scholarly journals Association between African Dust Transport and Acute Exacerbations of COPD in Miami

2020 ◽  
Vol 9 (8) ◽  
pp. 2496
Author(s):  
Miguel Pardinas Gutierrez ◽  
Paquita Zuidema ◽  
Mehdi Mirsaeidi ◽  
Michael Campos ◽  
Naresh Kumar
Keyword(s):  
Air Pollution ◽  
Particulate Matter ◽  
Ambient Temperature ◽  
Acute Exacerbation ◽  
Dust Storms ◽  
Saharan Dust ◽  
Dust Exposure ◽  
Chronic Obstructive ◽  
Copd Patients ◽  
Dust Events

Background: Air pollution is increasingly recognized as a risk factor for acute exacerbation of chronic obstructive pulmonary disease (COPD). Changing climate and weather patterns can modify the levels and types of air pollutants. For example, dust outbreaks increase particulate air pollution. Objective: This paper examines the effect of Saharan dust storms on the concentration of coarse particulate matter in Miami, and its association with the risk of acute exacerbation of COPD (AECOPD). Methods: In this prospective cohort study, 296 COPD patients (with 313 events) were followed between 2013 and 2016. We used Light Detection and Ranging (LIDAR) and satellite-based Aerosol Optical Depth (AOD) to identify dust events and quantify particulate matter (PM) exposure, respectively. Exacerbation events were modeled with respect to location- and time-lagged dust and PM exposures, using multivariate logistic regressions. Measurements and main results: Dust duration and intensity increased yearly during the study period. During dust events, AOD increased by 51% and particulate matter ≤2.5 µm in aerodynamic diameter (PM2.5) increased by 25%. Adjusting for confounders, ambient temperature and local PM2.5 exposure, one-day lagged dust exposure was associated with 4.9 times higher odds of two or more (2+ hereto after) AECOPD events (odds ratio = 4.9; 95% CI = 1.8–13.4; p < 0.001). Ambient temperature exposure also showed a significant association with 2+ and 3+ AECOPD events. The risk of AECOPD lasted up to 15 days after dust exposure, declining from 10× higher on day 0 to 20% higher on day 15. Conclusions: Saharan dust outbreaks observed in Miami elevate the concentration of PM and increase the risk of AECOPD in COPD patients with recurring exacerbations.

scholarly journals A comparative study of chest CT findings regarding the effects of regional dust exposure on patients with COPD living in urban areas and rural areas near cement plants

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Junghyun Kim ◽  
Bom Kim ◽  
So Hyeon Bak ◽  
Yeon-Mok Oh ◽  
Woo Jin Kim
Keyword(s):  
Sex Education ◽  
Rural Areas ◽  
Urban Areas ◽  
Smoking Status ◽  
Statistical Significance ◽  
Dust Exposure ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Wall Area ◽  
Copd Patients

Abstract Background The clinical and radiological presentation of chronic obstructive pulmonary disease (COPD) is heterogenous depending on the characterized sources of inflammation. This study aimed to evaluate COPD phenotypes associated with specific dust exposure. Methods This study was designed to compare the characteristics, clinical outcomes and radiological findings between two prospective COPD cohorts representing two distinguishing regions in the Republic of Korea; COPD in Dusty Area (CODA) and the Korean Obstructive Lung Disease (KOLD) cohort. A total of 733 participants (n = 186 for CODA, and n = 547 for KOLD) were included finally. A multivariate analysis to compare lung function and computed tomography (CT) measurements of both cohort studies after adjusting for age, sex, education, body mass index, smoking status, and pack-year, Charlson comorbidity index, and frequency of exacerbation were performed by entering the level of FEV1(%), biomass exposure and COPD medication into the model in stepwise. Results The mean wall area (MWA, %) became significantly lower in COPD patients in KOLD from urban and metropolitan area than those in CODA cohort from cement dust area (mean ± standard deviation [SD]; 70.2 ± 1.21% in CODA vs. 66.8 ± 0.88% in KOLD, p = 0.028) after including FEV1 in the model. COPD subjects in KOLD cohort had higher CT-emphysema index (EI, 6.07 ± 3.06 in CODA vs. 20.0 ± 2.21 in KOLD, p < 0.001, respectively). The difference in the EI (%) was consistently significant even after further adjustment of FEV1 (6.12 ± 2.88% in CODA vs. 17.3 ± 2.10% in KOLD, p = 0.002, respectively). However, there was no difference in the ratio of mean lung density (MLD) between the two cohorts (p = 0.077). Additional adjustment for biomass parameters and medication for COPD did not alter the statistical significance after entering into the analysis with COPD medication. Conclusions Higher MWA and lower EI were observed in COPD patients from the region with dust exposure. These results suggest that the imaging phenotype of COPD is influenced by specific environmental exposure.

