scholarly journals Gout as a Risk Factor for Dry Eye Disease: A Population-Based Cohort Study

2019 ◽  
Vol 8 (1) ◽  
pp. 62 ◽  
Author(s):  
Chia-Yi Lee ◽  
Hung-Chi Chen ◽  
Chi-Chin Sun ◽  
Hung-Yu Lin ◽  
Ko-Hsiu Lu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Age Related Macular Degeneration ◽  
Eye Disease ◽  
Cumulative Probability ◽  
Control Group ◽  
Study Group ◽  
Research Database ◽  
Increased Risk

This study evaluated the effect of gout on the risk of dry eye disease (DED) by using the National Health Insurance Research Database (NHIRD). Data for 30,192 gout patients (21,081 men and 9111 women) and 30,192 non-gout patients (21,005 men and 9187 women) were analyzed. Approximately 1 million patients were randomly sampled from the NHIRD registry. After applying exclusion criteria, patients diagnosed with gout were enrolled in the study group. Thereafter, each individual in the study group underwent the matching process via the propensity score with another non-gout individual, which constituted the control group. The main outcome was defined as the development of DED in accordance with the corresponding International Classification of Diseases, Ninth Revision. In addition to DED, other risk factors including age, sex, and urbanization, and several co-morbidities were included in the multivariate model. The incidence of DED with the adjusted hazard ratio (aHR) and cumulative probability were evaluated in the gout and non-gout patients. A total of 2913 DED events were observed in the study group, whereas 2631 DED events were observed in the control group. A higher incidence rate ratio was found in the study group after adjustment (aHR: 1.065). Moreover, the cumulative probability indicated a significantly increased risk of DED in the study group (p = 0.001). The other potential risk factors of DED according to the multivariate analysis include older age, female gender, higher degree of urbanization, keratopathy, age-related macular degeneration, glaucoma, cataract, ischemic heart disease, hyperlipidemia, peripheral vascular disease, chronic pulmonary disease, rheumatic disease, peptic ulcer disease, liver disease, and malignancy. In conclusion, gout increased the risk of DED after adjustment, and the risk is positively correlated to a longer disease period.

scholarly journals The Development of Dry Eye Disease after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study

2020 ◽  
Vol 17 (11) ◽  
pp. 3829
Author(s):  
Chia-Yi Lee ◽  
Kun-Lin Yang ◽  
Chi-Chin Sun ◽  
Jing-Yang Huang ◽  
Hung-Chih Chen ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Sinus Surgery ◽  
Eye Disease ◽  
Cumulative Probability ◽  
Control Group ◽  
Study Group ◽  
Diagnostic Code ◽  
Research Database

We aim to evaluate the risk of dry eye disease (DED) occurrence in patients with surgery-indicated chronic rhinosinusitis (CRS) via the national health insurance research database in Taiwan. After exclusion, patients with a diagnostic code of CRS and had received functional endoscopic sinus surgery (FESS) were regarded as having surgery-indicated CRS and enrolled in the study group, then each patient in the study group was age- and gender-matched to four non-CRS patients that served as the control group. The outcome was considered as the development of DED and Cox proportional hazard regression was used for the statistical analysis, which involved multiple potential risk factors of DED. A total of 6076 patients with surgery-indicated CRS that received FESS and another 24,304 non-CRS individuals were enrolled after exclusion. There were 317 and 770 DED events in the study group and the control group during the 16-year follow-up interval, and the study group demonstrated a significantly higher adjusted hazard ratio (1490, 95% confidence intervals (CI): 1.303-1.702) of DED development compared to the control group in the multivariable analysis. In addition, the cumulative probability analysis illustrated a positive correlation of DED occurrence and the disease period of surgery-indicated CRS (p < 0.0001). In the subgroup analysis, both genders revealed a higher but not significant incidence of developing DED in the study group. In conclusion, the existence of surgery-indicated CRS will increase the risk of developing DED, which correlated to the disease interval.

scholarly journals Association between asthma and dry eye disease: a meta-analysis based on observational studies

