scholarly journals iBTA-Induced Biotube® Blood Vessels: 2020 Update

2021 ◽  
Vol 1 (1) ◽  
pp. 3-13
Author(s):  
Yasuhide Nakayama ◽  
Ryuji Higashita ◽  
Yasuyuki Shiraishi ◽  
Tadashi Umeno ◽  
Tsutomu Tajikawa ◽  
...  
Keyword(s):  
Blood Vessels ◽  
Small Diameter ◽  
General Medicine ◽  
Medical Engineering ◽  
Dialysis Patients ◽  
Practical Applications ◽  
Advanced Medical Technology ◽  
Artificial Blood Vessels ◽  
Immunological Rejection ◽  
Life Threatening

Blood access is a lifeline for dialysis patients. However, serious problems such as stenosis or obstruction of access blood vessels, which are life-threatening conditions in daily clinical practice, still remain. One of the most promising candidates for solving these problems may be Biotube blood vessels. More than 20 years have passed since the development of in-body tissue architecture (iBTA), a technology for preparing tissues for autologous implantation in patients. The tissues obtained by iBTA do not elicit immunological rejection, which is one of the ultimate goals of regenerative medical engineering; however, their practical applications were quite challenging. The seemingly unorthodox iBTA concepts that do not follow the current pre-established medical system may not be readily accepted in general medicine. In contrast, there are many diseases that cannot be adequately addressed even with the latest and most advanced medical technology. However, iBTA may be able to save patients with serious diseases. It is natural that the development of high-risk medical devices that do not fit the corporate logic would be avoided. In order to actively treat such largely unattached diseases, we started Biotube Co., Ltd. with an aim to contribute to society. Biotubes induced by iBTA are collagenous tubular tissues prepared in the patient’s body for autologous implantation. The application of Biotubes as tissues for vascular implantation has been studied for many years. Biotubes may have excellent potential as small-diameter artificial blood vessels, one of the most difficult to clinically achieve. Their possibility is currently being confirmed in preclinical tests. Biotubes may save hundreds of thousands of patients worldwide annually from amputation. In addition, we aim to eliminate the recuring access vascular problems in millions of dialysis patients. This study provides an update on the current development status and future possibilities of Biotubes and their preparation molds, Biotube Makers.

Control of weft yarn or density improves biocompatibility of PET small diameter artificial blood vessels

2017 ◽  
Vol 106 (3) ◽  
pp. 954-964 ◽  
Author(s):  
Xingyou Hu ◽  
Tao Hu ◽  
Guoping Guan ◽  
Shaoting Yu ◽  
Yufen Wu ◽  
...  
Keyword(s):  
Blood Vessels ◽  
Small Diameter ◽  
Weft Yarn ◽  
Artificial Blood ◽  
Artificial Blood Vessels

Electrostatic Self-Assemble Modified Electrospun Poly-L-Lactic Acid/Poly-Vinylpyrrolidone Composite Polymer and Its Potential Applications in Small-Diameter Artificial Blood Vessels

2020 ◽  
Vol 16 (1) ◽  
pp. 101-110 ◽  
Author(s):  
Fei Xu ◽  
Yubo Fan
Keyword(s):  
Lactic Acid ◽  
Blood Vessels ◽  
Photoelectron Spectroscopy ◽  
Laser Scanning ◽  
Electrospun Fiber ◽  
Average Molecular Weight ◽  
Small Diameter ◽  
Ph Change ◽  
Artificial Blood ◽  
Artificial Blood Vessels

Large (> 6 mm) artificial blood vessels have been successfully employed in clinic practice. However, small-diameter (< 6 mm) synthetic grafts have not been applied due to their hydrophobicity. In this study, poly-vinylpyrrolidone (PVP) was introduced into poly-L-lactic acid (PLLA) to prepare biodegradable small-diameter electrospun blood vessels which were further modified via electrostatic self-assembly (ESA). The characteristics of PLLA/PVP films were investigated by scanning electron microscopy (SEM), contact angle measurement and mechanical property testing. The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM. Next, the surface of ESA-modified electrospun fiber films was analyzed through SEM and photoelectron spectroscopy (XPS). The degradation characteristics of these films were investigated through SEM observation, weight loss, viscosity average molecular weight reduction, and pH change in the testing solutions as well. The films were also subcutaneously implanted in rabbits to analyze the biocompatibility. The results of these experiments showed that electrospun films with PVP possessed a good structure and improved hydrophilicity. The films assembled with chitosan/heparin by ESA were beneficial to VSMCs survival and had excellent blood compatibilities. The data indicated these films were biodegradable with good tissue compatibility. In conclusion, we successfully obtained biodegradable small-diameter blood vessels through electrospinning PLLA/PVP and modifying this blend's surface using ESA. The study provided a feasible method for making small-diameter synthetic blood vessels with improved hydrophilic and anticoagulant properties.

