scholarly journals Response Predictivity to Neoadjuvant Therapies in Breast Cancer: A Qualitative Analysis of Background Parenchymal Enhancement in DCE-MRI

2021 ◽  
Vol 11 (4) ◽  
pp. 256
Author(s):  
Daniele La Forgia ◽  
Angela Vestito ◽  
Maurilia Lasciarrea ◽  
Maria Colomba Comes ◽  
Sergio Diotaiuti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Therapy ◽  
Menopausal Status ◽  
Therapy Response ◽  
Predictive Marker ◽  
Intermediate Step ◽  
Fibroglandular Tissue ◽  
Background Parenchymal Enhancement ◽  
Pre Treatment ◽  
Parenchymal Enhancement

Background: For assessing the predictability of oncology neoadjuvant therapy results, the background parenchymal enhancement (BPE) parameter in breast magnetic resonance imaging (MRI) has acquired increased interest. This work aims to qualitatively evaluate the BPE parameter as a potential predictive marker for neoadjuvant therapy. Method: Three radiologists examined, in triple-blind modality, the MRIs of 80 patients performed before the start of chemotherapy, after three months from the start of treatment, and after surgery. They identified the portion of fibroglandular tissue (FGT) and BPE of the contralateral breast to the tumor in the basal control pre-treatment (baseline). Results: We observed a reduction of BPE classes in serial MRI checks performed during neoadjuvant therapy, as compared to baseline pre-treatment conditions, in 61.3% of patients in the intermediate step, and in 86.7% of patients in the final step. BPE reduction was significantly associated with sequential anthracyclines/taxane administration in the first cycle of neoadjuvant therapy compared to anti-HER2 containing therapies. The therapy response was also significantly related to tumor size. There were no associations with menopausal status, fibroglandular tissue (FGT) amount, age, BPE baseline, BPE in intermediate, and in the final MRI step. Conclusions: The measured variability of this parameter during therapy could predict therapy effectiveness in early stages, improving decision-making in the perspective of personalized medicine. Our preliminary results suggest that BPE may represent a predictive factor in response to neoadjuvant therapy in breast cancer, warranting future investigations in conjunction with radiomics.

Impact of menopausal status on background parenchymal enhancement and fibroglandular tissue on breast MRI

2012 ◽  
Vol 22 (12) ◽  
pp. 2641-2647 ◽  
Author(s):  
Valencia King ◽  
Yajia Gu ◽  
Jennifer B. Kaplan ◽  
Jennifer D. Brooks ◽  
Malcolm C. Pike ◽  
...  
Keyword(s):  
Menopausal Status ◽  
Breast Mri ◽  
Fibroglandular Tissue ◽  
Background Parenchymal Enhancement ◽  
Parenchymal Enhancement

scholarly journals Correlation Between Mammographic Breast Density, Breast Tissue Type in Ultrasonography, Fibroglandular Tissue, and Background Parenchymal Enhancement in Magnetic Resonance Imaging

2018 ◽  
Vol 12 ◽  
pp. 117822341877197 ◽  
Author(s):  
Afsaneh Alikhassi ◽  
Seyedeh Nooshin Miratashi Yazdi ◽  
Hedieh Akbari ◽  
Sona Akbari Kia ◽  
Masoud Baikpour
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Breast Density ◽  
Menopausal Status ◽  
Mammographic Breast Density ◽  
Resonance Imaging ◽  
Imaging Studies ◽  
Background Parenchymal Enhancement ◽  
Parenchymal Enhancement

Objective: Breast cancer is the most common malignancy in the female population, and imaging studies play a critical role for its early detection. Mammographic breast density (MBD) is one of the markers used to predict the risk stratification of breast cancer in patients. We aimed to assess the correlations among MBD, ultrasound breast composition (USBC), fibroglandular tissue (FGT), and the amount of background parenchymal enhancement (BPE) in magnetic resonance imaging, after considering the subjects’ menopausal status. Methods: In this retrospective cross-sectional study, the medical records’ archives in a tertiary referral hospital were reviewed. Data including age, menopausal status, their mammograms, and ultrasound assessments were extracted from their records. All of their imaging studies were reviewed, and MBD, USBC, FGT, and BPE were determined, recorded, and entered into SPSS software for analysis. Results: A total of 121 women (mean age = 42.7 ± 11.0 years) were included, of which 35 out of 115 (30.4%) had reached menopause. Using the Jonckheere-Terpstra test for evaluating the trends among above mentioned 4 radiologic characteristics in the total sample population, a significant positive relation was found between each of these paired variables: (1) USBC-MBD ( P = .006), (2) FGT-MBD ( P = .001), (3) USBC-BPE ( P = .046), (4) USBC-FGT ( P = .036), and (5) BPE-FGT ( P < .001). These trends were not found to be significant among premenopausal subjects. Conclusions: Considering the trends between different measures of breast density in the 3 radiologic modalities, these factors can be used interchangeably in certain settings.

scholarly journals Fibroglandular Tissue and Background Parenchymal Enhancement on Breast MR Imaging Correlates With Breast Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Xiaoxin Hu ◽  
Luan Jiang ◽  
Chao You ◽  
Yajia Gu
Keyword(s):  
Breast Cancer ◽  
Lesion Group ◽  
Control Group ◽  
Control Groups ◽  
Fibroglandular Tissue ◽  
Cancer Group ◽  
Background Parenchymal Enhancement ◽  
Significant Difference ◽  
Benign Group ◽  
Parenchymal Enhancement

