scholarly journals Radiation Biomarkers in Large Scale Human Health Effects Studies

2020 ◽  
Vol 10 (4) ◽  
pp. 155 ◽  
Author(s):  
Jayne Moquet ◽  
Kai Rothkamm ◽  
Stephen Barnard ◽  
Elizabeth Ainsbury

Following recent developments, the RENEB network (Running the European Network of biological dosimetry and physical retrospective dosimetry) is in an excellent position to carry out large scale molecular epidemiological studies of ionizing radiation effects, with validated expertise in the dicentric, fluorescent in situ hybridization (FISH)-translocation, micronucleus, premature chromosome condensation, gamma-H2AX foci and gene expression assays. Large scale human health effects studies present complex challenges such as the practical aspects of sample logistics, assay costs, effort, effect modifiers and quality control/assurance measures. At Public Health England, the dicentric, automated micronucleus and gamma-H2AX radiation-induced foci assays have been tested for use in a large health effects study. The results of the study and the experience gained in carrying out such a large scale investigation provide valuable information that could help minimise random and systematic errors in biomarker data sets for health surveillance analyses going forward.

Food Safety ◽  
2016 ◽  
Vol 4 (1) ◽  
pp. 14-27 ◽  
Author(s):  
Yun Yun Gong ◽  
Sinead Watson ◽  
Michael N Routledge

Author(s):  
PA Ganichev

Introduction: Polymer products have become inexpensive, convenient and widely used in all spheres of everyday life recently. Microplastics are found in seawater, wastewater, fresh water, foodstuffs, and air. Over the past few years, the presence of microplastics in treated tap and bottled water has been reported, raising questions and concerns about their potential human health effects. Objective: To summarize and systematize the results of studying health effects of exposure to microplastics in potable water. Materials and methods: A literature review was done based on ten topical articles and reviews published in 2014–2021 out of 64 sources found in the PubMed and Scopus international databases and the Russian Science Citation Index (RSCI). Results and conclusions: Generalization and systematization of the published research data demonstrated the lack of strong evidence to draw conclusions about human health effects of microplastics. Information on toxicokinetics and toxicodynamics of ingested microplastic particles is absent just like the studies of the most common shapes and sizes of plastic particles and health risks from exposure to such particles in drinking water.


1995 ◽  
Vol 3 (1) ◽  
pp. 121-144 ◽  
Author(s):  
Jerome O. Nriagu ◽  
Abdul Kabir

The widening use of chromium and its compounds by local industries has led to a growing concern about the effects of chromium contamination on the Canadian environment. This report summarizes the data on Canadian sources and the concentrations of chromium in air, water, sediments, soil, terrestrial wildlife and aquatic biota. It reviews what little is currently known about the cycling of chromium in Canadian ecoystems, and the need for measuring Cr(III) and Cr(VI) rather than total Cr in the environmental media is emphasized. The potential effects of elevated levels of chromium on plants, soil microorganisms, wildlife, and aquatic biota are discussed. The human health effects are not covered. The conclusion is reached that chromium pollution has become a threat to Canadian ecosystems, especially at the local scale where the ambient chromium concentrations in some surface waters, sediments, and soils are now close to or above the toxicity threshold for a number of the more sensistive organisms.Key words: chromium pollution, chromium toxicity, chromium chemistry, chromium emission, bioaccumulation of chromium.


2014 ◽  
Vol 62 (18) ◽  
pp. 3867-3876 ◽  
Author(s):  
Francesca Giampieri ◽  
José M. Alvarez-Suarez ◽  
Maurizio Battino

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