scholarly journals Effects of Mangosteen pericarp Extract to Clinical Improvements, The Plasma Level of IL-6 and Malondialdehyde in Acute Exacerbation of COPD Patients

2018 ◽  
Vol 38 (3) ◽  
pp. 164-172
Author(s):  
Khilyatul Baroroh ◽  
Suradi Suradi ◽  
Ade Rima
Keyword(s):  
Treatment Group ◽  
Plasma Level ◽  
Length Of Stay ◽  
Acute Exacerbation ◽  
Clinical Symptoms ◽  
Control Group ◽  
Chronic Obstructive ◽  
Copd Patients ◽  
Significant Difference ◽  
And Control

Background: Amplification of inflammation in acute exacerbation of chronic obstructive pulmonary disease (COPD) increases inflammatory mediators and oxidative stress in the airways, pulmonary and systemic circulation that are characterized by increased plasma level of IL-6 and MDA, resulting in worsening of clinical symptoms. Xanthones in mangosteen pericarp have anti-inflammatory and antioxidant effects, potentially as an adjuntive therapy in acute exacerbations of COPD. Methods: The aim of this study was to determine the effect of mangosteen pericarp extract to clinical improvements, plasma level of IL-6 and MDA of acute exacerbation COPD patients. A clinical trial of experimental with pretest and posttest was conducted on 34 acute exacerbation of COPD patients in Dr. Moewardi Hospital Surakarta and Dr. Ario Wirawan Lung Hospital Salatiga from April until May 2016. The sample was taken by consecutive sampling. Subjects were divided by randomized double blind technique into the treatment group (n=17) received mangosteen pericarp extract 2x1100mg/day and control group (n = 17) received placebo. Clinical improvements were measured in CAT score and length of stay. CAT score, plasma level of IL-6 and MDA were measured on admission and at discharge. Length of stay based on the number of days of care in hospitals. Results: There was significant difference (p=0,011) towards decreased of IL-6 plasma level between treatment group (-2,17 ± 3,46 pg/ mL) and control group (+1,67 ± 6,81 pg/mL). There were no significant difference towards decreased of length of stay (p=0,34) between treatment group (4,12 ± 1,54 days) and control group (5,24 ± 2,49 days), towards decreased of CAT score (p=0,252) between treatment group (-19,18 ± 3,96) and control group (-18,24 ± 2,75), and towards decreased of MDA plasma level (p=0,986) between treatment group (+0,03 ± 0,36μmol/L) and control group (+0,35 ± 1,58). Conclusions: The addition of mangosteen pericarp extract 2x1100mg/day during hospitalization was significantly lowered plasma levels of IL-6, but were not significant in lowering the CAT score, shortening the length of stay, and reducing the increase in plasma level of MDA.

scholarly journals RELATIONSHIP OF MEAN PLATELET VOLUME WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ITS SEVERITY- AN OBSERVATIONAL STUDY

2021 ◽  
Vol 9 (10) ◽  
pp. 423-428
Author(s):  
Kishore Kumar Sharma ◽  
Mani Ram Kumhar ◽  
Mayank Shrivastav ◽  
Harsh Tak
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Body Mass Index ◽  
Acute Exacerbation ◽  
Mean Platelet Volume ◽  
Chronic Obstructive ◽  
Platelet Volume ◽  
Obstructive Pulmonary Disease ◽  
Bode Index ◽  
Copd Patients ◽  
Relationship Of

