scholarly journals Sonic Hedgehog Is a Member of the Hh/DD-Peptidase Family That Spans the Eukaryotic and Bacterial Domains of Life

2018 ◽  
Vol 6 (2) ◽  
pp. 12 ◽  
Author(s):  
Henk Roelink
Keyword(s):  
Sonic Hedgehog ◽  
Domains Of Life

scholarly journals Sonic Hedgehog is a member of the Hh/DD-peptidase family that spans the eukaryotic and bacterial domains of life

2018 ◽  
Author(s):  
Henk Roelink
Keyword(s):  
Catalytic Activity ◽  
Sonic Hedgehog ◽  
Birth Defect ◽  
Bacterial Gene ◽  
Bacterial Proteins ◽  
Gene Coding ◽  
Domains Of Life ◽  
Hh Signaling ◽  
Congenital Birth Defect ◽  
Stable Forms

AbstractSonic Hedgehog (Shh) coordinates Zn2+ in a manner that resembles that of peptidases. The ability of Shh to undergo autoproteolytic processing is impaired in mutants that affect the Zn2+ coordination, while mutating residues essential for catalytic activity results in more stable forms of Shh. The residues involved in Zn2+ coordination in Shh are found mutated in some individuals with the congenital birth defect holoprosencephaly, demonstrating their importance in development. Highly conserved Shh domains are found a parts of some bacterial proteins that are members of the larger family of DD-peptidases, supporting the notion that Shh acts as a peptidase. Whereas this Hh/DD-peptidase motif is present in Hedgehog (Hh) proteins of nearly all animals, it is not present in Drosophila Hh, indicating that Hh signaling in fruit flies is derived, and perhaps not a good model for vertebrate Shh signaling. Sequence analysis of Hh proteins and their possible evolutionary precursors suggest that the evolution of modern Hh might have involved horizontal transfer of a bacterial gene coding of a Hh/DD-peptidase into a Cnidarian ancestor, recombining to give rise to modern Hh.

672: Regulation of Cavernous Nerve Injury-Induced Apoptosis by Sonic Hedgehog

2007 ◽  
Vol 177 (4S) ◽  
pp. 225-225
Author(s):  
Carol A. Podlasek ◽  
Yi Tang ◽  
Cynthia L. Meraz ◽  
Kevin E. McKenna ◽  
Kevin T. McVary
Keyword(s):  
Nerve Injury ◽  
Sonic Hedgehog ◽  
Cavernous Nerve ◽  
Induced Apoptosis ◽  
Cavernous Nerve Injury

Crosstalk between Sonic hedgehog and CRH pathways leading to a synergic effect on ACTH secretion

2004 ◽  
Vol 112 (S 1) ◽  
Author(s):  
G Vila ◽  
M Theodoropoulou ◽  
M Papazoglou ◽  
J Stalla ◽  
U Renner ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Synergic Effect ◽  
Acth Secretion
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