BMJ Open ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. e045275
Author(s):  
Qun Huang ◽  
Yanlin Zheng ◽  
Chuantao Zhang ◽  
Wanjie Wang ◽  
Tingting Liao ◽  
...  
Keyword(s):  
Dry Eye ◽  
Subgroup Analysis ◽  
Observational Studies ◽  
Data Extraction ◽  
Meta Analysis ◽  
Population Based ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Control Group ◽  
Increased Risk

ObjectiveThis study aimed to systematically review the relationship between dry eye disease (DED) and asthma based on published population-based studies.Data sourcesPubMed, EMBASE and ISI Web of Science from their inception were searched up to October 2019.Study selectionObservational studies addressing the association between asthma and DED will be eligible.Data extraction and synthesisTwo reviewers independently conducted the data extraction and quality assessment. We used a random-effects model for all analyses. Subgroup analysis according to ethnicity was performed to test the influence of ethnicity on the association.Main outcomes and measuresSix independent studies (a total of 45 215 patients with asthma and 232 864 control subjects) were included in this review and had an average of seven stars by the Newcastle-Ottawa Scale. Our current findings suggest that the prevalence of DED was higher in the asthma group than in the control group (Z=7.42, p<0.00001; OR 1.29, 95% CI 1.20 to 1.38). In the subgroup analysis by ethnicity, Australian, Caucasian and Asian patients with asthma showed an increased risk of DED.

scholarly journals Assessment of Prevalence and Risk Factors of Dry Eye Disease among Study Group

2020 ◽  
Vol 9 (3) ◽  
pp. 1-4
Author(s):  
Madhavi Chevuturu
Keyword(s):  
Risk Factors ◽  
Dry Eye ◽  
Contact Lens ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Study Group ◽  
Ocular Allergy ◽  
Ocular Surgery ◽  
Steroid Use ◽  
The Difference

Background: Dry eye is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance.   The present study was conducted to assess prevalence and risk factors of dry eye diseases among the study group. Subjects and Methods:  The present study was conducted from February 2018 to July 2018 on 184 patients of both genders visiting the Department of Ophthalmology Mediciti institute of medical sciences with eye complaints. Slit-lamp biomicroscopy with a cobalt blue filter was used to investigate the tear film layer, and the interval from the last blink to the appearance of the first random dry spot on the cornea was noted. Schirmer’s test was performed. Whatman filter paper no 41 was placed in the lower fornix at the lateral one-third of the lower lid margin. Results: Age groups 40-50 years had 52, 50-60 years had 98 and 60-70 years had 34 patients. There were 110 males and 74 females. The difference was significant (P< 0.05). 64 (58.1%) males and 40 (54%) had a dry eye disease. The prevalence found to be 61.9%. The severity of DED was mild in 25%, moderate in 46% and severe in 29%. The difference was significant (P< 0.05). Risk factors of DED were steroid use in 14%, smoking in 56%, alcoholism in 24%, computer job in 78%, systemic allergy in 4%, ocular allergy in 32%, contact lens use in 17% and previous ocular surgery in 7%. The difference was significant (P< 0.05). Conclusion: The author found that the prevalence rate of dry eyes was 61.9%. Risk factors of DED were steroid use, smoking, alcoholism, computer job, systemic allergy, ocular allergy, contact lens use and previous ocular surgery.

scholarly journals Oral Hyaluronic Acid Supplementation for the Treatment of Dry Eye Disease: A Pilot Study

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Yeseul Kim ◽  
Chan Hee Moon ◽  
Bo-Yeon Kim ◽  
Sun Young Jang
Keyword(s):  
Hyaluronic Acid ◽  
Dry Eye ◽  
Ocular Surface ◽  
Controlled Trial ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Control Group ◽  
Study Group ◽  
Schirmer Test ◽  
Ocular Surface Disease Index

