scholarly journals The Potential of Cannabidiol as a Treatment for Psychosis and Addiction: Who Benefits Most? A Systematic Review

2019 ◽  
Vol 8 (7) ◽  
pp. 1058 ◽  
Author(s):  
Albert Batalla ◽  
Hella Janssen ◽  
Shiral S. Gangadin ◽  
Matthijs G. Bossong
Keyword(s):  
Substance Use ◽  
Substance Use Disorders ◽  
Psychotic Disorders ◽  
Cannabis Use ◽  
Standardized Measures ◽  
Positive Effects ◽  
Promising Tool ◽  
Potential Biomarker ◽  
Endogenous Cannabinoid ◽  
The Relationship

The endogenous cannabinoid (eCB) system plays an important role in the pathophysiology of both psychotic disorders and substance use disorders (SUDs). The non-psychoactive cannabinoid compound, cannabidiol (CBD) is a highly promising tool in the treatment of both disorders. Here we review human clinical studies that investigated the efficacy of CBD treatment for schizophrenia, substance use disorders, and their comorbidity. In particular, we examined possible profiles of patients who may benefit the most from CBD treatment. CBD, either as monotherapy or added to regular antipsychotic medication, improved symptoms in patients with schizophrenia, with particularly promising effects in the early stages of illness. A potential biomarker is the level of anandamide in blood. CBD and THC mixtures showed positive effects in reducing short-term withdrawal and craving in cannabis use disorders. Studies on schizophrenia and comorbid substance use are lacking. Future studies should focus on the effects of CBD on psychotic disorders in different stages of illness, together with the effects on comorbid substance use. These studies should use standardized measures to assess cannabis use. In addition, future efforts should be taken to study the relationship between the eCB system, GABA/glutamate, and the immune system to reveal the underlying neurobiology of the effects of CBD.

scholarly journals The Relationship of Manic Episodes and Drug Abuse to Sexual Risk Behavior in Patients with Co-Occurring Bipolar and Substance Use Disorders: a 15-Month Prospective Analysis

2010 ◽  
Vol 15 (8) ◽  
pp. 1829-1833 ◽  
Author(s):  
Christina S. Meade ◽  
Garrett M. Fitzmaurice ◽  
Amy K. Sanchez ◽  
Margaret L. Griffin ◽  
Leah J. McDonald ◽  
...  
Keyword(s):  
Substance Use ◽  
Drug Abuse ◽  
Risk Behavior ◽  
Sexual Risk ◽  
Substance Use Disorders ◽  
Sexual Risk Behavior ◽  
Prospective Analysis ◽  
Relationship Of ◽  
The Relationship

scholarly journals Adolescent cannabis use, baseline prodromal symptoms and the risk of psychosis

2018 ◽  
Vol 212 (4) ◽  
pp. 227-233 ◽  
Author(s):  
Antti Mustonen ◽  
Solja Niemelä ◽  
Tanja Nordström ◽  
Graham K. Murray ◽  
Pirjo Mäki ◽  
...  
Keyword(s):  
Substance Use ◽  
General Population ◽  
Birth Cohort ◽  
Psychotic Disorders ◽  
Temporal Order ◽  
Population Based ◽  
Cannabis Use ◽  
Prodromal Symptoms ◽  
Increased Risk ◽  
Icd 10

BackgroundThe association between cannabis use and the risk of psychosis has been studied extensively but the temporal order still remains controversial.AimsTo examine the association between cannabis use in adolescence and the risk of psychosis after adjustment for prodromal symptoms and other potential confounders.MethodThe sample (n = 6534) was composed of the prospective general population-based Northern Finland Birth Cohort of 1986. Information on prodromal symptoms of psychosis and cannabis use was collected using questionnaires at age 15–16 years. Participants were followed up for ICD-10 psychotic disorders until age 30 years using nationwide registers.ResultsThe risk of psychosis was elevated in individuals who had tried cannabis five times or more (hazard ratio, (HR) = 6.5, 95% CI 3.0–13.9). The association remained statistically significant even when adjusted for prodromal symptoms, other substance use and parental psychosis (HR = 3.0, 95% CI 1.1–8.0).ConclusionsAdolescent cannabis use is associated with increased risk of psychosis even after adjustment for baseline prodromal symptoms, parental psychosis and other substance use.Declaration of interestNone.

Substance Use Disorders and Intentional Injury

2014 ◽  
Author(s):  
S. Janet Kuramoto-Crawford ◽  
Holly C. Wilcox
Keyword(s):  
Substance Use ◽  
Alcohol Use ◽  
Substance Use Disorders ◽  
Partner Violence ◽  
Alcohol Use Disorders ◽  
Research Attention ◽  
Intentional Injuries ◽  
Drug Use Disorders ◽  
The Relationship

Intentional injuries affect millions of lives worldwide. The authors provide an overview of the epidemiological and preventive evidence on the relationship between substance use disorders (SUD) and intentional injuries. Emphasis is placed on suicide and intimate partner violence, as each area has received substantial research attention in relation to SUD. There is robust epidemiological evidence on the relationship between SUD, notably with alcohol use disorders, and most intentional injuries. Research has focused on the identification of factors that distinguish individuals with alcohol use disorders who are at particularly high risk for intentional injuries. Characterization of those with other drug use disorders who are at risk for engaging in intentional injuries and the role of SUD in intentional injuries has been less extensively investigated. The authors conclude with a discussion of public health approaches to the prevention of intentional injuries among individuals with SUD.

Psychotic Disorders and Substance Use Disorders

2020 ◽  
pp. 1341-1355
Author(s):  
Daniele Carretta ◽  
Francesco Bartoli ◽  
Giuseppe Carrà
Keyword(s):  
Substance Use ◽  
Substance Use Disorders ◽  
Psychotic Disorders

The relationship between anxiety and substance use disorders among individuals with severe affective disorders

2002 ◽  
Vol 43 (4) ◽  
pp. 245-252 ◽  
Author(s):  
Renee D. Goodwin ◽  
David A. Stayner ◽  
Matthew J. Chinman ◽  
Ping Wu ◽  
Jacob Kraemer Tebes ◽  
...  
Keyword(s):  
Substance Use ◽  
Substance Use Disorders ◽  
Affective Disorders ◽  
The Relationship

The relationship between treatment for substance use disorders and stigma

2014 ◽  
Vol 140 ◽  
pp. e112-e113
Author(s):  
Magdalena Kulesza ◽  
S.E. Ramsey ◽  
R. Brown ◽  
M.E. Larimer
Keyword(s):  
Substance Use ◽  
Substance Use Disorders ◽  
The Relationship

Psychotic Disorders and Substance Use Disorders

2014 ◽  
pp. 2013-2034
Author(s):  
Daniele Carretta ◽  
Massimo Clerici ◽  
Francesco Bartoli ◽  
Giuseppe Carrà
Keyword(s):  
Substance Use ◽  
Substance Use Disorders ◽  
Psychotic Disorders
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