scholarly journals Effect of Silymarin Supplementation in Lung and Liver Histological Modifications during Exercise Training in a Rodent Model

2021 ◽  
Vol 6 (3) ◽  
pp. 72
Author(s):  
Nancy Vargas-Mendoza ◽  
Marcelo Angeles-Valencia ◽  
Ángel Morales-González ◽  
Mauricio Morales-Martínez ◽  
Eduardo Madrigal-Bujaidar ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Exercise Training ◽  
Lipid Content ◽  
Wistar Rats ◽  
Muscle Size ◽  
Cell Recovery ◽  
Pulmonary Tissue ◽  
Histological Changes ◽  
Male Wistar Rats ◽  
Intrahepatic Lipid

Background: Exercise training induces adaptive physiological and morphological modifications in the entire organism; however, excessive loads of training may increase damage in tissues. The purpose of this study was to evaluate the effect of silymarin in lung and liver histological changes in rats subjected to exercise training (ET). Methods: Male Wistar rats were subjected to an 8-week ET treadmill program 5 days per week, 60 min/session, and were previously administered 100 mg ascorbic acid or 100 mg of silymarin. Results: Silymarin increased alveolar and bronchial muscle size, improve vascularization, and reduced tissue inflammation. In liver, silymarin promoted the reduction of lipid content. Conclusion: Silymarin supplementation may improve inflammation in pulmonary tissue after 8 weeks of the ET treadmill program, improve cell recovery, and reduce intrahepatic lipid content.

scholarly journals Effect of Diabetes Induction and Exercisetraining on the Level of Ascorbic Acid and Muscle SVCT2 in Male Wistar Rats

2020 ◽  
Author(s):  
Akbar Ghalavand ◽  
Pezhman Motamedi ◽  
Hamid Rajabi ◽  
Neda Khaledi
Keyword(s):  
Ascorbic Acid ◽  
Exercise Training ◽  
Soleus Muscle ◽  
Wistar Rats ◽  
Training Session ◽  
Exercise Program ◽  
Significant Difference ◽  
Male Wistar Rats ◽  
Healthy Control ◽  
Diabetes Induction

Introduction: Sodium-dependent vitamin C transporter 2 (SVCT2) plays an important role in the transfer of ascorbic acid to slow-twitch fiber. The purpose of this study was investigating the effect of diabetes induction and exercise training on the level of ascorbic acid and muscle SVCT2 in rats. Methods: In this experimental study, 20 male Wistar rats were randomly divided into four groups (n=5 per group): 1) healthy control 2) diabetic control, 3) diabetic exercise, 4) sham. Diabetic was induced by injection of Streptozotocin solution (55 mg / kg). The exercise program was performed 6 weeks of aerobic running on Treadmill, 5 sessions per week and each training session for 20-40 minutes at an intensity of 50-70 VO2max. Homogeneous tissue of soleus muscle and serum was analyzed to evaluate the effect of exercise training on ascorbic acid metabolism. Data were analyzed by SPSS version 18 software and one-wayANOVA test (P ≤ 0.05). Results: The results showed that there was significant differences (P < 0.05) between the level muscle and serum ascorbic acid in diabetic and diabetic + exercise groups compare to the healthy control and sham groups. But no significant differences was found in SVCT2 of Soleus muscle between groups (P> 0.05).. Conclusion: Induction of diabetes induces a decrease in muscle levels of ascorbic acid, which appears to be associated with a decrease in serum ascorbic acid levels, since no significant difference was found in SVCT2 levels. Also, exercise training had no significant effect on serum and muscle ascorbic acid levels of muscle SVCT2 levels.

scholarly journals Effects of Long-Term Administration of Lithium and Hydrochlorothiazide in Rats

1999 ◽  
Vol 6 (2) ◽  
pp. 87-93 ◽  
Author(s):  
Felicia Loghin ◽  
Adriana Olinic ◽  
Daniela-Saveta Popa ◽  
Carmen Socaciu ◽  
Sorin E. Leucuta
Keyword(s):  
Wistar Rats ◽  
Histopathological Examination ◽  
Concomitant Administration ◽  
Histological Changes ◽  
Association Group ◽  
Term Administration ◽  
Male Wistar Rats ◽  
Kidney Liver ◽  
Lithium Lactate

The biochemical and histological changes following 60 days administration of daily doses equivalent to 1/20 LD50 of lithium lactate and hydrochlorothiazide, as such and in association, were studied in male Wistar rats. No mortality or overt signs of toxicity were observed during the experiment and the serum activities of transaminases, alkaline phosphatase and cholinesterase were not significantly modified compared to controls. The histopathological examination of all the investigated organs: kidney, liver, brain and spleen, revealed significant lesions which were time-dependant and more pronounced in the association group. Although the changes were mostly inflammatory and conqestive, it was proved that the concomitant administration of lithium and hydrochlorothiazid is potentially dangerous, increasing lithium’s nephrotoxicity and the thiazide diuretic's hepatotoxicity.

