scholarly journals Role of New Antifungal Agents in the Treatment of Invasive Fungal Infections in Transplant Recipients: Isavuconazole and New Posaconazole Formulations

2015 ◽  
Vol 1 (3) ◽  
pp. 345-366 ◽  
Author(s):  
Julius Li ◽  
Cynthia Nguyen ◽  
Julia Garcia-Diaz
Keyword(s):  
Antifungal Agents ◽  
Fungal Infections ◽  
Invasive Fungal Infections ◽  
Transplant Recipients

scholarly journals Assessment of the Role of 1,3-β-d-Glucan Testing for the Diagnosis of Invasive Fungal Infections in Adults

2021 ◽  
Vol 72 (Supplement_2) ◽  
pp. S102-S108
Author(s):  
F Lamoth ◽  
H Akan ◽  
D Andes ◽  
M Cruciani ◽  
O Marchetti ◽  
...  
Keyword(s):  
Fungal Infections ◽  
Organ Transplant ◽  
Invasive Fungal Infections ◽  
Clinical Settings ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Hematologic Cancer ◽  
Pretest Likelihood ◽  
Solid Organ Transplant Recipients

Abstract Detection of 1,3-β-d-glucan (BDG) in serum has been evaluated for its inclusion as a mycological criterion of invasive fungal infections (IFI) according to EORTC and Mycoses Study Group (MSG) definitions. BDG testing may be useful for the diagnosis of both invasive aspergillosis and invasive candidiasis, when interpreted in conjunction with other clinical/radiological signs and microbiological markers of IFI. However, its performance and utility vary according to patient population (hematologic cancer patients, solid-organ transplant recipients, intensive care unit patients) and pretest likelihood of IFI. The objectives of this article are to provide a systematic review of the performance of BDG testing and to assess recommendations for its use and interpretation in different clinical settings.

The role of complement in invasive fungal infections. Die Rolle des Komplements bei invasiven Pilzinfektionen

Mycoses ◽  
2004 ◽  
Vol 47 (3-4) ◽  
pp. 93-103 ◽  
Author(s):  
Cornelia Speth ◽  
Gunter Rambach ◽  
Cornelia Lass-Florl ◽  
Manfred P. Dierich ◽  
Reinhard Wurzner
Keyword(s):  
Fungal Infections ◽  
Invasive Fungal Infections

scholarly journals Incidence of Invasive Fungal Infections Among Lung Transplant Recipients: A Multicenter Study

2015 ◽  
Vol 2 (suppl_1) ◽  
Author(s):  
Rajal K. Mody ◽  
Angela Cleveland ◽  
Robin Avery ◽  
Mindy Schuster ◽  
Fernanda Silveira ◽  
...  
Keyword(s):  
Multicenter Study ◽  
Lung Transplant ◽  
Fungal Infections ◽  
Invasive Fungal Infections ◽  
Transplant Recipients ◽  
Lung Transplant Recipients

scholarly journals Autopsy dissection techniques and investigations in deaths due to COVID-19 triggered fungal infections - A diagnostic review

2021 ◽  
Vol 8 (4) ◽  
pp. 207-213
Author(s):  
Himanshi Narang ◽  
Amit Patil
Keyword(s):  
Fungal Infection ◽  
Paranasal Sinuses ◽  
Fungal Infections ◽  
Invasive Disease ◽  
Invasive Fungal Infections ◽  
Correct Interpretation ◽  
Research Papers ◽  
Dissection Techniques ◽  
Second Wave

The COVID-19 pandemic, which originated from Wuhan, China, has rapidly spread worldwide, including India. As India grappled with the second wave, COVID-triggered fungal infection has suddenly risen tremendously, raising a sense of panic in the country. The fungal infection in COVID-19 includes Mucormycosis and Aspergillosis, as common fungal infections primarily affecting rhino-orbital structures. Many research papers have published postmortem findings in autopsies conducted on COVID-19 decedents, thereby helping to understand this contagious disease's pathogenesis. But, with the arrival of COVID-triggered fungal infection, which is a crucial invasive disease responsible for fatality, very few research papers have commented on the postmortem findings of invasive fungal infections affecting the rhino-orbital and craniocerebral structures in COVID-19 deaths. Therefore, the role of invasive fungal infection due to COVID-19 illness must be established in the causation of deaths in COVID-19 patients. This review research deals with autopsy dissection techniques and possible postmortem findings of invasive fungal infections involving the nasal and paranasal sinuses and orbital structures in COVID-19 deaths. The findings of fungal infection affecting nasal and paranasal systems may not differ in live patients and in a deceased; however, it is essential that correct interpretation of the postmortem findings aided by pre-or post-autopsy investigations is necessary to establish the role of covid triggered fungal infection in such deaths.

Systemic Antifungal Agents

2018 ◽  
Author(s):  
Brett A Melnikoff ◽  
René P Myers
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Antifungal Agents ◽  
Fungal Infections ◽  
Antifungal Prophylaxis ◽  
Morbidity And Mortality ◽  
Transplant Recipients ◽  
Therapeutic Approaches ◽  
Timely Fashion ◽  
Antifungal Chemotherapy

Fungal infections remain an important cause of morbidity and mortality in surgical settings, with critically ill patients, transplant recipients, and sick neonates all especially vulnerable. Fungal infections remain an important cause of morbidity and mortality in surgical settings, with critically ill patients, transplant recipients, and sick neonates all especially vulnerable. Despite the development of a number of new and useful antifungal agents in the past decade and the noteworthy improvements in therapeutic approaches to fungal infections, physicians’ ability to diagnose these infections in a timely fashion remains limited, and patient outcomes remain poor. Antifungal prophylaxis has emerged as a potential means of reducing the occurrence of serious fungal infections. In patient populations estimated to be at high risk for acquiring a fungal infection, antifungal prophylaxis has reduced infection rates by about 50%; however, it has not been shown to significantly improve mortality. This review discusses both established and newly approved systemic antifungal agents. Tables list characteristics of currently available antifungals and antifungal chemotherapy. This review contains 2 tables and 32 references Key words: antifungal chemotherapy, antifungal prophylaxis, antifungals, Candida prophylaxis, systemic antifungal medications

scholarly journals Isavuconazole—Animal Data and Clinical Data

2020 ◽  
Vol 6 (4) ◽  
pp. 209
Author(s):  
Livio Pagano ◽  
Chiara Cattaneo ◽  
Martina Quattrone ◽  
Margherita Oberti ◽  
Maria Mazzitelli ◽  
...  
Keyword(s):  
Clinical Data ◽  
Fungal Infections ◽  
Invasive Fungal Infections ◽  
Hematological Patients ◽  
Animal Data

The treatment of invasive fungal infections has deeply evolved in the last years with the inclusion of new antifungals, mainly new azoles (i.e., posaconazole, isavuconazole), to the therapeutic armamentarium. This review focuses on the role of isavuconazole for treating the most important invasive fungal infections both in animals and humans (hematological and non-hematological patients).

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