scholarly journals Fabrication of Poly-l-lactic Acid/Dicalcium Phosphate Dihydrate Composite Scaffolds with High Mechanical Strength—Implications for Bone Tissue Engineering

2015 ◽  
Vol 6 (4) ◽  
pp. 1036-1053 ◽  
Author(s):  
Nida Tanataweethum ◽  
Wai Liu ◽  
W. Goebel ◽  
Ding Li ◽  
Tien Chu
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Mechanical Strength ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Dicalcium Phosphate ◽  
Dicalcium Phosphate Dihydrate ◽  
Composite Scaffolds ◽  
High Mechanical Strength ◽  
Phosphate Dihydrate

scholarly journals Poly(propylene fumarate) reinforced dicalcium phosphate dihydrate cement composites for bone tissue engineering

2012 ◽  
Vol 100A (7) ◽  
pp. 1792-1802 ◽  
Author(s):  
Daniel L. Alge ◽  
Jeffrey Bennett ◽  
Trevor Treasure ◽  
Sherry Voytik-Harbin ◽  
W. Scott Goebel ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Dicalcium Phosphate ◽  
Cement Composites ◽  
Dicalcium Phosphate Dihydrate ◽  
Phosphate Dihydrate ◽  
Poly Propylene

Preparation of PLLA/HAP/β-TCP Composite Scaffold for Bone Tissue Engineering

2014 ◽  
Vol 513-517 ◽  
pp. 143-146 ◽  
Author(s):  
Xue Jun Wang ◽  
Tao Lou ◽  
Jing Yang ◽  
Zhen Yang ◽  
Kun Peng He
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Lactic Acid ◽  
Phase Separation ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Scaffold ◽  
Thermally Induced Phase Separation ◽  
Composite Scaffolds ◽  
Thermally Induced

In this study, a nanofibrous poly (L-lactic acid) (PLLA) scaffold reinforced by Hydroxyapatite (HAP) and β-tricalcium phosphate (β-TCP) was fabricated using the thermally induced phase separation method. The composite scaffold morphology showed a nanofibrous PLLA matrix and evenly distributed β-TCP/HAP particles. The composite scaffold had interconnective micropores and the pore size ranged 2-10 μm. Introducing β-TCP/HAP particles into PLLA matrix significantly improved the mechanical properties of the composite scaffold. In summary, the new composite scaffolds show a great deal promise for use in bone tissue engineering.

scholarly journals A Composite Hydrogel with High Mechanical Strength, Fluorescence, and Degradable Behavior for Bone Tissue Engineering

Polymers ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1112 ◽  
Author(s):  
Yanqin Wang ◽  
Yanan Xue ◽  
Jinghui Wang ◽  
Yaping Zhu ◽  
Yu Zhu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Mechanical Strength ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
High Strength ◽  
Bone Substitutes ◽  
Composite Hydrogel ◽  
Poly Vinyl Alcohol ◽  
High Mechanical Strength

In this work, to obtain a novel composite hydrogel with high mechanical strength, fluorescence and degradable behavior for bone tissue engineering, we prepare a nanofiller and double-network (DN) structure co-enhanced carbon dots/hydroxyapatite/poly (vinyl alcohol) (CDs/HA/PVA) DN hydrogel. The composite hydrogels are fabricated by a combination of two fabrication techniques including chemical copolymerization and freezing‒thawing cycles, and further characterized by FTIR, XRD, etc. Additional investigations focus on the mechanical properties of the hydrogel with varying mass ratios of CDs to PVA, HA to PVA and different numbers of freezing/thawing cycles. The results show that the as-prepared CDs3.0/HA0.6/PVA DN9 hydrogel has optimized compression properties (Compression strength = 3.462 MPa, Young’s modulus = 4.5 kPa). This is mainly caused by the synergism effect of the nanofiller and chemical and physical co-crosslinking. The water content and swelling ratio of the CDs/HA/PVA SN and DN gels are also systematically investigated to reveal the relationship of their microstructural features and mechanical behavior. In addition, in vitro degradation tests of the CDs/HA/PVA DN hydrogel show that the DN hydrogels have a prominent degradable behavior. So, they have potential to be used as high-strength, self-tracing bone substitutes in the biomedical engineering field.

