scholarly journals Uterus Transplantation with Live Donors: Screening Candidates in One French Center

2020 ◽  
Vol 9 (6) ◽  
pp. 2001 ◽  
Author(s):  
Marie Carbonnel ◽  
Aurelie Revaux ◽  
Elena Menzhulina ◽  
Lea Karpel ◽  
Renaud Snanoudj ◽  
...  
Keyword(s):  
International Society ◽  
Limiting Factors ◽  
Second Step ◽  
Initial Screening ◽  
Inclusion Criteria ◽  
Screening Process ◽  
Uterus Transplantation ◽  
Individual Interviews ◽  
Live Donors ◽  
The Future

We report our experience regarding the profile and screening process of potential recipients (R) and their live donors (D) in our Uterus transplantation (UTx) trial from 2014 to 2020. The initial screening was performed using medical questionnaires and consultations. The second step of the screening consisted of two individual interviews with an independent multidisciplinary committee. Then, a complete medical, biological and imaging assessment of the directed living D, the R, and her partner was performed over a two-day hospitalization. A total of 239 women contacted our department: 165 potentials R and 74 potentials D. During the first step of screening, 141 R and 45 D were excluded. Only 12 R/D pairs were pursued. During inclusion, 10 R/D pairs were excluded. One R/D pair is still under evaluation. Finally, only 1 R/D pair was definitively included (0.6%), which led us to perform the first French UTx in March 2019 with a successful graft. The primary limiting factors of inclusion were due to very strict criteria and difficulty of having a suitable directed living D. The International Society of UTx (ISUTx) guidelines based on worldwide results of trials can help ease our inclusion criteria in the future while remaining safe for patients.

Voce voco. Ariadne in Ovids Heroides und die ‘weibliche’ Stimme

Mnemosyne ◽  
2012 ◽  
Vol 65 (2) ◽  
pp. 219-237
Author(s):  
Christoph Pieper
Keyword(s):  
Literary Tradition ◽  
Female Voice ◽  
Male Dominance ◽  
Second Step ◽  
Roman Literature ◽  
Literary Character ◽  
The Future ◽  
In The Beginning ◽  
Female Perspective

Abstract The article analyses how Ovid in the 10th letter of his Heroides experiments with the concept of a female voice within Roman literature. Ovid constructs Ariadne as a literary speaker against the background of (1) the Augustan elegiac tradition with its mostly male speakers, (2) the earlier phases of the Ariadne-myth in which Ariadne’s fate is determined by men (Theseus and Bacchus), and (3) the reception of this myth in Catullus’ famous ecphrasis in carmen 64. In the beginning of Heroides 10, Ovid shows how Ariadne develops consciousness of her own ability to speak. She develops from a heterodiegetic (epic) narrator to a homodiegetic (elegiac) speaker. In a second step, however, Ovid demonstrates that Ariadne is not only generally inexperienced in the field of literature, but that her attempt to re-shape her own story from a female perspective must necessarily fail. Her literary character cannot be separated from the previous (male) myth. At the end of the letter, she accepts her own literary immaturity when she asks Theseus to be the future narrator of her own fate. By showing that Ovid in his Ariadne-letter actually stages the failure of his protagonist’s attempt to free herself from a male literary tradition, I suggest that the Heroides should not be read as female literature, but as texts which reaffirm male dominance within Roman literary society.

Revision Rates After Total Ankle Replacement: A Comparison of Clinical Studies and Arthroplasty Registers

2021 ◽  
pp. 107110072110538
Author(s):  
Georg Hauer ◽  
Reinhard Hofer ◽  
Markus Kessler ◽  
Jan Lewis ◽  
Lukas Leitner ◽  
...  
Keyword(s):  
Clinical Studies ◽  
Revision Rate ◽  
Mobile Bearing ◽  
Total Ankle Replacement ◽  
Second Step ◽  
Fixed Bearing ◽  
Inclusion Criteria ◽  
Level Of Evidence ◽  
Ankle Replacement ◽  
Significant Difference

Background: The aim of this study was to assess the outcome of total ankle replacement (TAR) regarding revision rates by comparing clinical studies of the last decade to data displayed in arthroplasty registers. The secondary aim was to evaluate whether dependent clinical studies show a superior outcome to independent publications. Additionally, revision rates of mobile bearing implants (MB-TARs) were compared to those of fixed bearing implants (FB-TARs). Methods: Clinical studies on TARs between 2010 and 2020 were systematically reviewed, with the endpoint being a revision for any reason. The parameter “revision rate per 100 observed component years (CYs)” was calculated for each publication. The pooled revision rate for clinical studies was compared to the data reported in arthroplasty registers. In a second step, revision rates were subdivided and analyzed for independent and dependent publications and for FB-TARs and MB-TARs. Results: A total of 43 publications met the inclusion criteria comprising 5806 TARs. A revision rate of 1.8 per 100 observed CYs was calculated, corresponding to a 7-year revision rate of 12.6%. The 3 arthroplasty registers included showed revision rates ranging from 8.2% to 12.3% after 7 years. No significant difference between dependent and independent publications nor between FB-TARs and MB-TARs was detected. Conclusion: Revision rates of clinical studies and arthroplasty registers are comparable. Surgeons can compare their own revision rates with those from this study. Dependent studies do not seem to be biased, and no superiority for one bearing type can be described. Level of Evidence: Level III, systematic review of level III studies

