scholarly journals PRP and PRF—Subgroups and Divisions When Used in Dentistry

2021 ◽  
Vol 11 (10) ◽  
pp. 944
Author(s):  
Paulina Pietruszka ◽  
Izabela Chruścicka ◽  
Irena Duś-Ilnicka ◽  
Anna Paradowska-Stolarz
Keyword(s):  
Systematic Review ◽  
Growth Factors ◽  
Personalized Medicine ◽  
Platelet Rich Plasma ◽  
Platelet Rich Fibrin

Blood derivates, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), are autogenous sources of many growth factors that are involved in the healing and regeneration of tissues, and for this reason, are used in dentistry treatments. This fact also contributes to the growing interest in these biomaterials in regenerative personalized medicine. The multitude of platelet-rich forms creates many possibilities for their use. This semi-systematic review describes and compares the methods of obtaining properties and potential uses of these materials in personalized treatments.

scholarly journals The effectiveness of platelet concentrations in periodontal surgeries

2018 ◽  
Vol 6 (2) ◽  
pp. 61 ◽  
Author(s):  
Ronad Al-Azem ◽  
Neveen Ali ◽  
Diana Mostafa
Keyword(s):  
Case Report ◽  
Growth Factors ◽  
Bone Graft ◽  
Tissue Regeneration ◽  
Platelet Rich Plasma ◽  
Research Process ◽  
Platelet Concentrates ◽  
Platelet Rich Fibrin ◽  
Barrier Membrane ◽  
Concentrated Growth Factors

Platelets release several growth factors which stimulate tissue regeneration. Several techniques for platelet concentrates such as platelet rich plasma (PRP), plasma rich in growth factors (PRGF), platelet rich fibrin (PRF) and concentrated growth factors (CGF) have been introduced in dental surgeries for the prevention of hemorrhage and acceleration of tissue regeneration. However, a fabricating growth factors-enriched bone graft matrix which is called “sticky bone” has been demonstrated to provide stabilization in bony defects. In this article, we presented the method of preparing and utilizing CGF and sticky bone and evaluate the effect of CGF mixed with bone graft and CGF barrier membrane in periodontal surgeries.Methodology: We used websites such as PubMed, Scopus, and ISI Web of knowledge to get related articles about this subject. The research process involved specific key words " concentrated growth factor”- “Platelet rich fibrin”- growth factors-enriched bone graft” - “sticky bone” to find more articles which published from 2007 to March 2018.Results: We reviewed 48 articles, 43 articles were excluded. Only five articles have been conducted. Original human studies and case report were included.Conclusion: We concluded that the use of sticky bone and CGF is effective in bone grafting and implant.  

scholarly journals Treatment of venous ulcers with growth factors: systematic review and meta-analysis

2019 ◽  
Vol 72 (1) ◽  
pp. 200-210 ◽  
Author(s):  
Magali Rezende de Carvalho ◽  
Isabelle Andrade Silveira ◽  
Beatriz Guitton Renaud Baptista de Oliveira
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Growth Factors ◽  
Growth Factor ◽  
Randomized Clinical Trials ◽  
Platelet Rich Plasma ◽  
Meta Analysis ◽  
Intervention Group ◽  
Complete Healing ◽  
Venous Ulcers

ABSTRACT Objective: To identify evidence about the effects of growth factor application on venous ulcer healing. Method: Systematic review and meta-analysis, including Randomized Clinical Trials. Searches: Ovid MEDLINE, EMBASE, CINAHL, Cochrane CENTRAL, LILACS, Web of Science, Digital Library of Theses and Dissertations; Google Scholar and list of references. Results: 802 participants were recruited from the 10 included studies: 472 in the intervention group (growth factors) and 330 as control. The relative risk for the complete healing outcome was 1.06 [95% CI 0.92-1.22], p = 0.41. Participants who received Platelet-Rich Plasma and Epidermal Growth Factor showed a slight tendency to achieve complete healing, but without statistical relevance (p <0.05). Most of the studies were classified as moderate risk of bias. Conclusion: The effect of the application of growth factors for complete healing in venous ulcers is not clear, and clinical trials with methodological quality are required for more accurate recommendations.

