scholarly journals Role of Adipokines in the Association between Thyroid Hormone and Components of the Metabolic Syndrome

2019 ◽  
Vol 8 (6) ◽  
pp. 764 ◽  
Author(s):  
Alessandro P. Delitala ◽  
Angelo Scuteri ◽  
Edoardo Fiorillo ◽  
Edward G. Lakatta ◽  
David Schlessinger ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Thyroid Hormone ◽  
Regression Models ◽  
Causal Effect ◽  
Positive Association ◽  
The Metabolic Syndrome ◽  
Standardized Regression Coefficients ◽  
The Impact

Metabolic syndrome (MS) increases cardiovascular risk. The role of thyroid hormone on components of MS is unclear. We analyzed a sample of 4733 euthyroid subjects from SardiNIA study. In female thyrotropin (TSH) was significantly and positively associated with triglycerides (Standardized regression coefficients (β) = 0.081, p < 0.001). Free thyroxine (FT4) was positively associated with HDL (β = 0.056, p < 0.01), systolic blood pressure (SBP) (β = 0.059, p < 0.001), diastolic blood pressure (DBP) (β = 0.044, p < 0.01), and fasting glucose (β = 0.046, p < 0.01). Conversely, FT4 showed a negative association with waist circumference (β = −0.052, p < 0.001). In TSH was positively associated with triglycerides (β = 0.111, p < 0.001) and FT4 showed a positive association with DBP (β = 0.51, p < 0.01). The addition of leptin and adiponectin to the regression models did not substantially change the impact of thyroid hormones on components of MS. Our data suggest that, even within the euthyroid range, excess of truncal adipose tissue is associated with variations in FT4. Leptin and adiponectin exert an additive effect rather than a causal effect. Additional studies should be performed to determine the clinical significance of this finding.

scholarly journals Electronic Cigarette Use and Metabolic Syndrome Development: A Critical Review

Toxics ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 105
Author(s):  
Ilona Górna ◽  
Marta Napierala ◽  
Ewa Florek
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Arterial Blood Pressure ◽  
Abdominal Obesity ◽  
Critical Review ◽  
Lifestyle Modifications ◽  
The Metabolic Syndrome ◽  
Arterial Blood ◽  
The Impact

The metabolic syndrome is a combination of several metabolic disorders, such as cardiovascular disease, atherosclerosis, and type 2 diabetes. Lifestyle modifications, including quitting smoking, are recommended to reduce the risk of metabolic syndrome and its associated complications. Not much research has been conducted in the field of e-cigarettes and the risk of metabolic syndrome. Furthermore, taking into account the influence of e-cigarettes vaping on the individual components of metabolic syndrome, i.e, abdominal obesity, insulin resistance, dyslipidemia and elevated arterial blood pressure, the results are also ambiguous. This article is a review and summary of existing reports on the impact of e-cigarettes on the development of metabolic syndrome as well as its individual components. A critical review for English language articles published until 30 June 2020 was made, using a PubMed (including MEDLINE), Cochrane, CINAHL Plus, and Web of Science data. The current research indicated that e-cigarettes use does not affect the development of insulin resistance, but could influence the level of glucose and pre-diabetic state development. The lipid of profile an increase in the TG level was reported, while the influence on the level of concentration of total cholesterol, LDL fraction, and HDL fraction differed. In most cases, e-cigarettes use increased the risk of developing abdominal obesity or higher arterial blood pressure. Further research is required to provide more evidence on this topic.

scholarly journals Blood pressure decrease with ingestion of a soya product (kinako) or fish oil in women with the metabolic syndrome: role of adiponectin and nitric oxide

2012 ◽  
Vol 108 (8) ◽  
pp. 1435-1442 ◽  
Author(s):  
Andréa Name Colado Simão ◽  
Marcell Alysson Batisti Lozovoy ◽  
Larissa Danielle Bahls ◽  
Helena Kaminami Morimoto ◽  
Tathiana Name Colado Simão ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Fish Oil ◽  
Inflammatory Markers ◽  
Inflammatory Marker ◽  
Control Group ◽  
Treatment Groups ◽  
The Metabolic Syndrome ◽  
Baseline Values