Preschool Vision Screening in Pediatric Practice: A Study From the Pediatric Research in Office Settings (PROS) Network

PEDIATRICS ◽  
1992 ◽  
Vol 89 (5) ◽  
pp. 834-838 ◽  
Author(s):  
Richard C. Wasserman ◽  
Candace A. Croft ◽  
Sarah E. Brotherton
Keyword(s):  
Cross Sectional Study ◽  
Vision Screening ◽  
Initial Screening ◽  
Sectional Study ◽  
Older Children ◽  
Pediatric Practice ◽  
Screening Process ◽  
Cross Sectional ◽  
Health Supervision

In this cross-sectional study, the vision-screening process is described for 8417 children aged 3 to 5 seen for health supervision in a group of 102 pediatric practices in 23 states and Puerto Rico. Three hundred forty children who failed screening (63% of those who failed) were followed up 2 months after initial screening. The sample was 52% male, 86% white, 9% black, 3% Hispanic, and 1% Asian. Vision screening was attempted on 66% of children overall. Pediatricians' reasons for not screening were "not routine" (44%), "too young" (40%), and "screening done previously" (17%). Younger children were less likely to be screened than older children (39% of those aged 3), and Hispanics were less likely to be screened than other ethnic groups (P < .001). Thirty-three percent of children received no screening for latent strabismus. Two months later, 50% of parents whose child had failed a vision test were unaware of this fact on questionnaire follow-up. Eighty-five percent of children referred to an eye specialist had made or kept an appointment. It is concluded that pediatricians need to increase vision screening among younger preschool children and communicate more effectively to parents the results of screening failure.

Ethics of uterus transplantation with live donors

2014 ◽  
Vol 102 (1) ◽  
pp. 40-43 ◽  
Author(s):  
Michael Olausson ◽  
Liza Johannesson ◽  
Daniel Brattgård ◽  
Cesar Diaz-Garcia ◽  
Cecilia Lundmark ◽  
...  
Keyword(s):  
Uterus Transplantation ◽  
Live Donors

scholarly journals Search forMycobacterium aviumSubspeciesparatuberculosisAntigens for the Diagnosis of Paratuberculosis

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
María Laura Mon ◽  
Mariana Viale ◽  
Guido Baschetti ◽  
Fiorella Alvarado Pinedo ◽  
Andrea Gioffre ◽  
...  
Keyword(s):  
Recombinant Proteins ◽  
Mycobacterium Avium ◽  
Bovine Tuberculosis ◽  
Cross Reactivity ◽  
Second Step ◽  
Initial Screening ◽  
Combined Application ◽  
Form Part

The aim of this study was to evaluate a wide panel of antigens ofMycobacterium aviumsubsp.paratuberculosis(MAP) to select candidates for the diagnosis of paratuberculosis (PTB). A total of 54 recombinant proteins were spotted onto nitrocellulose membranes and exposed to sera from animals with PTB (n=25), healthy animals (n=10), and animals experimentally infected withM. bovis(n=8). This initial screening allowed us to select seven antigens: MAP 2513, MAP 1693, MAP 2020, MAP 0038, MAP 1272, MAP 0209c, and MAP 0210c, which reacted with sera from animals with PTB and showed little cross-reactivity with sera from healthy animals and animals experimentally infected withM. bovis. The second step was to evaluate the antigen cocktail of these seven antigens by ELISA. For this evaluation, we used sera from animals with PTB (n=25), healthy animals (n=26), and animals experimentally infected withM. bovis(n=17). Using ELISA, the cocktail of the seven selected MAP antigens reacted with sera from 18 of the 25 animals with PTB and did not exhibit cross-reactivity with healthy animals and only low reactivity with animals with bovine tuberculosis. The combined application of these antigens could form part of a test which may help in the diagnosis of PTB.

scholarly journals The Key Role of Warm and Cold Ischemia in Uterus Transplantation: A Review

2019 ◽  
Vol 8 (6) ◽  
pp. 760 ◽  
Author(s):  
Antoine Tardieu ◽  
Ludivine Dion ◽  
Vincent Lavoué ◽  
Pauline Chazelas ◽  
Pierre Marquet ◽  
...  
Keyword(s):  
Deceased Donor ◽  
Cold Ischemia ◽  
Uterus Transplantation ◽  
Uterine Contractions ◽  
Live Donors ◽  
Promising Treatment ◽  
Deceased Donors ◽  
Ischemia Tolerance ◽  
Large Animals

