scholarly journals Omentin Is Independently Associated with Stroke Severity and Ipsilateral Carotid Artery Stenosis in Patients with Acute Cerebral Ischemia

2021 ◽  
Vol 10 (24) ◽  
pp. 5797
Author(s):  
Maria Chondrogianni ◽  
Vaia Lambadiari ◽  
Aristeidis H. Katsanos ◽  
Maria Ioanna Stefanou ◽  
Lina Palaiodimou ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Linear Regression ◽  
Carotid Stenosis ◽  
Clinical Characteristics ◽  
Regression Coefficient ◽  
Stroke Severity ◽  
Linear Regression Coefficient ◽  
Nihss Score ◽  
Acute Cerebral Ischemia ◽  
Ischemic Attack

Mounting evidence indicates an association between adipokines and inflammation-related atherosclerosis. Here, we sought to investigate the association of vaspin and omentin with clinical characteristics and outcomes of patients with acute cerebral ischemia (ACI). Consecutive ACI patients were evaluated within 24 h from symptom-onset. Stroke aetiology was classified using TOAST criteria. Adipokines were assayed using quantikine enzyme immunoassay commercially available kits. Stroke severity was assessed by NIHSS-score, and ipsilateral carotid stenosis (≥50% by NASCET criteria) by ultrasound and CT/MR angiography. Major cerebrovascular events were assessed at three months. We included 135 ACI patients (05 (78%) and 30 (22%) with acute ischemic stroke and transient ischemic attack, respectively; mean age ± SD: 59 ± 10 years; 68% men; median NIHSS-score: 3 (IQR:1–7)). Omentin was strongly correlated to admission stroke severity (Spearman rho coefficient: +0.303; p < 0.001). Patients with ipsilateral carotid stenosis had higher omentin levels compared to patients without stenosis (13.3 ± 8.9 ng/mL vs. 9.5 ± 5.5 ng/mL, p = 0.014). Increasing omentin levels were independently associated with higher stroke severity (linear regression coefficient = 0.290; 95%CI: 0.063–0.516; p = 0.002) and ipsilateral carotid stenosis (linear regression coefficient = 3.411; 95%CI: 0.194–6.628; p = 0.038). No association of vaspin with clinical characteristics and outcomes was found. Circulating omentin may represent a biomarker for the presence of atherosclerotic plaque, associated with higher stroke severity in ACI patients.

Abstract TMP90: Frequency and Risk Factors for Early Neurological Deterioration Among Hyperacute Cerebral Ischemia Patients Treated With and Without Thrombolysis

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Christa D Brown ◽  
Gilda Avila-Rinek ◽  
Nerses Sanossian ◽  
Sidney Starkman ◽  
Scott Hamilton ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cerebral Ischemia ◽  
Fold Increase ◽  
Information Criteria ◽  
Neurological Deterioration ◽  
Stroke Severity ◽  
Acute Cerebral Ischemia ◽  
Early Neurological Deterioration ◽  
Prior Stroke ◽  
Iv Tpa

Background: Early neurological deterioration (END) is a feared complication of acute cerebral ischemia. However, estimates of END frequency vary widely, rates have not been systematically examined in hyperacute patients presenting within the first 2h of onset, nor separately in patients treated with and without thrombolysis, and risk factors for END have not been well delineated. Methods: We analyzed patients with a final diagnosis of acute cerebral ischemia in the NIH FAST-MAG Phase 3 multicenter clinical trial. END was defined as worsening post-admission by ≥ 4 NIHSS points up to Day 4. We separately analyzed patients who did and did not receive IV tPA. Results: Among 1245 acute cerebral ischemia patients transported by EMS to 55 stroke centers, time from last known well (LKW) to ED arrival was median 59 mins (IQR 80-46), and 36.1% received IV tPA. Overall, 211 (16.9%) experienced END by Day 4, with a greater proportion of END in tPA than non-tPA patients (21.2% vs 14.5%, p=0.003). In multivariate analysis, from 26 candidate variables, among tPA recipients, independent predictors of END were: age (OR 1.03/year, 95%CI 1.01-1.05), diastolic BP (OR 1.01/mm Hg, 95%CI 1.00-1.03), prior stroke (OR 1.65, 95%CI 0.98-2.77), glucose (OR 11.06/10 fold increase, 95%CI 1.90-64.44), and worse ASPECTS score (OR 0.85/point, 95%CI 0.78-0.92). Among non-tPA recipients, independent predictors of END were: more severe NIHSS (OR 1.08/point, 95%CI 1.05-1.11), glucose (OR 8.88/10 fold increase, 95%CI 1.83-43.12), and h/o hypertension (OR 2.62/mm Hg, 95%CI 1.25-5.48), with Akaike information criteria identifying SBP, shorter LKW-to-ED time, and absence of anticoagulant agents as additional contributors. C statistics for these models were 0.68 for tPA patients and 0.73 for non-tPA patients. Conclusions: Among hyperacute cerebral ischemia patients, END occurs in 1 in 5 who receive tPA, and 1 in 7 who do not receive tPA. Greater initial stroke severity (on neurologic exam or imaging), higher glucose, and hypertension increase risk of END for both lytic and non-lytic patients, with older age and prior stroke additionally increasing END risk with tPA. Models based on these risk factors show fair to good performance identifying patients who will experience END after hospital admission.

