scholarly journals The Interaction between Genetic Polymorphisms in FTO and TCF7L2 Genes and Dietary Intake with Regard to Body Mass and Composition: An Exploratory Study

2019 ◽  
Vol 9 (1) ◽  
pp. 11 ◽  
Author(s):  
Lara Nasreddine ◽  
Reem Akika ◽  
Aurelie Mailhac ◽  
Hani Tamim ◽  
Nathalie Zgheib
Keyword(s):  
Muscle Mass ◽  
Body Mass ◽  
Body Fat ◽  
Risk Allele ◽  
Eastern Mediterranean ◽  
Population Sample ◽  
Saturated Fat ◽  
Candidate Snps ◽  
Nucleotide Polymorphisms ◽  
Mediterranean Populations

In contrast to the large number of genetic studies on obesity, there has been significantly less nutrigenetics investigation of the interaction between diet and single nucleotide polymorphisms (SNPs) in obesity, especially within Eastern Mediterranean populations. The aim of this study was to evaluate the potential interactions between three candidate SNPs, namely, rs1558902 and rs9939609 in the fat mass and obesity (FTO) gene and the rs7903146 variant of the Transcription factor 7 like 2 (TCF7L2) gene, and macronutrient intake with regard to obesity, body fat, and muscle composition. Three hundred and eight healthy Lebanese adults were included in this study. Data collection included a questionnaire for demographics and lifestyle in addition to a detailed dietary assessment using a culture-specific 80-item semi-quantitative food frequency questionnaire. This was coupled with anthropometric measurements and peripheral blood withdrawal for DNA and genotyping using Taqman allele discrimination assays. The two FTO candidate SNPs were not associated with risk of obesity in this population sample, yet there was a trend, though not a significant one, towards lower muscle mass among carriers of the risk allele of either FTO SNPs. To our knowledge, these results have not been previously reported. As for the TCF7L2 rs7903146 variant, results were congruent with the literature, given that individuals who were homozygous for the risk allele had significantly higher body mass index (BMI) and body fat despite lower intakes of saturated fat. Similar interactions, though not significant, were shown with muscle mass, whereby individuals who were homozygous for the risk allele had lower muscle mass with higher intakes of saturated fat, a result that, to our knowledge, has not been previously reported.

scholarly journals Effects of a novel mobile health intervention compared to a multi-component behaviour changing program on body mass index, physical capacities and stress parameters in adolescents with obesity: a randomized controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
A. Stasinaki ◽  
D. Büchter ◽  
C.-H. I. Shih ◽  
K. Heldt ◽  
S. Güsewell ◽  
...  
Keyword(s):  
Health Care ◽  
Body Mass Index ◽  
Muscle Mass ◽  
Body Mass ◽  
Body Fat ◽  
Mobile Health ◽  
Health Intervention ◽  
Randomized Controlled ◽  
Physical Capacities ◽  
Stress Parameters

Abstract Background Less than 2% of overweight children and adolescents in Switzerland can participate in multi-component behaviour changing interventions (BCI), due to costs and lack of time. Stress often hinders positive health outcomes in youth with obesity. Digital health interventions, with fewer on-site visits, promise health care access in remote regions; however, evidence for their effectiveness is scarce. Methods This randomized controlled not blinded trial (1:1) was conducted in a childhood obesity center in Switzerland. Forty-one youth aged 10–18 years with body mass index (BMI) > P.90 with risk factors or co-morbidities or BMI > P.97 were recruited. During 5.5 months, the PathMate2 group (PM) received daily conversational agent counselling via mobile app, combined with standardized counselling (4 on-site visits). Controls (CON) participated in a BCI (7 on-site visits). We compared the outcomes of both groups after 5.5 (T1) and 12 (T2) months. Primary outcome was reduction in BMI-SDS (BMI standard deviation score: BMI adjusted for age and sex). Secondary outcomes were changes in body fat and muscle mass (bioelectrical impedance analysis), waist-to-height ratio, physical capacities (modified Dordel-Koch-Test), blood pressure and pulse. Additionally, we hypothesized that less stressed children would lose more weight. Thus, children performed biofeedback relaxation exercises while stress parameters (plasma cortisol, stress questionnaires) were evaluated. Results At intervention start median BMI-SDS of all patients (18 PM, 13 CON) was 2.61 (obesity > + 2SD). BMI-SDS decreased significantly in CON at T1, but not at T2, and did not decrease in PM during the study. Muscle mass, strength and agility improved significantly in both groups at T2; only PM reduced significantly their body fat at T1 and T2. Average daily PM app usage rate was 71.5%. Cortisol serum levels decreased significantly after biofeedback but with no association between stress parameters and BMI-SDS. No side effects were observed. Conclusions Equally to BCI, PathMate2 intervention resulted in significant and lasting improvements of physical capacities and body composition, but not in sustained BMI-SDS decrease. This youth-appealing mobile health intervention provides an interesting approach for youth with obesity who have limited access to health care. Biofeedback reduces acute stress and could be an innovative adjunct to usual care.

