scholarly journals Long-Term Morbidity and Mortality after First and Recurrent Cardiovascular Events in the ARTPER Cohort

2020 ◽  
Vol 9 (12) ◽  
pp. 4064
Author(s):  
Marina Escofet Peris ◽  
Maria Teresa Alzamora ◽  
Marta Valverde ◽  
Rosa Fores ◽  
Guillem Pera ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Cardiovascular Event ◽  
Cardiovascular Events ◽  
Cardiac Event ◽  
Ankle Brachial Index ◽  
Mediterranean Population ◽  
Risk Of Recurrence ◽  
Factors Associated ◽  
Peripheral Arterial ◽  
Low Cardiovascular Risk

Background: Cardiovascular events are a major cause of mortality and morbidity worldwide. The risk of recurrence after a first cardiovascular event has been documented in the international literature, although not as extensively in a Mediterranean population-based cohort with low cardiovascular risk. There is also ample, albeit contradictory, research on the recurrence of stroke and myocardial infarctions (MI) after a first event and the factors associated with such recurrence, including the role of pathological Ankle-Brachial Index (ABI). Methods: The Peripheral Arterial ARTPER study is aimed at deepening our knowledge of patient evolution after a first cardiovascular event in a Mediterranean population with low cardiovascular risk treated at a primary care centre. We study overall recurrence, cardiac and cerebral recurrence. We studied participants in the ARTPER prospective observational cohort, excluding patients without cardiovascular events or with unconfirmed events and patients who presented arterial calcification at baseline or who died. In total, we analyzed 520 people with at least one cardiovascular event, focusing on the presence and type of recurrence, the risk factors associated with recurrence and the behavior of the ankle-brachial index (ABI) as a predictor of risk. Results: Between 2006 and 2017, 46% of patients with a first cardiovascular event experienced a recurrence of some type; most recurrences fell within the same category as the first event. The risk of recurrence after an MI was greater than after a stroke. In our study, recurrence increased with age, the presence of peripheral arterial disease (PAD), diabetes and the use of antiplatelets. Diabetes mellitus was associated with all types of recurrence. Additionally, patients with an ABI < 0.9 presented more recurrences than those with an ABI ≥ 0.9. Conclusions: In short, following a cardiac event, recurrence usually takes the form of another cardiac event. However, after having a stroke, the chance of having another stroke or having a cardiac event is similar. Lastly, ABI < 0.9 may be considered a predictor of recurrence risk.

Adhesion molecules and cardiovascular risk in peripheral arterial disease

2005 ◽  
Vol 93 (03) ◽  
pp. 559-563 ◽  
Author(s):  
Vittorio Schiano ◽  
Francesco Scopacasa ◽  
Massimo Chiariello ◽  
Antonio Silvestro ◽  
Gregorio Brevetti
Keyword(s):  
Cardiovascular Risk ◽  
Peripheral Arterial Disease ◽  
Adhesion Molecule ◽  
Cardiovascular Event ◽  
Plasma Levels ◽  
Ankle Brachial Index ◽  
Arterial Disease ◽  
Prognostic Impact ◽  
Risk Indicator ◽  
Peripheral Arterial

SummaryAlthough intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) play a relevant role in atherosclerosis, little is known about the prognostic impact of their soluble forms (s) in patients with peripheral arterial disease (PAD). The aim of this prospective study was to verify whether plasma levels of s ICAM-1 and s VCAM-1 predict cardiovascular risk in PAD, and improve the prognostic value of the ankle/brachial index (ABI) alone. Accordingly, plasma levels of sICAM-1 and sVCAM-1, and the ABI were measured in 75 PAD patients who were monitored for a mean of 24±13 months. Twenty-two (29.3%) patients had a cardiovascular event (15 coronary, 3 cerebrovascular and 4 peripheral events). Plasma levels of sVCAM-1 were 618±258 ng/mL in patients with and 496±164 ng/mL in those without an event (p= 0.016). The corresponding sICAM-1 values were 344±239 ng/mL and 275±99 ng/mL (p= 0.079). The cardiovascular event rate was higher in patients with sVCAM-1 levels above the median than in those with sVCAM-1 below the median (p=0.0027 by log rank test). Independent predictors of events were sVCAM-1 levels above the median (p=0.005) and an ABI below the median (p= 0.001). Amongst patients with ABI below the median, the occurrence of sVCAM-1 above the median was associated with a 3.4-fold increase in risk (95% CI 1.308 to 9.573, p= 0.013). In conclusion, increased plasma levels of sVCAM-1 have a negative prognostic impact in PAD and improve the predictive value of ABI, which is currently the most powerful risk indicator in these patients.

scholarly journals Cardiovascular Risk Factors Associated With Peripheral Arterial Disease in a Mediterranean Population

