scholarly journals New Strategies for Rehabilitation and Pharmacological Treatment of Fatigue Syndrome in Multiple Sclerosis

2020 ◽  
Vol 9 (11) ◽  
pp. 3592
Author(s):  
Ewa Zielińska-Nowak ◽  
Lidia Włodarczyk ◽  
Joanna Kostka ◽  
Elżbieta Miller
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Daily Basis ◽  
Whole Body ◽  
Clinical Scales ◽  
Effective Strategies ◽  
Advantages And Disadvantages ◽  
Fatigue Syndrome ◽  
The Central Nervous System

Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system (CNS), with an inflammatory demyelinating basis and a progressive course. The course of the disease is very diverse and unpredictable. Patients face many problems on a daily basis, such as problems with vision; sensory, balance, and gait disturbances; pain; muscle weakness; spasticity; tremor; urinary and fecal disorders; depression; and rapidly growing fatigue, which significantly influences quality of life among MS patients. Excessive fatigue occurs in most MS patients in all stages of this disease and is named MS-related fatigue. The crucial issue is the lack of effective treatment; therefore, this review focuses not only on the most common treatment methods, but also on additional novel therapies such as whole-body cryotherapy (WBC), functional electrical stimulation (FES), and non-invasive brain stimulation (NIBS). We also highlight the advantages and disadvantages of the most popular clinical scales used to measure fatigue. The entire understanding of the origins of MS-related fatigue may lead to the development of more effective strategies that can improve quality of life among MS patients. A literature search was performed using MEDLINE, EMBASE, and PEDro databases.

The Quality of Life in Multiple Sclerosis Patients Living in the North Region, Depending on Cognitive Status

10.12737/5911 ◽  
2014 ◽  
Vol 21 (3) ◽  
pp. 104-108
Author(s):  
Молчанова ◽  
Zh. Molchanova
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Cognitive Status ◽  
Rapid Progression ◽  
The North ◽  
Real Increase ◽  
The Central Nervous System ◽  
Assess Quality ◽  
Multiple Sclerosis Patients

Multiple sclerosis is the most frequent disease of the central nervous system. An increase in multiple sclerosis frequency was registered in several countries including Russia. This may be associated with better multiple sclerosis diagnosis and treatment, better data collection and real increase in multiple sclerosis incidence. Early disability and its rapid progression emphasize the medico-social importance of multiple sclerosis. Neuropsychological disturbances are often observed in multiple sclerosis, being one of the important components in the formation of clinical disease. 43 patients living in the North region with definite multiple sclerosis and mild or moderate disability were tested with expended neuropsychological, neurological and study of quality of life. The purpose of the study was to analyze the role of cognitive, emotional and personal peculiarities at multiple sclerosis on quality of life. To assess quality of life the authors used SF-36. The results of this study of quality of life revealed significant differences in the physical, role and social components depending on the cognitive peculiarities.

scholarly journals Fatigue Syndrome, Depression and the Quality of Life in Patients with Multiple Sclerosis

2017 ◽  
Vol 6 (2) ◽  
pp. 81-87
Author(s):  
Dorota Halicka ◽  
Joanna Tarasiuk ◽  
Michał Szczepański ◽  
Agata Krajewska ◽  
Alina Kułakowska
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Fatigue Syndrome

scholarly journals Fatigue and Affective Manifestations in Multiple Sclerosis—A Cluster Approach

2019 ◽  
Vol 10 (1) ◽  
pp. 10 ◽  
Author(s):  
Samar S. Ayache ◽  
Moussa A. Chalah
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Economic Cost ◽  
Cluster Approach ◽  
High Prevalence ◽  
The Central Nervous System ◽  
Chronic Autoimmune Disease

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, characterized by a high prevalence in young people, a drastic impact on the quality of life, and an important economic cost to society [...]

