scholarly journals Association of LINC00673 Genetic Variants with Progression of Oral Cancer

2021 ◽  
Vol 11 (6) ◽  
pp. 468
Author(s):  
Shih-Chi Su ◽  
Chiao-Wen Lin ◽  
Po-Chung Ju ◽  
Lun-Ching Chang ◽  
Chun-Yi Chuang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymphatic Spread ◽  
Clinicopathological Parameters ◽  
Individual Snps ◽  
Increased Risk ◽  
Incidence And Mortality ◽  
The Impact

Oral squamous cell carcinoma (OSCC) is a multifactorial malignancy, and its high incidence and mortality rate remain a global public health burden. Polymorphisms in the long intergenic noncoding RNA 673 (LINC00673) have been currently connected to the predisposition to various cancer types. The present study attempted to explore the impact of LINC00673 gene polymorphisms on the risk and progression of OSCC. Three LINC00673 single-nucleotide polymorphisms (SNPs), including rs11655237, rs9914618, and rs6501551, were evaluated in 1231 OSCCC cases and 1194 cancer-free controls. We did not observe any significant association of three individual SNPs with the risk of OSCC between the case and control group. However, while assessing the clinicopathological parameters, patients carrying at least one minor allele of rs9914618 (GA and AA; OR, 1.286; 95% CI, 1.008–1.642; p = 0.043) were found to develop lymph node metastasis more often compared to those who are homozygous for the major allele. Further stratification analyses revealed that this genetic correlation with increased risk of lymphatic spread was further fortified in habitual betel quid chewers (OR, 1.534; 95% CI, 1.160–2.028; p = 0.003) or smokers (OR, 1.320; 95% CI, 1.013–1.721; p = 0.040). Moreover, through analyzing the dataset from The Cancer Genome Atlas (TCGA), we found that elevated LINC00673 levels were associated with the development of large tumors in patients with head and neck squamous cell carcinoma and the risk of lymphatic spread in smokers. These data demonstrate a joint effect of LINC00673 rs9914618 with betel nut chewing or smoking on the progression of oral cancer.

scholarly journals Age And Gender Predilection Of Habits And Oral Cancer Among An Outpatient Population Visiting A Dental Hospital

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 1850-1854
Author(s):  
Anubhav Das ◽  
Gheena S ◽  
Ravindra Kumar Jain
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
P Value ◽  
Age Group ◽  
Heavy Smoking ◽  
Increased Risk ◽  
Risk Of Cancer

Oral Squamous Cell Carcinoma (OSCC) is the most common neoplasm representing more than 80% of all oral cancer cases. Squamous cell carcinoma is defined as a “malignant epithelial neoplasm exhibiting squamous differentiation as characterized by the formation of keratin and/ or the presence of intercellular bridges”.Most of the epidemiological studies have revealed that heavy smoking and alcohol intake are the most important risk factors for oral cancer. Poor dental hygiene, accompanied by tooth loss, certain oncogenic viruses have been associated with an increased risk of cancer. The purpose of this study was to analyze the gender and age predilection of habits and oral cancer among an outpatient population visiting a dental college. This was a retrospective study (2019-2020) in which data on 34 Oral Squamous Cell Carcinoma(OSCC) were investigated. The patient records were reviewed and analysed between January 2019 and March 2020. All the 34 patient data were tabulated in excel, reviewed and was classified according to the border's grading system. Following which data was imported to SPSS software by IBM for descriptive statistical analysis and chi-square test was performed. A significant association between OSCC and age group (45-50 Years) was observed though it was statistically insignificant. (p value=0.64). Males have a higher incidence of OSCC compared to females in the same age group. A significant association is observed between Gutka, Smoking and pan chewing with OSCC. OSCC is the most commonly occurring oral cancer and there is a high predilection of the OSCC with age, gender and habits. Dentists play a key role in screening, detection and treatment of oral malignancies and can help in educating the public to bring about more awareness towards prevention of Oral Cancer.

scholarly journals Carcinoma espinocelular em assoalho bucal: relato de caso

2020 ◽  
Vol 8 (11) ◽  
Author(s):  
Dannilo Wiklymber Roldao Mendonça ◽  
Helinaldo Corrêa da Conceicao ◽  
Gleicy Gomes de Lima ◽  
Maria de Fátima Araújo ◽  
Lioney Nobre Cabral ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Rio De Janeiro ◽  
Matched Pair ◽  
Incidence And Mortality ◽  
Head Neck ◽  
Carcinoma Of The Tongue

