scholarly journals Association of Regional Bone Synthetic Activities of Vertebral Corners and Vertebral Bodies Quantified Using 18F-Fluoride Positron Emission Tomography with Bone Mineral Density on Dual Energy X-ray Absorptiometry in Patients with Ankylosing Spondylitis

2020 ◽  
Vol 9 (8) ◽  
pp. 2656
Author(s):  
Keunyoung Kim ◽  
Kyoungjune Pak ◽  
In-Joo Kim ◽  
Seong-Jang Kim ◽  
Dong Hyun Sohn ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Positron Emission Tomography ◽  
Lumbar Vertebrae ◽  
Dual Energy ◽  
Emission Tomography ◽  
Mineral Density ◽  
X Ray ◽  
Positron Emission ◽  
Vertebral Bodies ◽  
18F Fluoride

We investigated whether the bone-synthetic activities of vertebral bodies or vertebral corners quantified using 18F-fluoride positron emission tomography (PET) was associated with bone mineral density (BMD) at the corresponding lumbar vertebrae in ankylosing spondylitis (AS) at each vertebra level. We analyzed 48 lumbar vertebrae in 12 AS patients who underwent 18F-fluoride PET and dual energy X-ray absorptiometry (DXA). The mean standardized uptake values (SUVmean) of the vertebral body and corners from L1 to L4 were measured using the spatially separated region of interest (ROI). The L1–L4 BMDs were calculated based on the DXA (“conventional BMD”). The BMD of the internal vertebral bodies was measured by manually drawing ROIs to represent the trabecular BMD (“alternative BMD”). After adjusting the within-patient correlation, the 18F-fluoride SUVmean of the vertebral corners but not that of vertebral bodies was significantly related with the conventional BMD of the vertebra. Otherwise, the 18F-fluoride uptake of both the vertebral and vertebral bodies was significantly related with the alternative BMD. The bone-synthetic activities of the vertebral corners may be more closely related with BMD than those of the vertebral bodies, suggesting that the effects of regional bone metabolism at the vertebral corners and bodies on BMD differ in AS.

scholarly journals Influence of Hydroxyapatite Coating for the Prevention of Bone Mineral Density Loss and Bone Metabolism after Total Hip Arthroplasty: Assessment Using 18F-Fluoride Positron Emission Tomography and Dual-Energy X-Ray Absorptiometry by Randomized Controlled Trial

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Taro Tezuka ◽  
Naomi Kobayashi ◽  
Choe Hyonmin ◽  
Masatoshi Oba ◽  
Yushi Miyamae ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Positron Emission Tomography ◽  
Controlled Trial ◽  
Dual Energy ◽  
Emission Tomography ◽  
Mineral Density ◽  
X Ray ◽  
Randomized Controlled ◽  
Ha Coating ◽  
Positron Emission

Background. Hydroxyapatite- (HA-) coated implants tend to achieve good osteoinductivity and stable clinical results; however, the influence of the coating on the prevention of bone mineral density (BMD) loss around the implant is unclear. The purpose of this randomized controlled trial was to evaluate the effectiveness of HA-coated implants for preventing BMD loss and to determine the status of bone remodeling after total hip arthroplasty (THA), making comparisons with non-HA-coated implants. Methods. A total of 52 patients who underwent primary THA were randomly allocated to HA and non-HA groups. BMD was measured by dual-energy X-ray absorptiometry (DEXA) at 1 week postoperation to form a baseline measurement, and then 24 weeks and 48 weeks after surgery. The relative change in BMD was evaluated for regions of interest (ROIs) based on the Gruen zone classifications. 18F-fluoride positron emission tomography (PET) was performed at 24 weeks postsurgery, and the maximum standardized uptake values (SUVmax) were evaluated in the proximal (HA-coated) and distal (non-HA-coated) areas in both groups. Results. There were significant differences in BMD loss in ROIs 3 and 6 (p=0.03), while no significant difference was observed in ROI 7 at either 24 or 48 weeks postsurgery. There was no significant correlation between PET uptake and BMD (24 or 48 weeks) in either group. Conclusion. The influence of a HA coating in terms of BMD preservation is limited. No significant correlation was found between BMD and SUVmax measured by PET, either with or without the use of a HA coating.