Background & Objectives: Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation and inflammation. Mean platelet volume (MPV) may be used as a marker of inflammation. We aimed to study the association between MPV and COPD patients during acute attack and relationship of MPV with severity of COPD by FEV1 (%predicted), BODE Index, PaO2, mMRC grade and 6MWD test. Methods: 100 patients with COPD (50 with acute exacerbation and 50 with stable COPD) and 30 healthy controls were enrolled in the study. Mean platelet volume (MPV), spirometry, arterial blood gases, body mass index, renal function tests and BODE index (body mass index, airflow obstruction,dyspnoea and exercise) were assessed. Level of MPV was compared between cases and controls. Results: Of 100 COPD patients, 87(87%) were male and 13(13%)were female.MPV was significantly higher in COPD patients than control and also higher in acute exacerbation group than stable COPD (p=0.001). Interpretation & Conclusions: In the present study,MPV remain in normal range in all COPD patients, but MPV values were significantly higher in COPD cases compared with control.Increased MPV was associated with acute exacerbation and also increasing with severity of COPD.

scholarly journals Sleep Quality in Chronic Obstructive Pulmonary Disease With High Risk of Acute Exacerbation

2021 ◽  
Author(s):  
Chong Xing ◽  
Hui Shen ◽  
Wenyang Li ◽  
Wei Wang
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
High Risk ◽  
Sleep Quality ◽  
Acute Exacerbation ◽  
Overlap Syndrome ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Sleep Parameters

Abstract This was a prospective case-control study aimed to explore the sleep quality, especially sleep-related disorders, among chronic obstructive pulmonary disease (COPD) patients with high risk of acute exacerbation, and to determine the risk factors. We enrolled COPD patients with acute exacerbation or health control visited the first hospital of China Medical University from October 1st, 2017 to October 28th, 2018. The subjective and objective sleep parameters were compared among them, and then the stepwise multiple regression analysis were performed. We found that COPD patients with high risk of acute exacerbation had decreased subjective and objective sleep quality. Patients with COPD-obstructive sleep apnea overlap syndrome revealed decreased slow wave sleep than patients with COPD alone. The subjective sleep parameters were correlated with the frequency of acute exacerbation, dyspnea index and Epworth sleepiness score. The objective sleep parameters were related to the degree of airflow obstruction, COPD Assessment Test score and the Modified British Medical Research Council dyspena score. So, we believe that the subjective and objective sleep quality of patients with high risk of acute exacerbations of COPD was poor, and the sleep quality of patients with overlap syndrome was worse than that of patients with COPD alone.

Sources of Air Pollution

2018 ◽  
pp. 220-258
Author(s):  
Abderrezak Khelfi
Keyword(s):  
Air Pollution ◽  
Particulate Matter ◽  
Adverse Effects ◽  
Chemical Reactions ◽  
Dust Storms ◽  
Pollution Sources ◽  
Atmospheric Gases ◽  
Secondary Pollutants ◽  
Harmful Substances ◽  
Life On Earth

This chapter describes how air is a complex natural gaseous system essential to support life on Earth. Air pollution comes from a wide variety of sources, which discharge of harmful substances into the atmosphere, causing adverse effects to humans and the environment. They can be natural or anthropogenic. Natural air pollution sources are multiple and include volcanic eruption, fire, ocean vapors, dust storms and fermentation of organic materials. However, the range and quantities of chemicals discharged into the atmosphere from industry, transport, agriculture, energy production, domestic heating, and many other human activities, have increased dramatically. Some pollutants are emitted directly into the atmosphere and are known as primary pollutants (NOx, SOx, particulate matter, etc.). Others are formed in the air as a result of chemical reactions with other pollutants and atmospheric gases; these are known as secondary pollutants like ozone. This chapter provides an overview on air pollution sources as well as the ways in which pollutants can affect human health and the environment.

scholarly journals Winter Is Coming: A Socio-Environmental Monitoring and Spatiotemporal Modelling Approach for Better Understanding a Respiratory Disease

2018 ◽  
Vol 7 (11) ◽  
pp. 432 ◽  
Author(s):  
Lukas Marek ◽  
Malcolm Campbell ◽  
Michael Epton ◽  
Simon Kingham ◽  
Malina Storer
Keyword(s):  
Air Pollution ◽  
Census Data ◽  
Hospital Admissions ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Disease Patterns ◽  
Copd Patients ◽  
Composition Factors ◽  
Individual Composition ◽  
Modelling Approach

