scholarly journals Decreased Bioelectrical Impedance Phase Angle in Hospitalized Children and Adolescents with Newly Diagnosed Type 1 Diabetes: A Case-Control Study

2018 ◽  
Vol 7 (12) ◽  
pp. 516 ◽  
Author(s):  
Paweł Więch ◽  
Dariusz Bazaliński ◽  
Izabela Sałacińska ◽  
Monika Binkowska-Bury ◽  
Bartosz Korczowski ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Pediatric Patients ◽  
Cell Mass ◽  
Bioelectrical Impedance ◽  
Case Control ◽  
Lower Percentage ◽  
Diabetic Patients ◽  
Body Cell Mass ◽  
Newly Diagnosed

The aim of this study was to assess the body composition and nutritional status of hospitalized pediatric patients with newly diagnosed type 1 diabetes by using bioelectrical impedance analysis (BIA) with phase angle (PA) calculation. PA is considered to be a useful and very sensitive indicator of the nutritional and functional status, and it has not yet been evaluated in such a population. Sixty-three pediatric patients aged 4 to 18 years, with newly diagnosed type 1 diabetes, were included in the study. The control group consisted of 63 healthy children and adolescents strictly matched by gender and age in a 1:1 case: control manner. In both groups, BIA with PA calculation was performed. Diabetic patients, in comparison to control subjects, had a highly significantly lower PA of 4.85 ± 0.86 vs. 5.62 ± 0.81, p < 0.001. They also demonstrated a lower percentage of body cell mass (BCM%), 46.89 ± 5.67% vs. 51.40 ± 4.19%, p < 0.001; a lower body cell mass index (BCMI), 6.57 ± 1.80% vs. 7.37 ± 1.72%, p = 0.004; and a lower percentage of muscle mass (MM%), 44.61 ± 6.58% vs. 49.40 ± 7.59%, p < 0.001, compared to non-diabetic controls. The significantly lower PA value in diabetic patients indicate their worse nutritional and functional status compared to healthy subjects. To assess the predictive and prognostic value of this finding in this population, further prospective studies involving larger sample of patients are required.

Decreased Bioelectrical Impedance Phase Angle in Children and Adolescents with Newly Diagnosed Type 1 Diabetes—A Case-Control Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2256-PUB
Author(s):  
PAWEł WIECH ◽  
DARIUSZ BAZALINSKI ◽  
MONIKA BINKOWSKA-BURY ◽  
BARTOSZ KORCZOWSKI ◽  
MARIUSZ DąBROWSKI
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Phase Angle ◽  
Case Control Study ◽  
Bioelectrical Impedance ◽  
Case Control ◽  
Newly Diagnosed ◽  
Control Study

scholarly journals Hemoglobin A1c Trajectory in Pediatric Patients with Newly Diagnosed Type 1 Diabetes

2019 ◽  
Vol 21 (8) ◽  
pp. 456-461 ◽  
Author(s):  
Priya Prahalad ◽  
Jaden Yang ◽  
David Scheinker ◽  
Manisha Desai ◽  
Korey Hood ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Hemoglobin A1c ◽  
Pediatric Patients ◽  
Newly Diagnosed

Diabetic euglycemic ketoacidosis in newly diagnosed type 1 diabetes mellitus during Ramadan fasting

2015 ◽  
Vol 28 (3-4) ◽  
Author(s):  
Veysel Nijat Baş ◽  
Salih Uytun ◽  
Yasemin Altuner Torun
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Glycogen Storage ◽  
Diabetic Patients ◽  
Newly Diagnosed ◽  
Ramadan Fasting ◽  
Glucose Levels ◽  
Glycogen Storage Diseases

AbstractReal euglycemic diabetic ketoacidosis [DKA; blood glucose <200 mg/dL (11.1 mmol/L)] is rare, and long-lasting starvation conditions due to intervening diseases in type 1 diabetes mellitus patients may also cause it. Euglycemic DKA is also reported in insulin-dependent diabetics with depression, alcoholics, glycogen storage diseases, and chronic liver disease apart from pregnant cases. This case report is presented to emphasize the importance of evaluation of acid-base state, urine glucose, and ketone values at the application in all newly diagnosed type 1 diabetic patients with normal glucose levels by defining euglycemic DKA that resulted from long-lasting starvation during Ramadan fasting in a newly diagnosed 14-year-old male patient.

Type 1 Diabetic Serum Interferes with Pancreatic β-cell Ca2+ -Handling

2007 ◽  
Vol 27 (6) ◽  
pp. 321-326 ◽  
Author(s):  
N. Dekki ◽  
R. Nilsson ◽  
S. Norgren ◽  
S. M. Rössner ◽  
I. Appelskog ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Ethnic Background ◽  
Diabetic Patients ◽  
Pancreatic Β Cell ◽  
Newly Diagnosed ◽  
Β Cells ◽  
Β Cell ◽  
First Degree Relatives ◽  
Type 1 Diabetic Patients

The aim of this study was to clarify the frequency of patients with type 1 diabetes that have serum that increases pancreatic β-cell cytoplasmic free Ca2+ concentration, [Ca2+]i, and if such an effect is also present in serum from first-degree relatives. We also studied a possible link between the serum effect and ethnic background as well as presence of autoantibodies. Sera obtained from three different countries were investigated as follows: 82 Swedish Caucasians with newly diagnosed type 1 diabetes, 56 Americans with different duration of type 1 diabetes, 117 American first-degree relatives of type 1 diabetic patients with a mixed ethnic background and 31 Caucasian Finnish children with newly diagnosed type 1 diabetes. Changes in [Ca2+]i, upon depolarization, were measured in β-cells incubated overnight with sera from type 1 diabetic patients, first-degree relatives or healthy controls. Our data show that there is a group constituting approximately 30% of type 1 diabetic patients of different gender, age, ethnic background and duration of the disease, as well as first-degree relatives of type 1 diabetic patients, that have sera that interfere with pancreatic β-cell Ca2+-handling. This effect on β-cell [Ca2+]i could not be correlated to the presence of autoantibodies. In a defined subgroup of patients with type 1 diabetes and first-degree relatives a defect Ca2+-handling may aggravate development of β-cell destruction.