Hemoperitoneum in a Peritoneal Dialysis Patient: Ruptured Ectopic Pregnancy

2018 ◽  
Vol 38 (6) ◽  
pp. 455-456 ◽  
Author(s):  
Orly F. Kohn ◽  
Sandra Culbertson ◽  
Yolanda T. Becker
Keyword(s):  
Differential Diagnosis ◽  
Peritoneal Dialysis ◽  
Ectopic Pregnancy ◽  
Dialysis Patient ◽  
Surgical Intervention ◽  
Peritoneal Dialysis Patient ◽  
Dialysis Patients ◽  
Childbearing Age ◽  
Life Threatening ◽  
High Index Of Suspicion

Hemoperitoneum is a well-recognized complication in female peritoneal dialysis (PD) patients of childbearing age. Bloody effluent is commonly of minor nature, presenting during menstruation or midcycle, resolving after a few rapid exchanges without a need for further intervention. One must remain vigilant, however, and consider a broader differential diagnosis when hemoperitoneum is persistent or severe, as it indicates a serious and potentially life-threatening etiology. We report 2 episodes of hemoperitoneum in a PD patient occurring more than 1.5 years apart, with different underlying etiologies. The more dramatic second episode was due to a ruptured ectopic pregnancy, a condition which had not been reported as a cause of hemoperitoneum in dialysis patients to date and requires a high index of suspicion and prompt surgical intervention.

Scaffolds in tissue engineering of blood vessels

2010 ◽  
Vol 88 (9) ◽  
pp. 855-873 ◽  
Author(s):  
Divya Pankajakshan ◽  
Devendra K. Agrawal
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Blood Vessels ◽  
Vascular Tissue ◽  
Small Diameter ◽  
Biological Scaffolds ◽  
Hemodynamic Forces ◽  
Biodegradable Scaffolds

Tissue engineering of small diameter (<5 mm) blood vessels is a promising approach for developing viable alternatives to autologous vascular grafts. It involves in vitro seeding of cells onto a scaffold on which the cells attach, proliferate, and differentiate while secreting the components of extracellular matrix that are required for creating the tissue. The scaffold should provide the initial requisite mechanical strength to withstand in vivo hemodynamic forces until vascular smooth muscle cells and fibroblasts reinforce the extracellular matrix of the vessel wall. Hence, the choice of scaffold is crucial for providing guidance cues to the cells to behave in the required manner to produce tissues and organs of the desired shape and size. Several types of scaffolds have been used for the reconstruction of blood vessels. They can be broadly classified as biological scaffolds, decellularized matrices, and polymeric biodegradable scaffolds. This review focuses on the different types of scaffolds that have been designed, developed, and tested for tissue engineering of blood vessels, including use of stem cells in vascular tissue engineering.

scholarly journals Right ventricular thrombus, a challenge in imaging diagnostics: a case series

2021 ◽  
Author(s):  
Massimo Barbagallo ◽  
Daryl Naef ◽  
Pascal Köpfli ◽  
Urs Hufschmid ◽  
Tilo Niemann ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Case Series ◽  
General Medicine ◽  
High Sensitivity ◽  
Cost Effective ◽  
Ventricular Thrombus ◽  
Threatening Condition ◽  
Life Threatening ◽  
Therapeutic Decision Making ◽  
Sensitivity Specificity

Abstract Background Presence of right ventricular thrombus (RVT) is a rare but life-threatening condition, thus immediate diagnosis and therapy are mandatory. Unfortunately, detection and distinction from intraventricular tumor masses or vegetations represents a complex task. Furthermore, consecutive therapy is principally led by clinical presentation without considering morphological features of the thrombus. Current literature suggests a multimodal non-invasive imaging approach. In this paper, we discuss the role of cardiac magnetic resonance (CMR) for the detection of RVT in patients with pulmonary embolism (PE). We consider the relatively expensive and not broadly available imaging procedure and weigh it up to its assumed high sensitivity, specificity and importance for differential diagnosis and therapeutic decision making. Case Summary In this case series we report three cases of RVT with concomitant PE, whereof two were missed during routine cardiac workup by transthoracic echocardiography (TTE) and computer tomography (CT). CMR led to detection and further characterization of the thrombi in both cases. These patients were diagnosed and treated at the Cantonal Hospital of Baden in the division of General Medicine. Conclusions CMR reliably detects and characterizes RVT, even under unfavourable conditions for echocardiography such as arrhythmia, adiposity or in posterior position of RVT. Obtained information could facilitate the choice of therapeutic approach (anticoagulation vs. systemic lysis, vs. surgical thrombectomy). Future risk-stratification scores will promote cost-effective use of CMR.

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