Chronic Obstructive Pulmonary Disease is a progressive lung disease affecting the respiratory function of every sixth New Zealander and over 300 million people worldwide. In this paper, we explored how the combination of social, demographical and environmental conditions (represented by increased winter air pollution) affected hospital admissions due to COPD in an urban area of Christchurch (NZ). We juxtaposed the hospitalisation data with dynamic air pollution data and census data to investigate the spatiotemporal patterns of hospital admissions. Spatial analysis identified high-risk health hot spots both overall and season specific, exhibiting higher rates in winter months not solely due to air pollution, but rather as a result of its combination with other factors that initiate deterioration of breathing, increasing impairments and lead to the hospitalisation of COPD patients. From this we found that socioeconomic deprivation and air pollution, followed by the age and ethnicity structure contribute the most to the increased winter hospital admissions. This research shows the continued importance of including both individual (composition) and area level (composition) factors when examining and analysing disease patterns.

Particulate matter air pollution and ambient temperature

2015 ◽  
Vol 33 (10) ◽  
pp. 2032-2038 ◽  
Author(s):  
Paolo Giorgini ◽  
Melvyn Rubenfire ◽  
Ritabrata Das ◽  
Theresa Gracik ◽  
Lu Wang ◽  
...  
Keyword(s):  
Air Pollution ◽  
Particulate Matter ◽  
Ambient Temperature

scholarly journals Lymphocytes Apoptosis in Patients with Acute Exacerbation of Asthma

1999 ◽  
Vol 8 (4-5) ◽  
pp. 237-243 ◽  
Author(s):  
Agnès Hamzaoui ◽  
Kamel Hamzaoui ◽  
Habib Salah ◽  
Abdellatif Chabbou
Keyword(s):  
Acute Exacerbation ◽  
Mononuclear Cells ◽  
Allergic Inflammation ◽  
Induced Sputum ◽  
Chronic Obstructive ◽  
Complex Method ◽  
Healthy Controls ◽  
Asthmatic Patients ◽  
Copd Patients ◽  
Tnf Α

Asthma is characterized by airway inflammation, which can be now assessed by the analysis of induced sputum . Ten patients with asthma were investigated during acute exacerbation for the quantification of apoptosis, for Bcl-2 and Fas expression, in induced sputum lymphocytes. They were compared to 12 patients with chronic obstructive pulmonary disease (COPD), and 10 healthy controls. Spontaneous apoptosis was determined by staining nuclei with propidium iodide, and analyzed with a FACScan. Bcl-2 was measured by Western blotting, and results were obtained by densitometric scanning, done by the gel proanalyser. The investigation of Fas was performed using the streptavidin-biotin preroxidase-complex method. Patients with asthma and patients with COPD exhibited a significant increase of cellularity, percentage of neutrophils, eosinophils and lymphocytes when compared to healthy controls. Apoptosis in induced sputum mononuclear cells was found decreased in patients with asthma compared to COPD patients and healthy controls. The quantification of apoptosis was measured after exposure to anticytokine antibodies. Anti-TNF-α antibody blocked the apoptosis in both patients groups and healthy controls, suggesting that TNF-α acted as an inducer of apoptosis. Anti-IL-10 blocked apoptosis completely exclusively in patients with asthma. Bcl-2 expression was found to be increased in induced sputum mononuclear cells from patients with asthma, compared to healthy controls and patients with COPD. Expression of Fas could be detected in patients with asthma, at a lower level than COPD patients and healthy controls. Distinct mechanisms of apoptosis were found in patients with asthma and patients with COPD, characterized by different levels of Bcl-2 and Fas expression. Induction of apoptosis should be a beneficial process in allergic inflammation traduced in induced sputum mononuclear cells. The apoptosis process is assumed by two different mechanisms in asthma and COPD. Our findings indicated that in asthmatic patients, activated lymphocytes accumulate in the bronchi; because of their prolonged survival that maintains inflammation.

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