scholarly journals First Report of Sublingual Gland Ducts: Visualization by Dynamic MR Sialography and Its Clinical Application

2020 ◽  
Vol 9 (11) ◽  
pp. 3676 ◽  
Author(s):  
Tatsurou Tanaka ◽  
Masafumi Oda ◽  
Nao Wakasugi-Sato ◽  
Takaaki Joujima ◽  
Yuichi Miyamura ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Clinical Application ◽  
Time Dependent ◽  
Sublingual Gland ◽  
Maximum Area ◽  
First Report ◽  
Adult Volunteers ◽  
Dynamic Mr

This study was done to determine whether the sublingual gland ducts could be visualized and/or their function assessed by MR sialography and dynamic MR sialography and to elucidate the clinical significance of the visualization and/or evaluation of the function of sublingual gland ducts by clinical application of these techniques. In 20 adult volunteers, 19 elderly volunteers, and 7 patients with sublingual gland disease, morphological and functional evaluations were done by MR sialography and dynamic MR sialography. Next, four parameters, including the time-dependent changes (change ratio) in the maximum area of the detectable sublingual gland ducts in dynamic MR sialographic images and data were analyzed. Sublingual gland ducts could be accurately visualized in 16 adult volunteers, 12 elderly volunteers, and 5 patients. No significant differences in the four parameters in detectable duct areas of sublingual glands were found among the three groups. In one patient with a ranula, the lesion could be correctly diagnosed as a ranula by MR sialography because the mass was clearly derived from sublingual gland ducts. This is the first report of successful visualization of sublingual gland ducts. In addition, the present study suggests that MR sialography can be more useful in the diagnosis of patients with lesions of sublingual gland ducts.

Vascular Permeability: Quantitative Measurement with Double-Echo Dynamic MR Imaging—Theory and Clinical Application

Radiology ◽  
2000 ◽  
Vol 214 (3) ◽  
pp. 912-917 ◽  
Author(s):  
Hidemasa Uematsu ◽  
Masayuki Maeda ◽  
Norihiro Sadato ◽  
Tsuyoshi Matsuda ◽  
Yoshiyuki Ishimori ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Vascular Permeability ◽  
Clinical Application ◽  
Quantitative Measurement ◽  
Dynamic Mr Imaging ◽  
Imaging Theory ◽  
Dynamic Mr

Haloperidol in the Treatment of Stuttering

1977 ◽  
Vol 130 (4) ◽  
pp. 370-373 ◽  
Author(s):  
T. J. Murray ◽  
Patrick Kelly ◽  
Lynda Campbell ◽  
Kathy Stefanik
Keyword(s):  
Drug Therapy ◽  
Side Effects ◽  
Partial Response ◽  
Clinical Significance ◽  
Double Blind ◽  
Haloperidol Treatment ◽  
Adult Volunteers ◽  
Poor Concentration

SummaryHaloperidol treatment for stuttering was examined in a double-blind cross-over study of 26 adult volunteers with long-standing stuttering. Most had had unsuccessful speech and drug therapy. During the three-month study, their speech and stuttering patterns were repeatedly evaluated from videotaped readings of a standard passage and during spontaneous speaking. Of the 18 patients completing the trial 11 were significantly more improved on haloperidol than on placebo, three benefited equally from both, and four were unchanged. Improvement over placebo was indicated by fewer dysfluencies, increased speed of speaking, and reduced secondary 'struggle’ phenomena. Side effects were common on a dosage of 3 mg haloperidol daily. Poor concentration, akathisia and dystonic movements caused 8 patients to discontinue the trial despite significant improvement in 5 of them. Although 'statistically significant’ improvement occurred in most patients on haloperidol, the ‘clinical significance’ of this form of therapy will be limited by the partial response, the need for continuous medication, the side effects of haloperidol and the attitude of stutterers to this type of therapy.

scholarly journals In vivo Selection of Imipenem Resistance Among Ceftazidime-Avibactam-Resistant, Imipenem-Susceptible Klebsiella pneumoniae Isolate With KPC-33 Carbapenemase