2019 ◽  
Vol 58 (6) ◽  
pp. e827-e828
Author(s):  
Gabriela Goncalves Martins ◽  
Daniel Gil Sala ◽  
Cristina Tello Diaz ◽  
Xavier Tenezaca Sari ◽  
Carlos Marrero Eligio de la puente ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Peripheral Arterial Disease ◽  
Cardiovascular Risk Factors ◽  
Arterial Disease ◽  
Mediterranean Population ◽  
Factors Associated ◽  
Peripheral Arterial

scholarly journals Factors Associated with Cardiovascular Risk in High School Students of a Public School in the City of Santiago de Cali, Colombia

2020 ◽  
Vol 18 (1) ◽  
pp. 24 ◽  
Author(s):  
Carmelina Zorrilla-López ◽  
Juan David Ceballos-Santacruz ◽  
Christian Daniel Ramírez-Giraldo ◽  
Brayan Esneider Patiño-Palma ◽  
Pedro Calero-Saa
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Cardiovascular Risk ◽  
Cardiovascular Diseases ◽  
Alcohol Consumption ◽  
Body Mass ◽  
Educational Institution ◽  
Factors Associated ◽  
The City ◽  
Low Cardiovascular Risk

Introduction: Cardiovascular diseases are the leading cause of death worldwide, and they have become a problem of interest of public health, both for developed and developing countries. In this regard, the decrease in time devoted to physical activity and the increase of sedentary activities stand out, thus making physical inactivity one of the many risk factors for Cardiovascular diseases. The objective was to determine the factors associated with cardiovascular risk in students of an educational institution in the city of Cali, Colombia. Materials and Methods: It is an observational and analytical epidemiological study with a sample of 227 randomly selected students, with 95 % reliability. To determine the level of physical activity in schoolchildren, researchers applied the international IPAQ physical activity questionnaire, and took anthropometric measures such as weight, height, and waist and hip circumference. Results: 96 % of the participants presented low cardiovascular risk. Likewise, the variables that showed a statistically significant association with cardiovascular risk were alcohol consumption and body mass index, which predict 81 % of the possibility of being at risk. Conclusions: The low cardiovascular risk and the high level of physical activity prevailed in the evaluated schoolchildren, significant differences regarding gender were observed, finding that men have higher values in weight, height, and waist/hip ratio compared to females. Finally, it was established that the factors associated with cardiovascular risk are body mass index and alcohol consumption.

scholarly journals Vascular Aging Detected by Peripheral Endothelial Dysfunction Is Associated With ECG‐Derived Physiological Aging

2021 ◽  
Vol 10 (3) ◽  
Author(s):  
Takumi Toya ◽  
Ali Ahmad ◽  
Zachi Attia ◽  
Michal Cohen‐Shelly ◽  
Ilke Ozcan ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Events ◽  
Reactive Hyperemia ◽  
Major Adverse Cardiovascular Events ◽  
Vascular Aging ◽  
Peripheral Arterial Tonometry ◽  
Arterial Tonometry ◽  
Peripheral Arterial

Background An artificial intelligence algorithm that detects age using the 12‐lead ECG has been suggested to signal “physiologic age.” This study aimed to investigate the association of peripheral microvascular endothelial function (PMEF) as an index of vascular aging, with accelerated physiologic aging gauged by ECG‐derived artificial intelligence–estimated age. Methods and Results This study included 531 patients who underwent ECG and a noninvasive PMEF assessment using reactive hyperemia peripheral arterial tonometry. Abnormal PMEF was defined as reactive hyperemia peripheral arterial tonometry index ≤2.0. Accelerated or delayed physiologic aging was calculated by the Δ age (ECG‐derived artificial intelligence–estimated age minus chronological age), and the association between Δ age and PMEF as well as its impact on composite major adverse cardiovascular events were investigated. Δ age was higher in patients with abnormal PMEF than in patients with normal PMEF (2.3±7.8 versus 0.5±7.7 years; P =0.01). Reactive hyperemia peripheral arterial tonometry index was negatively associated with Δ age after adjustment for cardiovascular risk factors (standardized β coefficient, –0.08; P =0.048). The highest quartile of Δ age was associated with an increased risk of major adverse cardiovascular events compared with the first quartile of Δ age in patients with abnormal PMEF, even after adjustment for cardiovascular risk factors (hazard ratio, 4.72; 95% CI, 1.24–17.91; P =0.02). Conclusions Vascular aging detected by endothelial function is associated with accelerated physiologic aging, as assessed by the artificial intelligence–ECG Δ age. Patients with endothelial dysfunction and the highest quartile of accelerated physiologic aging have a marked increase in risk for cardiovascular events.

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