Levels of soluble TREM-1 in children with newly diagnosed type 1 diabetes and their siblings without type 1 diabetes: a Danish case-control study

2016 ◽  
Vol 18 (8) ◽  
pp. 749-754 ◽  
Author(s):  
Steffen U. Thorsen ◽  
Christian B. Pipper ◽  
Henrik B. Mortensen ◽  
Kristin Skogstrand ◽  
Flemming Pociot ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Case Control Study ◽  
Case Control ◽  
Newly Diagnosed ◽  
Control Study

scholarly journals Association of Prodromal Type 1 Diabetes With School Absenteeism of Danish Schoolchildren: A Population-Based Case-Control Study of 1,338 Newly Diagnosed Children

Diabetes Care ◽  
2020 ◽  
Vol 43 (11) ◽  
pp. 2886-2888
Author(s):  
Peter R. Thingholm ◽  
Amanda Gaulke ◽  
Tine M. Eriksen ◽  
Jannet Svensson ◽  
Niels Skipper
Keyword(s):  
Type 1 Diabetes ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
School Absenteeism ◽  
Newly Diagnosed ◽  
Control Study

Gastrointestinal symptoms in pediatric patients with type 1 diabetes mellitus

2020 ◽  
Vol 33 (2) ◽  
pp. 185-190
Author(s):  
Suna Selbuz ◽  
Ayşe Derya Buluş
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Abdominal Pain ◽  
Glycemic Control ◽  
Type 1 Diabetes Mellitus ◽  
Pediatric Patients ◽  
Stool Examination ◽  
Diabetic Patients ◽  
Gi Symptoms

AbstractBackgroundVarious gastrointestinal (GI) symptoms are associated with diabetes. Common GI complaints associated with the manifestation of the disease include abdominal pain, diarrhea, nausea, bloating and vomiting. There have been very few studies examining GI problems of pediatric patients with type 1 diabetes mellitus (T1DM). The aims of this study were to find out the prevalence of GI symptoms in pediatric patients with T1DM and to determine the correlation among such symptoms, duration of diabetes and glycemic control.MethodsOne hundred and thirty-seven (median age 13.2 years, female 45.3%) patients with T1DM were examined. Demographic features, GI symptoms, signs and physical examination findings of the patients were recorded by pediatric gastroenterology specialists for the differential diagnosis and exclusion of other etiologies. Complete blood count, blood glucose, lipid profile, electrolytes, amylase, lipase, celiac antibodies and glycated hemoglobin (HbA1c) levels were evaluated and stool examination was performed. Endoscopy was performed on the patients who had refractory GI complaints. Gastric emptying (GE) time was evaluated using GE scintigraphy.ResultsOverall, 74 (54%) patients had ≥1 GI complaints. Patients often reported gastroesophageal reflux (32.8%) and abdominal pain (18%). The most significant findings in terms of GI symptoms were determined when patients were classified according to the glycemic control status. Reflux and dyspeptic symptoms were significantly more common in poorly or very poorly controlled diabetic patients (p=0.003 and p=0.004, respectively).ConclusionsDiabetes can affect the entire GI tract, and GI symptoms are common in pediatric patients. We recommend that T1DM patients be evaluated for GI symptoms.

scholarly journals 100 YEARS OF INSULIN: Arresting or curing type 1 diabetes: an elusive goal, but closing the gap

2021 ◽  
Vol 249 (2) ◽  
pp. T1-T11
Author(s):  
Pieter-Jan Martens ◽  
Conny Gysemans ◽  
Chantal Mathieu
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Adaptive Immune System ◽  
Future Research ◽  
Diabetic Patients ◽  
Technological Advances ◽  
Current Therapies

Type 1 diabetes is one of the most common chronic diseases in children and adolescents, but remains unpreventable and incurable. The discovery of insulin, already 100 years ago, embodied a lifesaver for people with type 1 diabetes as it allowed the replacement of all functions of the beta cell. Nevertheless, despite all technological advances, the majority of type 1 diabetic patients fail to reach the recommended target HbA1c levels. The disease-associated complications remain the true burden of affected individuals and necessitate the search for disease prevention and reversal. The recognition that type 1 diabetes is a heterogeneous disease with an etiology in which both the innate and adaptive immune system as well as the insulin-producing beta cells intimately interact, has fostered the idea that treatment to specific molecular or cellular characteristics of the patient groups will be needed. Moreover, robust and reliable biomarkers to detect type 1 diabetes in the early (pre-symptomatic) phases are wanted to preserve functional beta cell mass. The pitfalls of past therapeutics along with the perspectives of current therapies can open up the path for future research.

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