The Use of Computer Technology in Standardization of the Parameters of X-Ray Densitometry

10.12737/9082 ◽  
2015 ◽  
Vol 22 (1) ◽  
pp. 75-79
Author(s):  
Захаров ◽  
I. Zakharov
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Regional Differences ◽  
Lumbar Vertebrae ◽  
Dual Energy ◽  
Mineral Density ◽  
Population Database ◽  
X Ray ◽  
Computerized System

Currently, the radiation techniques are dominant in the diagnosis of osteoporosis, among them the dual-energy X-ray absorptiometry (DXA) is the leading. This method is based on the determination of bone mineral density. The article describes a computerized system Standart LS (Russia), which standardizes the parameters of bone mineral density, depending on the type of densitometry equipment and evaluates the results of X-ray densitometry taking into account a regional perspective. The developed program and population database of parameters of bone mineral density were the results of retrospective analysis of the dual-energy X-ray absorptiometry in 1504 women living in Kemerovo region. The dual-energy X-ray absorptiometry was performed with a bone densitometer Lunar-DPX-NT (GE Healthcare, UK). Initially, the bone mineral density of the first-fourth lumbar vertebrae was studied; then, the standardization of other parameters of densitometric systems was carried out (Hologic, Norland). The algorithm of the computer program consists of three phases: the introduction of parameters of bone mineral density, the standardization and the processing according to a type of densitometer and an age of a subject. After data processing, the values of Z-criteria are given out according to the recommendations of the International Society for Clinical Densitometry. The developed computerized system will contribute to a more accurate assessment of bone mineral density in the women, taking into account regional differences.

Bone mineral density distribution in thoracic and lumbar vertebrae: An ex vivo study using dual energy X-ray absorptiometry

Bone ◽  
2006 ◽  
Vol 38 (2) ◽  
pp. 286-288 ◽  
Author(s):  
Andrew M. Briggs ◽  
John D. Wark ◽  
Susan Kantor ◽  
Nicola L. Fazzalari ◽  
Alison M. Greig ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Density Distribution ◽  
Bone Mineral ◽  
Ex Vivo ◽  
Lumbar Vertebrae ◽  
Dual Energy ◽  
Mineral Density ◽  
X Ray ◽  
Ex Vivo Study ◽  
Bone Mineral Density Distribution

scholarly journals Relationship between Weight, Body Mass Index, and Bone Mineral Density in Men Referred for Dual-Energy X-Ray Absorptiometry Scan in Isfahan, Iran

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Mohammad Reza Salamat ◽  
Amir Hossein Salamat ◽  
Iraj Abedi ◽  
Mohsen Janghorbani
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Body Mass ◽  
Bone Mineral ◽  
Lumbar Vertebrae ◽  
Dual Energy ◽  
Overweight And Obesity ◽  
Osteoporosis Prevention ◽  
Mineral Density ◽  
X Ray

Objective.Although several studies have investigated the association between body mass index (BMI) and bone mineral density (BMD), the results are inconsistent. The aim of this study was to further investigate the relation between BMI, weight and BMD in an Iranian men population.Methods.A total of 230 men 50-79 years old were examined. All men underwent a standard BMD scans of hip (total hip, femoral neck, trochanter, and femoral shaft) and lumbar vertebrae (L2-L4) using a Dual-Energy X-ray Absorptiometry (DXA) scan and examination of body size. Participants were categorised in two BMI group: normal weight <25.0 kg/m2and overweight and obese, BMI ≥ 25 kg/m2.Results.Compared to men with BMI ≥ 25, the age-adjusted odds ratio of osteopenia was 2.2 (95% CI 0.85, 5.93) and for osteoporosis was 4.4 (1.51, 12.87) for men with BMI < 25. It was noted that BMI and weight was associated with a high BMD, compatible with a diagnosis of osteoporosis.Conclusions.These data indicate that both BMI and weight are associated with BMD of hip and vertebrae and overweight and obesity decreased the risk for osteoporosis. The results of this study highlight the need for osteoporosis prevention strategies in elderly men as well as postmenopausal women.

scholarly journals The value of bone mineral density assessment by dual-energy x-ray absorptiometry for prediction of cardiovascular mortality in patients treated with hemodialysis

2020 ◽  
Vol 92 (6) ◽  
pp. 33-36
Author(s):  
Sergey O. Mazurenko ◽  
Yakov A. Nakatis ◽  
Aleksander A. Enkin ◽  
Konstantin G. Staroselsky ◽  
Aleksander N. Vasiliev ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Prognostic Significance ◽  
Lumbar Vertebrae ◽  
Dual Energy ◽  
Mineral Density ◽  
Cox Regression Analysis ◽  
X Ray ◽  
Risk Of Death ◽  
Increased Risk

Aim. Determine whether bone mineral density (BMD) assessed by dual-energy x-ray absorptiometry can be used as predictor of increased risk of death in hemodialysis patients. Materials and methods. A prospective study was performed of 516 patients with chronic kidney disease treated with hemodialysis (men 265, women 251, mean age 44.811.4 years) who were observed for 5.73.2 years. Before inclusion in the study, in all patients was analyzed bone mineral density using dual-energy X-ray absorptiometry in three standard departments: lumbar vertebrae, proximal femur and distal forearm. The probability analysis of the outcome was carried out using the KaplanMeier method and Cox. Results. During follow-up period 111 (21.5%) patients died, 50.5% from cardiovascular events. Survival analysis by KaplanMeier method allowed to prove the increased risk of death from cardiovascular pathology in hemodailysis patients with low bone mineral density of all evaluated areas. Step-by-step multivariate Cox regression analysis showed that the T score of the femur, showing the difference of BMD of the patient with normal value of BMD for young adult, had the greatest prognostic significance. Conclusion. Reduced bone mineral density in patients receiving hemodialysis is associated with an increased risk of death from cardiovascular disease. Dual energy x-ray absorptiometry can be used for assessment of this risk.