scholarly journals The Acute Stroke or Transient Ischemic Attack Treated with Ticagrelor and Aspirin for Prevention of Stroke and Death (THALES) trial: Rationale and design

2019 ◽  
Vol 14 (7) ◽  
pp. 745-751 ◽  
Author(s):  
S Claiborne Johnston ◽  
Pierre Amarenco ◽  
Hans Denison ◽  
Scott R Evans ◽  
Anders Himmelmann ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Acute Stroke ◽  
Antiplatelet Therapy ◽  
Transient Ischemic Attack ◽  
Dual Antiplatelet Therapy ◽  
Bleeding Event ◽  
Severe Bleeding ◽  
Major Hemorrhage ◽  
Acute Cerebral Ischemia ◽  
Ischemic Attack

Rationale In patients with acute cerebral ischemia, the rate of stroke, myocardial infarction, or death during 90 days was reported to be non-significantly lower with ticagrelor compared with aspirin, with no increase in major hemorrhage. Dual antiplatelet therapy may be more effective in this setting. Aim To investigate whether ticagrelor combined with aspirin are superior to aspirin alone in preventing stroke or death in patients with non-severe, non-cardioembolic ischemic stroke or high-risk transient ischemic attack. Design The Acute Stroke or Transient Ischemic Attack Treated with Ticagrelor and Aspirin for Prevention of Stroke and Death (THALES) trial is a randomized, placebo-controlled, double-blind, event-driven study. Patients will be randomized within 24 h of onset of acute ischemic symptoms. THALES is expected to randomize 13,000 at ∼450 sites worldwide, to collect 764 primary outcome events. Study treatments are ticagrelor 180 mg loading dose on day 1, then 90 mg twice daily on days 2–30, or matching placebo. All patients will also receive open-label aspirin 300–325 mg on day 1, then 75–100 mg once daily on days 2–30. Study outcomes The primary efficacy outcome is time to the composite endpoint of stroke or death through 30-day follow-up. The primary safety outcome is time to first severe bleeding event. Discussion The THALES trial will provide important information about the benefits and risks of dual antiplatelet therapy with ticagrelor and aspirin in patients with acute cerebral ischemia in a global setting (funding: AstraZeneca). Clinical Trial Registration URL http://www.clinicaltrials.gov . Unique identifier: NCT03354429.

Mathematical coupling of data: correction of a common error for linear calculations

1986 ◽  
Vol 60 (1) ◽  
pp. 335-343 ◽  
Author(s):  
L. F. Moreno ◽  
H. H. Stratton ◽  
J. C. Newell ◽  
P. J. Feustel
Keyword(s):  
Linear Regression ◽  
Regression Coefficient ◽  
Pearson Correlation ◽  
Pearson Correlation Coefficient ◽  
Linear Regression Coefficient ◽  
Common Error ◽  
The Common ◽  
The Relationship ◽  
Scientific Environment ◽  
Mathematical Coupling

