scholarly journals What Difference Does it Make? Risk-Taking Behavior in Obesity after a Loss is Associated with Decreased Ventromedial Prefrontal Cortex Activity

2019 ◽  
Vol 8 (10) ◽  
pp. 1551 ◽  
Author(s):  
Trevor Steward ◽  
Asier Juaneda-Seguí ◽  
Gemma Mestre-Bach ◽  
Ignacio Martínez-Zalacaín ◽  
Nuria Vilarrasa ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Risk Taking ◽  
Sensation Seeking ◽  
Brain Regions ◽  
Ventromedial Prefrontal Cortex ◽  
Control Group ◽  
Adult Women ◽  
Healthy Weight ◽  
Risky Choices ◽  
Risk Taking Behavior

Altered activity in decision-making neural circuitry may underlie the maladaptive food choices found in obesity. Here, we aimed to identify the brain regions purportedly underpinning risk-taking behavior in individuals with obesity. Twenty-three adult women with obesity and twenty-three healthy weight controls completed the Risky Gains Task during functional magnetic resonance imaging (fMRI). This task allows participants to choose between a safe option for a small, guaranteed monetary reward and risky options with larger rewards. fMRI analyses comparing losing trials to winning trials found that participants with obesity presented decreased activity in the left anterior insula in comparison to controls (p < 0.05, AlphaSim corrected). Moreover, left insula activation during losses vs. wins was negatively correlated with UPPS-P questionnaire sensation seeking scores. During safe vs. risky trials following a loss, the control group exhibited increased activation in the ventromedial prefrontal cortex (vmPFC) (p < 0.05, AlphaSim corrected) in comparison to the OB group. Moreover, vmPFC response in the obesity group during post-loss trials was negatively correlated with risky choices on the task overall. As a whole, our findings support that diminished tuning of the insula towards interoceptive signals may lead to a lack of input to the vmPFC when weighing the costs and benefits of risky choices.

Developmental changes and individual differences in risk and perspective taking in adolescence

2008 ◽  
Vol 20 (4) ◽  
pp. 1213-1229 ◽  
Author(s):  
Eveline A. Crone ◽  
L. Bullens ◽  
E. A. A. van der Plas ◽  
E. J. Kijkuit ◽  
P. D. Zelazo
Keyword(s):  
Risk Taking ◽  
Perspective Taking ◽  
Sensation Seeking ◽  
Developmental Change ◽  
Age Groups ◽  
Risky Choices ◽  
Efficient Integration ◽  
Risk Taking Behavior ◽  
The Difference ◽  
The Individual

AbstractDespite the assumed prevalence of risk-taking behavior in adolescence, the laboratory evidence of risk taking remains scarce, and the individual variation poorly understood. Drawing from neuroscience studies, we tested whether risk and reward orientation are influenced by the perspective that adolescents take when making risky decisions. Perspective taking was manipulated by cuing participants prior to each choice whether the decision was made for “self,” or from the perspective of an “other” (the experimenter in Experiment 1; a hypothetical peer in Experiment 2). In Experiment 1, we show a developmental decrease in risk-taking behavior across different stages of adolescence. In addition, all age groups made fewer risky choices for the experimenter, but the difference between self and other was larger in early adolescence. In Experiment 2, we show that high sensation-seeking (SS) adolescents make more risky choices than low SS adolescents, but both groups make a similar differentiation for other individuals (low risk-taking or high risk-taking peers). Together, the results show that younger adolescents and high SS adolescents make more risky choices for themselves, but can appreciate that others may make fewer risky choices. The developmental change toward more rational decisions versus emotional, impulsive decisions may reflect, in part, more efficient integration of others’ perspectives into one's decision making. These developmental results are discussed regarding brain systems important for risk taking and perspective taking.

scholarly journals Neural network modelling reveals changes in directional connectivity between cortical and hypothalamic regions in obesity

2020 ◽  
Author(s):  
Katharina Voigt ◽  
Adeel Razi ◽  
Ian H. Harding ◽  
Zane B. Andrews ◽  
Antonio Verdejo-Garcia
Keyword(s):  
Prefrontal Cortex ◽  
Information Flow ◽  
Computational Modelling ◽  
Brain Regions ◽  
Ventromedial Prefrontal Cortex ◽  
Measured Signal ◽  
Healthy Weight ◽  
Top Down ◽  
Obese People ◽  
Homeostatic State