Model of spontaneous obesity in aging male Wistar rats

1990 ◽  
Vol 259 (6) ◽  
pp. R1117-R1125 ◽  
Author(s):  
F. D. Newby ◽  
M. DiGirolamo ◽  
G. A. Cotsonis ◽  
M. H. Kutner
Keyword(s):  
Body Weight ◽  
Lipid Content ◽  
Wistar Rats ◽  
Lipid A ◽  
Curvilinear Relationship ◽  
Body Lipid ◽  
Fat Depots ◽  
Male Wistar Rats ◽  
Total Body ◽  
Relationship Of

We analyzed retrospectively data from 148 chow-fed male Wistar rats killed between the age of 6 wk and 2 yr while varying in body weight from 136 to 917 g. The purpose of this study was to clarify the relationship of body weight and body lipid content with the composition and cellularity of the epididymal and retroperitoneal fat depots. A positive linear association was found between body weight and body water or fat-free dry residue, whereas total body lipid exhibited a curvilinear relationship with body weight. The weight of the epididymal pads was linearly related to body weight but not to body lipid. In contrast, retroperitoneal pad weight was exponentially related to body weight and paralleled total body lipid. A strong linear correlation was found between total body lipid and weight (r = 0.959) or depot lipid content (r = 0.967) of the retroperitoneal fat pads. In this rat model of aging and spontaneous obesity, significant regional differences exist in adipose depot composition and cellularity. A practical outcome of this study is a simple and accurate prediction of body lipid content from the gravimetric determination of the retroperitoneal fat depots.

scholarly journals Local treatment with ascorbic acid accelerates recovery of post-sutured Achilles tendon in male Wistar rats

2019 ◽  
Vol 52 (9) ◽  
Author(s):  
M. Souza ◽  
S.A.S. Moraes ◽  
D.R. de Paula ◽  
A.A. Maciel ◽  
E.J.O. Batista ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Achilles Tendon ◽  
Wistar Rats ◽  
Local Treatment ◽  
Male Wistar Rats

scholarly journals Comparative studies on the hypercholesterolaemia induced by excess dietary tyrosine or polychlorinated biphenyls in rats

1986 ◽  
Vol 56 (2) ◽  
pp. 509-517 ◽  
Author(s):  
Sahoshi Nagaoka ◽  
Mitsuhiro Kato ◽  
Yoritaka Aoyama ◽  
Akira Yoshida†
Keyword(s):  
Ascorbic Acid ◽  
Polychlorinated Biphenyls ◽  
Comparative Studies ◽  
Wistar Rats ◽  
Serum Levels ◽  
Liver Lipids ◽  
Male Wistar Rats

1. The effects of dietary polychlorinated biphenyls (PCB) and excess tyrosine on serum and liver lipids, urinary ascorbic acid and catecholamines were compared in male Wistar rats.2. Serum levels of cholesterol, urinary ascorbic acid, norepinephrine, epinephrine, dopamine and histamine were significantly increased in rats given either PCB or excess tyrosine.3. The hypercholesterolaemia induced by PCB or excess tyrosine was blocked by the adrenergic α-blocker, phenoxybenzamine.4. The present results suggest causal interrelations between the hypercholesterolaemia induced by dietary PCB or excess tyrosine and the secretion of catecholamines.

scholarly journals Effect of Continuous Exercise Training on Protein Levels of SIRT3 and OGG1 in the Liver Tissue of Male Wistar Rats

2019 ◽  
Vol 27 (5) ◽  
pp. 97-107
Author(s):  
Zufa Zanjirian ◽  
Mohammad Esmaeil Afzal pour ◽  
Hadi Sarir ◽  
Mohsen Mohammadnia Ahmadi ◽  
◽  
...  
Keyword(s):  
Exercise Training ◽  
Liver Tissue ◽  
Wistar Rats ◽  
Continuous Exercise ◽  
Protein Levels ◽  
Male Wistar Rats

scholarly journals Effects of exercise training on intrahepatic lipid content in humans