2021 ◽  
Vol 12 ◽  
Author(s):  
Chunlei Wang ◽  
Jiankang Zhao ◽  
Zhibo Liu ◽  
Aihua Sun ◽  
Lingxiao Sun ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Clinical Significance ◽  
Capsular Polysaccharide ◽  
Selective Pressure ◽  
Dynamic Change ◽  
Wild Type ◽  
First Report ◽  
Emergence Of Resistance

We describe in vivo evolution of carbapenem and ceftazidime-avibactam resistance by analyzing four longitudinal Klebsiella pneumoniae clinical isolates from a patient with pneumonia following antimicrobial treatment. The patient had fever, cough associated with expectoration, and new infiltration was found on the chest CT. Antimicrobial susceptibility was determined, and whole genome sequencing (WGS) was performed to investigate its dynamic change of resistance phenotype. Population analysis profile was performed to investigate the population of Klebsiella pneumoniae. The infection started with a KPC-2-producing K. pneumoniae (ZRKP01, ceftazidime-avibactam-S/carbapenem-R). Then, after ceftazidime-avibactam treatment, the strain switched to D179Y mutant that is KPC-33 (ZRKP02, ceftazidime-avibactam-R/carbapenem-S), which restored carbapenem susceptibility. However, the restored carbapenem susceptibility in vivo was not stable and the subsequent use of imipenem against KPC-33-producing K. pneumoniae infection resulted in a reversion of KPC-2 producers (ZRKP03 and ZRKP04, ceftazidime-avibactam-S/carbapenem-R). Genetic analysis demonstrated that all four K. pneumoniae isolates belonged to sequence type 11and had identical capsular polysaccharide (KL47), identical porin genes, and same plasmid replicon types. Phylogenetic analysis indicated that four K. pneumoniae isolates showed a high degree of relatedness. Single nucleotide polymorphisms analysis indicated that the number of mutations observed in the KPC-33 isolate was more than in the wild-type KPC-2 isolates and the four KPC-Kp isolates evolved from a longitudinal evolution of K. pneumoniae harboring blaKPC-2 gene. This is the first report to observe the in vivo evolution of wild-type KPC-2 to KPC-33 and then the reversion to its original wild-type KPC-2. Through WGS, we demonstrated the role of selective pressure of antibiotic in the mutation and reversion of blaKPC genes, which leading to the dynamic change of KPC enzymes and the dynamic emergence of resistance to ceftazidime-avibactam and carbapenems.Statement: Recently, studies reported the emergence of ceftazidime-avibactam-resistant strains. The KPC mutations mediating ceftazidime-avibactam resistance are generally associated with the restoration of carbapenem susceptibility. However, clinical significance of this observation is unclear. In this manuscript, we demonstrate the role of selective pressure of antibiotic in the mutation and reversion of blaKPC genes, which leading to the dynamic change of KPC enzymes and the dynamic emergence of resistance to ceftazidime-avibactam and carbapenems. To the best of our knowledge, this is the first report to observe the in vivo evolution of wild-type KPC-2 to KPC-33 and then the reversion to its original wild-type KPC-2. It should be noted that understanding the clinical significance of this observation is of critical importance, and reversion to carbapenem susceptibility would not imply a potential role for carbapenems monotherapy. We hope our study will draw attention to clinicians, so that this agent can be used most effectively for the longest period of time.

scholarly journals Time-dependent variation of ionized calcium in serum samples

2019 ◽  
Vol 29 (3) ◽  
pp. 570-578 ◽  
Author(s):  
Antonija Perović ◽  
Marina Njire Bratičević
Keyword(s):  
Clinical Significance ◽  
Statistical Significance ◽  
Wilcoxon Test ◽  
Time Dependent ◽  
Ionized Calcium ◽  
Anova Analysis ◽  
Serum Samples ◽  
Arterial Blood ◽  
Significant Difference ◽  
Clinically Significant

