scholarly journals The Association between Tear Film Thickness as Measured with OCT and Symptoms and Signs of Dry Eye Disease: A Pooled Analysis of 6 Clinical Trials

2020 ◽  
Vol 9 (11) ◽  
pp. 3791
Author(s):  
Gerhard Garhöfer ◽  
Valentin Aranha Dos Santos ◽  
Hannes Stegmann ◽  
Doreen Schmidl ◽  
Narine Adzhemian ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Film Thickness ◽  
Dry Eye ◽  
Tear Film ◽  
Pooled Analysis ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Break Up ◽  
Symptoms And Signs ◽  
Schirmer I Test

Purpose: To determine the association between tear film thickness (TFT) as measured with ultra-high resolution optical coherence tomography (UHR-OCT) and signs and symptoms of dry eye disease (DED). Methods: A total of 450 eyes from 225 patients with DED from six different randomized clinical trials were included in this pooled analysis. In all subjects, TFT was measured with a custom-built UHR-OCT system. Symptoms of DED were quantified using a standardized Ocular Surface Disease Index (OSD)I questionnaire and clinical signs including tear film break up time (TFBUT) and Schirmer I test were assessed. Associations of the average TFT with OSDI, TFBUT, and Schirmer I test were calculated using a linear regression analysis. Results: The average TFT of the included sample (mean age, 45.0 ± 13.3 years; 65% female) was 4.2 ± 0.5 µm and the OSDI 36.2 ± 10.4. A significant negative correlation was found between TFT and OSDI (r = −0.36 to −0.31; p < 0.001). Tear break up time and Schirmer I test were not correlated with OSDI. Significant albeit weak correlations were found between TFT and TFBUT (r = 0.17 to 0.25; p < 0.01) as well as Schirmer I (r = 0.36 to 0.37; p < 0.001). Subgroup analysis revealed that the correlation was stronger in the subjects with abnormal Schirmer I (<15 mm; r = 0.50 to 0.54; p < 0.001). Conclusions: The present study demonstrates an objective measurement of TFT using a novel OCT approach for DED that correlates with symptoms and signs of DED. Our data are consistent with the idea that TFT represents the aqueous-deficient component of DED.

Simplified Classification of Tear Film Break-Up Patterns and Their Clinicopathological Correlations in Patients With Dry Eye Disease

2020 ◽  
Vol 47 (1) ◽  
pp. 15-19
Author(s):  
Hee Dong Eom ◽  
Jae Uk Jung ◽  
Kyoung-Pil Lee ◽  
Jeongho Kim ◽  
Dong Hee Yoon ◽  
...  
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Clinicopathological Correlations ◽  
Break Up

scholarly journals Reliability and efficacy of maximum fluorescein tear break-up time in diagnosing dry eye disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yujie Mou ◽  
Huan Xiang ◽  
Lin Lin ◽  
Kelan Yuan ◽  
Xin Wang ◽  
...  
Keyword(s):  
Dry Eye ◽  
Roc Analysis ◽  
Close Correlation ◽  
Dry Eye Disease ◽  
Disease Index ◽  
Eye Disease ◽  
Ocular Surface Disease Index ◽  
Ocular Symptoms ◽  
Break Up ◽  
Schirmer I Test

AbstractThis study aims to investigate the reliability and efficacy of maximum fluorescein tear break-up time (FTBUTmax) in diagnosing dry eye disease (DED). 147 participants were enrolled in this study. Ocular symptoms were assessed by Ocular Surface Disease Index (OSDI). The fluorescein tear break-up time (FTBUT) examination, corneal fluorescein staining (CFS), and Schirmer I test were performed on both eyes. Each participant underwent 3 consecutive FTBUT tests, and five types of FTBUT values including FTBUTmax, the minimum FTBUT (FTBUTmin), the first FTBUT (FTBUT1), the average of three FTBUTs (FTBUT123) and the average of the first and second FTBUT (FTBUT12) were recorded. FTBUTmax was larger than the other FTBUT values, but no differences were found among the values of FTBUT1, FTBUT123, FTBUT12 and FTBUTmin. In the ROC analysis, FTBUTmax had the largest or the second largest area under the ROC (AUROC) in all three DED diagnostic criteria, while FTBUTmin had the least AUROC of them. ROC efficacy of FTBUTmax was significantly higher than that of FTBUT123, FTBUT12, FTBUT1 and FTBUTmin in the OSDI criteria and higher than that of FTBUT1 and FTBUTmin in Schirmer I test and CFS tests. FTBUTmax has a close correlation with OSDI, Schirmer I test and CFS, and is an effective tool for the DED diagnosis.

scholarly journals Reliability and Efficacy of Maximum Fluorescein Tear Break-Up Time in Diagnosing Dry Eye Disease

2021 ◽  
Author(s):  
Yujie Mou ◽  
Huan Xiang ◽  
Lin Lin ◽  
Kelan Yuan ◽  
Xin Wang ◽  
...  
Keyword(s):  
Dry Eye ◽  
Roc Analysis ◽  
Close Correlation ◽  
Dry Eye Disease ◽  
Disease Index ◽  
Eye Disease ◽  
Ocular Surface Disease Index ◽  
Ocular Symptoms ◽  
Break Up ◽  
Schirmer I Test

Abstract This study aims to investigate the reliability and efficacy of maximum fluorescein tear break-up time (FTBUTmax) in diagnosing dry eye disease (DED). 147 participants were enrolled in this study. Ocular symptoms were assessed by Ocular Surface Disease Index (OSDI). The fluorescein tear break-up time (FTBUT) examination, corneal fluorescein staining (CFS), and Schirmer I test were performed on both eyes. Each participant underwent 3 consecutive FTBUT tests, and five types of FTBUT values including FTBUTmax, the minimum FTBUT (FTBUTmin), the first FTBUT (FTBUT1), the average of three FTBUTs (FTBUT123) and the average of the first and second FTBUT (FTBUT12) were recorded. FTBUTmax was larger than the other FTBUT values, but no differences were found among the values of FTBUT1, FTBUT123, FTBUT12 and FTBUTmin. In the ROC analysis, FTBUTmax had the largest or the second largest area under the ROC (AUROC) in all three DED diagnostic criteria, while FTBUTmin had the least AUROC of them. ROC efficacy of FTBUTmax was significantly higher than that of FTBUT123, FTBUT12, FTBUT1 and FTBUTmin in the OSDI criteria and higher than that of FTBUT1 and FTBUTmin in Schirmer and CFS tests. FTBUTmax has a close correlation with OSDI, Schirmer I test and CFS, and is an effective tool for the DED diagnosis.

Tear Film Thickness After Treatment With Artificial Tears in Patients With Moderate Dry Eye Disease

Cornea ◽  
2015 ◽  
Vol 34 (4) ◽  
pp. 421-426 ◽  
Author(s):  
Doreen Schmidl ◽  
Leopold Schmetterer ◽  
Katarzyna J. Witkowska ◽  
Angelika Unterhuber ◽  
Valentin Aranha dos Santos ◽  
...  
Keyword(s):  
Film Thickness ◽  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Artificial Tears

scholarly journals The effect of preservative free hydrocortisone 0.335% eye drops on tear film thickness in patients with moderate to severe dry eye disease

2019 ◽  
Vol 97 (S263) ◽  
Author(s):  
Doreen Schmidl ◽  
Martin Kallab ◽  
Nikolaus Hommer ◽  
Stephan Szegedi ◽  
Hannes Stegmann ◽  
...  
Keyword(s):  
Film Thickness ◽  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Eye Drops ◽  
Preservative Free
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