ObjectivesTo evaluate the association of breast cancer with both the background parenchymal enhancement intensity and volume (BPEI and BPEV, respectively) and the amount of fibroglandular tissue (FGT) using an automatic quantitative assessment method in breast magnetic resonance imaging (MRI).Materials and MethodsAmong 17,274 women who underwent breast MRI, 132 normal women (control group), 132 women with benign breast lesions (benign group), and 132 women with breast cancer (cancer group) were randomly selected and matched by age and menopausal status. The area under the receiver operating characteristic curve (AUC) was compared in Cancer vs Control and Cancer vs Benign groups to assess the discriminative ability of BPEI, BPEV and FGT.ResultsCompared with the control groups, the cancer group showed a significant difference in BPEV with a maximum AUC of 0.715 and 0.684 for patients in premenopausal and postmenopausal subgroup, respectively. And the cancer group showed a significant difference in BPEV with a maximum AUC of 0.622 and 0.633 for patients in premenopausal and postmenopausal subgroup, respectively, when compared with the benign group. FGT showed no significant difference when breast cancer group was compared with normal control and benign lesion group, respectively. Compared with the control groups, BPEI showed a slight difference in the cancer group. Compared with the benign group, no significant difference was seen in cancer group.ConclusionIncreased BPEV is correlated with a high risk of breast cancer While FGT is not.

scholarly journals Association between MRI background parenchymal enhancement and lymphovascular invasion and estrogen receptor status in invasive breast cancer

2019 ◽  
Vol 92 (1103) ◽  
pp. 20190417 ◽  
Author(s):  
Jun Li ◽  
Yin Mo ◽  
Bo He ◽  
Qian Gao ◽  
Chunyan Luo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Invasive Breast Cancer ◽  
Clinical Characteristics ◽  
Lymphovascular Invasion ◽  
Menopausal Status ◽  
Pathological Examination ◽  
Background Parenchymal Enhancement ◽  
Parenchymal Enhancement ◽  
Er Status

Objectives: In magnetic resonance imaging (MRI), background parenchymal enhancement (BPE) is associated with breast cancer risk, but the associations between BPE and clinical characteristics and histological features are unknown. This study aimed to investigate the association between BPE and clinical characteristics (including age, menopausal status, and tumor histological characteristics) in patients with invasive breast cancer. Methods: This was a retrospective study of 163 patients with invasive breast cancer (164 lesions, 1 patient had bilateral cancer) confirmed by surgery and pathological examination, treated between January 2014 and December 2016 at our university (Kunming Medical University). The patients were divided into two groups: extremely minimal and mild enhancement (low BPE group, n = 78) vs moderate and marked enhancement (high BPE group, n = 86). Results: Compared with the low BPE group, the high BPE group showed higher frequencies of patients < 50 years of age (88% vs 38%, p < 0.0001), premenopausal (87% vs 29%, p < 0.0001), T1 staging (35% vs 15%, p = 0.027), Grade II (57% vs 37%, p = 0.03), lymphovascular invasion (83% vs 13%, p < 0.0001), and positive estrogen receptor (ER) (79% vs 42%, p < 0.0001). The Spearman correlation coefficients (r) between BPE and age, menopausal status, lymphovascular invasion, and ER status were −0.521 (p < 0.0001), –0.588 (p < 0.0001), 0.697 (p < 0.0001), and 0.377 (p < 0.0001), respectively. Conclusion: BPE is negatively associated with age and menopausal status, and is positively associated with lymphovascular invasion and positive ER status. Advances in knowledge: BPE is not correlated with T staging and histological classification in patients with invasive breast cancer.

scholarly journals Breast cancer and background parenchymal enhancement at breast magnetic resonance imaging: a meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Na Hu ◽  
Jinghao Zhao ◽  
Yong Li ◽  
Quanshui Fu ◽  
Linwei Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Breast Magnetic Resonance Imaging ◽  
Meta Analysis ◽  
Resonance Imaging ◽  
High Background ◽  
Background Parenchymal Enhancement ◽  
Breast Magnetic Resonance ◽  
Parenchymal Enhancement

Abstract Background The background parenchymal enhancement at breast magnetic resonance imaging use to predict breast cancer attracts many searchers to draw a possible relationship. However, the results of their relationships were conflicting. This meta-analysis was performed to assess breast cancer frequency associations with background parenchymal enhancement. Methods A systematic literature search up to January 2020 was performed to detect studies recording associations between breast cancer frequency and background parenchymal enhancement. We found thirteen studies including 13,788 women at the start with 4046 breast cancer. We calculated the odds ratio (OR) and the 95% confidence intervals (CIs) between breast cancer frequency and background parenchymal enhancement by the dichotomous technique with a random or fixed-effect model. Results Women with minimal or mild background parenchymal enhancement at breast magnetic resonance imaging did not have any risk of breast cancer compared to control women (OR, 1.20; 95% CI 0.54–2.67). However, high background parenchymal enhancement at breast magnetic resonance imaging (OR, 2.66; 95% CI 1.36–5.19) and moderate (OR, 2.51; 95% CI 1.49–4.21) was associated with a significantly higher rate of breast cancer frequency compared to control women. Conclusions Our meta-analysis showed that the women with high and moderate background parenchymal enhancement at breast magnetic resonance imaging have higher risks, up to 2.66 fold, of breast cancer. We suggest that women with high or moderate background parenchymal enhancement at breast magnetic resonance imaging to be scheduled for more frequent follow-up and screening for breast cancer to avoid any complications.

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