scholarly journals Real-World Database Examining the Association between Sjögren’s Syndrome and Chronic Rhinosinusitis

2019 ◽  
Vol 8 (2) ◽  
pp. 155 ◽  
Author(s):  
Geng-He Chang ◽  
Yu-Cheng Chen ◽  
Ko-Ming Lin ◽  
Yao-Hsu Yang ◽  
Chia-Yen Liu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Chronic Rhinosinusitis ◽  
Sjögren’S Syndrome ◽  
Independent Risk Factor ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sinus Surgery ◽  
Disease Spectrum ◽  
Sjögren‘S Syndrome

Objective: To investigate the risk of chronic rhinosinusitis (CRS) among patients with Sjögren’s syndrome (SS). Method: A total of 18,723 patients diagnosed with SS between 1997 and 2011 were retrospectively analyzed. Moreover, 59,568 patients without SS were matched to patients with SS at a 1:4 ratio on the basis of sex, age, urbanization level, income level, and the comorbidities of rhinitis and nasal sepal deviation. Patients were followed up until death or the end of the study period (31 December, 2013). The primary outcome was the occurrence of CRS. Results: The cumulative incidence of CRS was significantly higher in patients with SS than in those without SS (p < 0.001). The adjusted Cox proportional hazard model showed that patients with SS had a significantly higher incidence of CRS (hazard ratio, 2.51; 95% confidence interval, 2.22–2.84; p < 0.001). Sensitivity and subgroup analyses demonstrated SS was an independent risk factor for CRS. The dosage of intranasal corticosteroid spray used was not different between the SS and non-SS groups. Fewer patients with CRS in the SS group underwent sinus surgery (82/407 (20.2%)) than those in the non-SS group (179/667 (26.8%)) and this finding was statistically significant (p = 0.013). The number of operations did not differ significantly between patients with CRS in the SS and non-SS groups. Conclusions: SS is an independent risk factor for CRS. Our study extends the disease spectrum and prompts physicians to be aware of potential CRS occurrence after SS.

scholarly journals Aryl Hydrocarbon Receptor-Mediated Induction of EBV Reactivation as a Risk Factor for Sjögren’s Syndrome

2012 ◽  
Vol 188 (9) ◽  
pp. 4654-4662 ◽  
Author(s):  
Hiroko Inoue ◽  
Kenji Mishima ◽  
Sachi Yamamoto-Yoshida ◽  
Ryoko Ushikoshi-Nakayama ◽  
Yoichi Nakagawa ◽  
...  
Keyword(s):  
Risk Factor ◽  
Aryl Hydrocarbon Receptor ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Ebv Reactivation ◽  
Aryl Hydrocarbon ◽  
Sjögren‘S Syndrome

scholarly journals Primary Sjögren’s syndrome as independent risk factor for subclinical atherosclerosis

2022 ◽  
Vol 9 (1) ◽  
pp. 20-25
Author(s):  
Marta Novella-Navarro ◽  
◽  
José Luis Cabrera-Alarcón ◽  
José Luis Rosales-Alexander ◽  
Jorge Juan González-Martín ◽  
...  
Keyword(s):  
Risk Factor ◽  
Independent Risk Factor ◽  
Sjögren's Syndrome ◽  
Subclinical Atherosclerosis ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Sjögren‘S Syndrome

Is Sjogren's syndrome a risk factor/contraindication for dental implants? An umbrella review

2021 ◽  
Author(s):  
Ana Waleska Pessôa Barros ◽  
Pedro Henrique da Hora Sales ◽  
Alessandra de Albuquerque Tavares Carvalho ◽  
Preeyan Patel ◽  
Stephen Porter ◽  
...  
Keyword(s):  
Risk Factor ◽  
Dental Implants ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Umbrella Review ◽  
Sjögren‘S Syndrome

The association of Raynaud’s phenomenon/syndrome with scleroderma and Sjögren’s syndrome – a meta-analysis

VASA ◽  
2008 ◽  
Vol 37 (Supplement 73) ◽  
pp. 26-32 ◽  
Author(s):  
Schlattmann ◽  
Höhne ◽  
Plümper ◽  
Heidrich
Keyword(s):  
Quantitative Analysis ◽  
Sjögren’S Syndrome ◽  
Mixture Model ◽  
Sjögren's Syndrome ◽  
Meta Analysis ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Raynaud’S Syndrome ◽  
Raynaud's Syndrome ◽  
Sjögren‘S Syndrome

Background: In order to analyze the prevalence of Raynaud’s syndrome in diseases such as scleroderma and Sjögren’s syndrom – a meta-analysis of published data was performed. Methods: The PubMed data base of the National Library of Medicine was used for studies dealing with Raynaud’s syndrome and scleroderma or Raynaud’s syndroem and Sjögren’s syndrom respectively. The studies found provided data sufficient to estimate the prevalence of Raynaud’s syndrome. The statistical analysis was based on methods for a fixed effects meta-analysis and finite mixture model for proportions. Results: For scleroderma a pooled prevalence of 80.9% and 95% CI (0.78, 0.83) was obtained. A mixture model analysis found four latent classes. We identified a class with a very low prevalence of 11%, weighted with 0.15. On the other hand there is a class with a very high prevalence of 96%. Analysing the association with Sjögren’s syndrome, the pooled analysis leads to a prevalence of Raynaud’s syndrome of 32%, 95% CI(26.7%, 37.7%). A mixture model finds a solution with two latent classes. Here, 38% of the studies show a prevalence of 18.8% whereas 62% observe a prevalence of 38.3%. Conclusion: There is strong variability of studies reporting the prevalence of Raynaud’s syndrome in patients suffering from scleroderma or Sjögren’s syndrome. The available data are insufficient to perform a proper quantitative analysis of the association of Raynaud’s phenomenon with scleroderma or Sjögren’s syndrome. Properly planned and reported epidemiological studies are needed in order to perform a thorough quantitative analysis of risk factors for Raynaud’s syndrome.

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