scholarly journals Correlation of a feline muscle mass score with body composition determined by dual-energy X-ray absorptiometry

2011 ◽  
Vol 106 (S1) ◽  
pp. S57-S59 ◽  
Author(s):  
Kathryn E. Michel ◽  
Wendy Anderson ◽  
Carolyn Cupp ◽  
Dorothy P. Laflamme
Keyword(s):  
Body Composition ◽  
Lean Body Mass ◽  
Muscle Mass ◽  
Body Mass ◽  
Body Fat ◽  
Convergent Validity ◽  
Dual Energy ◽  
Rater Agreement ◽  
Lean Tissue ◽  
X Ray

Body condition scoring (BCS) systems primarily assess body fat. Both overweight and underweight animals may have loss of lean tissue that may not be noted using standard BCS systems. Catabolism of lean tissue can occur rapidly, may account for a disproportionate amount of body mass loss in sick cats and can have deleterious consequences for outcome. Therefore, along with evaluation of body fat, patients should undergo evaluation of muscle mass. The aims of the present study were first to evaluate the repeatability and reproducibility of a 4-point feline muscle mass scoring (MMS) system and second to assess the convergent validity of MMS by dual-energy X-ray absorptiometry (DXA). MMS was as follows: 3, normal muscle mass; 2, slight wasting; 1, moderate wasting; 0, severe wasting. For the first aim, forty-four cats were selected for evaluation based on age and BCS, and for the second aim, thirty-three cats were selected based on age, BCS and MMS. Cats were scored by ten different evaluators on three separate occasions. Body composition was determined by DXA. Inter- and intra-rater agreement were assessed using kappa analysis. Correlation between MMS and BCS, age, percentage lean body mass and lean body mass (LBM) was determined using Spearman's rank-order correlation. The MMS showed moderate inter-rater agreement in cats that scored normal or severely wasted (κ = 0·48–0·53). Intra-rater agreement was substantial (κ = 0·71–0·73). The MMS was significantly correlated with BCS (r 0·76, P < 0·0001), age (r − 0·75, P < 0·0001), LBM (g) (r 0·62, P < 0·0001) and percentage LBM (r − 0·49, P < 0·0035). Additional investigation is needed to determine whether the MMS can be refined and to assess its clinical applicability.

scholarly journals Body composition and maximal oxygen consumption in adult soccer players in the Republic of Macedonia

2015 ◽  
Vol 5 (3) ◽  
pp. 85-92
Author(s):  
Jasmina Pluncevikj Gligoroska ◽  
Sanja Manchevska ◽  
Ljudmila Efremova ◽  
Lidija Todorovska ◽  
Slobodan Nikolic
Keyword(s):  
Body Composition ◽  
Oxygen Consumption ◽  
Muscle Mass ◽  
Body Mass ◽  
Body Fat ◽  
Maximal Oxygen Consumption ◽  
Age Groups ◽  
Total Sample ◽  
Soccer Players ◽  
Mean Values

Introduction: The purpose of this study was to investigate the relationship between active and passive body mass components and maximal aerobic consumption (VO2max) in adult male soccer players.Methods: The study involved seven hundred (700) male soccer players, mean age 25.06 ± 4.41 years (range 18 to 35), divided in six age groups. Body composition was assessed according the anthropometric protocol by Matiegka, and relative muscle mass (MM%), bone (BM%) and fat (BF%)  and absolute muscle mass (MMkg), bone (BMkg) and fat (BFkg) components were calculated. The Bruce protocol (incremental multistage treadmill test) was used for the estimation of maximal oxygen consumption.Results: Mean values of body mass components for total sample were as follows: muscle mass (MM%)= 52.75 ± 2.63%, bone mass (BM%)=16.63 ± 1.29% and body fat (BF%)=14.12 ± 1.54%.  Mean VO2max was 48.89±5.17 ml/kg/minute. Relative muscle mass (MM%) showed similar values across age different groups (ANOVA: F=2.174; p=0.06) while absolute muscle mass (MMkg) showed tendency of increment with age (ANOVA: F=2.136; p=0.01). Body fat (BFkg and BF%) was statistically higher in the older groups (ANOVA F=3.737; p<0.01; ANOVA F=4.117; p<0.01). Weak positive correlation between VO2 max and muscle component (r=0.243; p<0.001) and a weak negative correlation between VO2max and body fat (r=-0.08;p<0.05) were found.Conclusions: Our results confirm the assumption that subjects with larger muscle mass have greater endurance and higher maximal oxygen consumption compared to subjects with larger body fat component. 

