scholarly journals Fungal Biofilms 2020

2021 ◽  
Vol 7 (8) ◽  
pp. 603
Author(s):  
Célia F. Rodrigues ◽  
Jesus A. Romo
Keyword(s):  
Healthcare Costs ◽  
Fungal Infections ◽  
Mortality Rates ◽  
Multidrug Resistant ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Effective Response ◽  
Multidrug Resistant Pathogens ◽  
Global Threat

Fungal infections are an important and increasing global threat, carrying not only high morbidity and mortality rates, but also extraordinary healthcare costs. Without an effective response, it is predicted that 10 million people will die per year because of multidrug-resistant pathogens. [...]

scholarly journals Review: Research Toward Safer Resection of the Cirrhotic Liver

HPB Surgery ◽  
2000 ◽  
Vol 11 (5) ◽  
pp. 285-297 ◽  
Author(s):  
M. A. J. Moser ◽  
N. M. Kneteman ◽  
G. Y. Minuk
Keyword(s):  
Surgical Technique ◽  
Liver Function ◽  
Mortality Rates ◽  
Cirrhotic Liver ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Hepatic Surgery ◽  
Postoperative Course ◽  
Cirrhotic Patients ◽  
Surgery Resection

Despite recent advances in hepatic surgery, resection of the cirrhotic liver continues to be fraught with high morbidity and mortality rates. As a result, for many patients requiring resection of HCC the postoperative course is complicated and the probability of cure is diminished by coexisting cirrhosis. In this review, we discuss the characteristics of the cirrhotic liver which make it poorly tolerant of resection and the most common complications that follow such surgery. The main purpose of this paper is to review recent attempts to identify interventions that might be beneficial to cirrhotic patients undergoing resection. These interventions include assessment of liver reserve, advances in surgical technique, and improvement in liver function and regeneration.

scholarly journals ANTI-CANDIDA ALBICANS ACTIVITY OF THE ASSOCIATION OF CITRONELAL WITH ANFOTERICIN B OR WITH CETOCONAZOLE

2019 ◽  
Vol 16 (31) ◽  
pp. 250-257
Author(s):  
Patrícia Duarte Costa SILVA ◽  
Brenda Lavínia Calixto dos SANTOS ◽  
Gustavo Lima SOARES ◽  
Wylly Araújo de OLIVEIRA
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Amphotericin B ◽  
Inhibitory Concentration ◽  
Fungal Infections ◽  
Pathogenic Fungi ◽  
Mortality Rates ◽  
New Drugs ◽  
High Morbidity ◽  
Isolated Species

Fungal infections caused by species of the genus Candida are responsible for high morbidity and mortality rates, mainly affecting immunocompromised individuals. Among fungi, Candida albicans is the most frequently isolated species of clinical specimens. A problem associated with increased resistance of pathogenic fungi to the agents used in the therapeutic regimen and the limited number of drugs to cure these infections. As a result, the search for new drugs with antifungal activity has become increasingly important. The aim of this study is to study the antifungal activity of citronellal alone and in combination with amphotericin B or ketoconazole. The Minimal Inhibitory Concentration of citronellal, amphotericin B and ketoconazole against strains of Candida albicans were evaluated by the microdilution technique, and the Minimum Fungicide Concentration of citronellal against the same strains was also performed. Through the checkerboard methodology the effect of the combination of citronelal with amphotericin B or with ketoconazole was determined. This study showed that the association of citronellal with ketoconazole was shown to be an additive against one of the strains of C. albicans and indifferent to another strain. While the combined activity of citronellal and amphotericin B demonstrated an indifferent effect on the strains tested.

scholarly journals Current Antimycotics, New Prospects, and Future Approaches to Antifungal Therapy

Antibiotics ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 445 ◽  
Author(s):  
Gina Wall ◽  
Jose L. Lopez-Ribot
Keyword(s):  
Drug Development ◽  
Drug Interactions ◽  
Fungal Infections ◽  
Mortality Rates ◽  
Clinical Development ◽  
Antifungal Drugs ◽  
High Morbidity ◽  
Eukaryotic Organisms ◽  
Emergence Of Resistance ◽  
Compromised Patients

Fungal infections represent an increasing threat to a growing number of immune- and medically compromised patients. Fungi are eukaryotic organisms and, as such, there is a limited number of selective targets that can be exploited for antifungal drug development. This has also resulted in a very restricted number of antifungal drugs that are clinically available for the treatment of invasive fungal infections at the present time—polyenes, azoles, echinocandins, and flucytosine. Moreover, the utility of available antifungals is limited by toxicity, drug interactions and the emergence of resistance, which contribute to high morbidity and mortality rates. This review will present a brief summary on the landscape of current antifungals and those at different stages of clinical development. We will also briefly touch upon potential new targets and opportunities for novel antifungal strategies to combat the threat of fungal infections.

