scholarly journals Effects of Electron Beam Irradiation on 3D-Printed Biopolymers for Bone Tissue Engineering

2021 ◽  
Vol 5 (7) ◽  
pp. 182
Author(s):  
Conrad Mastalerz ◽  
Isabelle Vroman ◽  
Xavier Coqueret ◽  
Sébastien Alix
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Extrusion Process ◽  
Poly Lactic Acid ◽  
Inorganic Filler ◽  
Great Promise ◽  
Breaking Strain ◽  
3D Printed ◽  
Dimensional Printing

Implanting scaffolds designed for the regeneration or the replacement of bone tissue damaged by diseases and injuries requires specially designed biomaterials that promote cell adhesion. However, the biodegradation rate of these scaffolds based on a single material is uniform. Four-dimensional printing appears to be a promising method to control this aspect by changing the shape and/or the intrinsic properties of 3D-printed objects under the influence of external stimuli. Two main classes of biomaterials and biocomposites based on biopolyesters, namely poly(lactic acid) (PLA) and poly(caprolactone) (PCL), were used in this study. Each of them was mixed with the inorganic filler hydroxyapatite (HA), which is a component of natural bone. The biocomposites and biomaterials were prepared using the melt extrusion process and then shaped using a 3D printer. Three-dimensional specimens showed a decrease in elongation at break and breaking strain due to variations of crystallinity. The crystallinity of irradiated samples increased slightly with irradiation and a new crystalline phase was observed in the case of the PLA. Four-dimensional printing of biomaterials using electron radiation shows great promise for bone tissue engineering based on biocomposite scaffolds and other medical applications.

Poly(dopamine) coating of 3D printed poly(lactic acid) scaffolds for bone tissue engineering

2015 ◽  
Vol 56 ◽  
pp. 165-173 ◽  
Author(s):  
Chia-Tze Kao ◽  
Chi-Chang Lin ◽  
Yi-Wen Chen ◽  
Chia-Hung Yeh ◽  
Hsin-Yuan Fang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Poly Lactic Acid ◽  
3D Printed

scholarly journals Three-dimensionally printed polycaprolactone/multicomponent bioactive glass scaffolds for potential application in bone tissue engineering

2020 ◽  
Vol 6 (1) ◽  
pp. 57-69
Author(s):  
Amirhosein Fathi ◽  
Farzad Kermani ◽  
Aliasghar Behnamghader ◽  
Sara Banijamali ◽  
Masoud Mozafari ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Three Dimensional ◽  
Layer By Layer ◽  
Composite Scaffolds ◽  
3D Printed ◽  
Co Doped

AbstractOver the last years, three-dimensional (3D) printing has been successfully applied to produce suitable substitutes for treating bone defects. In this work, 3D printed composite scaffolds of polycaprolactone (PCL) and strontium (Sr)- and cobalt (Co)-doped multi-component melt-derived bioactive glasses (BGs) were prepared for bone tissue engineering strategies. For this purpose, 30% of as-prepared BG particles (size <38 μm) were incorporated into PCL, and then the obtained composite mix was introduced into a 3D printing machine to fabricate layer-by-layer porous structures with the size of 12 × 12 × 2 mm3.The scaffolds were fully characterized through a series of physico-chemical and biological assays. Adding the BGs to PCL led to an improvement in the compressive strength of the fabricated scaffolds and increased their hydrophilicity. Furthermore, the PCL/BG scaffolds showed apatite-forming ability (i.e., bioactivity behavior) after being immersed in simulated body fluid (SBF). The in vitro cellular examinations revealed the cytocompatibility of the scaffolds and confirmed them as suitable substrates for the adhesion and proliferation of MG-63 osteosarcoma cells. In conclusion, 3D printed composite scaffolds made of PCL and Sr- and Co-doped BGs might be potentially-beneficial bone replacements, and the achieved results motivate further research on these materials.

scholarly journals Systematic characterization of 3D-printed PCL/β-TCP scaffolds for biomedical devices and bone tissue engineering: Influence of composition and porosity

2018 ◽  
Vol 33 (14) ◽  
pp. 1948-1959 ◽  
Author(s):  
Arnaud Bruyas ◽  
Frank Lou ◽  
Alexander M. Stahl ◽  
Michael Gardner ◽  
William Maloney ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biomedical Devices ◽  
3D Printed ◽  
Image Position

Abstract

3D printed porous polycaprolactone/oyster shell powder (PCL/OSP) scaffolds for bone tissue engineering

2018 ◽  
Vol 5 (4) ◽  
pp. 045403 ◽  
Author(s):  
Wenfeng Luo ◽  
Shuangying Zhang ◽  
Yuewei Lan ◽  
Chen Huang ◽  
Chao Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Oyster Shell ◽  
3D Printed ◽  
Oyster Shell Powder ◽  
Shell Powder
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