scholarly journals Left Atrial Volumetric and Deformation Analysis in Adult Patients with Dextro-Transposition of the Great Arteries (Insights from the CSONGRAD Registry and MAGYAR-Path Study)

2020 ◽  
Vol 9 (2) ◽  
pp. 463
Author(s):  
Attila Nemes ◽  
Gergely Rácz ◽  
Árpád Kormányos ◽  
Péter Domsik ◽  
Anita Kalapos ◽  
...  
Keyword(s):  
Left Atrial ◽  
Adult Patients ◽  
Deformation Analysis ◽  
Long Term Effects ◽  
Atrial Contraction ◽  
Functional Features ◽  
Senning Operation ◽  
And Gender ◽  
Mustard Procedure

Background: In complete or dextro-transposition of the great arteries (dTGA), the aorta and the pulmonary artery are transposed. The present study was designed to examine dTGA-associated left atrial (LA) volumetric and functional abnormalities in adult patients late after repair and to compare their results to those of healthy controls. Methods: The present study consisted of 15 dTGA patients (30.3 ± 8.1 years, 9 males), the patients had Mustard (n = 8) or Senning (n = 7) procedure performed. Their results were compared to those of 36 age- and gender-matched healthy subjects (28.7 ± 1.5 years, 24 males). Results: Increased maximum LA volume and reduced LA emptying fractions respecting the cardiac cycle could be demonstrated in our dTGA patients. LA stroke volumes representing all LA functions were significantly reduced. Peak LA circumferential, longitudinal, and area strains and LA circumferential, longitudinal, and area strains measured at atrial contraction were reduced in our dTGA patients. Most LA strains were reduced in patients having Mustard surgery compared to controls and patients undergoing Senning operation. Conclusions: Significant LA volumetric and functional abnormalities could be demonstrated in adult patients with dTGA late after repair. Senning procedure seems to have more beneficial long-term effects on LA volumetric and functional features as compared to the Mustard procedure.

Long-term effects of tiagabine monotherapy on cognition and mood in adult patients with chronic partial epilepsy

2006 ◽  
Vol 8 (4) ◽  
pp. 750-755 ◽  
Author(s):  
Marja Äikiä ◽  
Leena Jutila ◽  
Tuuli Salmenperä ◽  
Esa Mervaala ◽  
Reetta Kälviäinen
Keyword(s):  
Partial Epilepsy ◽  
Adult Patients ◽  
Long Term Effects

scholarly journals P324 Left atrial deformation analysis by 2D speckle tracking echocardiography in liver cirrhosis is a potential new tool for a better characterization of cirrhotic cardiomyopathy

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
R C Rimbas ◽  
L M Luchian ◽  
A M Chitroceanu ◽  
M Rimbas ◽  
S I Visoiu ◽  
...  
Keyword(s):  
Strain Rate ◽  
Diastolic Dysfunction ◽  
Left Atrial ◽  
Speckle Tracking Echocardiography ◽  
Filling Pressure ◽  
Deformation Analysis ◽  
Cirrhotic Cardiomyopathy ◽  
Atrial Contraction

Abstract Funding Acknowledgements “This work was supported by a grant of Ministery of Research and Innovation, CNCS-UEFISCDI, project number PN-III-P1-1-TE-2016-0669, within PNCDI III” Background Cirrhotic cardiomyopathy (CCM) is defined as a cardiac dysfunction that includes mainly diastolic dysfunction (DD), generated by liver cirrhosis (LC). Its present diagnosis is based mostly on 2D conventional transthoracic echocardiography (TTE), with focus on diastolic dysfunction. However, there is no standardized algorithm for diagnosis of CCM. Role of the new methods, such as speckle tracking echocardiography (STE), for the diagnosis of CCM is still controversial. Aim. To assess left atrial (LA) function by STE in LC, on top of conventional TTE, in order to establish role of LA function for the diagnosis of CCM. Methods 107 subjects were assessed by TTE and STE: 52 patients with LC (57 ± 9 yrs, 23 males), free of any cardiovascular disease or diabetes, and 55 age-matched normal subjects. TTE was used to measure LV indexed volumes and ejection fraction (LVEF), E/E’ ratio, left atrial volume index (LAVi), and systolic pulmonary arterial pressure (sPAP); STE to measure global longitudinal strain (GLS) and LA functions: reservoir function by strain from MVC to MVO (LASr) and positive strain rate (LASRr), conduit function by strain from MVO to onset of atrial contraction (LAScd) and early negative strain rate during conduit phase (LASRcd), LA pump function by negative strain at MVC (LASct) and late negative strain rate during atrial contraction phase (LASRct) (Figure). NTproBNP was measured in all patients. Results LC patients vs. controls had lower SBP (112 ± 15 vs. 122 ± 12, P < 0.001), higher LV volumes and NTproBNP, but similar LVEF. They had lower GLS, and higher E/E’, LAVi, and sPAP, suggesting higher LV filling pressure (Table). Meanwhile, they had lower LA reservoir, conduit, and pump functions(Table). By using current algorithm for the diagnosis of DD, 21% of LC patients had DD, 48% had no DD, and 31% had indeterminate grade. By adding assessment of LA reservoir function by STE (LASr < 35%) to the DD algorithm, 50% of patients had DD, without any indeterminate cases. Conclusion LC patients have longitudinal systolic LV dysfunction, diastolic dysfunction with higher estimated LV filling pressure, and lower LA reservoir, conduit, and pump functions. By adding LA deformation analysis by STE to the current diagnosis algorithm, better characterization of CCM is possible. Table Group (N) NTproBNP ng/ml GLS (%) E/E’ LAVi (ml/m2) sPAP (mmHg) LASr (%) LASRr LAScd (%) LASRcd LASRct LC (52) 215 ± 258 -20.8 ± 3 8.5 ± 2.3 44 ± 14 27 ± 9 28 ± 9 1.29 ± 0.4 14.7 ± 8.1 -1.2 ± 0.42 -1.64 ± 0.47 Controls (55) 44 ± 43 -22 ± 2 7.6 ±2.3 28 ±6.5 21 ± 8 35 ± 4 1.54 ± 0.4 18.3 ± 6.7 -1.7 ± 0.61 -1.93 ± 0.44 P value <0.001 0.05 0.05 0.001 0.003 0.011 0.002 0.014 0.001 0.002 Abstract P324 Figure

