scholarly journals Epidemiological Features of the Bladder Neck Rest Position and Mobility

2020 ◽  
Vol 9 (8) ◽  
pp. 2413
Author(s):  
Edyta Horosz ◽  
Andrzej Pomian ◽  
Aneta Zwierzchowska ◽  
Wojciech Lisik ◽  
Wojciech Majkusiak ◽  
...  
Keyword(s):  
Bladder Neck ◽  
Pelvic Organ ◽  
Obese Patients ◽  
Obese Women ◽  
Pelvic Floor Ultrasound ◽  
Factors Associated ◽  
Rest Position ◽  
Epidemiological Features ◽  
Vaginal Deliveries ◽  
Functional Factors

The data concerning epidemiological determinants of the bladder neck (BN) mobility are scarce. The aim of the study was to determine epidemiological features and identify factors influencing BN position at rest and BN mobility in patients without pelvic organ prolapse (POP). Seven hundred and ninety-six patients that attended two outpatient clinics were enrolled in the study. Position and mobility of the BN were measured with the use of pelvic floor ultrasound. Demographic and functional factors that were hypothesized to influence BN mobility were assessed. Vaginal deliveries (VDs) and age ≥65 were associated with lower BN position at rest. Higher BN mobility was observed in women with stress urinary incontinence (SUI). In obese women, higher BN position and lower BN mobility was observed compared to non-obese women, and it was correlated with longer urethras in this group of patients. VDs and their number were associated with increased BN mobility, independently of body mass index (BMI). To conclude, obesity, VDs, and age are factors associated with changes in bladder neck position at rest and its mobility. Higher BMI correlates with restricted BN mobility, and, therefore, the incidence of SUI in obese patients is probably not connected to BN hypermobility.

scholarly journals The value of blood serotonin for effective weight loss in obese women

2015 ◽  
Vol 12 (3) ◽  
pp. 31-35
Author(s):  
Natal'ya Vadimovna Anikina ◽  
Elena Nikolaevna Smirnova
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Clinical Laboratory ◽  
Normal Weight ◽  
Obese Patients ◽  
Obese Women ◽  
Endothelin 1 ◽  
Excessive Accumulation ◽  
Made In

Introduction. Obesity is a disorder of energy balance, which leads to excessive accumulation of fat. In recent years, many important discoveries were made in this field, including the discovery of hormones produced by adipose tissue and the identification of many of the central and peripheral pathways of energy balance.Objective. To study the levels of hormones that affect appetite and metabolism in women with obesity baseline and after weight loss while taking sibutramine.Materials and methods. The study included 56 women aged 42,9±9,5 years, with a BMI of 34,6±6,1 kg/m2. All patients underwent clinical, laboratory and instrumental examination. Hormonal study included determination of serotonin, leptin, ghrelin, endothelin-1, adiponectin.Results: In women with obesity we identified hyperleptinemia and increased serotonin levels. The decrease in body weight in patients receiving sibutramine was accompanied by lower levels of serotonin, leptin, ghrelin, endothelin-1, and increase of adiponectin.Conclusions: Obese patients have significantly elevated levels of leptin, serotonin, ghrelin compared to women of normal weight. Sibutramine treatment leads to a decrease in serotonin, leptin, ghrelin and is more effective in women with a BMI less than 36,5 kg/m2.

scholarly journals Shock of birth evaluation of neurologic status of term newborn in the first 48 hours of life

1996 ◽  
Vol 54 (3) ◽  
pp. 361-368 ◽  
Author(s):  
Rudimar Dos Santos Riesgo ◽  
Alexandre Tellechea Rotta ◽  
Newra Tellechea Rotta
Keyword(s):  
Muscle Tone ◽  
Mode Of Delivery ◽  
Factors Associated ◽  
Vaginal Deliveries ◽  
Term Newborns ◽  
Consecutive Term ◽  
Perinatal Data ◽  
The Relationship ◽  
Tendon Reflexes ◽  
Neurologic Findings

The shock of birth is a transient depression of muscle tone and deep tendon reflexes seen in newborn babies shortly after birth. We evaluated the shock of birth in a sample of 313 consecutive term newborns at 4, 24 and 48 hours of life. We correlated neurologic findings on examination with maternal, obstetric and perinatal data. Special attention was given to the relationship between the mode of delivery and shock of birth. Of the maternal data, factors associated with the shock of birth were obstetric gestational age, previous gestations, abortions or previous vaginal deliveries. Presence of stained amniotic fluid at birth was associated with the shock of birth. There was also a correlation between shock of birth and newborn sex, birth weight, thoracic circumference and the Battaglia and Lubchenco classification. The shock of birth lasted less than 24 hours in 70% of the newborns and less than 48 hours in 84.3%. We conclude that the mode of delivery, vaginal or cesarean section, did not influence the shock of birth. We also established the duration and factors associated with this phenomenon.

