scholarly journals The Potential Prognostic Value of a Novel Hematologic Marker Fibrinogen-to-Lymphocyte Ratio in Head and Neck Adenoid-Cystic Carcinoma

2021 ◽  
Vol 11 (11) ◽  
pp. 1228
Author(s):  
Faris F. Brkic ◽  
Stefan Stoiber ◽  
Marlene Friedl ◽  
Tobias Maier ◽  
Gregor Heiduschka ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Disease Free Survival ◽  
Threshold Value ◽  
Late Recurrence ◽  
Study Cohort ◽  
Lymphocyte Ratio ◽  
Adenoid Cystic ◽  
Long Term Survivors

Many patients with adenoid-cystic carcinoma (ACC) experience an indolent course of disease over many years but face late recurrence, and long-term survivors are rare. Due to its infrequent occurrence, it is hard to predict outcome in these patients. The fibrinogen-to-lymphocyte ratio (FLR) was recently proposed as an outcome prognosticator in different cancer entities. We aimed to investigate its prognostic relevance in patients with head and neck ACC. This retrospective analysis was performed including all patients treated for ACC between 1998 and 2020. The FLR ratio was calculated based on pretreatment values (0–7 days). The study cohort was dichotomized based on optimized threshold value and compared for differences in outcome (overall survival (OS) and disease-free survival (DFS)). In the cohort of 39 included patients, the OS was significantly longer in the low (n = 28) compared to the high pretreatment FLR group (n = 11) (median OS 150.5 months, 95% confidence intervals (CI) 85.3–215.7 months vs. 29.4 months, 95% CI not reached; p = 0.0093). Similarly, the DFS was significantly longer in the low FLR group (median DFS 74.5 months, 95% CI 30.6–118.4 months vs. 11.0 months, 95% CI 5.1–16.9 months; p = 0.019). The FLR is an easily obtainable and simple marker and may be a valuable outcome prognosticator in patients with ACC. Further studies are needed for validation of our results.

scholarly journals Long-Term Outcomes of Personalized Stereotactic Ablative Brachytherapy for Recurrent Head and Neck Adenoid Cystic Carcinoma after Surgery or External Beam Radiotherapy: A 9-Year Study

2021 ◽  
Vol 11 (9) ◽  
pp. 839
Author(s):  
Yi Chen ◽  
Jinzhao Dai ◽  
Yuliang Jiang ◽  
Zhe Ji ◽  
Ping Jiang ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Local Control ◽  
External Beam Radiotherapy ◽  
Objective Response ◽  
External Beam ◽  
Long Term Outcomes ◽  
Adenoid Cystic ◽  
Recurrent Head

The management of recurrent head and neck adenoid cystic carcinoma (HNACC) remains a problematic challenge. This study aims to evaluate the long-term outcomes of personalized stereotactic ablative brachytherapy (SABT) as a salvage treatment for recurrent HNACC after surgery or external beam radiotherapy (EBRT). 21 patients with recurrent HNACC after surgery or EBRT successfully underwent iodine-125 (I-125) seed SABT from May 2011 to November 2019. The objective response rate (ORR), disease control rate (DCR), local control time (LCT), overall survival (OS), symptomatic relief and adverse events (AEs) were analyzed. Following SABT, the ORR and DCR were 85.7% and 100%, respectively. The 3-, and 5-year LCT rates were 68.8% and 55.1%, respectively, and the 3- and 5-year OS rates were 85.9% and 66.2%, respectively. Furthermore, univariate analyses showed that higher D90 (>137.1 Gy) was a strong positive prognostic factor of LCT (p < 0.05). The pain disappeared in one patient 3 months after SABT and partial pain improvement was observed in nine patients 1 to 6 months after SABT. Additionally, dyspnea was relieved in one patient with the tumor involving the trachea. The major AEs were mild intraoperative hemorrhage and skin/mucosal toxicities which were generally graded ≤2 and well-tolerated. Personalized SABT was an effective and safe alternative option for recurrent HNACC after the previous failure of surgery or EBRT. The parameter of D90 may influence the local control.