O câncer de boca representa um problema de saúde pública em todo o mundo, das neoplasias malignas que podem afetar a cavidade oral, o carcinoma espinocelular (CEC), destaca-se por cerca de 90% de todas as lesões malignas diagnosticadas na boca. Descrever o diagnóstico de um caso de (CEC) em região de assoalho bucal em um paciente tabagista. Paciente com 43 anos de idade, sexo masculino, melanoderma, garimpeiro, cor parda, compareceu ao atendimento na Policlínica Odontológica da Universidade do Estado do Amazonas (UEA) para exame estomatológico de rotina. Durante a anamnese o paciente relatou ser tabagista e etilista há mais de 30 anos e fazia uso de cigarros de maconha frequentemente. Ainda através da anamnese, soube-se que o paciente foi exposto por muito tempo à luz solar quando o mesmo trabalhava como garimpeiro. Mencionou também sentir bastante dor e ardência na região da lesão. Diante das informações clínicas colhidas, chegou-se à hipótese diagnóstica de (CEC). O diagnóstico foi confirmado por meio de biopsia incisional e exame histopatológico, com posterior encaminhamento para tratamento médico junto ao centro de controle de oncologia de Manaus (AM). Compete ao cirurgião-dentista diagnosticar e tratar em conjunto com outras especialidades, já que o diagnóstico precoce desta neoplasia torna-se essencial.Descritores: Neoplasias Bucais; Carcinoma de Células Escamosas; Soalho Bucal.ReferênciasFerlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M et al. Cancer incidence and mortality wordwide: sources, methods and major patterns in Globocan 2012. Int J Cancer. 2015;136(5):E359-386.Instituto Nacional de Câncer Jose Alencar Gomes da Silva. Estimativa 2018: incidência de câncer no Brasil / Coordenação de Prevenção e Vigilância. – Rio de Janeiro: INCA, 2017.Dib LL, Sabba LMB, Marques LA, Araújo NS. Fatores prognósticos em carcinoma de bordas de língua: análise clínica e histopatológica. Acta Oncol Bras. 1994;14(2):88-93.Regezi JA, Sciubba JJ, Jordan RCK. Patologia oral: correlações clinicopatológicas. 5. Ed. Rio de Janeiro: Elsevier; 2008.Neville BW, Damm DD, Alen CM, Bouquot JE.  Patologia oral e maxilofacial. Rio de Janeiro: Elsevier; 2009.Abreu MAMM, Pimentel DRN, Silva OMP, Blachman IT, Michalany NS, Hirata CH et al. Squamous cell carcinoma of the lip: assessment of prognostic factors. Rev Bras Otorrinolaringol. 2004;70(6):765-70.Oliveira LR, Ribeiro Silva A, Zucoloto S. Perfil da incidência e da sobrevida de pacientes com carcinoma epidermóide oral em uma população brasileira. J Bras Patol Med Lab. 2006;42(5):385-92.Figuero Ruiz E, Carretero Peláez MA, Cerero Lapiedra R, Esparza Gómez G, Moreno López LA. Effects of the consumption of alcohol in the oral cavity: relationship with oral cancer. Med Oral. 2004;9(1):14-23.Fardin M, Freitas SM, Dedivitis RA, Rapoport A, Denardin OVP, A-Sobrinho J. Fatores de risco no prognóstico do câncer da boca: estudo de 1440 casos. Rev Bras Cirurgia Cabeça Pescoço. 2004;33(1):27-33.Silva PSL, Leão VML, Scarpel RD. Caracterização da população portadora de câncer de boca e orofaringe atendida no setor de cabeça e pescoço em hospital de referência na cidade de Salvador – BA. Rev CEFAC. 