The aim of the present study was to verify the effects of fish oil and a soya-based product on inflammatory markers and endothelial function measured by NO in women with the metabolic syndrome (MetS). A total of sixty-five women (mean age: 47·9 (sd9·98) years) were studied in a 90-d parallel, randomised design. A control group maintained their usual diet; the second group received 29 g/d of soyabean (kinako); the third group received 3 g/d of fish oiln-3 fatty acids; and the fourth group received fish oil (3 g/d) and kinako (29 g/d). Anthropometric, blood pressure (BP), inflammatory markers, anti-inflammatory marker (adiponectin) and NO concentrations were evaluated. In relation to the baseline values, the group that received fish oil and kinako concomitantly presented a statistically significant decrease in systolic BP (SBP;P < 0·05), whereas there was a significant decrease in diastolic BP (DBP) in the control group (P < 0·05), kinako group (P < 0·01) and fish oil group (P < 0·01) after 90 d. There was a significant increase in adiponectin (P < 0·01) and NO values (P < 0·05) after 90 d in the kinako and fish oil groups. Differences between treatment groups verified a significant decrease (P < 0·05) in DBP in the kinako group after 90 d when compared to the results obtained from the fish oil and kinako groups. In conclusion, the findings of increased serum adiponectin and NO metabolite levels after 90 d, both in the fish oil and soya groups, reinforce the importance of the influence of adiponectin and NO levels on BP decrease in patients with the MetS.

scholarly journals Impact of sports participation on components of metabolic syndrome in adolescents: ABCD Growth Study 

2021 ◽  
Author(s):  
Verônica Alves Menezes ◽  
Wésley Torres ◽  
Eduardo Duarte de Lima Mesquita ◽  
Lucas Gabriel Moraes Chagas ◽  
Ana Elisa von Ah Morano ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Colorimetric Method ◽  
Sports Participation ◽  
P Value ◽  
Growth Study ◽  
Small Magnitude ◽  
The Metabolic Syndrome ◽  
The Impact ◽  
Moderate Magnitude

Abstract Objective The objective of this study was to analyze the impact of sports participation (12 months of practice) on components of the metabolic syndrome of both sexes.Methods Observational longitudinal study, party of the study entitled “Analysis of Behaviors of Children During Growth” (ABCD Growth Study), Presidente Prudente, SP. The sample consisted of 171 adolescents [112 boys and 59 girls], the groups were divided between non-sport and sport, according to the inclusion criteria: age 11 to 17 years; absence of known diseases previously diagnosed; no regular use of medications related to blood pressure or lipid metabolism; involvement in sports in the las 12 months (sports group) for at least one year without any regular involvement in sports training routines or physical exercises (non-sports group), signed written consent form parents and adolescents. The high-density cholesterol lipoproteins (HDL-c), triglycerides (TG), and glucose were analyzed by the dry chemical colorimetric method and processed biochemically. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were assessed using an automatic device. Body fat (BF) was estimated using a densitometry scanner. Ethnicity, sex, maturity, and body weight were treated as covariates.Results The adolescents involved in the sport were younger [p-value = 0.001] and with lower PVC [p-value = 0.001] than the non-sport group. The differences () after 12 months were of greater magnitude for the sports group when compared to non-sports group [p-value = 0.013], glucose (moderate magnitude in favor of the sports group; p-value = 0.001), HDL-c (small magnitude in favor of the sports group; p-value = 0.0015) and MetS (moderate magnitude in favor of the sports group; p-value = 0.001). Sport with high cardiorespiratory demand has more pronounced benefits than other groups. Sport seems to have a positive relationship in the variables sports participation, weekly volume, and load intensity. Conclusion Sports practice in adolescents had a protective effect on the metabolic components of the metabolic syndrome.

scholarly journals Hypertension control and risk of colonic diverticulosis

2019 ◽  
Vol 12 ◽  
pp. 175628481985573
Author(s):  
Li-Xian Yeo ◽  
Tzu-Hsiang Tseng ◽  
Wei-Liang Chen ◽  
Tung-Wei Kao ◽  
Li-Wei Wu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Logistic Regression ◽  
Regression Models ◽  
Antihypertensive Medication ◽  
Positive Association ◽  
Antihypertensive Drug Therapy ◽  
Logistic Regression Models ◽  
Epidemiologic Evidence ◽  
Asymptomatic Patients