Review of concentration yields in commercially available platelet-rich plasma (PRP) systems: a call for PRP standardization

2019 ◽  
Vol 44 (6) ◽  
pp. 652-659 ◽  
Author(s):  
Priyal P Fadadu ◽  
Anthony J Mazzola ◽  
Corey W Hunter ◽  
Timothy T Davis
Keyword(s):  
Systematic Review ◽  
Growth Factors ◽  
Platelet Rich Plasma ◽  
White Cell Count ◽  
Pain Medicine ◽  
Inclusion Criteria ◽  
Separation Systems ◽  
Platelet Concentration ◽  
Large Heterogeneity ◽  
Promising Treatment

Platelet-rich plasma (PRP) has become increasingly popular in pain medicine with hopes of becoming a safe, effective alternative to routine treatments. However, given its autologous nature, PRP injectate may differ depending on the specific manufacturer and protocol. Currently, there is no standardization of reporting protocol. This systematic review compiles and standardizes values on PRP preparation and final product composition of platelets, white cell count, and growth factors for ease of comparison. On review of 876 studies, 13 studies were selected according to our inclusion criteria. Data from 33 PRP systems and protocols were extracted and standardized. Overall, PRP final product concentrations as well as PRP preparation protocols varied widely between systems. However, platelet concentration was directly correlated with both volume of blood collected and device centrifugal force. In conclusion, there is a large heterogeneity between PRP separation systems that must be resolved for proper study of this promising treatment.

scholarly journals Efficacy of Platelet Rich Plasma and Platelet Rich Fibrin in Periodontal Regeneration: Systematic Review.

2018 ◽  
Vol 4 (3) ◽  
pp. 1196-1202
Author(s):  
Felipe Cid
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Platelet Rich Plasma ◽  
Periodontal Regeneration ◽  
The Body ◽  
Blood Collection ◽  
Platelet Rich Fibrin ◽  
Positive Effects ◽  
And Function

Regeneration is defined as the reproduction or reconstruction of a lost part or injury of the body in such a way that the architecture and function of the lost or injured tissue are completely restored. The goal of regenerative periodontal therapy is to restore the structure and function of the periodontium. The positive effects of Platelet-rich plasma (PRP) are attributed to the angiogenic, mitogenic and proliferative capacities of growth factors such as platelet-derived growth factor, transforming growth factor and vascular endothelial growth factor. Platelet-rich fibrin (PRF) is a second generation platelet concentrate that allows fibrin membranes enriched with platelets and growth factors to be obtained after starting an anticoagulant-free blood collection without any biomechanical artificial modification. The objective of this review is to know the efficacy of platelet-rich plasma and platelet-rich fibrin in the periodontal regeneration of intrabony defects. The clinical implications for this autologous material are promising. Further long term, larger, multicentred randomized controlled clinical trials are required to determine the effects of PRP and PRF on the regeneration of alveolar bone due to periodontal disease.

scholarly journals Use of autologous platelet derivatives for secondary alveoloplasty in patients with cleft lip and palate: a protocol for a systematic review and meta-analysis

2021 ◽  
Author(s):  
Andres Campolo ◽  
Claudia Heider ◽  
Ismael Canete ◽  
Francisca Verdugo ◽  
Rocio Bravo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Platelet Rich Plasma ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Platelet Rich Fibrin ◽  
Alveolar Bone Grafting ◽  
Autologous Platelet

Objective: To assess the effectiveness and safety of autologous platelet derivatives, specifically platelet-rich plasma (PRP) or platelet-rich fibrin (PRF), for secondary alveoloplasty in patients with cleft lip and palate. Eligibility criteria: We will include randomized trials evaluating the effect of autologous platelet derivatives on newly bone formed after secondary alveoloplasty in cleft lip and palate patients. Two reviewers will independently screen each study for eligibility, data extraction, and bias assessment using the Cochrane "risk of bias" tool. We will pool the results using meta-analysis and apply the GRADE system to assess the certainty of the evidence for each outcome. Data sources: A comprehensive search will include all relevant randomized controlled trials (RCTs), the ongoing investigation reported in specialty congresses and trials regardless of language or publication status (published, unpublished, in press, and progress). We will conduct searches in the following databases: Cochrane Central Register of Controlled Trials (CENTRAL), PUBMED, Embase, and LILACS. We will screen trial registries and other sources in order to identify articles that might have been missed in the electronic searches. Ethics and dissemination: As researchers will not access information that could identify an individual participant, obtaining ethical approval was waived. Keywords: Platelet-rich fibrin; Platelet-rich plasma; Secondary alveoloplasty; Cleft lip; cleft palate; Alveolar Bone Grafting; Systematic review, protocol, meta-analysis

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