2009;11(3):441-47.Souza LRB, Ferraz KD, Pereira NS, Martins MV. Conhecimento acerca do câncer bucal e atitudes frente à sua etiologia e prevenção em um grupo de horticultores de Teresina (PI). Rev Bras Cancerol. 2012;58(1):31-9.Syrjänen S, Lodi G, von Bultzingslowen I, Aliko A, Arduino P, Campisi G et al. Human papilloma viruses in oral carcinoma and oral potentially malignant disorders: a systematic review. Oral Dis. 2011;17(Suppl 1):58-72.Vidal AKL, Caldas Júnior AF, Mello RJV, Brandão VRA, Rocha GI, Taromaru E. J Bras Patol Med Lab. 2004;40(1):21-6.Sina M, Pedram M, Ghojazadeh M, Kochaki A, Aghbali A. P53 gene codon 72 polymorphism in patients with oral squamous cell carcinoma in the population of northern Iran. Med Oral Patol Oral Cir Bucal. 2014;19(6):e550-55.Marchioni DML, Fisberg RM, Gois Filho JF, Kowalski LP, Carvalho MB, Abrahão M et al. Fatores dietéticos e câncer oral: estudo caso-controle na região metropolitana de São Paulo, Brasil. Cad Saúde Pública. 2007;23(3):553-64.Paiva M, Pileggi C, Nobile CGA, Angelillo IF. Association between fruit and vegetable consumption and oral cancer: a meta-analysis of observational studies. Am J Clin Nutr. 2006;83(5):1126-34.Brown LM, Moradi T, Gridley G, Plato N, Dosemeci M, Fraumeni Jr JF. Exposures in the paiting trades and paint manufacturing industry and risck among men and women in Sweden. J Occup Environ Med. 2002;44(3):258-64.Silva MFA. Avaliação da condição de saúde bucal e da qualidade de vida em pacientes com câncer de cabeça e pescoço após radioterapia [monografia]. Campina Grande: UEPB; 2012.Coaracy AEV, Lopes FF, Cruz MCFN, Bastos EG. Correlação entre os dados clínicos e histopatológicos dos casos de carcinoma espinocelular oral do Instituto Maranhense de Oncologia Aldenora Bello, em São Luís, MA. J Bras Patol Med Lab. 2008;44(1): 31-5.Iamarron A, Pattanaporn K, Pongsiriwet S, Wanachantararak S, Prapayasatok S,Jittidecharaks S et al. Analysis of 587 cases of oral squamous cell carcinoma in northern Thailand with a focus on young people. Int J Oral Maxillofac Surg. 2004;33(1):84-8.Sassi LM, Oliveira BV, Pedruzzi PAG, Ramo GHA, Stramandinoli RT, Gugelmin G et al. Carcinoma espinocelular de boca em paciente jovem: relato de caso e avaliação dos fatores de risco. RSBO. 2010;7(1):105-9.Friedlander PL, Schantz SP, Shaha AR, Yu G, Shah JP. Squamous cell carcinoma of the tongue in young patients: a matched-pair analysis. Head Neck. 1998;20(5):363-68.Gomes LC, Macena FCS, Ferreira VS, Barreto VR. Revisão de Literatura: câncer de boca - diagnóstico e fatores de riscos associados. Rev Interdisciplinar em saúde. 2018;5(4):655-70.Myers JN, Elkins T, Roberts D, Byers RM. Squamous cell carcinoma of the tongue in young adults: increasing incidence and factors that predict treatment outcomes. Otolaryngol Head Neck Surg. 2000;122(1):44-51.Souza DP. Carcinoma espinocelular relacionado ao hábito de mascar tabaco: relato de caso clínico [monografia]. Manaus: Universidade do Estado do Amazonas – UEA; 2017.