Background: The prevalence of diverticulosis has increased in our aging population, but the risk factors for diverticulosis are not fully understood. The role of hypertension in the risk of diverticulosis remains uncertain. This study investigated whether hypertension is associated with asymptomatic colorectal diverticulosis. Methods: This study enrolled asymptomatic patients who received a colonoscopy as part of a health check. Hypertension was defined by actual measured blood pressure. Logistic regression models were used to examine the relationship between hypertension and diverticulosis. In addition, we established three logistic regression models for covariate adjustment, and further stratified patients with hypertension into three subgroups based on their type of hypertension. Results: The study group consisted of 2748 participants, including 141 participants with diverticulosis and 2607 participants without diverticulosis. After adjustments for potential covariates, the odds ratio (OR) for having diverticulosis was 1.83 (95% confidence interval, 1.21–2.75, p = 0.004) in the hypertension group compared with the group without hypertension. In subgroup analyses, hypertension without antihypertensive medication use, and hypertension despite the use of antihypertensive medication were also significantly associated with the occurrence of asymptomatic diverticulosis (OR = 1.73, p = 0.028; OR = 2.07, p = 0.013, respectively). Current normal blood pressure under antihypertensive drug therapy was not associated with diverticulosis (OR = 1.74, p = 0.092). Conclusions: Our findings suggest a positive association between hypertension and diverticulosis. Participants with poorly controlled blood pressure were found to have a higher risk of asymptomatic diverticulosis. Our study presents epidemiologic evidence for future prevention strategies against diverticulosis.

scholarly journals Copper-Fructose Interactions: A Novel Mechanism in the Pathogenesis of NAFLD

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1815 ◽  
Author(s):  
Ming Song ◽  
Miriam Vos ◽  
Craig McClain
Keyword(s):  
Metabolic Syndrome ◽  
Causal Effect ◽  
Critical Role ◽  
Metabolic Effects ◽  
Nonalcoholic Fatty Liver ◽  
Copper Status ◽  
Fructose Intake ◽  
The Metabolic Syndrome ◽  
High Fructose

Compelling epidemiologic data support the critical role of dietary fructose in the epidemic of obesity, metabolic syndrome and nonalcoholic fatty liver disease (NAFLD). The metabolic effects of fructose on the development of metabolic syndrome and NAFLD are not completely understood. High fructose intake impairs copper status, and copper-fructose interactions have been well documented in rats. Altered copper-fructose metabolism leads to exacerbated experimental metabolic syndrome and NAFLD. A growing body of evidence has demonstrated that copper levels are low in NAFLD patients. Moreover, hepatic and serum copper levels are inversely correlated with the severity of NAFLD. Thus, high fructose consumption and low copper availability are considered two important risk factors in NAFLD. However, the causal effect of copper-fructose interactions as well as the effects of fructose intake on copper status remain to be evaluated in humans. The aim of this review is to summarize the role of copper-fructose interactions in the pathogenesis of the metabolic syndrome and discuss the potential underlying mechanisms. This review will shed light on the role of copper homeostasis and high fructose intake and point to copper-fructose interactions as novel mechanisms in the fructose induced NAFLD.

Metabolic Syndrome, a Cardiovascular Disease Risk Factor: Role of Adipocytokines and Impact of Diet and Physical Activity

2004 ◽  
Vol 29 (6) ◽  
pp. 808-829 ◽  
Author(s):  
Lindsay E. Robinson ◽  
Terry E. Graham
Keyword(s):  
Physical Activity ◽  
Insulin Resistance ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
The Metabolic Syndrome ◽  
Key Words Insulin ◽  
Diet And Physical Activity ◽  
The Impact

The metabolic syndrome comprises an array of cardiovascular disease (CVD) risk factors such as abdominal obesity, dyslipidemia, hypertension, and glucose intolerance. Insulin resistance and/or increased abdominal (visceral) obesity have been suggested as potential etiological factors. More recently, increasing evidence has associated insulin resistance and subclinical inflammation involving cytokines derived from adipose tissue, or adipocytokines. Despite the fact that precise mechanisms have yet to be established, there is a significant role for both diet and physical activity to improve the many factors associated with the metabolic syndrome, including modulation of various adipocytokines. Although both diet and physical activity have been studied for their ability to modify cytokines in more traditional inflammatory conditions, such as rheumatoid arthritis, they have been less studied in relation to inflammation as an underlying cause of the metabolic syndrome and/or CVD. A more thorough understanding of the clustering of metabolic abnormalities and their underlying etiology will help to define diet and physical activity guidelines for preventing and treating the metabolic syndrome, an important aspect of CVD prevention. This paper will address potential underlying causes of the metabolic syndrome, with a focus on the putative mechanistic role of adipocytokines, and will discuss the impact of diet and physical activity on the metabolic syndrome. Key words: insulin resistance syndrome, obesity, adipose tissue, skeletal muscle, cytokines, TNF-α, IL-6, PAI-1, inflammation, nutrition, exercise

scholarly journals Copper-Fructose Interactions: A Novel Mechanism in the Pathogenesis of NAFLD

