not cause any negative growth effects, since the specific growth rate and glucose uptake rate remained unchanged. The identification and elimination of the responsible acetyltransferase gene, as presented here, display key contributions of a superior C. glutamicum strain producing diaminopentane as a future building block for bio-based polyamides.

Chlorination of some indole derivatives with ethyl N,N-dichlorocarbamate

1970 ◽  
Vol 48 (3) ◽  
pp. 422-428 ◽  
Author(s):  
J. M. Muchowski
Keyword(s):  
Carboxylic Acid ◽  
Indole Derivatives ◽  
Sole Product

The sole product obtained from the reaction of indole-2-carboxylic acid and ethyl N,N-dichlorocarbamate was 3,3,5-trichlorooxindole (7). In contrast, methyl indole-2-carboxylate gave a mixture of methyl-3,5-dichlorooxindole-3-carboxylate (10) and methyl-3,5,7-trichlorooxindole-3-carboxylate (11), the same products as obtained from the chlorination of methyl indole-3-carboxylate. The structures of these products were confirmed by degradation to known compounds and/or by synthesis, and mechanisms for their formation were suggested.

Structural preferences for the double bond position in some unsaturated 3,3-diphenylpyrrolidines

1970 ◽  
Vol 48 (23) ◽  
pp. 3742-3745 ◽  
Author(s):  
M. M. A. Hassan ◽  
A. F. Casy
Keyword(s):  
Double Bond ◽  
Methyl Iodide ◽  
Quaternary Salt ◽  
Double Bond Position ◽  
Magnesium Bromide ◽  
Free Base ◽  
Spectroscopic Evidence ◽  
Structural Preferences ◽  
Ethyl Magnesium Bromide ◽  
Sole Product

The reaction between 3,3-diphenyl-3-cyano-1-methylpropyl isocyanate and ethyl magnesium bromide leads to 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline rather than the isomeric 2-ethylidenepyrrolidine. The protonated N-methyl analogue (identical with a major metabolite of methadone) retains the 1-pyrroline structure, but the free base is a cis-trans mixture of the corresponding 2-ethylidenepyrrolidines; the cis Me/Ph isomer preponderates and is the sole product (obtained as a quaternary salt) when the mixture is treated with methyl iodide. 5-Methyl-2-methylene-3,3-diphenylpyrrolidine, a lower homologue of the methadone metabolite, isomerizes to a 1-pyrroline derivative when protonated or methylated. All structural conclusions are based on i.r. and p.m.r. spectroscopic evidence.

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