Emergent Right Hemicolectomies

2005 ◽  
Vol 71 (8) ◽  
pp. 653-657 ◽  
Author(s):  
Amy D. Wyrzykowski ◽  
David V. Feliciano ◽  
Timothy A. George ◽  
Lorraine N. Tremblay ◽  
Grace S. Rozycki ◽  
...  
Keyword(s):  
Damage Control ◽  
Primary Anastomosis ◽  
Bowel Perforation ◽  
Demographic Data ◽  
Wound Dehiscence ◽  
Mortality Rates ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Trauma Patients ◽  
Abdominal Abscess

Emergent right hemicolectomies have historically been associated with surprisingly high morbidity and mortality rates. A retrospective review of emergent right hemicolectomies over a 7-year period was performed to assess current morbidity and mortality. Emergent right hemicolectomy was defined as a procedure performed for an acute abdomen with no formal preoperative cleansing of the colon. Demographic data, diagnostic evaluation, length of stay and outcomes were evaluated. Over the study period, 122 emergent right hemicolectomies were performed on both general surgery and trauma patients. The average patient was 52.9 ± 18.5 years old, and the majority of patients (66.4%) were male. The indications for the procedures performed were bowel perforation (51), hemorrhage (25), cancer (16), benign obstruction (14), phlegmon (8), ischemia (6), or other (2). Resection with primary anastomosis was performed in 98 patients, 16 had an end ileostomy, and 8 underwent damage control procedures in which gastrointestinal continuity was not reestablished at the time of the original operation. Postoperative complications developed in 48 patients (39.3%). The majority of the complications (83.3%) were related to infection including intra-abdominal abscess (21 patients), sepsis (16), and wound infection (5). Other complications included anastomotic leak (5), wound dehiscence (3), stoma-related (3) and postoperative bowel obstruction (2). The patients who developed complications did not differ from those who had an uneventful postoperative course in terms of age, indication for procedure, or presence of intra-abdominal abscess or gross contamination at the time of the original procedure. The overall mortality rate was 13 per cent. Patients who died were older than those who lived (63 ± 19 vs 52 ± 18; P = 0.03) and were significantly more likely to have evidence of shock on presentation ( P = 0.0013). Emergent right hemicolectomies continue to be associated with high morbidity and mortality rates. The most common complications are related to infection. Age and manifestations of shock at the time of admission are strong predictors of mortality.

scholarly journals A rare case of myelodysplastic syndrome with refractory thrombocytopenia

2015 ◽  
Vol 7 (3) ◽  
Author(s):  
Waqas Jehangir ◽  
John Webb ◽  
Shilpi Singh ◽  
Sabrina Arshed ◽  
Shuvendu Sen ◽  
...  
Keyword(s):  
Rare Case ◽  
Treatment Options ◽  
Gene Mutations ◽  
Mortality Rates ◽  
Morbidity And Mortality ◽  
Genetic Mutations ◽  
Specific Gene ◽  
High Morbidity ◽  
Risk Patients ◽  
Evidenced Based

Myelodysplastic syndromes (MDS) represent a variety of clonal abnormalities, possibly preleukemic and display numerous phenotypic manifestations. Specific mutations carry high morbidity and mortality rates due to cell line dysplasia. MDS commonly presents with symptoms related to anemia, and approximately two-thirds will develop thrombocytopenia, a rare, but potentially lethal complication that increases complexity in treatment and morbidity, and may be due to unique genetic mutations leading to refractory thrombocytopenia, ultimately leading to an overall reduction in survival. Careful identification and monitoring of this patient subdivision can significantly reduce morbidity and mortality, and potential identification of specific gene mutations and advances in treatment options will hopefully provide guidance on detecting at-risk patients in the future. We present a case of a man with MDS-U (karyotype 46, XY, del (20) (q11.2q13.3) (20) with no detected <em>JAK2</em> <em>V617F</em> mutation), who in despite of appropriate evidenced based treatment, continued to exhibit refractory thrombocytopenia.

An Immersed Porous Boundary Method for Computational Fluid Dynamics of Blood Flow in Aneurysms With Flow Diverters

2012 ◽  
Author(s):  
Viorel Mihalef ◽  
Puneet Sharma ◽  
Ali Kamen ◽  
Thomas Redel
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Blood Flow ◽  
Subarachnoid Hemorrhage ◽  
Cerebral Artery ◽  
Intracranial Aneurysms ◽  
Mortality Rates ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Flow Diverters

Intracranial aneurysms are pathological dilatations of a cerebral artery that may suffer rupture and lead to subarachnoid hemorrhage. Such a condition presents high morbidity and mortality rates for the patients concerned.

scholarly journals Morbidity and Mortality Outcomes of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy at a Single Institution in Japan

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Akiyoshi Mizumoto ◽  
Emel Canbay ◽  
Masamitsu Hirano ◽  
Nobuyuki Takao ◽  
Takayuki Matsuda ◽  
...  
Keyword(s):  
Postoperative Complications ◽  
Peritoneal Carcinomatosis ◽  
Intraperitoneal Chemotherapy ◽  
Cytoreductive Surgery ◽  
Hyperthermic Intraperitoneal Chemotherapy ◽  
Mortality Rates ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Single Institution ◽  
Crs And Hipec