Introduction: Uterus transplantation (UTx) is a promising treatment for uterine infertility that has resulted in several births since 2014. Ischemia is a key step in organ transplantation because it may lead to changes jeopardizing graft viability. Method: We performed a systematic review of animal and human studies relating to uterine ischemia. Results: We retained 64 studies published since 2000. There were 35 studies in animals, 24 in humans, and five literature reviews. Modest preliminary results in large animals and humans are limited but encouraging. In small animals, pregnancies have been reported to occur after 24 h of cold ischemia (CI). In ewes, uterine contractions have been detected after 24 h of CI. Furthermore, it has been shown in animals that uterine tolerance to CI and to warm ischemia (WI) can be increased by pharmacological products. In women, mean CI time in studies of births from uteri obtained from live donors was between 2 h 47 min and 6 h 20 min from a deceased donor; with only one birth in this case. Muscle contractions have also been demonstrated in myometrial samples from women, after six or more hours of CI. Conclusion: The uterus seems to be able to tolerate a prolonged period of CI, of at least six hours. Studies of the ischemia tolerance of the uterus and ways to improve it are essential for the development of UTx, particularly for procedures using grafts from deceased donors.

Development of a Pipeline Surface Loading Screening Process

2006 ◽  
Author(s):  
David J. Warman ◽  
Jules Chorney ◽  
Mike Reed ◽  
James D. Hart
Keyword(s):  
Ground Surface ◽  
Theoretical Models ◽  
Operating Pressure ◽  
Initial Screening ◽  
Buried Pipelines ◽  
Surface Loading ◽  
Design Factor ◽  
Screening Process ◽  
Simplified Approach ◽  
Design Basis

Pipeline Operators receive numerous requests annually to cross their pipelines. In many of these cases detailed analysis using a number of different methods are performed since no simplified approach is available. The Canadian Energy Pipeline Association (CEPA) with Kiefner and Associates, Inc. undertook the development of a screening methodology for vehicle loading. The hope is a standard approach to these analyses might be established to assist pipeline operating companies. This paper describes an approach detailing the development and implementation of a simplified screening process to assess the effects of surface loads on buried pipelines. A design basis was established based on a literature review to identify theoretical models, standards, codes, and recommended practices that are currently used to assess the surface loading effects on buried pipelines. This design basis was incorporated into a methodology utilized to develop a screening tool which provides a simple “pass/no pass” determination and is based on attributes which are generally easy to obtain (e.g., wheel or axle load, ground surface loading pressure, depth of cover, maximum allowable operating pressure and design factor). Situations which pass the initial screening would require no additional analysis while situations that do not pass the initial screening may need to be evaluated on a more detailed basis. Simplified graphs have been developed to assist in additional screening prior to performing a more detailed evaluation.

Quantitation in Neuropathology

1989 ◽  
Vol 8 (1) ◽  
pp. 225-232 ◽  
Author(s):  
B. Broxup ◽  
G. Losos ◽  
G. Yipchuck
Keyword(s):  
Statistical Analysis ◽  
Quantitative Evaluation ◽  
Computer Technology ◽  
Nervous Tissue ◽  
Quantitative Methods ◽  
Tissue Preparation ◽  
Initial Screening ◽  
Tier Ii ◽  
The Future ◽  
Dose Responses

Qualitative neuropathologic evaluations are appropriate for initial screening of compounds for neurotoxicity. In the future, advances in tissue preparation and computer technology will make quantitative evaluation of some nervous tissue structures more routine. These evaluations will be used as part of tier II studies to determine dose-responses or no-effect levels. Quantitative methods can enable small but significant differences to be detected, and the data can be subjected to statistical analysis.

scholarly journals The Mental Health Crises of the Families of COVID-19 Victims: A Qualitative Study

2020 ◽  
Author(s):  
fateme mohammadi ◽  
Khodayar Oshvandi ◽  
Farshid Shamsaei ◽  
Fateme Cheraghi ◽  
mostafa bijani
Keyword(s):  
Mental Health ◽  
Content Analysis ◽  
Cultural Context ◽  
Job Insecurity ◽  
Qualitative Content Analysis ◽  
Individual Interviews ◽  
Medical Centers ◽  
Purposeful Sampling ◽  
The Future ◽  
Data Saturation

Abstract Background: The bereaved families of COVID-19 victims are among the most vulnerable social groups in the COVID-19 pandemic. This highly infectious and contagious disease has afflicted these families with numerous psychological crises which have not been studied much yet. The present study is an attempt at investigating the psychological challenges and issues which the families of COVID-19 victims are faced with. The present study aims to identify the Mental Health crises which the families of COVID-19 deceased victims are going through.Methods: A qualitative research, the present study uses a conventional content analysis design. The participants were 16 members of the families of COVID-19 victims selected from medical centers in Iran from February to May 2020 via purposeful sampling. Sampling continued to the point of data saturation Data were collected via semi-structured individual interviews conducted online. The collected data were analyzed according to the conventional qualitative content analysis approach.Results: Analyses of the data yielded two main themes—emotional shock and fear of the future—with nine categories. Conclusion: The families of COVID-19 deceased victims are affected by various psychological crises which have exposed them to a deep sense of loss and emotional shock. In addition, the instability in the family following the loss of a family member and job insecurity due to the COVID crisis have caused them to be very worried about the future. Therefore, there is an urgent need for a cultural context which recognizes and supports all the various aspects of the mental health of these families.

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