AbstractObesity has been ascribed to corticostriatal regions taking control over homeostatic areas. To test this assumption, we applied an effective connectivity approach to reveal the direction of information flow between brain regions and the valence of connections (excitatory versus inhibitory) as a function of adiposity and homeostatic state. Forty-one participants (21 overweight/obese) underwent two resting-state fMRI scans: after overnight fasting (hunger) and following a standardised meal (satiety). We used spectral dynamic causal modelling to unravel hunger and adiposity related changes in directed connectivity between cortical, insular, striatal and hypothalamic regions. During hunger, as compared to satiety, we found increased excitation of the ventromedial prefrontal cortex over the ventral striatum and hypothalamus, suggesting enhanced top-down modulation compensating energy depletion. Adiposity was associated with increased excitation of the anterior insula over the hypothalamus across the hunger and satiety conditions. The interaction of hunger and adiposity yielded decreased intra-cortical excitation from the dorsolateral to the ventromedial prefrontal cortex. Our findings suggest that obesity is associated with persistent top-down excitation of the hypothalamus, regardless of homeostatic state, and hunger-related reductions of dorsolateral to ventromedial prefrontal inputs. These findings are compatible with eating without hunger and reduced self-regulation views of obesity.Significance StatementObesity is a leading contributor to morbidity and mortality. Neurobiological theories propose that, in obese people, corticostriatal regions take over homeostatic areas. Neuroimaging-based functional connectivity is well-poised to unravel such abnormalities by examining between-regions communication, but existing studies have only measured signal covariance, not direction and valence of connectivity. We applied computational modelling to reveal the direction of information flow between brain regions and excitatory/inhibitory valence of connections in obese versus healthy-weight participants. Obesity associated with heightened top-down excitation from the insula to hypothalamus, and reduced excitation within prefrontal regions. Findings have two advantages relative to current knowledge: demonstrate theory-based directional abnormalities, i.e. cortical regions taking over homeostatic areas; and inform brain stimulation therapies targeting cortical input to lower-level regions.

Sexual Coercion in the College Population: A Form of Risk-Taking Behavior

2017 ◽  
Vol 35 (23-24) ◽  
pp. 5276-5291
Author(s):  
Alisa R. Garner ◽  
Laura C. Spiller ◽  
Patrick Williams
Keyword(s):  
Decision Making ◽  
Risk Taking ◽  
Sexual Coercion ◽  
Sensation Seeking ◽  
Outcome Expectation ◽  
College Population ◽  
Risk Taking Behavior ◽  
Reckless Behavior ◽  
Decision Making Model ◽  
The Relationship

The purpose of this study was to examine whether a decision-making model of risk-taking behavior, specifically impulsivity, positive and negative outcome expectation, and sensation seeking, can be extended to motivation for perpetration of sexual coercion. Participants included 276 sexually active college students between the ages of 18 and 25 years old who completed a set of questionnaires: (a) Sexual Experiences Survey, (b) Sensation Seeking Scales, (c) Cognitive Appraisal of Risky Events, (d) Barratt Impulsiveness Scale, and (e) Reckless Behavior Questionnaire. Multiple regression analyses were utilized to examine the relationship between these decision-making models and sexually coercive behaviors. General risk-taking behaviors were positively correlated with acts of sexual coercion, r = .16, p < .01. The predictor variables accounted for a significant amount of the variance in sexual coercion, R2 = .11, F(4, 246) = 7.57, p < .01. Only sensation seeking contributed unique variance to our model of sexual coercion, β = .27, t = 4.06, p < .01. Interventions to reduce sexual coercion may be more successful if they target those high in risk-taking. Similarly, prevention efforts informed by research on how to engage and hold the attention of sensation seeking youth may be more successful.

Social bonding and music: Evidence from lesions to the ventromedial prefrontal cortex

2021 ◽  
Vol 44 ◽  
Author(s):  
Amy M. Belfi
Keyword(s):  
Prefrontal Cortex ◽  
Social Bonding ◽  
Brain Regions ◽  
Ventromedial Prefrontal Cortex ◽  
Neurobiological Model ◽  
Social And Emotional ◽  
The Social ◽  
Emotional Effects

Abstract The music and social bonding (MSB) hypothesis suggests that damage to brain regions in the proposed neurobiological model, including the ventromedial prefrontal cortex (vmPFC), would disrupt the social and emotional effects of music. This commentary evaluates prior research in persons with vmPFC damage in light of the predictions put forth by the MSB hypothesis.