Background. Even though cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are associated with a high morbidity and mortality rates, it has been reported that CRS and HIPEC improved survival of selected patients with peritoneal carcinomatosis. We aimed to report morbidity and mortality results of CRS and HIPEC from a single institution in Japan.Methods and Results. Total of 284 procedures of CRS were performed on patients with pseudomyxoma peritonei, peritoneal carcinomatosis (PC) from colon cancer and gastric cancer between 2007 and 2011 in our institution. The morbidity rate was 49% of all procedure, and grades I/II and grades III/IV complications were 28% and 17%, respectively. Most frequent complication was surgical site infections including intraabdominal abscess. The mortality rate was 3.5%, and reoperation was needed in 11% of all procedures. Univariate and multivariate analysis showed peritoneal carcinomatosis index (PCI) greater than 20 was the only significant factor for occurrence of postoperative complications (P<0.01). In contrast, HIPEC significantly reduced postoperative complications (P<0.05).Conclusions. The morbidity and mortality rates of our institution are comparable with previous reports that are in acceptable rates. Optimal patient selection such as patients with PCI less than 20 seems to be of paramount importance to CRS and HIPEC.

scholarly journals Cholera Case Study on Broiler Poultry Collected from Communities Farm in Banda Aceh Using Pathology Method

2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Zainuddin Z
Keyword(s):  
Broiler Chickens ◽  
Pasteurella Multocida ◽  
Mortality Rates ◽  
Morbidity And Mortality ◽  
Bacterial Disease ◽  
High Morbidity ◽  
Northern Iran ◽  
Fowl Cholera ◽  
The World

Fowl cholera is an infectious bacterial disease that is widespread in poultry in the world caused by Pasteurellamultocida. The disease infects both fowl and wild poultry. Poultry become more sensitive to the disease on advance age of chicken and on laying chicken. Generally, thisdisease infects breeding flocks of males with the aged of 33 weeks, and in breeding flocks at age 35 weeks with the symptoms of increasedmortality, and wattle and leg swelling. P multocida infection in chickens aged 25 weeks was reported in Korea. In northern Iran, cholera hasbeen reported endemic in poultry breeders. In chickens, this disease can be manifested in the acute and chronic forms. Generally, fowl cholera isasepticemic disease characterized by high morbidity and mortality rates, usually runs an acute, but in an endemic area the poultry is lesssensitive to this disease, thus,it was grouped to chronic disease. Chronic form of fowl cholera may occur after the outbreak. Recently, fowlcholera incidence in broiler chickens is becoming more common. These cases are associated with farm conditions that are very unhygienic andthe contact between chickens and carrier animals. In Indonesia P. multocida has been isolated from sudden deathlaying hens and broilers. InAceh province incidence of cholera in poultry broiler farms and chicken is quite high, the rate of morbidity and mortality are high.____________________________________________________________________________________________________________________Key words: chicken, fowl cholera, Pasteurella multocida

scholarly journals Caspofungin Inhibits Mixed Biofilms of Candida albicans and Methicillin-Resistant Staphylococcus aureus and Displays Effectiveness in Coinfected Galleria mellonella Larvae

2021 ◽  
Author(s):  
Gaby Scheunemann ◽  
Bruna N. Fortes ◽  
Nilton Lincopan ◽  
Kelly Ishida
Keyword(s):  
Staphylococcus Aureus ◽  
Candida Albicans ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Galleria Mellonella ◽  
Bloodstream Infections ◽  
Mortality Rates ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Methicillin Resistant ◽  
Content Type

Infections by microorganisms resistant to antimicrobials is a major challenge that leads to high morbidity and mortality rates and increased time and cost with hospitalization. It was estimated that 27 to 56% of bloodstream infections by C. albicans are polymicrobial, with S. aureus being one of the microorganisms commonly coisolated worldwide.

scholarly journals Electrical injuries in adult patients – 3 years overview

2021 ◽  
Vol 16 (3) ◽  
pp. 387-393
Author(s):  
Andreea GROSU-BULARDA ◽  
◽  
Mihaela-Cristina ANDREI ◽  
Adrian FRUNZĂ ◽  
Florin-Vlad HODEA ◽  
...  
Keyword(s):  
Multidisciplinary Treatment ◽  
Mortality Rates ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Clear Understanding ◽  
Electric Injuries ◽  
Burn Unit ◽  
Injured Patients ◽  
Optimal Therapeutic Strategy ◽  
Electrical Injuries

Electrocutions are a particular type of trauma, usually affecting young active people, leading to high morbidity and mortality rates in extensive injured patients. Those patients require complex, multidisciplinary treatment in specialized burn centers. We conducted a three-year retrospective study in the Burn Unit of the Clinical Emergency Hospital Bucharest, Romania, aiming to identify different factors that characterize electrical injuries, with the goal to improve our clinical practice, in order to decrease overall complications, the morbidity and mortality rates and obtain an optimal functional prognosis for those severely injured patients. Patient-related and injury-related parameters were analyzed, and particularities observed in our burn unit were noted. A clear understanding of the physiopathology of those injuries and their complications is essential for providing an optimal therapeutic strategy. Rapid initiation of systemic supportive measures, accurate diagnostic and an adequate surgical treatment, correctly conducted, are essential for improving the vital and functional prognostic of patients who suffer electric injuries.

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