2018 ◽  
Author(s):  
Ming Song ◽  
Miriam Vos ◽  
Craig McClain
Keyword(s):  
Metabolic Syndrome ◽  
Causal Effect ◽  
Critical Role ◽  
Metabolic Effects ◽  
Nonalcoholic Fatty Liver ◽  
Copper Status ◽  
Fructose Intake ◽  
The Metabolic Syndrome ◽  
High Fructose

Compelling epidemiologic data support the critical role of dietary fructose in the epidemic of obesity, metabolic syndrome and nonalcoholic fatty liver disease (NAFLD). The metabolic effects of fructose on the development of metabolic syndrome and NAFLD are not completely understood. High fructose intake impairs copper status, and copper-fructose interactions have been well documented in rats. Altered copper-fructose metabolism leads to exacerbated experimental metabolic syndrome and NAFLD. A growing body of evidence has demonstrated that copper levels are low in NAFLD patients. Moreover, hepatic and serum copper levels are inversely correlated with the severity of NAFLD. Thus, high fructose consumption and low copper availability are considered two important risk factors in NAFLD. However, the causal effect of copper-fructose interactions as well as the effects of fructose intake on copper status remain to be evaluated in humans. The aim of this review is to summarize the role of copper-fructose interactions in the pathogenesis of the metabolic syndrome and discuss the potential underlying mechanisms. This review will shed light on the role of copper homeostasis and high fructose intake and point to copper-fructose interactions as novel mechanisms in the fructose induced NAFLD.

scholarly journals Exercise in the Metabolic Syndrome

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Saeid Golbidi ◽  
Azam Mesdaghinia ◽  
Ismail Laher
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Oxygen Species ◽  
Induce Insulin Resistance ◽  
The Metabolic Syndrome ◽  
Pathophysiological Role ◽  
The Impact ◽  
Global Population ◽  
Muscular Metabolism

The metabolic syndrome is a clustering of obesity, diabetes, hyperlipidemia, and hypertension that is occurring in increasing frequency across the global population. Although there is some controversy about its diagnostic criteria, oxidative stress, which is defined as imbalance between the production and inactivation of reactive oxygen species, has a major pathophysiological role in all the components of this disease. Oxidative stress and consequent inflammation induce insulin resistance, which likely links the various components of this disease. We briefly review the role of oxidative stress as a major component of the metabolic syndrome and then discuss the impact of exercise on these pathophysiological pathways. Included in this paper is the effect of exercise in reducing fat-induced inflammation, blood pressure, and improving muscular metabolism.

Role of genetic factors in the development of hypertension in young patients with metabolic syndrome

2020 ◽  
pp. 23-32
Author(s):  
Elena Korneeva ◽  
Mikhail Voevoda ◽  
Sergey Semaev ◽  
Vladimir Maksimov
Keyword(s):  
Metabolic Syndrome ◽  
High Risk ◽  
Arterial Hypertension ◽  
Genetic Factors ◽  
Young Patients ◽  
Integrin Αiibβ3 ◽  
Ace Gene ◽  
The Metabolic Syndrome

Results of the study related to polymorphism of ACE gene (rs1799752)‎, integrin αIIbβ3, and CSK gene (rs1378942) influencing development of arterial hypertension in young patients with metabolic syndrome are presented. Hypertension as a component of the metabolic syndrome was detected in 15.0% of young patients. Prevalence of mutant alleles of the studied genes among the examined patients was quite high, so homozygous DD genotype was found in 21.6%, and mutant D allele of the ACE gene in 47.4%. A high risk of hypertension in patients with MS was detected in carriers of the T allele of the CSK (rs1378942) gene – 54.8%, which was most often observed in a combination of polymorphic ACE and CSK gene loci (p = 0.0053).

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