scholarly journals The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Eder da Silva Dolens ◽  
Mauricio Rocha Dourado ◽  
Alhadi Almangush ◽  
Tuula A. Salo ◽  
Clarissa Araujo Gurgel Rocha ◽  
...  
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Histopathological Features ◽  
Increased Risk ◽  
The Impact

ObjectiveOver many decades, studies on histopathological features have not only presented high-level evidence of contribution for treatment directions and prognosis of oral squamous cell carcinoma (OSCC) but also provided inconsistencies, making clinical application difficult. The 8th TNM staging system of OSCC has acknowledged the importance of some histopathological features, by incorporating depth of invasion (DOI) to T category and extranodal extension (ENE) to N category. The aim of this systematic review with meta-analysis is to determine the most clinically relevant histopathological features for risk assessment and treatment planning of OSCC and to elucidate gaps in the literature.MethodsA systematic review was conducted using PRISMA guidelines, and the eligibility criteria were based on population, exposure, comparison, outcome, and study type (PECOS). PubMed, Cochrane, Scopus, and Web of Science were searched for articles exploring the impact of histopathological features on OSCC outcomes with Cox multivariate analysis. Pooled data were subjected to an inverse variance method with random effects or fixed effect model, and the risk of bias was evaluated using quality in prognosis studies (QUIPS). Quality of evidence was assessed with the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria.ResultsThe study included 172 articles published from 1999 to 2021. Meta-analyses confirmed the prognostic potential of DOI, ENE, perineural invasion, lymphovascular invasion, and involvement of the surgical margins and brought promising results for the association of bone invasion, tumor thickness, and pattern of invasion with increased risk for poor survival. Although with a small number of studies, the results also revealed a clinical significance of tumor budding and tumor-stroma ratio on predicted survival of patients with OSCC. Most of the studies were considered with low or moderate risk of bias, and the certainty in evidence varied from very low to high.ConclusionOur results confirm the potential prognostic usefulness of many histopathological features and highlight the promising results of others; however, further studies are advised to apply consistent designs, filling in the literature gaps to the pertinence of histopathological markers for OSCC prognosis.Systematic Review RegistrationInternational Prospective Register of Systematic Reviews (PROSPERO), identifier CRD42020219630.

scholarly journals Diet-induced obesity accelerates oral carcinogenesis by recruitment and functional enhancement of myeloid-derived suppressor cells

2021 ◽  
Vol 12 (10) ◽  
Author(s):  
Jianmin Peng ◽  
Qinchao Hu ◽  
Xijuan Chen ◽  
Chunyang Wang ◽  
Jiayu Zhang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Suppressor Cells ◽  
Underlying Mechanism ◽  
Clinical Samples ◽  
Acid Uptake ◽  
Myeloid Derived Suppressor Cells ◽  
Increased Risk ◽  
The Impact

AbstractAlthough obesity has been associated with an increased risk and aggressiveness of many types of carcinoma, whether it promotes squamous cell carcinoma remains unclear. To reveal the role of obesity in oral squamous cell carcinoma (OSCC) initiation and development, we used 4NQO-induced OSCC model mice to examine the impact of dietary obesity on carcinogenesis. The results showed that high-fat diet (HFD)-induced obesity significantly promoted the incidence of OSCC and altered the local immune microenvironment with the expansion of CD11b+Gr1+ myeloid-derived suppressor cells (MDSCs). The underlying mechanism that induced an immunosuppressive local microenvironment in obesity was the recruitment of MDSCs through the CCL9/CCR1 axis and enhancement of MDSC immunosuppressive function via intracellular fatty acid uptake. Furthermore, clinical samples verified the increase in infiltrated CD33+ (a marker of human MDSCs) cells in obese OSCC patients, and data from the TCGA dataset confirmed that CD33 expression was positively correlated with local adipocytes in OSCC. Survival analysis showed that enrichment of adipocytes and high expression of CD33 were associated with poor prognosis in OSCC patients. Strikingly, depletion of MDSCs significantly ameliorated HFD-promoted carcinogenesis in 4NQO-induced model mice. These findings indicate that obesity is also an important risk factor for OSCC, and cancer immunotherapy, especially targeting MDSCs, may exhibit greater antitumor efficacy in obese patients.

scholarly journals Lack of Salivary Long Non-Coding RNA XIST Expression Is Associated with Increased Risk of Oral Squamous Cell Carcinoma: A Cross-Sectional Study

2021 ◽  
Vol 10 (19) ◽  
pp. 4622
Author(s):  
Tzong-Ming Shieh ◽  
Chung-Ji Liu ◽  
Shih-Min Hsia ◽  
Valendriyani Ningrum ◽  
Chiu-Chu Liao ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cancer Tissue ◽  
Xist Expression ◽  
Increased Risk ◽  
Cancer Morbidity ◽  
Lncrna Xist

Studies have shown that there is a disparity between males and females in south-east Asia with regard to oral cancer morbidity. A previous study found that oral cancer tissue showed loss of heterozygosity of the X-linked lncRNA XIST gene. We suggest that XIST may play an important role in oral cancer morbidity when associated with sex. Saliva contains proteins and RNAs that are potential biomarkers for the diagnosis of diseases. This study investigated salivary XIST expression and the correlation to clinical–pathological data among oral squamous cell carcinoma patients. Salivary XIST expression was only observed in females, and a high proportion of females with OSCC lack salivary lncRNA XIST expression (88%). The expression showed no correlation with alcohol consumption, betel quid chewing, or cigarette smoking habits. People lacking salivary lncRNA XIST expression had a significantly increased odds ratio of suffering from OSCC (OR = 19.556, p < 0.001), particularly females (OR = 33.733, p < 0.001). The ROC curve showed that salivary lncRNA XIST expression has acceptable discrimination accuracy to predict the risk of OSCC (AUC = 0.73, p < 0.01). Lack of salivary lncRNA XIST expression was associated with an increased risk of OSCC. We provided an insight into the role of salivary lncRNA XIST as a biomarker to predict the morbidity of OSCC.