scholarly journals Preliminary result on trabecular bone score (TBS) in lumbar vertebrae with experimentally altered microarchitecture

2013 ◽  
Vol 86 (1) ◽  
Author(s):  
M. Di Stefano ◽  
G.C. Isaia ◽  
D. Cussa ◽  
G.L. Panattoni
Keyword(s):  
Trabecular Bone ◽  
Cancellous Bone ◽  
Trabecular Bone Score ◽  
Lumbar Vertebrae ◽  
Dual Energy ◽  
Mineral Density ◽  
X Ray ◽  
Vertebral Bodies ◽  
Preliminary Research ◽  
Qualitative Parameter

The aim of this preliminary research is to investigate the reliability of a new qualitative parameter, called Trabecular Bone Score (TBS), recently proposed for evaluating the microarchitectural arrangement of cancellous bone in scans carried out by dual energy X-ray absorptiometry (DXA). Vertebral bodies of 15 fresh samples of lumbar spines of adult pig were analysed either in basal conditions and with altered microarchitecture of the cancellous bone obtained by progressive drilling. The examined bony areas do not show changes in bone mineral density (BMD), whereas TBS values decrease with the increasing alteration of the vertebral microtrabecular structure. Our preliminary data seem to confirm the reliability of TBS as a qualitative parameter useful for evaluating the microarchitectural strength in bony areas quantitatively analysed by DXA.

scholarly journals POS0045 LEAST SIGNIFICANT CHANGE IN BONE DENSITOMETRY IN PATIENTS WITH OBESITY

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 227.2-228
Author(s):  
D. Claire ◽  
M. Geoffroy ◽  
L. Kanagaratnam ◽  
C. Isabelle ◽  
A. Hittinger ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
General Population ◽  
Bone Mineral ◽  
Bone Densitometry ◽  
Dual Energy ◽  
Mineral Density ◽  
Least Significant Change ◽  
X Ray ◽  
Significant Change

Background:Dual energy X-ray absoprtiometry is the reference method to mesure bone mineral density (1). Loss of bone mineral density is significant if it exceeds the least significant change. The threshold value used in general population is 0,03 g/cm2 (2). Patients with obesity are known for having a higher bone mineral density due to metabolism and physiopathology characteristics (3,4).Objectives:The aim of our study was to determine the least significant change in bone densitometry in patients with obesity.Methods:We conducted an interventionnal study in 120 patients with obesity who performed a bone densitometry. We measured twice the bone mineral density at the lumbar spine, the femoral neck and the total hip in the same time (5,6). We determined the least significant change in bone densitometry from each pair of measurements, using the Bland and Altman method. We also determined the least significant change in bone densitometry according to each stage of obesity.Results:The least significant change in bone densitometry in patients with obesity is 0,046g/cm2 at the lumbar spine, 0.069 g/cm2 at the femoral neck and 0.06 g/cm2 at the total hip.Conclusion:The least significant change in bone densitometry in patients with obesity is higher than in general population. These results may improve DXA interpretation in this specific population, and may personnalize their medical care.References:[1]Lees B, Stevenson JC. An evaluation of dual-energy X-ray absorptiometry and comparison with dual-photon absorptiometry. Osteoporos Int. mai 1992;2(3):146-52.[2]Briot K, Roux C, Thomas T, Blain H, Buchon D, Chapurlat R, et al. Actualisation 2018 des recommandations françaises du traitement de l’ostéoporose post-ménopausique. Rev Rhum. oct 2018;85(5):428-40.[3]Shapses SA, Pop LC, Wang Y. Obesity is a concern for bone health with aging. Nutr Res N Y N. mars 2017;39:1-13.[4]Savvidis C, Tournis S, Dede AD. Obesity and bone metabolism. Hormones. juin 2018;17(2):205-17.[5]Roux C, Garnero P, Thomas T, Sabatier J-P, Orcel P, Audran M, et al. Recommendations for monitoring antiresorptive therapies in postmenopausal osteoporosis. Jt Bone Spine Rev Rhum. janv 2005;72(1):26-31.[6]Ravaud P, Reny JL, Giraudeau B, Porcher R, Dougados M, Roux C. Individual smallest detectable difference in bone mineral density measurements. J Bone Miner Res. août 1999;14(8):1449-56.Disclosure of Interests:None declared.

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