2Hz-Electroacupuncture Attenuates Conditioned Cue-Evoked Heroin-Seeking Behavior and Increase CB2-Rs Expression in Relapse-Relevant Brain Regions in Heroin-Addicted Rats

2014 ◽  
Vol 998-999 ◽  
pp. 164-168 ◽  
Author(s):  
Lin Chen ◽  
Bao Miao Ma ◽  
Kai Yue ◽  
Qin Ru ◽  
Xiang Tian ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Rat Model ◽  
Fixed Ratio ◽  
Brain Regions ◽  
Inhibitory Effect ◽  
Control Group ◽  
Self Administration ◽  
Seeking Behavior

In order to investigate the influence of electroacupuncture on heroin seeking behavior and the expression of CB2-Rs in the relapse-relevant brain regions, heroin self-administration rat model which represents the heroin relapse behaviors was developed with progressive fixed ratio program. The model rats were randomly divided into 3 groups: control group, heroin-addicted group and 2Hz electroacupuncture group (stimulating on acupoints zusanli and sanyinjiao). The expression of CB2-Rs in the relapse-relevant brain regions were assessed with immunohistochemistry technologies. The reinstatement of heroin seeking behavior induced by conditioned cue priming showed that compared with the heroin-addicted group, active pokes in the 2Hz electroacupuncture group decreased significantly (p<0.05). Compared with the control group, the expression of CB2-Rs in prefrontal cortex (PFC) and nucleus accumbens (NAc) was significantly decreased (p<0.05) in heroin-addicted group and increaseed significantly recover (p<0.05) in the 2Hz electroacupuncture group. Our present results showed that 2Hz-electroacupuncture could attenuate the conditioned cue-evoked heroin-seeking behavior and the inhibitory effect was mediated partially by the increase CB2-Rs expression in relapse-relevant brain regions in heroin-addicted rats.

scholarly journals Decreasing Ventromedial Prefrontal Cortex Activity During Sequential Risk-Taking: An fMRI Investigation of the Balloon Analog Risk Task

2012 ◽  
Vol 6 ◽  
Author(s):  
Tom Schonberg ◽  
Craig R. Fox ◽  
Jeanette A. Mumford ◽  
Eliza Congdon ◽  
Christopher Trepel ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Risk Taking ◽  
Ventromedial Prefrontal Cortex

scholarly journals The Role of the Ventromedial Prefrontal Cortex in Public Good and Public Bad Games: Evidence From a tDCS Study

2021 ◽  
Vol 15 ◽  
Author(s):  
Yuyou Chen ◽  
Xinbo Lu ◽  
Yuzhen Li ◽  
Lulu Zeng ◽  
Ping Yu ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Public Good ◽  
Cooperative Behavior ◽  
Brain Regions ◽  
Ventromedial Prefrontal Cortex ◽  
Decision Making Process ◽  
The Public ◽  
Gains And Losses ◽  
Public Good Games

Although humans constitute an exceptionally cooperative species that is able to collaborate on large scales for common benefits, cooperation remains a longstanding puzzle in biological and social science. Moreover, cooperation is not always related to resource allocation and gains but is often related to losses. Revealing the neurological mechanisms and brain regions related to cooperation is important for reinforcing cooperation-related gains and losses. Recent neuroscience studies have found that the decision-making process of cooperation is involved in the function of the ventromedial prefrontal cortex (VMPFC). In the present study, we aimed to investigate the causal role of the VMPFC in cooperative behavior concerning gains and losses through the application of transcranial direct current stimulation (tDCS). We integrated cooperation-related gains and losses into a unified paradigm. Based on the paradigm, we researched cooperation behaviors regarding gains in standard public good games and introduced public bad games to investigate cooperative behavior regarding losses. Our study revealed that the VMPFC plays different roles concerning gains and losses in situations requiring cooperation. Anodal stimulation over the VMPFC decreased cooperative behavior in public bad games, whereas stimulation over the VMPFC did not change cooperative behavior in public good games. Moreover, participants’ beliefs about others’ cooperation were changed in public bad games but not in public good games. Finally, participants’ cooperative attitudes were not influenced in the public good or public bad games under the three stimulation conditions.