scholarly journals The Impact Of Ten Weeks Of Bodyweight Training On The Level Of Physical Fitness And Selected Parameters Of Body Composition In Women Aged 21-23 Years

2015 ◽  
Vol 22 (2) ◽  
pp. 64-68 ◽  
Author(s):  
Krzysztof Lipecki ◽  
Bartosz Rutowicz
Keyword(s):  
Body Composition ◽  
Physical Fitness ◽  
Muscle Mass ◽  
Body Mass ◽  
Body Fat ◽  
Aerobic Capacity ◽  
Lower Extremities ◽  
Training Programme ◽  
Physical Capacity ◽  
The Impact

Abstract Introduction. The aim of the study was to assess the impact of 10 weeks of bodyweight training on selected elements of body composition (body mass, muscle mass, and the percentage of body fat and water) and components of physical fitness (strength, strength endurance, flexibility, and aerobic capacity) of women aged 21-23 years who do not practise sports professionally. Material and methods. The study involved 15 women whose mean age was 22 years 2 months. Their body mass and composition were assessed using a TANITA BC-1000 scale, and the following parameters of physical fitness were measured: the strength and power of the upper and lower extremities; the strength endurance of the shoulders, shoulder girdle, and trunk; as well as their flexibility and physical capacity. The assessment was performed twice, that is before and after the completion of the 10-week programme. Results. The study revealed that the 10-week bodyweight training programme had caused a minor increase in body mass (1.16%) and body fat percentage (2.43%), while muscle mass and body water percentage had not changed. As far as physical fitness is concerned, the bodyweight exercises had had a positive impact on all of the elements of physical fitness which were measured, including statistically significant increases in the explosive strength of the lower extremities (5.6%; p<0.01), strength endurance of the trunk (10.7%; p<0.01), and aerobic capacity (33.3%; p<0.05). Conclusions. Without a properly balanced diet and nutrition control, the bodyweight training programme had a small impact on the parameters of body composition. It was, however, an effective way of enhancing general physical fitness: apart from improving muscle strength and endurance, it also increased physical capacity and flexibility.

Body mass index continues to accurately predict percent body fat as women age despite changes in muscle mass and height

2015 ◽  
Vol 22 (7) ◽  
pp. 727-730 ◽  
Author(s):  
Tova Ablove ◽  
Neil Binkley ◽  
Sarah Leadley ◽  
James Shelton ◽  
Robert Ablove
Keyword(s):  
Body Mass Index ◽  
Muscle Mass ◽  
Body Mass ◽  
Body Fat ◽  
Percent Body Fat

scholarly journals The Effects of Low-Energy Moderate-Carbohydrate (MCD) and Mixed (MixD) Diets on Serum Lipid Profiles and Body Composition in Middle-Aged Men: A Randomized Controlled Parallel-Group Clinical Trial

2020 ◽  
Vol 17 (4) ◽  
pp. 1332 ◽  
Author(s):  
Małgorzata Magdalena Michalczyk ◽  
Adam Maszczyk ◽  
Petr Stastny
Keyword(s):  
Body Composition ◽  
Muscle Mass ◽  
Body Mass ◽  
Body Fat ◽  
Density Lipoprotein ◽  
Low Energy ◽  
C Reactive Protein ◽  
Middle Aged ◽  
Reactive Protein ◽  
Body Fat Content

Carbohydrate-restricted diets have become very popular due to their numerous health benefits. The aim of this study was to determine the influence of 4 weeks of a well-planned, low-energy moderate-carbohydrate diet (MCD) and a low-energy mixed diet (MixD) on the lipoprotein profile, glucose and C-reactive protein concentrations, body mass, and body composition in middle-aged males. Sixty middle-aged males were randomly assigned to the following groups: hypocaloric MCD (32% carbohydrates, 28% proteins, and 40% fat), hypocaloric MixD (50% carbohydrates, 20% proteins, and 30% fat), and a conventional (control) diet (CD; 48% carbohydrates, 15% proteins, and 37% fat). The participants who were classified into the MCD and MixD groups consumed 20% fewer calories daily than the total daily energy expenditure (TDEE). Baseline and postintervention fasting triacylglycerol (TG), LDL (low-density lipoprotein) cholesterol (LDL-C), HDL (high-density lipoprotein) cholesterol (HDL-C), total cholesterol (tCh), glucose (Gl), and C-reactive protein were evaluated. Body mass (BM) and body composition changes, including body fat (BF), % body fat (PBF), and muscle mass (MM), were monitored. Compared with MixD and CD, MCD significantly changed the fasting serum concentrations of TG (p < 0.05), HDL-C (p < 0.05), LDL-C (p < 0.05), tCh (p < 0.05), and glucose (p < 0.01). Additionally, body fat content (kg and %) was significantly reduced (p < 0.05) after MCD compared with MixD and CD. After the MixD intervention, BM and MM decreased (p < 0.05) compared with baseline values. Compared with baseline, after the MixD, BM, MM, tCh, LDL-C, and TG changed significantly. The 4 week low-energy MCD intervention changed lipoproteins, glucose, and body fat to a greater extent than the low-energy MixD. A hypocaloric MCD may be suggested for middle-aged male subjects who want to lose weight by reducing body fat content without compromising muscle mass.

