scholarly journals Metabolic Profile and Myocardial Performance of Renal Transplant Recipients Participating in Unsupervised Physical Exercise as a Prescription Program

2018 ◽  
Vol 3 (3) ◽  
pp. 46 ◽  
Author(s):  
Luciano Moscarelli ◽  
Francesco Sofi ◽  
Gabriele Mascherini ◽  
Vittorio Bini ◽  
Chiara Ingletto ◽  
...  

Introduction: Renal transplant recipients (RTRs) are at high cardiovascular risk (CV) compared to the general population, especially after surgical treatment. The literature supports the role of supervised exercise intervention; however no data are available regarding the effects of unsupervised exercise programs. We investigated whether a home exercise program could reduce CV risk in RTR based on possible changes in renal and cardiometabolic parameters and myocardial performance measured by echocardiography. Methods: From a large cohort of 60 RTRs, 30 RTRs (12 females and 18 males 48.3 ± 12.3 years) participated in individualized and unsupervised training programs for 6 months, at moderate intensity. Cardiometabolic risk factors, anthropometric parameters, lipid and glycemic blood sample profiles were studied as was myocardial performance from the 2D echo examination at T0, and T6 months. Results: The lipid profile remained in the range of a low level of risk, although there was no significant improvement, whereas myocardial performance, in particular the EF, was significantly improved. Conclusions: A home exercise program for at least 6 months produces positive effects on myocardial function and helps maintain a low cardiovascular risk profile. The trend supports the importance of highlighting the role of a correct reconditioning of lifestyle in RTR, from the exercise program without supervision to moderate intensity, where well tolerated.

Nephron ◽  
2021 ◽  
pp. 1-13
Author(s):  
Ana Elena Rodríguez-Rodríguez ◽  
Esteban Porrini ◽  
Mads Hornum ◽  
Javier Donate-Correa ◽  
Raúl Morales-Febles ◽  
...  

Post-transplant diabetes mellitus (PTDM) is a frequent and relevant complication after renal transplantation: it affects 20–30% of renal transplant recipients and increases the risk for cardiovascular and infectious events. Thus, understanding pathogenesis of PTDM would help limiting its consequences. In this review, we analyse novel aspects of PTDM, based on studies of the last decade, such as the clinical evolution of PTDM, early and late, the reversibility rate, diagnostic criteria, risk factors, including pre-transplant metabolic syndrome and insulin resistance (IR) and the interaction between these factors and immunosuppressive medications. Also, we discuss novel pathogenic factors, in particular the role of β-cell function in an environment of IR and common pathways between pre-existing cell damage and tacrolimus-induced toxicity. The relevant role of prediabetes in the pathogenesis of PTDM and cardiovascular disease is also addressed. Finally, current evidence on PTDM treatment is discussed.


2009 ◽  
Vol 23 (6) ◽  
pp. 914-920 ◽  
Author(s):  
Inga Soveri ◽  
Sadollah Abedini ◽  
Hallvard Holdaas ◽  
Alan Jardine ◽  
Niclas Eriksson ◽  
...  

2012 ◽  
Vol 94 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Inga Soveri ◽  
Ingar Holme ◽  
Hallvard Holdaas ◽  
Klemens Budde ◽  
Alan G. Jardine ◽  
...  

2018 ◽  
Vol 102 ◽  
pp. S654
Author(s):  
Zbigniew Heleniak ◽  
Karolina Komorowska-Jagielska ◽  
Alicja Dębska-Ślizień

2017 ◽  
Vol 34 (2) ◽  
pp. 247-253 ◽  
Author(s):  
Guillermo Gervasini ◽  
Enrique Luna ◽  
Guadalupe Garcia-Pino ◽  
Lilia Azevedo ◽  
Sonia Mota-Zamorano ◽  
...  

2014 ◽  
Vol 39 (4) ◽  
pp. 308-314 ◽  
Author(s):  
Ivana Mikolasevic ◽  
Sanjin Racki ◽  
Luka Zaputovic ◽  
Vesna Lukenda ◽  
Branka Sladoje-Martinovic ◽  
...  

2019 ◽  
Vol 51 (Supplement) ◽  
pp. 122
Author(s):  
Beatrice Leone ◽  
Luciano Moscarelli ◽  
Elena Zappelli ◽  
Chiara Ingletto ◽  
Marco Mandoli ◽  
...  

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