Development of a Novel Hybrid Porous Scaffold for Bone Tissue Engineering: Forsterite Nanopowder Reinforced Chitosan

2013 ◽  
Vol 587 ◽  
pp. 249-254 ◽  
Author(s):  
Francesca Scalera ◽  
Francesca Gervaso ◽  
Kunjalukkal Padmanabhan Sanosh ◽  
Ilaria Elena Palamà ◽  
Simona Dimida ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Mechanical Strength ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Porous Scaffold ◽  
Osteosarcoma Cell ◽  
Composite Scaffolds ◽  
Human Osteosarcoma ◽  
Chitosan Matrix ◽  
Human Osteosarcoma Cells

In order to induce bone regeneration several natural and synthetic materials have been proposed. However, single-phase scaffolds present some insurmountable disadvantages such as poor mechanical strength or brittleness and too low or too high degradation rate. In order to overcome these drawbacks, composite systems can be an interesting and promising option. In the present work a novel hybrid porous scaffold for bone tissue engineering is proposed. Chitosan/Forsterite (Ch/FS) composite scaffolds were prepared by freeze-drying method using a chitosan/forsterite ratio of 90/10. The FS nanopowder (Mg2SiO4) is synthesized using a simple solgel based method. The FS composition was checked by XRD analysis. The macrostructure of the Ch/FS scaffolds were analyzed by SEM, the FS distribution within the chitosan matrix observed by EDS, the mechanical strength measured by compression test in PBS and the biocompatibility of the composite on human osteosarcoma cell line (MG-63) verified by MTT assay after 48 hours. The porosity appears interconnected and with a pore size ranging from 1 to 100 μm. The FS is overall distributed within the chitosan matrix. The compression strength of composite scaffolds increased with respect to the pure chitosan scaffolds of more than two times (from 0.8 to 1.9 KPa) and the composites did not show any toxicity effect on human osteosarcoma cells.

scholarly journals Three-dimensionally printed polycaprolactone/multicomponent bioactive glass scaffolds for potential application in bone tissue engineering

2020 ◽  
Vol 6 (1) ◽  
pp. 57-69
Author(s):  
Amirhosein Fathi ◽  
Farzad Kermani ◽  
Aliasghar Behnamghader ◽  
Sara Banijamali ◽  
Masoud Mozafari ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Three Dimensional ◽  
Layer By Layer ◽  
Composite Scaffolds ◽  
3D Printed ◽  
Co Doped

AbstractOver the last years, three-dimensional (3D) printing has been successfully applied to produce suitable substitutes for treating bone defects. In this work, 3D printed composite scaffolds of polycaprolactone (PCL) and strontium (Sr)- and cobalt (Co)-doped multi-component melt-derived bioactive glasses (BGs) were prepared for bone tissue engineering strategies. For this purpose, 30% of as-prepared BG particles (size <38 μm) were incorporated into PCL, and then the obtained composite mix was introduced into a 3D printing machine to fabricate layer-by-layer porous structures with the size of 12 × 12 × 2 mm3.The scaffolds were fully characterized through a series of physico-chemical and biological assays. Adding the BGs to PCL led to an improvement in the compressive strength of the fabricated scaffolds and increased their hydrophilicity. Furthermore, the PCL/BG scaffolds showed apatite-forming ability (i.e., bioactivity behavior) after being immersed in simulated body fluid (SBF). The in vitro cellular examinations revealed the cytocompatibility of the scaffolds and confirmed them as suitable substrates for the adhesion and proliferation of MG-63 osteosarcoma cells. In conclusion, 3D printed composite scaffolds made of PCL and Sr- and Co-doped BGs might be potentially-beneficial bone replacements, and the achieved results motivate further research on these materials.

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