Introduction: The aim of this study was to compare ionized calcium (iCa) concentrations in arterial heparinized blood and venous serum and to investigate time-dependent variation of iCa in serum samples centrifuged and analysed at different times. Materials and methods: Ionized calcium was measured (N = 25) in arterial blood within 20 min after puncture, and in serum within 10 min after centrifugation conducted 30 min after sampling. Effect of time between sampling and centrifugation was examined in three tubes (N = 30) centrifuged 15, 30 and 60 min after sampling, and analysed within 10 min. Effect of time between centrifugation and analysis was investigated in three tubes (N = 31) centrifuged 30 min after sampling and analysed: 0-10, 30-40 and 90-100 min after centrifugation. Ionized calcium was measured on the Siemens RapidLab 348EX analysers. Statistical significance was tested using Wilcoxon test and ANOVA analysis. Clinical significance was judged against reference change values (RCV). Results: No statistically significant difference was found between iCa in arterial blood and serum (P = 0.274). A statistically significant decrease was found: in tubes centrifuged 60 and 15 min after sampling versus 30 min (P = 0.005, P = 0.003); and in tubes analysed 30-40 and 90-100 min after centrifugation versus 0-10 min (P = 0.021, P = 0.027). Clinically significant changes were observed: 60 versus 30 min (centrifugation) and 90-100 versus 0-10 and 30-40 min (analysis). Conclusions: Timely analysed arterial blood and serum samples can be used interchangeably. To avoid clinically significant variations, serum tubes should be centrifuged within 30 min after sampling, and analysis should be performed within 30 min after centrifugation.

Time-dependent analysis of incidence, risk factors and clinical significance of pneumothorax after percutaneous lung biopsy

2017 ◽  
Vol 28 (3) ◽  
pp. 1328-1337 ◽  
Author(s):  
Woo Hyeon Lim ◽  
Chang Min Park ◽  
Soon Ho Yoon ◽  
Hyun-Ju Lim ◽  
Eui Jin Hwang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Significance ◽  
Lung Biopsy ◽  
Time Dependent ◽  
Incidence Risk ◽  
Percutaneous Lung Biopsy ◽  
Time Dependent Analysis

scholarly journals Clinical Significance of Segmental Chromosomal Aberrations in Patients with Neuroblastoma: First Report in Korean Population

2020 ◽  
Vol 35 (14) ◽  
Author(s):  
Hana Lim ◽  
Meong Hi Son ◽  
Ju Kyung Hyun ◽  
Hee Won Cho ◽  
Hee Young Ju ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Chromosomal Aberrations ◽  
Korean Population ◽  
First Report

First report of Pandoraea norimbergensis isolated from food—potential clinical significance

2001 ◽  
Vol 18 (1) ◽  
pp. 113-114 ◽  
Author(s):  
John E. Moore ◽  
Tom Coenye ◽  
Peter Vandamme ◽  
J. Stuart Elborn
Keyword(s):  
Clinical Significance ◽  
First Report ◽  
Food Potential

scholarly journals A REVIEW OF ADHOSHAKHAGAT KSHIPRA MARMA AND ITS CLINICAL SIGNIFICANCE

2020 ◽  
Vol 8 (04) ◽  
Author(s):  
Snehal Vishwas Maske
Keyword(s):  
Clinical Practice ◽  
Clinical Significance ◽  
Clinical Application ◽  
Close Association ◽  
The Body ◽  
Great Toe ◽  
Upper And Lower Extremities ◽  
Traumatic Effect ◽  
Structural Entity ◽  
Second Toe

There are 107 vital points spread over the body called as MARMA. All the marmas are seat of prana. Owing to this close association of chetana, injury to marma will produce severe sufferings. KSHIPRA marma is one of the Shakhagat marma situated on both upper and lower extremities and are four in number. It is situated between the great toe and the second toe of the foot with a dimension of half Angula. Based on predominant structural entity it is a Snayu marma. While classifying on the basis of traumatic effect it is a Kalantara pranhara marma. Trauma to this marma causes death due to convulsions. Understanding marma is very important in clinical practice of Ayurveda. Even the prognosis of disease depends upon the extent of involvement of marma points. This review will give a complete summary of KSHIPRA marma regarding its location, structural entity and clinical application.

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