scholarly journals Artificial Intelligence in Ophthalmology: A Meta-Analysis of Deep Learning Models for Retinal Vessels Segmentation

2020 ◽  
Vol 9 (4) ◽  
pp. 1018 ◽  
Author(s):  
Md. Mohaimenul Islam ◽  
Tahmina Nasrin Poly ◽  
Bruno Andreas Walther ◽  
Hsuan Chia Yang ◽  
Yu-Chuan (Jack) Li
Keyword(s):  
Systematic Review ◽  
Deep Learning ◽  
High Performance ◽  
Meta Analysis ◽  
Retinal Disease ◽  
High Sensitivity ◽  
Retinal Vessel ◽  
Vessel Segmentation ◽  
Retinal Vessels ◽  
Retinal Vessel Segmentation

Background and Objective: Accurate retinal vessel segmentation is often considered to be a reliable biomarker of diagnosis and screening of various diseases, including cardiovascular diseases, diabetic, and ophthalmologic diseases. Recently, deep learning (DL) algorithms have demonstrated high performance in segmenting retinal images that may enable fast and lifesaving diagnoses. To our knowledge, there is no systematic review of the current work in this research area. Therefore, we performed a systematic review with a meta-analysis of relevant studies to quantify the performance of the DL algorithms in retinal vessel segmentation. Methods: A systematic search on EMBASE, PubMed, Google Scholar, Scopus, and Web of Science was conducted for studies that were published between 1 January 2000 and 15 January 2020. We followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) procedure. The DL-based study design was mandatory for a study’s inclusion. Two authors independently screened all titles and abstracts against predefined inclusion and exclusion criteria. We used the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool for assessing the risk of bias and applicability. Results: Thirty-one studies were included in the systematic review; however, only 23 studies met the inclusion criteria for the meta-analysis. DL showed high performance for four publicly available databases, achieving an average area under the ROC of 0.96, 0.97, 0.96, and 0.94 on the DRIVE, STARE, CHASE_DB1, and HRF databases, respectively. The pooled sensitivity for the DRIVE, STARE, CHASE_DB1, and HRF databases was 0.77, 0.79, 0.78, and 0.81, respectively. Moreover, the pooled specificity of the DRIVE, STARE, CHASE_DB1, and HRF databases was 0.97, 0.97, 0.97, and 0.92, respectively. Conclusion: The findings of our study showed the DL algorithms had high sensitivity and specificity for segmenting the retinal vessels from digital fundus images. The future role of DL algorithms in retinal vessel segmentation is promising, especially for those countries with limited access to healthcare. More compressive studies and global efforts are mandatory for evaluating the cost-effectiveness of DL-based tools for retinal disease screening worldwide.

scholarly journals Retinal Vessel Segmentation Algorithm Based on Residual Convolution Neural Network

2021 ◽  
Vol 9 ◽  
Author(s):  
Shuang Xu ◽  
Zhiqiang Chen ◽  
Weiyi Cao ◽  
Feng Zhang ◽  
Bo Tao
Keyword(s):  
Neural Network ◽  
Retinal Vessel ◽  
Vessel Segmentation ◽  
Segmentation Algorithm ◽  
Convolution Neural Network ◽  
Superior Performance ◽  
Retinal Vessels ◽  
Fundus Images ◽  
Data Set ◽  
Retinal Vessel Segmentation

Retinal vessels are the only deep micro vessels that can be observed in human body, the accurate identification of which has great significance on the diagnosis of hypertension, diabetes and other diseases. To this end, a retinal vessel segmentation algorithm based on residual convolution neural network is proposed according to the characteristics of the retinal vessels on fundus images. Improved residual attention module and deep supervision module are utilized, in which the low-level and high-level feature graphs are joined to construct the encoder-decoder network structure, and atrous convolution is introduced to the pyramid pooling. The experiments result on the fundus image data set DRIVE and STARE show that this algorithm can obtain complete retinal vessel segmentation as well as connected vessel stems and terminals. The average accuracy on DRIVE and STARE reaches 95.90 and 96.88%, and the average specificity is 98.85 and 97.85%, which shows superior performance compared to other methods. This algorithm is verified feasible and effective for retinal vessel segmentation of fundus images and has the ability to detect more capillaries.

scholarly journals Impact of Novel Image Preprocessing Techniques on Retinal Vessel Segmentation

Electronics ◽  
2021 ◽  
Vol 10 (18) ◽  
pp. 2297
Author(s):  
Toufique A. Soomro ◽  
Ahmed Ali ◽  
Nisar Ahmed Jandan ◽  
Ahmed J. Afifi ◽  
Muhammad Irfan ◽  
...  
Keyword(s):  
Blood Vessels ◽  
Retinal Disease ◽  
Retinal Vessel ◽  
Vessel Segmentation ◽  
Low Contrast ◽  
The Public ◽  
Retinal Blood Vessels ◽  
Retinal Vessel Segmentation ◽  
Automated Screening ◽  
Traditional Image

Segmentation of retinal vessels plays a crucial role in detecting many eye diseases, and its reliable computerized implementation is becoming essential for automated retinal disease screening systems. A large number of retinal vessel segmentation algorithms are available, but these methods improve accuracy levels. Their sensitivity remains low due to the lack of proper segmentation of low contrast vessels, and this low contrast requires more attention in this segmentation process. In this paper, we have proposed new preprocessing steps for the precise extraction of retinal blood vessels. These proposed preprocessing steps are also tested on other existing algorithms to observe their impact. There are two steps to our suggested module for segmenting retinal blood vessels. The first step involves implementing and validating the preprocessing module. The second step applies these preprocessing stages to our proposed binarization steps to extract retinal blood vessels. The proposed preprocessing phase uses the traditional image-processing method to provide a much-improved segmented vessel image. Our binarization steps contained the image coherence technique for the retinal blood vessels. The proposed method gives good performance on a database accessible to the public named DRIVE and STARE. The novelty of this proposed method is that it is an unsupervised method and offers an accuracy of around 96% and sensitivity of 81% while outperforming existing approaches. Due to new tactics at each step of the proposed process, this blood vessel segmentation application is suitable for computer analysis of retinal images, such as automated screening for the early diagnosis of eye disease.

Deep learning-enabled ultra-widefield retinal vessel segmentation with an automated quality-optimized angiographic phase selection tool

Eye ◽  
2021 ◽  
Author(s):  
Duriye Damla Sevgi ◽  
Sunil K. Srivastava ◽  
Charles Wykoff ◽  
Adrienne W. Scott ◽  
Jenna Hach ◽  
...  
Keyword(s):  
Deep Learning ◽  
Retinal Vessel ◽  
Vessel Segmentation ◽  
Phase Selection ◽  
Selection Tool ◽  
Retinal Vessel Segmentation
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