scholarly journals Adherence to Anti-Osteoporotic Treatment and Clinical Implications after Hip Fracture: A Systematic Review

2021 ◽  
Vol 11 (5) ◽  
pp. 341
Author(s):  
Ramona Dobre ◽  
Dan Alexandru Niculescu ◽  
Răzvan-Cosmin Petca ◽  
Răzvan-Ionuț Popescu ◽  
Aida Petca ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hip Fracture ◽  
Fracture Risk ◽  
Healthcare Professionals ◽  
Review Of The Literature ◽  
Treatment Adherence And Compliance ◽  
Pubmed Database ◽  
Second Fracture ◽  
Hip Fracture Mortality

The role of anti-osteoporotic treatment as part of the secondary prevention after hip fracture in terms of mortality and re-fracture risk has been studied, and the results are promising. Decreased treatment adherence and compliance is a problem that needs to be addressed by healthcare professionals. A systematic review of the literature was performed using the PubMed database with terms that included hip fracture, mortality, second fracture, and specific anti-osteoporotic treatment. We included 28 articles, 21 regarding mortality and 20 re-fracture rates in hip fracture patients. All studies showed lower mortality after hip fracture associated with anti-osteoporotic treatment, mostly bisphosphonate agents. The re-fracture risk is still debatable, since conflicting data were found. Although most of the studies showed notable effects on mortality and re-fracture rates associated with anti-osteoporotic treatment, we still need more data to validate the actual results.

scholarly journals The association of fracture risk in atrial fibrillation patients and long-term anticoagulant therapy category: a systematic review and meta-analysis

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e10683
Author(s):  
Jun Chen ◽  
Lingchun Lyu ◽  
Jiayi Shen ◽  
Chunlai Zeng ◽  
Cheng Chen ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Systematic Review ◽  
Hip Fracture ◽  
Fracture Risk ◽  
Hip Fractures ◽  
Observational Studies ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Hip Fracture Risk ◽  
Significant Difference

Objective Our study aimed to assess the risk of all fractures and hip fractures in patients with atrial fibrillation (AF) who took non-vitamin K antagonist oral anticoagulants (NOACs) compared to warfarin. Methods We searched PubMed, Embase, and Cochrane Library and Clinical Trials.gov Website. Reviewed related researches up to January 31, 2020, to identify studies with more than 12 months of follow-up data. The protocol for this systematic review and meta-analysis has been registered in the International Prospective Register of Systematic Reviews (PROSPERO Number: CRD42020156893). Results We included five RCT studies, and five observational studies that contained a total of 326,846 patients in our meta-analysis. Our meta-analysis showed that patients taken NOACs had no significant all fracture risk (RR = 0.91, 95% CI [0.81–1.01]) and hip fracture risk (RR = 0.92, 95% CI [0.82–1.03]) compared with those taken warfarin. Subanalysis showed that the risk of all fractures and hip fractures treated by NOACs were significant lower compared with warfarin in observational studies compared with RCT studies. Also, a subanalysis across the duration of anticoagulation showed the NOACs users have lower all fracture risk than warfarin users when the duration of anticoagulation ≤2 years (RR = 0.89, 95% CI [0.80–0.99]). Further analysis, significant lower all fracture risk in the rivaroxaban therapy (RR = 0.81; 95% CI [0.76–0.86]) compared with warfarin but no statistical significance in hip fracture. There were no significant difference of all fracture risk and hip fracture risk in dabigatran, apixaban, and edoxaban therapy compared with warfarin. Conclusion The meta-analysis demonstrated that NOACs associated with a significantly lower all fracture risk compared with warfarin when the duration of anticoagulation more than 2 years. Rivaroxaban users had lower risk of all fracture than warfarin users in AF patients. But there was no evidence to verify apixaban, edoxaban, and dabigatranin could decrease all fracture and hip fracture risk compared with warfarin.

The Role of the Social Worker in the Adult Critical Care Unit: A Systematic Review of the Literature

2011 ◽  
Vol 50 (2) ◽  
pp. 143-157 ◽  
Author(s):  
Katherine Hartman-Shea ◽  
Anne Hahn ◽  
Joanne Fritz Kraus ◽  
Grace Cordts ◽  
Jonathan Sevransky
Keyword(s):  
Systematic Review ◽  
Critical Care ◽  
Social Worker ◽  
Critical Care Unit ◽  
Review Of The Literature ◽  
The Social

Role of metalloproteinases and their inhibitors in the development of abdominal aortic aneurysm: current insights and systematic review of the literature

Chirurgia ◽  
2017 ◽  
Vol 30 (5) ◽  
Author(s):  
Lucia Butrico ◽  
Andrea Barbetta ◽  
Salvatore Ciranni ◽  
Michele Andreucci ◽  
Pasquale Mastroroberto ◽  
...  
Keyword(s):  
Systematic Review ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Review Of The Literature ◽  
Abdominal Aortic

scholarly journals Role of Bcl-2 as a prognostic factor for survival in lung cancer: a systematic review of the literature with meta-analysis

2003 ◽  
Vol 89 (1) ◽  
pp. 55-64 ◽  
Author(s):  
B Martin ◽  
M Paesmans ◽  
T Berghmans ◽  
F Branle ◽  
L Ghisdal ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Systematic Review ◽  
Prognostic Factor ◽  
Meta Analysis ◽  
Review Of The Literature
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