Purpose. To evaluate the clinical efficacy of oral hyaluronic acid (HA) in patients with dry eye disease (DED). Study Design. Prospective randomized controlled trial. Methods. This trial enrolled 54 subjects and they were randomized into the study or control group. The inclusion criteria were as follows: (1) >18 years of age; (2) distance best-corrected visual acuity ≥ 20/40 Snellen equivalent in each eye; (3) IOP ≤ 21 mmHg in both eyes; (4) ocular surface disease index (OSDI) score of ≥18 and <65; (5) <10 seconds of tear break up time (TBUT); (6) >5 corneal spots of corneal fluorescein staining (CFS); and (7) ≤ 10 mm/5 min of the Schirmer test. All subjects were treated with a topical HA, and the study group was supplemented with oral HA. OSDI, TBUT, CFS, and the Schirmer test were evaluated for ocular surface parameters. Results. 24 patients were assigned in the study group. Significant improvement of OSDI, TBUT, and CFS was observed at 1 month and 3 months after oral HA administration in the study group. At baseline and follow-up at 1 and 3 months, OSDI scores were 61.8 ± 16.2, 47.3 ± 11.6, and 42.3 ± 9.1, respectively (P<0.001). TBUT was improved after treatment for 1 month and 3 months (4.2 ± 1.1; P=0.005 and 4.7 ± 1.1; P<0.012). There were also statistically significant improvements in the CSF (1.8 ± 1.0, 0.8 ± 0.7; P<0.001) at baseline compared with those at 1 month. Conclusions. A combined supplement of both oral and topical HA more efficiently improves corneal epithelial wound healing and related symptoms than topical HA alone, in DED.

Lack of Social Support and Social Trust as Potential Risk Factors for Dry Eye Disease: JPHC-NEXT Eye Study

2018 ◽  
Author(s):  
Chi Hoang Viet Vu ◽  
Miki Uchino ◽  
Motoko Kawashima ◽  
Akihiro Nishi ◽  
Christopher A. German ◽  
...  
Keyword(s):  
Risk Factors ◽  
Social Support ◽  
Dry Eye ◽  
Potential Risk ◽  
Social Trust ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Potential Risk Factors

scholarly journals The elevated risk of sight-threatening cataract in diabetes with retinopathy: a retrospective population-based cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chan-Wei Nien ◽  
Chia-Yi Lee ◽  
Hung-Chi Chen ◽  
Shih-Chun Chao ◽  
Hung-Jui Hsu ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Multivariable Analysis ◽  
Population Based ◽  
Cumulative Probability ◽  
Control Group ◽  
Study Group ◽  
Research Database ◽  
Proportional Hazard ◽  
Cox Proportional Hazard ◽  
Cox Proportional Hazard Regression

Abstract Background The effect of diabetic retinopathy (DR) on the development of sight-threatening cataracts was assessed using the National Health Insurance Research Database of Taiwan. Methods Patients diagnosed with diabetes mellitus (DM) and DR were enrolled in the study group. Age- and sex-matched DM individuals without DR and patients without DM served as the DM control group and non-DM control group, respectively, both with 1:4 ratios. The outcome was set as the performance of cataract surgery. Cox proportional hazard regression was used to calculate the adjusted hazard ratio (aHR) of DR considering multiple factors underlying cataract formation. Results A total of 3297 DR patients, 13,188 DM control patients and 13,188 non-DM control subjects were enrolled. The study group included 919 events of sight-threatening cataracts (27.87%), the DM control group included 1108 events (8.40%), and the non-DM control group included 957 events (7.26%). A multivariable analysis indicated that the study group presented a higher aHR of cataract surgery (2.93, 95% CI: 2.60–3.30) and a higher cumulative probability of cataract surgery than both the DM control and non-DM control groups (both log rank P < 0.001). In addition, both the proliferative DR (3.90, 95% CI: 3.42–4.45) and nonproliferative DR (2.35, 95% CI: 2.08–2.65) subgroups showed a higher aHR of cataract surgery than the DM control group. Conclusion The presence of DR increases the risk of sight-threatening cataracts that warrant surgery, and the effect is prominent among patients with both proliferative DR and nonproliferative DR.

scholarly journals Apigenin ameliorates ocular surface lesions in a rat model of dry eye disease

2019 ◽  
Vol 17 ◽  
pp. 205873921881868
Author(s):  
Limei Liu ◽  
Dongdong Wei ◽  
Hongkun Xu ◽  
Changhui Liu
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Histopathological Examination ◽  
Tear Film ◽  
Interleukin 10 ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Necrosis Factor Alpha