scholarly journals Long-term local control rates of patients with adenoid cystic carcinoma of the head and neck managed by surgery and postoperative radiation

2017 ◽  
Vol 127 (10) ◽  
pp. 2265-2269 ◽  
Author(s):  
Safina Ali ◽  
Frank L. Palmer ◽  
Nora Katabi ◽  
Nancy Lee ◽  
Jatin P. Shah ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Local Control ◽  
Postoperative Radiation ◽  
Adenoid Cystic

scholarly journals Prognostic Value of Preoperative Neutrophil-to -Lymphocyte Ratio in Adenoid Cystic Carcinoma of the Head and Neck

2021 ◽  
Author(s):  
XIN-RAN LI ◽  
LIN ZHOU ◽  
YU-XIN CHEN ◽  
NA LI ◽  
JIAN MENG
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Prognostic Value ◽  
Cox Regression ◽  
Neutrophil To Lymphocyte Ratio ◽  
Cutoff Value ◽  
Lymphocyte Ratio ◽  
Adenoid Cystic ◽  
Kaplan Meier ◽  
Chi Squared

Abstract BackgroundStudies in recent years have shown that the neutrophil-to-lymphocyte ratio (NLR) is associated with the survival and prognosis of patients with malignant tumors.However, the utility of the NLR in predicting outcomes in patients with adenoid cystic carcinoma (ACC) of the head and neck remains unclear. Here, we examined the prognostic value of the preoperative NLR in patients with ACC of the head and neck.MethodsThis study retrospectively analyzed 71 patients with a histopathological diagnosis of ACC from August 2005 to November 2020.The optimal cutoff value was obtained by receiver operating characteristic (ROC) analysis. The characteristics of the patients were evaluated using chi-squared tests.The value of the NLR used in predicting the outcomes of these patients was analyzed using Kaplan-Meier curves and Cox regression models.ResultsThe cutoff value of the NLR was 2.071. The chi-squared tests showed that a high NLR(>2.071)was associated with tumor stage and lymph node metastasis(LNM). Kaplan-Meier survival analysis showed that the NLR>2.071 group was correlated with a shorter Overall survival(P<0.05). In multivariate Cox regression analysis, high NLR (>2.071) and high age (>54 years) were independent risk factors predicting poorer outcomes in patients with ACC.ConclusionsWe suggest that the preoperative NLR is a useful biomarker for the prognosis of patients with ACC.

scholarly journals Prognosis and management of recurrent and/or metastatic head and neck adenoid cystic carcinoma

Oral Oncology ◽  
2021 ◽  
Vol 115 ◽  
pp. 105213
Author(s):  
Luigi Lorini ◽  
Laura Ardighieri ◽  
Anna Bozzola ◽  
Chiara Romani ◽  
Eliana Bignotti ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Adenoid Cystic

scholarly journals EP-1189 Adenoid Cystic Carcinoma Of The Head And Neck Treated With Carbon Ion Radiotherapy At CNAO

2019 ◽  
Vol 133 ◽  
pp. S659
Author(s):  
M. Bonora ◽  
B. Vischioni ◽  
D. Caivano ◽  
A. Hasegawa ◽  
V. Vitolo ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Carbon Ion Radiotherapy ◽  
Carbon Ion ◽  
Adenoid Cystic

scholarly journals Proton Therapy for Head and Neck Adenoid Cystic Carcinoma

2016 ◽  
Vol 96 (2) ◽  
pp. E369-E370
Author(s):  
R.L. Deraniyagala ◽  
C.M. Bryant ◽  
C.G. Morris ◽  
W.M. Mendenhall ◽  
D.J. Indelicato ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Proton Therapy ◽  
Adenoid Cystic
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