Factors associated with unsuccessful pessary fitting in women with symptomatic pelvic organ prolapse: Systematic review and metanalysis

2020 ◽  
Vol 39 (7) ◽  
pp. 1912-1921
Author(s):  
Suelene Costa Albuquerque Coelho ◽  
Luiz Gustavo Oliveira Brito ◽  
Camila Carvalho Araujo ◽  
Cássia Raquel Teatin Juliato
Keyword(s):  
Systematic Review ◽  
Pelvic Organ Prolapse ◽  
Pelvic Organ ◽  
Factors Associated ◽  
Fitting In

Problems of the Irradiation of the Pelvis Cancers in Obese Patients

1966 ◽  
Vol 52 (5) ◽  
pp. 319-334 ◽  
Author(s):  
Lorenzo Magno
Keyword(s):  
Gamma Rays ◽  
Normal Subjects ◽  
Correct Choice ◽  
The Body ◽  
Treatment Technique ◽  
Obese Patients ◽  
Obese Women ◽  
Moving Beam ◽  
Choice Of Treatment ◽  
Obese Subjects

The irradiation of the pelvis in obese patients meets biological and technical difficulties sometimes considered insuperable. Chiefly when it is necessary to irradiate a very large volume of tissues (for instance, in the case of the irradiation of the pelvis in uterus and ovary cancers) radiotherapy is sometimes considered unsuitable because of considerations concerning the integral dose to be reached, the acute or late reactions expected, difficulties in the choice of the irradiation technique and the execution itself of the therapy. Actually the irradiation of the pelvis in obese patients is clinically possible: it has been performed without complications by the author up to integral doses of 6 × 107 grads in 50 days. The most important problem is the correct choice of treatment technique: when Co 60 gamma rays are employed, obese patients must be irradiated by means of moving beam techniques. The author brings into evidence that obese women, bearing uterus carcinomas, can be irradiated by means of biaxial pendular techniques, employing the same parameters (field at axis, arc width, position of the axis) as in normal subjects. In effect the pelvis in obese subjects is in the center of the corporal section, as in thin subjects. The shape of isodoses in pendular axial irradiations, for Co 60, does not dipend from the dimensions of the body irradiated. The properties of high voltage moving beam radiotherapy turn to the advantage of obese patients. Technical difficulties, which are not negligible, may always be overcome with proper devise.

Biomechanical Factors Associated with Plantar Fasciitis in Non-obese Patients

2011 ◽  
Vol 29 (1) ◽  
pp. 9 ◽  
Author(s):  
Jong Hwa Lee ◽  
Sang Beom Kim ◽  
Kyeong Woo Lee ◽  
Dong Wook Han
Keyword(s):  
Plantar Fasciitis ◽  
Obese Patients ◽  
Factors Associated ◽  
Biomechanical Factors

Factors associated with lack of effective contraception among obese women in the United States

Contraception ◽  
2014 ◽  
Vol 90 (3) ◽  
pp. 265-271 ◽  
Author(s):  
Lisa S. Callegari ◽  
Karin M. Nelson ◽  
David E. Arterburn ◽  
Sarah W. Prager ◽  
Melissa A. Schiff ◽  
...  
Keyword(s):  
United States ◽  
The United States ◽  
Obese Women ◽  
Factors Associated ◽  
Effective Contraception

Factors associated with prospective leptin concentrations throughout pregnancy in pregestational normal weight, overweight and obese women

2014 ◽  
Vol 82 (1) ◽  
pp. 127-135 ◽  
Author(s):  
Ana Beatriz Franco-Sena ◽  
Livia Costa de Oliveira ◽  
Thatiana de Jesus Pereira Pinto ◽  
Dayana Rodrigues Farias ◽  
Juliana dos Santos Vaz ◽  
...  
Keyword(s):  
Normal Weight ◽  
Obese Women ◽  
Factors Associated

scholarly journals P140 Factors associated with development of NAFLD in patients with inflammatory bowel disease: a 5-year retrospective study on 225 patients

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S207-S208
Author(s):  
V Domislović ◽  
I Knežević-Štromar ◽  
M Premužić ◽  
M Brinar ◽  
D Vranešić Bender ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retrospective Study ◽  
Liver Disease ◽  
Liver Fibrosis ◽  
Obese Patients ◽  
Logrank Test ◽  
Factors Associated ◽  
Advanced Liver Fibrosis ◽  
Disease Specific