Correlation of CTCs with disease progression in Indian oral cancer patients.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e15541-e15541
Author(s):  
Jayant Khandare ◽  
Burhanuddin Qayyumi ◽  
Atul Bharde ◽  
Gourishankar Aland ◽  
Sreeja Jayant ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Clinicopathological Parameters ◽  
Depth Of Invasion ◽  
Advanced Stage ◽  
Pathological Features ◽  
Positive Correlation

e15541 Background: Head and neck squamous cell carcinoma is leading cancer in the India with Oral squamous cell carcinoma (OSCC) as the most frequent subtype. OSCC is classified as a locoregional disease and its increased frequency is attributed to lack of good biomarkers compared to other epithelial cancers. At the time of diagnosis, above 50% of cases present the manifestation of advanced-stage disease, and are predisposed to disease failure in spite of appropriate treatment. Thus, early diagnosis of OSCC can significantly reduce the disease burden. Here we describe regulatory approved method to establish Circulating tumor cells (CTCs) presence in OSCC Indian patients and its positive correlation with various clinicopathological parameters, suggesting the potential use of CTCs as a significant parameter to stratify oral cancer with respect to the disease advancement. Methods: In a cross-sectional observational study, 230 OSCC patients at the different pathological stage of the disease and treatment mode were enrolled. CTCs were isolated using approved OncoDiscover liquid biopsy technology (Drug controller general of India approved), platform technology based on immunomagnetic CTC enumeration. CTCs were detected for CK18 presence and well-defined, DAPI-stained nuclei. Enumerated CTC subsequently analyzed for various clinic-pathological parameters such as pstage, extra-capsular spread (ECS), lymphovascular emboli (LVE), perineural invasion (PNI) and depth of invasion (DOI). CTC cut off values were obtained to differentiate early vs advanced stages with respect to different clinical stages and parameters. Results: CTCs of OSCC patients correlated positively with the cancer stages (clinical as well as pathological) as well as aggressive pathological features. The presence of aggressive pathological features that often suggest the poor outcome of the disease, we observed a 25-50 % increase in CTC number. Early stage, treatment naïve patients had lower number of CTCs. Mean CTC number in advanced-stage patients was 50 % higher than early-stage OSCC patients. Conclusions: Considering a positive correlation of CTC number with various pathophysiological features, CTC can be contemplated as a reliable parameter to predict the disease outcome in oral cancer. The consistent presence of CTC across all disease stages also suggests a probable nature of OSCC as a biological systematic disease. Clinical trial information: CTRI/2018/03/012905.

scholarly journals Association of Microbiota with Oral Potential Malignant Disorder: A Mini Review

2021 ◽  
pp. 704-708
Author(s):  
Prasada Rao Namburi ◽  
Krishnan Mahalakshmi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oral Microbiota ◽  
Oral Potentially Malignant Disorders ◽  
Diagnosis And Prognosis ◽  
Increased Risk ◽  
Potentially Malignant

Most of the oral squamous cell carcinoma (OSCC) are often preceded by oral potentially malignant disorders (OPMDs). OPMDs are defined as oral mucosal lesions and conditions which are at increased risk for undergoing alteration to oral cancer. OPMDs grow in a complex tissue microenvironment to acquire oral squamous cell carcinoma (OSCC) characteristics. Oral microbiota associated with OPMD may appear as potential biomarkers as these species may help in the diagnosis and prognosis of OPMD to OSCC. This association of microbiota to OPMD and may be helpful in the early treatment before the initiation of oral cancer. This article reviews the literature on association between microbiota and Oral potential malignant disorders.

scholarly journals Understanding the role of potential pathways and its components including hypoxia and immune system in case of oral cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Leena Hussein Bajrai ◽  
Sayed Sartaj Sohrab ◽  
Mohammad Mobashir ◽  
Mohammad Amjad Kamal ◽  
Moshahid Alam Rizvi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Immune System ◽  
Oral Cancer ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Signaling Pathways ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Critical Pathways ◽  
The Impact