Information and resources important to the quality of life of people living with multiple sclerosis

2020 ◽  
Vol 26 (2) ◽  
pp. 92-104
Author(s):  
Malachy Bishop ◽  
Stuart Rumrill ◽  
Bradley McDaniels ◽  
Jian Li ◽  
Robert Fraser ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Psychosocial Health ◽  
Physical And Mental Health ◽  
Psychosocial Effects ◽  
Immune Mediated ◽  
Wide Range ◽  
The Central Nervous System ◽  
Types Of Information

AbstractMultiple sclerosis (MS) is a chronic, typically progressive immune-mediated disease characterized by inflammation and demyelination in the central nervous system (CNS), and is associated with a wide range of neurological, physical, and psychosocial effects. For people living with MS, access to relevant, timely, and accessible health information and resources may contribute to effective illness management, psychosocial health, and quality of life (QOL). In this study, we sought to increase understanding of the specific types of information most wanted by people with MS, as well as the sources and effects of this information. Specifically, we surveyed 748 adults with MS about (a) the sources from which they obtain information about MS, (b) the type of information that is most important in terms of improving their QOL, and (c) specific topics about which they would like to have more information, services, or resources. Content analysis of the qualitative results demonstrated the diversity of information sources accessed by people with MS and the importance of providing information through different formats and media. The participants prioritized information related to new MS medications and treatments, physical and mental health and wellness, and local opportunities for support. Implications for practicing rehabilitation counselors are discussed.

scholarly journals Multiple Sclerosis: Impact on Oral Hygiene, Dysphagia, and Quality of Life

2020 ◽  
Vol 17 (11) ◽  
pp. 3979
Author(s):  
Francesco Covello ◽  
Giovanni Ruoppolo ◽  
Camilla Carissimo ◽  
Giulia Zumbo ◽  
Carla Ferrara ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Oral Health ◽  
Oral Hygiene ◽  
Health Impact ◽  
Oral Health Status ◽  
Gingival Inflammation ◽  
Oral Health Impact Profile ◽  
The Central Nervous System

Multiple sclerosis (MS) is an autoimmune disease in which the immune system reacts by damaging the central nervous system, specifically myelin and oligodendrocytes. It is the most debilitating neurological disease among young adults, causing personal, familiar, social, and professional limitations. Multiple sclerosis can cause disturbances in the orofacial district, due to a demyelination process on the nerves of the head and neck district. The aim of this study was to evaluate the oral health status, dysphagia, and quality of life of patients affected by MS. For this study, 101 patients aged between 12 and 70 (47 males, 54 females) affected by MS were selected, and three questionnaires were handed out and anonymously filled in by them: An oral hygiene test, DYMUS (DYsphagia in MUltiple Sclerosis), and IOHIP-14 (Italian version Oral Health Impact Profile). Through the analysis of the questionnaires it was possible to observe pathological conditions, such as gingival inflammation, xerostomia, dysphagia, neuralgia, and dysarthria. Through the analysis it was possible to outline how the roles of a medical team, composed of a dentist, otolaryngologist, and dental hygienist, are fundamental in coping with other medical figures, during the whole development of the diseases, as well as to prevent possible complications.

scholarly journals Quality of Life of Children and Adolescents with Multiple Sclerosis—A Literature Review of the Quantitative Evidence

2021 ◽  
Vol 18 (16) ◽  
pp. 8645
Author(s):  
Slávka Mrosková ◽  
Eleonóra Klímová ◽  
Ľudmila Majerníková ◽  
Ľubomíra Tkáčová
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Literature Review ◽  
Children And Adolescents ◽  
Future Research ◽  
Quantitative Evidence ◽  
The Social ◽  
The Central Nervous System ◽  
Generic Module