Abstract Background Patients with IBD are at higher risk for non-alcoholic fatty liver disease (NAFLD) comparing to general population. Complex pathogenesis of NAFLD in IBD may be related to disease-specific risk factors such as chronic inflammation, steroid exposure, drug induced hepatotoxicity, malnutrition and alteration of gut microbiota, which is emerging as a major factor in the pathogenesis of NAFLD. The goal of the study was to investigate factors associated with NADLF and advanced liver fibrosis (ALF) in patients with CD and UC. Methods This is a retrospective study on IBD patients without extraintestinal manifestations and known liver disease. NAFLD was defined as Hepatic Steatosis Index (HSI) ≥ 36, and ALF was defined as FIB-4 ≥ 2.67. Predictors of NAFLD development were analysed using Kaplan–Meier and Cox regression analyses. Results In this retrospective study, we have included 225 IBD patients; 72.4% (n = 163) patients with CD and 27.6% (n = 62) patients with UC (median age 41.2 yr, 53.7% males) which were observed for a median of 4.6 years. There were 63.1% (n = 142) patients with normal BMI, 27.6% (n = 62) overweight and 9.3% (n = 21) obese patients. Obese patients had the highest HIS score 43.9 ± 5.9, following with overweight 37.8 ± 5.7 and normal BMI 30 ± 4.3 kg/m2, p < 0.001. During the follow-up obese and overweight patients had higher risk of developing NAFLD comparing to patients with normal BMI (obese HR = 11.1 95% CI 4.3–28.3 and overweight HR = 5.55 95% CI 3.4–9.1, Logrank test p < 0.001) (Figure 1). Regarding FIB-4 score there, was no difference among different BMI categories (p = 0.192), and there was no difference in ALF development in the follow-up period (Logrank test p = 0.91). In Cox proportional-hazards regression significant predictors for NAFLD development were dyslipidaemia HR=2.11, 95% CI 1.2–3.7, overweight HR=6 95% CI 3.6–10, and obesity HR=13.4, 95% CI 7–35. Conclusion NAFLD is frequent comorbidity in patients with CD and UC, which can lead to development of advanced liver fibrosis. Our results show that patients with IBD have a high risk of NAFLD development, whereas the increased risk for ALF was not observed. Overweight and obese patients and those with dyslipidemia should be closer monitored due to significantly higher risk of NAFLD. This study points out the complexity disease-specific risk factors and importance of better stratifying IBD patients at risk of NAFLD and advanced liver fibrosis.

scholarly journals Defective insulin signaling in placenta from pregnancies complicated by gestational diabetes mellitus

2009 ◽  
Vol 160 (4) ◽  
pp. 567-578 ◽  
Author(s):  
Michelle Colomiere ◽  
Michael Permezel ◽  
Clyde Riley ◽  
Gernot Desoye ◽  
Martha Lappas
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Signaling Pathway ◽  
Insulin Signaling ◽  
Placental Tissue ◽  
Insulin Signaling Pathway ◽  
Obese Patients ◽  
Obese Women ◽  
Normal Controls

ObjectiveStudies in adipose tissue and skeletal muscle suggest that impaired insulin action is due to defects in the insulin signaling pathway and may play a role in the pathophysiology of insulin resistance associated with gestational diabetes mellitus (GDM) and obesity. The present study tested the hypothesis that endogenous expression levels in the human term placenta of insulin signaling components are altered in placental tissue from GDM women in comparison with normal controls and maternal obesity.Design and methodsPlacental tissue was collected from normal, diet-controlled GDM, and insulin-controlled GDM in both non-obese and obese women (n=6–7 per group). Western blotting and quantitative RT-PCR was performed to determine the level of expression in the insulin signaling pathway.ResultsThere was a significant increase in insulin receptor (IR) substrate (IRS)-1 protein expression with a concurrent decrease in IRS-2 protein expression in non-obese women with insulin-controlled GDM compared with diet-controlled GDM and normal controls. Furthermore, a decrease in both protein and mRNA expression of phosphatidyl-inositol-3-kinase (PI3-K) p85α and glucose transporter (GLUT)-4 was observed in non-obese and obese women with insulin controlled GDM compared with normal controls. When comparing non-obese to obese patients, significant decreases in mRNA expression of IR-β, PI3K p85α and GLUT-4 was found in obese patients.ConclusionOur results suggest that post receptor defects are present in the insulin signaling pathway in placenta of women with pregnancies complicated by diabetes and obesity. In addition, expression studies demonstrate post receptor alterations in insulin signaling possibly under selective maternal regulation and not fetal regulation.

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