Diabetologia ◽  
2016 ◽  
Vol 59 (10) ◽  
pp. 2068-2079 ◽  
Author(s):  
Bram Brouwers ◽  
Matthijs K. C. Hesselink ◽  
Patrick Schrauwen ◽  
Vera B. Schrauwen-Hinderling
Keyword(s):  
Exercise Training ◽  
Lipid Content ◽  
Intrahepatic Lipid

scholarly journals Influence of S(+)-ketamine analgesia in renal intraoperative ischemia: histological study in rats

2006 ◽  
Vol 21 (4) ◽  
pp. 242-246 ◽  
Author(s):  
Eloy Rusafa Neto ◽  
Pedro Thadeu Galvão Vianna ◽  
Rosa Marlene Viero ◽  
Norma Sueli Pinheiro Módolo ◽  
Eliana Marisa Ganem ◽  
...  
Keyword(s):  
Heart Rate ◽  
Arterial Pressure ◽  
Rectal Temperature ◽  
Wistar Rats ◽  
Histological Study ◽  
Sodium Pentobarbital ◽  
Histological Changes ◽  
Renal Histology ◽  
Male Wistar Rats ◽  
Arterial Hemorrhage

PURPOSE: To study in rats the effect of S(+)ketamine on the renal histology after intraoperative hemorrhage. METHODS: Twenty male Wistar rats, anesthetized with sodium pentobarbital, were randomly divided in 2 groups: G1 - control (n=l0) and G2 - S(+)-ketamine (n=10), both submitted to arterial hemorrhage of 30% of volemia in 3 moments (10% each 10 min) 60 min after anesthesia. G2 received S(+)-ketamine, 15 mg. kg-1, i.m., 5 min after anesthesia and 55 min before the 1st hemorrhage moment (Ml). Medium arterial pressure (MAP), rectal temperature (T) and heart rate were monitored. The animals were sacrificed in M4, 30 min after the 3rd hemorrhage moment (M3) and the kidneys and blood collected from hemorrhage were utilized for histological study and hematocrit (Ht) determination. RESULTS: There were significant reduction of MAP, T, and Ht. The histological study verified G1 = G2 for tubular dilation, congestion, and necrosis. The total score addition were significant1y different and G2 > G 1. CONCLUSION: Hemorrhage and hypotension determined changes in kidney histology. The rise in catecholamine blood concentration probably was the cause of S(+)-ketamine-induced higher score of histological changes.

scholarly journals Melatonin effects on pulmonary tissue in the experimental model of Hepatopulmonary Syndrome

2019 ◽  
Vol 45 (3) ◽  
Author(s):  
Adriane Dal Bosco ◽  
Filipe Boeira Schedler ◽  
Josieli Raskopf Colares ◽  
Elisângela Gonçalves Schemitt ◽  
Renata Minuzzo Hartmann ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Weight Ratio ◽  
Hepatopulmonary Syndrome ◽  
Antioxidant Effect ◽  
Biliary Duct ◽  
Body Weight Ratio ◽  
Pulmonary Tissue ◽  
Male Wistar Rats ◽  
Hepatic Histology ◽  
And Oxidative Stress

ABSTRACT Objective: To evaluate the pulmonary alterations of animals with Hepatopulmonary Syndrome (HPS) submitted to Biliary Duct Ligature (BDL), as well as the antioxidant effect of Melatonin (MEL). Methods: Sixteen male Wistar rats, divided into four Sham groups: BDL group, Sham + MEL group and BDL + MEL. The pulmonary and hepatic histology, lipoperoxidation and antioxidant activity of lung tissue, alveolar-arterial O2 difference and lung / body weight ratio (%) were evaluated. Results: When comparing the groups, could be observed an increase of vasodilation and pulmonary fibrosis in the BDL group and the reduction of this in relation to the BDL + MEL group. It was also observed significant changes in the activity of catalase, ApCO2, ApO2 in the LBD group when compared to the other groups. Conclusion: The use of MEL has been shown to be effective in reducing vasodilation, fibrosis levels and oxidative stress as well as gas exchange in an experimental HPS model.

Sign in / Sign up

Export Citation Format

Share Document