Long-term effects of L- and N-type calcium channel blocker on uric acid levels and left atrial volume in hypertensive patients

2016 ◽  
Vol 31 (11) ◽  
pp. 1826-1833 ◽  
Author(s):  
Mitsuru Masaki ◽  
Toshiaki Mano ◽  
Akiyo Eguchi ◽  
Shohei Fujiwara ◽  
Masataka Sugahara ◽  
...  
Keyword(s):  
Uric Acid ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Left Atrial ◽  
Channel Blocker ◽  
Left Atrial Volume ◽  
Long Term Effects ◽  
Atrial Volume ◽  
Hypertensive Patients

scholarly journals Long-term effects of irbesartan on plasma aldosterone concentration and left atrial volume in hypertensive patients

2014 ◽  
Vol 63 (3) ◽  
pp. 205-210 ◽  
Author(s):  
Mitsuru Masaki ◽  
Kazuo Komamura ◽  
Akiko Goda ◽  
Shinichi Hirotani ◽  
Misato Otsuka ◽  
...  
Keyword(s):  
Left Atrial ◽  
Left Atrial Volume ◽  
Plasma Aldosterone ◽  
Long Term Effects ◽  
Atrial Volume ◽  
Plasma Aldosterone Concentration ◽  
Hypertensive Patients

scholarly journals Long-term effects of daily physical education throughout compulsory school on duration of physical activity in young adulthood: an 11-year prospective controlled study

2018 ◽  
Vol 4 (1) ◽  
pp. e000360 ◽  
Author(s):  
Amanda Lahti ◽  
Björn E Rosengren ◽  
Jan-Åke Nilsson ◽  
Caroline Karlsson ◽  
Magnus K Karlsson
Keyword(s):  
Physical Activity ◽  
Physical Education ◽  
Intervention Group ◽  
Controlled Study ◽  
Long Term Effects ◽  
Compulsory School ◽  
Physically Active ◽  
And Gender ◽  
Prospective Controlled Study

ObjectivesWe examined whether daily physical activity (PA) during compulsory school encourages children to be more physically active during the intervention and 4 years after termination of the programme.MethodsThis prospective controlled intervention study followed the same 124 children (81 children in an intervention group and 43 controls) aged 7.7±0.6 (mean±SD) during a 7-year PA intervention and 4 years after the intervention when the children were 18.7±0.3 years old. The intervention included daily school physical education (PE) (200 min/week), whereas the controls continued with the Swedish standard of 60 min/week. Using a questionnaire, we gathered data about total PA, leisure time PA and sedentary activities (SA). Group comparisons are adjusted for age and gender, and data are provided as means with 95% CIs.ResultsAt baseline, we found similar duration of PA and SA between groups. After a mean of 7 years with intervention, the intervention group was more physically active than the controls (+4.5 (2.9 to 6.0) hours/week), whereas SA was similar (+0.6 (−2.5 to 3.9) hours/week). Four years beyond the intervention, the intervention group was still more physically active than the controls (2.7 (0.8 to 4.7) hours/week), and SA was still similar (−3.9 (−9.7 to 1.7) hours/week).ConclusionsIntervention with daily school PE throughout compulsory school is associated with higher duration of PA not only during the intervention but also 4 years after termination of the programme.

scholarly journals Left Atrial Mechanical Functions in Professional Soccer Players: A Pilot Study

2017 ◽  
Vol 5 (11) ◽  
pp. 141
Author(s):  
Alper Kartal ◽  
Hasan Güngör ◽  
Reşat Kartal ◽  
Esin Ergin
Keyword(s):  
Left Atrium ◽  
Left Atrial ◽  
P Wave ◽  
Volume Index ◽  
Football Players ◽  
Professional Football ◽  
Control Subjects ◽  
Professional Soccer ◽  
Atrial Contraction