To study the effects of apigenin on dry eye disease (DED) in rats. Rats were divided into six groups: (I) normal control group, (II) DED control group, (III) vehicle control group, (IV) DED + apigenin 10 mg/kg, (V) DED + apigenin 20 mg/kg, and (VI) DED + apigenin 50 mg/kg. Schirmer test, tear film break-up time (BUT), and corneal fluorescein staining were used to evaluate the effects of apigenin on the ocular surface. The related inflammatory cytokines were detected by enzyme-linked immunosorbent assay (ELISA). Histopathological examination and inflammatory index were also performed. The results showed that administration of apigenin was shown a significant effect on the recovery of ocular surface function. Compared to the control group, apigenin treatment in DED rats significantly decreased the level of the tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6); however, the interleukin-10 (IL-10) level was increased. Histopathological examination further verified the anti-inflammatory effects of apigenin on DED rats. The results demonstrated that apigenin could protect DED rats via inhibition of inflammation, suggesting that it may have potential as a therapy for DED.

Lack of social support and social trust as potential risk factors for dry eye disease: JPHC-NEXT study

2019 ◽  
Vol 17 (2) ◽  
pp. 278-284 ◽  
Author(s):  
Chi Hoang Viet Vu ◽  
Miki Uchino ◽  
Motoko Kawashima ◽  
Kenya Yuki ◽  
Kazuo Tsubota ◽  
...  
Keyword(s):  
Risk Factors ◽  
Social Support ◽  
Dry Eye ◽  
Potential Risk ◽  
Social Trust ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Potential Risk Factors

Incidence and risk factors of symptomatic dry eye disease in Asian Malays from the Singapore Malay Eye Study

2017 ◽  
Vol 15 (4) ◽  
pp. 742-748 ◽  
Author(s):  
Ryan E.K. Man ◽  
Anuradha R. Veerappan ◽  
Shu-Pei Tan ◽  
Eva K. Fenwick ◽  
Charumathi Sabanayagam ◽  
...  
Keyword(s):  
Risk Factors ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease

scholarly journals Corneal Nerve Regeneration after Self-Retained Cryopreserved Amniotic Membrane in Dry Eye Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Thomas John ◽  
Sean Tighe ◽  
Hosam Sheha ◽  
Pedram Hamrah ◽  
Zeina M. Salem ◽  
...  
Keyword(s):  
Nerve Regeneration ◽  
Dry Eye ◽  
Amniotic Membrane ◽  
Signs And Symptoms ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Study Group ◽  
Corneal Sensitivity ◽  
Corneal Nerve

Purpose. To evaluate the efficacy of self-retained cryopreserved amniotic membrane (CAM) in promoting corneal nerve regeneration and improving corneal sensitivity in dry eye disease (DED).Methods. In this prospective randomized clinical trial, subjects with DED were randomized to receive CAM (study group) or conventional maximum treatment (control). Changes in signs and symptoms, corneal sensitivity, topography, and in vivo confocal microscopy (IVCM) were evaluated at baseline, 1 month, and 3 months.Results. Twenty subjects (age 66.9 ± 8.9) were enrolled and 17 completed all follow-up visits. Signs and symptoms were significantly improved in the study group yet remained constant in the control. IVCM showed a significant increase in corneal nerve density in the study group (12,241 ± 5083 μm/mm2at baseline, 16,364 ± 3734 μm/mm2at 1 month, and 18,827 ± 5453 μm/mm2at 3 months,p=0.015) but was unchanged in the control. This improvement was accompanied with a significant increase in corneal sensitivity (3.25 ± 0.6 cm at baseline, 5.2 ± 0.5 cm at 1 month, and 5.6 ± 0.4 cm at 3 months,p<0.001) and corneal topography only in the study group.Conclusions. Self-retained CAM is a promising therapy for corneal nerve regeneration and accelerated recovery of the ocular surface health in patients with DED. The study is registered at clinicaltrials.gov with trial identifier:NCT02764814.

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