scholarly journals Irreversible Electroporation for Prostate Cancer

Life ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 490
Author(s):  
Sean Ong ◽  
Matthew Leonardo ◽  
Thilakavathi Chengodu ◽  
Dominic Bagguley ◽  
Nathan Lawrentschuk
Keyword(s):  
Prostate Cancer ◽  
Functional Outcomes ◽  
Irreversible Electroporation ◽  
Focal Therapy ◽  
Safe Procedure ◽  
Short Term ◽  
Electrical Currents ◽  
Treatment Side Effects ◽  
Oncological Outcomes ◽  
Treat All

Although it can be lethal in its advanced stage, prostate cancer can be effectively treated when it is localised. Traditionally, radical prostatectomy (RP) or radiotherapy (RT) were used to treat all men with localised prostate cancer; however, this has significant risks of post-treatment side effects. Focal therapy has emerged as a potential form of treatment that can achieve similar oncological outcomes to radical treatment while preserving functional outcomes and decreasing rates of adverse effects. Irreversible electroporation (IRE) is one such form of focal therapy which utilises pulsatile electrical currents to ablate tissue. This modality of treatment is still in an early research phase, with studies showing that IRE is a safe procedure that can offer good short-term oncological outcomes whilst carrying a lower risk of poor functional outcomes. We believe that based on these results, future well-designed clinical trials are warranted to truly assess its efficacy in treating men with localised prostate cancer.

scholarly journals Focal irreversible electroporation for prostate cancer: functional outcomes and short-term oncological control

2015 ◽  
Vol 19 (1) ◽  
pp. 46-52 ◽  
Author(s):  
F Ting ◽  
M Tran ◽  
M Böhm ◽  
A Siriwardana ◽  
P J Van Leeuwen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Functional Outcomes ◽  
Irreversible Electroporation ◽  
Short Term

scholarly journals Survival and functional and oncological outcomes following intersphincteric resection for low rectal cancer: short-term results

2018 ◽  
Vol 46 (4) ◽  
pp. 1617-1625 ◽  
Author(s):  
Călin Molnar ◽  
Butiurca Vlad-Olimpiu ◽  
Botoncea Marian ◽  
Togănel Cornelia ◽  
Gurzu Simona
Keyword(s):  
Rectal Cancer ◽  
Survival Rate ◽  
Functional Outcomes ◽  
Intersphincteric Resection ◽  
Low Rectal Cancer ◽  
Study Patient ◽  
Reference Ranges ◽  
Short Term ◽  
Wexner Score ◽  
Oncological Outcomes

Objective This study was performed to evaluate the 1-year survival rate and functional outcomes of 20 patients who underwent intersphincteric resection (ISR) for low rectal cancer. Methods Twenty patients who underwent ISR for low rectal cancer were followed up for 1 year. Complications, functional outcomes objectified by the Wexner score, and oncological outcomes were assessed. Results The short-term survival rate was 100%. The median Wexner score was ≤10 in all patients at 12 months after surgery. Signs of local recurrence were absent, and antigen levels remained within the reference ranges 1 year postoperatively. Conclusions ISR is a feasible alternative in highly selected patients who primarily refuse a colostomy bag and present with type II or III tumors. In the present study, patient-reported continence was satisfactory, and the absence of a colostomy bag increased patients’ quality of life. The oncological outcomes were satisfactory at 1 year postoperatively.

scholarly journals Focal Therapy for Prostate Cancer with In-Bore MR–guided Focused Ultrasound: Two-Year Follow-up of a Phase I Trial—Complications and Functional Outcomes

Radiology ◽  
2017 ◽  
Vol 285 (2) ◽  
pp. 620-628 ◽  
Author(s):  
Kae Jack Tay ◽  
Christopher W. S. Cheng ◽  
Weber K. O. Lau ◽  
James Khoo ◽  
Choon Hua Thng ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Phase I ◽  
Functional Outcomes ◽  
Phase I Trial ◽  
Focused Ultrasound ◽  
Focal Therapy

scholarly journals Summary of Oncologic and Functional Outcomes

2020 ◽  
Vol 33 (03) ◽  
pp. 150-156 ◽  
Author(s):  
Roel Hompes ◽  
Marta Penna
Keyword(s):  
Functional Data ◽  
Functional Outcomes ◽  
Transanal Total Mesorectal Excision ◽  
Mesorectal Excision ◽  
Short Term ◽  
Oncological Outcomes ◽  
Randomized Controlled ◽  
Collaborative Studies ◽  
And Function

AbstractLarge cohort and collaborative studies to date have shown that the short-term oncological outcomes appear to be at least as good as traditional laparoscopic surgery. These results need confirmation in randomized controlled trials, which are currently underway (GRECCAR 11 and COLOR III). The functional data on transanal total mesorectal excision is still very scarce and more mature data on quality of life and function outcomes are eagerly awaited.

Focal Therapy of Prostate Cancer Using Irreversible Electroporation

2015 ◽  
Vol 18 (3) ◽  
pp. 147-152 ◽  
Author(s):  
Massimo Valerio ◽  
Hashim U. Ahmed ◽  
Mark Emberton
Keyword(s):  
Prostate Cancer ◽  
Irreversible Electroporation ◽  
Focal Therapy

scholarly journals High-Intensity Focused Ultrasound (HIFU) Focal Therapy for Localized Prostate Cancer with MRI-US Fusion Platform

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Chi-Hang Yee ◽  
Peter Ka-Fung Chiu ◽  
Jeremy Yuen-Chun Teoh ◽  
Chi-Fai Ng ◽  
Chi-Kwok Chan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Functional Outcomes ◽  
Case Series ◽  
Focal Therapy ◽  
High Intensity Focused Ultrasound ◽  
Localized Prostate Cancer ◽  
Lesion Volume ◽  
Significant Difference ◽  
The Mean

Objective. The study aimed at investigating the outcome of prostate HIFU focal therapy using the MRI-US fusion platform for treatment localization and delivery. Methods. It is a prospectively designed case series of HIFU focal therapy for localized prostate cancer. The inclusion criteria include clinical tumor stage ≤T2, visible index lesion on multiparametric MRI less than 20 mm in diameter, absence of Gleason 5 pattern on prostate biopsy, and PSA ≤ 20 ng/ml. HIFU focal therapy was performed in the conventional manner in the beginning 50% of the series, whereas the subsequent cases were performed with MRI-US fusion platform. The primary outcome was treatment failure rate which is defined by the need of salvage therapy. Secondary outcomes included tumor recurrence in follow-up biopsy, PSA change, perioperative complications, and postoperative functional outcomes. Results. Twenty patients underwent HIFU focal ablation. HIFU on an MRI-US fusion platform had a trend of a longer total operative time than the conventional counterpart (124.2 min vs. 107.1 min, p = 0.066 ). There was no difference in the mean ablation volume to lesion volume ratio between the two. The mean PSA percentage change from baseline to 6-month is more significant in the conventional group (63.3% vs. 44.6%, p = 0.035 ). No suspicious lesion was seen at 6-month mpMRI in all 20 patients. Two patients, one from each group, eventually underwent radical treatment because of the presence of clinically significant prostate cancer in the form of out-of-field recurrences during follow-up biopsy. No significant difference was observed before and after HIFU concerning uroflowmetry, SF-12 score, and EPIC-26 score. It was observed that energy used per volume was positively correlated with PSA density of the patient (r = 0.6364, p = 0.014 ). Conclusion. In conclusion, HIFU with conventional or MRI-US fusion platform provided similar oncological and functional outcomes.

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