AbstractThere are a few biological functions or phenomenon which are universally associated with majority of the cancers and hypoxia and immune systems are among them. Hypoxia often occurs in most of the cancers which helps the cells in adapting different responses with respect to the normal cells which may be the activation of signaling pathways which regulate proliferation, angiogenesis, and cell death. Similar to it, immune signaling pathways are known to play critical roles in cancers. Moreover, there are a number of genes which are known to be associated with these hypoxia and immune system and appear to direct affect the tumor growth and propagations. Cancer is among the leading cause of death and oral cancer is the tenth-leading cause due to cancer death. In this study, we were mainly interested to understand the impact of alteration in the expression of hypoxia and immune system-related genes and their contribution to head and neck squamous cell carcinoma. Moreover, we have collected the genes associated with hypoxia and immune system from the literatures. In this work, we have performed meta-analysis of the gene and microRNA expression and mutational datasets obtained from public database for different grades of tumor in case of oral cancer. Based on our results, we conclude that the critical pathways which dominantly enriched are associated with metabolism, cell cycle, immune system and based on the survival analysis of the hypoxic genes, we observe that the potential genes associated with head and neck squamous cell carcinoma and its progression are STC2, PGK1, P4HA1, HK1, SPIB, ANXA5, SERPINE1, HGF, PFKM, TGFB1, L1CAM, ELK4, EHF, and CDK2.

scholarly journals The Expression of Programmed Death Ligand-1 within Stages of Oral Squamous Cell Carcinoma: Immunohistochemical Analysis

2020 ◽  
pp. 59-68
Author(s):  
Moomal Aslam Khan ◽  
Serajuddaula Syed ◽  
Noor Ul Wahab ◽  
Saima Akram Butt ◽  
Jabbar Ahmed Qureshi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Statistical Significance ◽  
Clinicopathological Parameters ◽  
Immunohistochemical Expression ◽  
Programmed Death Ligand 1 ◽  
Programmed Death ◽  
Incidence And Mortality

Background: Oral squamous cell carcinoma is prevalent in South Asian countries with rising cases of its incidence and mortality. Despite advancements in treatment, survival and recurrence rates are poor. Immunotherapy is a novel therapeutic modality in immunooncology. Immune checkpoint proteins are under investigation for clinical implications amongst which Programmed Death Ligand-1 has shown valuable results in certain malignancies. Aims: To determine the immunohistochemical expression of Programmed Death Ligand-1(PD-L1) in oral squamous cell carcinoma and to find an association of Programmed Death Ligand-1 with stage and clinicopathological parameters of oral squamous cell carcinoma. Study Design: Cross-sectional study. Place and Duration of Study: Ziauddin Medical University, Karachi, 1 Year duration during 2018-2019. Methods: A total number of 140 biopsy confirmed cases of oral squamous cell carcinoma were recruited in the study. Immunohistochemical expression of Programmed Death Ligand-1 was evaluated and associated with the clinicopathological parameters of oral squamous cell carcinoma (OSCC). The data was statistically analyzed through Descriptive statistics and Chi square test by using SPSS v.20. Results: Out of 140 participants, 74% were males (n=103) and 26% were females (n=37). Programmed Death Ligand-1 positivity was observed in 62.1% of cases (n=87). The Mean age of the participants was 48.91 ± 11.7 years.  The most common site of cancer involvement was buccal mucosa and majority of participants were habitual of consuming chewable products i.e. Pan, Gutka and betel nut (89; 64%). Stage III and IV tumours comprised a major portion of cases in our study. (52; 37%), (56; 40%). A statistically significant p-value was noted for the association of Programmed Death Ligand-1 with stage II and IV tumours. (P-values: 0.029, 0.001)The association of Programmed Death Ligand-1 with other variables such as age, gender, ethnicity, sites or habits was not statistically significant. Conclusion: This study concludes that the statistical significance of Programmed Death Ligand-1 expression with tumour stage is suggestive of worsening prognosis and might have detrimental effects as tumour progresses in advanced stage. Programmed Death Ligand-1 positivity in patients having oral squamous cell carcinoma could be useful in future research in the light of cancer immunotherapy which has shown success in oncology.

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