Long-term regular exercise is associated with physiologic and morphologic alterations in the heart chambers. The aim of this study to evaluate left atrium (LA) phasic functions in professional football players and compare with control subjects. Left atrial volume was calculated at end-systole (Vmax), end-diastole and pre-atrial contraction by echocardiography in 20 professional male football players (mean age, 20.15+2.11 years) and 20 male control subjects (mean age, 22.3+1.49 years). Echocardiographic assessments were per­formed were performed using the criteria of the American Society of Echocardiography. The following LAVs were measured: maximal volume (Vmax), minimal volume (Vmin) and LAV before atrial contraction (VpreA) at the onset of the P wave of the simultaneously recorded ECG. Left atrial ejection fraction (LAEF), expansion index (LAEI), active emptying volume index (LAAEVI) and fraction(LAAEFr), passive emptying volume index (LAPEVI) and fraction (LAPEFr) were calculated. Baseline characteristics, demographics, two dimensional and tissue Doppler echocardiographic parameters were not statistically significant between the groups (Table 1). Both groups were similar in terms of Vmax index but Vmin index and VpreA index were significantly higher in football players. LAEF, LAEI, LAAEVI and LAAEFr were lesser in football player but they were not statistically significant. Also LAPEVI and LAPEFr were similar in both groups (Table 2). Professional football playing can be associated with morphologic alteration in left atrium mechanical functions. Further prospective, randomized, controlled trials with long term follow-up are necessary to make more robust interpretations of this issue.

Gender equality: Parental Leave design and evaluating its effects on fathers’ participation

2019 ◽  
pp. 187-204
Author(s):  
Ann-Zofie Duvander ◽  
Guðný Björk Eydal ◽  
Berit Brandth ◽  
Ingólfur V. Gíslason ◽  
Johanna Lammi-Taskula ◽  
...  
Keyword(s):  
Gender Equality ◽  
Parental Leave ◽  
Nordic Countries ◽  
Paid Work ◽  
Long Term Effects ◽  
Mothers And Fathers ◽  
Leave Policy ◽  
Leave Taking ◽  
And Gender

This chapter is about the design of Parental Leave policy and its relationship to leave-taking by fathers and gender equality more generally. The Nordic countries have historically emphasised gender equality in policymaking and have been in the forefront for introducing policies that encourage mothers and fathers to share responsibility for the care of children. Parental Leave is considered to be one such policy as it secures fathers’ rights to participate in the care of the child, with potentially long-term effects on their involvement with children and the division of unpaid and paid work. However, there are different designs for Parental Leave, and the chapter identifies the major dimensions in the design of Nordic Parental Leave policies and evaluates them in relation to their effect on gender equality. It also considers how to conceptualise and measure gender equality in association with Parental Leave.

scholarly journals Identifying Long-Term Effects of SARS-CoV-2 and Their Association with Social Determinants of Health in a Cohort of Over One Million COVID-19 Survivors

2021 ◽  
Author(s):  
Sumit Mukherjee ◽  
Meghana Kshirsagar ◽  
Nicholas Becker ◽  
Yixi Xu ◽  
William B Weeks ◽  
...  
Keyword(s):  
Social Determinants Of Health ◽  
Social Determinants ◽  
Determinants Of Health ◽  
P Value ◽  
Long Term Effects ◽  
Medical Claims ◽  
Icd 10 ◽  
And Gender ◽  
Medical Claims Database

Abstract Background: Despite an abundance of information on the risk factors of SARS-CoV-2, large scale studies of long-term effects are lacking. In this paper we analyzed a large medical claims database of US based individuals to identify common long-term effects as well as their associations with various social and medical risk factors.Methods: The medical claims database was obtained from a prominent US based claims data processing company, namely Change Healthcare. In addition to the claims data, the dataset also consisted of various social determinants of health such as race, income, education level and veteran status of the individuals. A self-controlled cohort design (SCCD) observational study was performed to identify ICD-10 codes whose proportion was significantly increased in the outcome period compared to the control period to identify significant long-term effects. A logistic regression-based association analysis was then performed between identified long-term effects and social determinants of health.Results: Among the over 1.37 million COVID patients in our datasets we found 36 out of 1,724 3-digit ICD-10 codes to be statistically significantly increased in the post-COVID period (p-value <0.05). We also found one combination of ICD-10 codes, corresponding to ‘other anemias’ and ‘hypertension’, that was statistically significantly increased in the post-COVID period (p-value <0.05). Our logistic regression-based association analysis with social determinants of health variables, after adjusting for comorbidities and prior conditions, showed that age and gender were significantly associated with the multiple long-term effects. Race was only associated with ‘other sepsis’, income was only associated with ‘Alopecia areata’, while education level was only associated with ‘Maternal infectious and parasitic diseases’ (p-value <0.05). Conclusion: We identified several long-term effects of SARS-CoV-2 through a self-controlled study on a cohort of over one million patients. Furthermore, we found that while age and gender are commonly associated with the long-term effects, other social determinants of health such as race, income and education levels have rare or no significant associations.

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