scholarly journals 2Hz-Electroacupuncture Attenuates Heroin-Seeking Behaviors via Adjusts CB1-Rs and CB2-Rs Expression in Relapse-Relevant Brain Regions of Heroin Self-Administration Rats

2019 ◽  
pp. 835-844
Author(s):  
L. CHEN ◽  
X.-K. GONG ◽  
C.-L. LENG ◽  
B.-M. MA ◽  
Q. RU ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Ventral Tegmental Area ◽  
Brain Regions ◽  
High Rate ◽  
Opiate Addiction ◽  
Control Group ◽  
Self Administration ◽  
Ventral Tegmental

Opiate addiction has a high rate of relapse. The accumulating evidence shows that electroacupuncture (EA) may be effective for the treatment of opiate relapse. However, the change of expression of CB1-Rs and CB2-Rs involve in 2Hz EA anti-relapse pathway is still unclear. To explore the changes of expression of CB1-Rs and CB2-Rs, heroin self-administration (SA) model rats were adopted and treated using 2Hz EA. The expressions of CB1-Rs and CB2-Rs were observed using immunohistochemistry method. The results showed that, compared with the control group, active pokes in the heroin-addicted group increased, while the active pokes decreased significantly in 2Hz EA group compared with heroin-addicted group. Correspondingly, the expression of CB1-Rs in prefrontal cortex (PFC), hippocampus (Hip), nucleus accumbens (NAc) and ventral tegmental area (VTA) all increased significantly while the expression of CB2-Rs in those relapse-relevant brain regions decreased obviously in heroin-addicted group when compared with the control group. In addition, the expression of CB1-Rs obviously decreased in the 2Hz EA group while the expression of CB2-Rs in those relapse-relevant brain regions increased significantly when compared with the heroin-addicted group. It indicated that 2Hz EA could attenuate the heroin-evoked seeking behaviors effectively. The anti-relapse effects of 2Hz EA might be related to the decrease of CB1-Rs and increase of CB2-Rs expression in relapse-relevant brain regions of heroin SA rats.

scholarly journals Examining Risk-Taking Behavior and Sensation Seeking Requirement in Extreme Athletes

2017 ◽  
Vol 6 (1) ◽  
pp. 330 ◽  
Author(s):  
Ali Agilonu ◽  
Gulsum Bastug ◽  
Tonguc Osman Mutlu ◽  
Adem Pala
Keyword(s):  
Risk Taking ◽  
Sensation Seeking ◽  
Female Athletes ◽  
Extreme Sports ◽  
Male Athletes ◽  
Adrenaline Release ◽  
Risk Taking Behavior ◽  
And Gender ◽  
Data Frequency

Extreme sports are sport branches which include actions, adventures, risks and difficulties more rather than other sports. Special materials are used in sport branches such as surfing, kite surfing, sailing, snowboarding, paragliding, diving, mountaineering, motor sports and adrenaline release is more rather than in other sport branches. On the contrary, the situation for being eager to seek excitement and take risks with a view to having new experiences has been observed. It has been considered whether sensation seeking requirement and risk-taking behavior had effects upon each other. The aim of the study was to analyze sensation seeking and risk-taking behavior in extreme athletes. Total 101 extreme athletes including 31 females, 70 males with an age average of 22.03 ± 6.77 participated in the research. In order to determine athletes’ sensation seeking levels, “Arnett Inventory of Sensation Seeking” developed by Arnett (1994) and in order to determine their risk-taking behavior, “Risk Involvement and Perception Scale” developed by Siegel et al. (1994) were used. In evaluation of research data, frequency analysis, independent t test, in determination of relation between risk-taking and sensation seeking, correlation test were utilized.In conclusion, significant differences were found in risk-taking behavior, sensation seeking requirement and gender variable among the extreme athletes. In the male athletes sensation seeking requirement and risk-taking behavior had higher averages than the female athletes. Among the extreme athletes, significant relations were determined between risk-taking behavior and sensation seeking requirement. When risk-taking behavior values were high, sensation seeking requirement values were regarded to be high.

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