Background: Multiple sclerosis (MS) is a chronic disease of the central nervous system that also develops in patients under 18 years of age. The disease negatively affects the quality of life (QoL) of children and adolescents. We conducted a literature review. The aim of the review was to identify the QoL of pediatric patients with MS and assess the factors determining their QoL. Methods: We analyzed studies published between 2000 and 2020 in PubMed, Scopus, Science Direct, Web of Science, and EBSCO databases. Results: In all, 17 studies were included in the review. The most common tool in assessing QoL was the generic module PedsQL. The range of mean/median global score of QoL was 53.8–81.7. The worst QoL was dominantly reported in the school and emotional spheres, on the contrary, the disease’s least determined area of QoL was the social and physical dimension. In particular, disability and fatigue were important predictors of QoL. Conclusions: MS negatively affects the school and emotional spheres in particular, so it is important to pay greater attention to these spheres of life of MS patients. As the review studies pay insufficient attention to the analysis of positive factors and their impact on the QoL of MS patients, research should integrate these phenomena. The use of MS-targeted tools in future research in the pediatric MS population is also appropriate.

The use of quality of life measures in multiple sclerosis research

2003 ◽  
Vol 9 (1) ◽  
pp. 63-72 ◽  
Author(s):  
M W Nortvedt ◽  
T Riise
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Disease Activity ◽  
Clinical Scales ◽  
Additional Information ◽  
Quality Of Life Measures ◽  
Quality Of Life Questionnaires ◽  
Study Designs ◽  
The Impact

Q uality of life research contributes knowledge essential to the health and healthcare of multiple sclerosis (MS) patients. This article reviews 83 MS studies in English that have presented data on quality of life. The studies may be classified into three categories, according to the application and the main focus: 1) evaluating the development and validity of quality of life questionnaires and clinical scales (n-27); 2) evaluating factors that might influence the quality of life or comparing the quality of life among various groups (n-37); and 3) using quality of life questionnaires as outcome measures in medical trials and other interventions (n-19). The studies have shown that quality of life questionnaires more broadly measure the impact of MS than do the most frequently used measures of disease activity and effects. Using quality of life measures provides additional information in evaluating the effects of treatment and in studying the development of the disease. Such information is crucial in planning interventions for MS patients. A challenge in this field is to improve the study designs, including reaching some agreement on how to measure the quality of life.

Comorbidity and Health-Related Quality of Life in People with Multiple Sclerosis

2009 ◽  
Vol 11 (1) ◽  
pp. 6-16 ◽  
Author(s):  
Sharon A. Warren ◽  
Karen V.L. Turpin ◽  
Sheri L. Pohar ◽  
C. Allyson Jones ◽  
K.G. Warren
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Urinary Incontinence ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Health Related Quality ◽  
Fatigue Syndrome ◽  
Related Quality ◽  
Health Related

This study examined associations between comorbidity and health-related quality of life (HRQL) in people with multiple sclerosis (MS). Data were derived from the Canadian Community Health Survey (CCHS) Cycle 1.1, a cross-sectional survey conducted by Statistics Canada. A nationally representative sample of community-dwelling Canadians was interviewed to determine whether they had been diagnosed with various chronic conditions. Participants were also administered the Health Utilities Index Mark 3 (HUI3) questionnaire to evaluate HRQL. Of the 131,535 participants, 335 reported having MS. Comorbidities listed by at least 10% of respondents with MS were assessed for their relation to HRQL, with age, sex, education, marital status, income, and number of comorbidities included as covariates. Respondents averaged 1.6 comorbidities. Eight comorbidities were experienced by at least 10% of respondents: back problems (35%), nonfood allergies (29%), urinary incontinence (28%), arthritis (26%), hypertension (17%), chronic fatigue syndrome (16%), depression (16%), and migraine (14%). Differences in HRQL between people with and without urinary incontinence, arthritis, hypertension, chronic fatigue syndrome, and depression were either clinically important or statistically significant at the .05 level in bivariate analyses. Only urinary incontinence and depression, however, were negatively associated with HRQL in a multivariate analysis, which explained 26% of the variance. Lower levels of education and receiving social assistance were also negatively associated with HRQL, with social assistance contributing more to the variance in HRQL than either comorbidity.

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