scholarly journals Association between Polymorphisms in Vitamin D Pathway-Related Genes, Vitamin D Status, Muscle Mass and Function: A Systematic Review

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3109
Author(s):  
Ermira Krasniqi ◽  
Arben Boshnjaku ◽  
Karl-Heinz Wagner ◽  
Barbara Wessner
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Muscle Mass ◽  
Vitamin D Supplementation ◽  
Healthy Adults ◽  
Candidate Snps ◽  
Nucleotide Polymorphisms ◽  
Vitamin D Status ◽  
Single Nucleotide ◽  
And Function

An association between vitamin D level and muscle-related traits has been frequently reported. Vitamin D level is dependent on various factors such as sunlight exposure and nutrition. But also on genetic factors. We, therefore, hypothesize that single nucleotide polymorphisms (SNPs) within the vitamin D pathway-related genes could contribute to muscle mass and function via an impact on vitamin D level. However, the integration of studies investigating these issues is still missing. Therefore, this review aimed to systematically identify and summarize the available evidence on the association between SNPs within vitamin D pathway-related genes and vitamin D status as well as various muscle traits in healthy adults. The review has been registered on PROSPERO and was conducted following PRISMA guidelines. In total, 77 studies investigating 497 SNPs in 13 different genes were included, with significant associations being reported for 59 different SNPs. Variations in GC, CYP2R1, VDR, and CYP24A1 genes were reported most frequently, whereby especially SNPs in the GC (rs2282679, rs4588, rs1155563, rs7041) and CYP2R1 genes (rs10741657, rs10766197, rs2060793) were confirmed to be associated with vitamin D level in more than 50% of the respective studies. Various muscle traits have been investigated only in relation to four different vitamin D receptor (VDR) polymorphisms (rs7975232, rs2228570, rs1544410, and rs731236). Interestingly, all of them showed only very low confirmation rates (6–17% of the studies). In conclusion, this systematic review presents one of the most comprehensive updates of the association of SNPs in vitamin D pathway-related genes with vitamin D status and muscle traits in healthy adults. It might be used for selecting candidate SNPs for further studies, but also for personalized strategies in identifying individuals at risk for vitamin D deficiency and eventually for determining a potential response to vitamin D supplementation.

scholarly journals EFFECTS OF A 6-WEEK CONTROLED EXERCISE PROGRAM AND SEMI-CONTROLED DIET ON BODY FAT AND SKELETAL MUSCLE MASS IN ADULTS

2019 ◽  
Vol 19 (1) ◽  
pp. 7-14 ◽  
Author(s):  
F Kukić ◽  
N Todorović ◽  
N Cvijanović
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Body Mass ◽  
Body Fat ◽  
Fat Mass ◽  
Skeletal Muscle Mass ◽  
Body Height ◽  
Exercise Program ◽  
Body Fat Mass ◽  
Dietary Regimen

Aim. To investigate the effects of a 6-week of controlled exercise program followed by a semi-controlled dietary regimen on indicators of body fat mass (BF) and skeletal muscle mass (SMM) of adults. Materials and methods. The sample consisted of 28 particpants with the main characteristics of the sample being: age = 29.70 ± 8.35 years, body height (BH) = 177.35 ± 9.36 cm, and body mass (BM) = 105.20 ± 27.06 kg. Body composition parameters, BM, body fat mass (BF), trunk fat (TF), skeletal muscle mass (SMM), percent of body fat (PBF), percent of skeletal muscle mass (PSMM), body mass index (BMI), and index of hypokinesia (IH) were collected before and after six weeks of exercise program and semi-controlled diet regimen. A Paired sample T-test and effect size (ES) were used to determine the effects and their magnitude of the treatment applied. Results. A 6-week treatment significantly affected investigated variables, wherein BF (–6.75 kg, p < 0.001), TF (–3.28 kg, p < 0.001), and SMM (–0.91 kg, p = 0.003) tissue decreased in a different degree, leading to a small but highly significant increase in PSMM (2.60 %, p < 0.001). A decrease in BF and SMM resulted in a significant reduction in BMI, while IH decreased in a smaller degree than BMI because PBF and PSMM changed inversely. Conclusion. Six weeks of a controlled exercise program 3 times/week and semi-controlled diet is an effective approach to the reduction of BM, BF, and TF and to increasing the movement potential by changing the proportions of PBF and PSMM.

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