The need frequently arises in the scientific environment to investigate the relationship between quantities that are calculated from a common set of directly measured variables. However, the presence of error in the common set of measured variables distorts the relationship among the calculated quantities and can lead to incorrect conclusions. This article presents a method of correcting for such distortions in the Pearson correlation coefficient and in the linear regression coefficient for linear calculations involving two measured variables. The errors considered may be either independent of, or proportional to, the value of the variable being measured. Tests to determine whether these popular coefficients have values significantly different from zero are presented. An example from the physiology literature is presented to illustrate these techniques.

scholarly journals Estimation and comparison of conventional and genomic breeding values in Holstein cattle of Antioquia, Colombia

2015 ◽  
pp. 4739-4753 ◽  
Author(s):  
Juan Zambrano A ◽  
Juan Rincón F ◽  
Albeiro López H ◽  
Julián Echeverri Z
Keyword(s):  
Linear Regression ◽  
Milk Yield ◽  
Conventional Method ◽  
Regression Coefficient ◽  
Rank Correlation ◽  
Breeding Value ◽  
Fat Percentage ◽  
Linear Regression Coefficient ◽  
Genomic Breeding ◽  
Breeding Values

ABSTRACT Objetive. To estimate and compare breeding values (EBV) using the conventional method (BLUP) and genomic breeding values (MEBV and GEBV) estimated through bayes C method for milk yield and milk quality traits in dairy cattle in Antioquia, Colombia. Materials and methods. Two methods were used to estimate breeding values: BLUP to estimate conventional breeding value (EBV) and bayes C to estimate genomic values (MEBV and GEBV). The traits evaluated were: milk yield (PL), protein percentage (PPRO), fat percentage (PGRA) and score somatic cell (SCS). The methods (BLUP and bayes C) were compared using Person correlation (rp), Spearman rank correlation (rs) and linear regression coefficient (b). Results. The Pearson and Spearman correlations among EBVs and genomic values (MEBV and GEBV) (rpMEBV;EBV and rsGEBV;EBV) were greater than 0.93 and the linear regression coefficients of EBVs on genomic values (MEBV and GEBV) (bMEBV;EBV, and bGEBV;EBV) ranged between 0.954 and 1.051 in all traits evaluated. Conclusions. The predictions of genomic values (MEBV and GEBV), using bayes C method were consistent with the predictions of the EBVs estimate through the conventional method (BLUP) in conditions of high Colombian tropic, allowing to obtain high associations between the breeding values.

scholarly journals The Effect Of Non Performance Loan (Npl) And Loan Deposit Ratio (Ldr) On Return On Asset (Roa) In Pt. Bank Rakyat Indonesia (Persero), Tbk

2021 ◽  
Vol 2 (1) ◽  
pp. 83-96
Author(s):  
Agung Rahmat Ilahi ◽  
Karona Cahya Susena ◽  
Wagini Wagini
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Regression Coefficient ◽  
Financial Statements ◽  
Coefficient Of Determination ◽  
Linear Regression Equation ◽  
Linear Regression Coefficient ◽  
Return On Assets ◽  
Collection Method ◽  
Regression Test

The purpose of this study was to determine the effect of Non Performance Loans (NPL) and Loan Deposit Ratio (LDR) on Return on Assets (ROA) at PT. Bank Rakyat Indonesia (Persero), Tbk. The sample in this study is the financial statements at PT. Bank Rakyat Indonesia (Persero), Tbk for the period 2010 to 2019 The data collection method uses the documentation method. The data analysis used is multiple linear regression, coefficient From the calculation of the multiple linear regression equation, it can be seen  that the results of the regression test: Y = 14.944– 1.072 X1 - 0.099X2. The coefficient of determination obtained is 0.846. This means that X1 (Non Performance Loan (NPL)) and X2 (Loan Deposit Ratio (LDR)) have an effect on Return on Assets (ROA) (Y) by 84.6% while the rest (100% - 84.6% = 15.4%) is influenced by other variables not examined in this study. The results of the t test show that there is a significant effect between NPL and LDR on Return on Assets (ROA) (Y) at PT. Bank Rakyat Indonesia (Persero), Tbk partially or separately The results of the F test show that there is a significant influence between NPL and LDR on Return on Assets (ROA) (Y) at PT. Bank Rakyat Indonesia (Persero), Tbk simultaneously or collectively.of determination and hypothesis testing.

scholarly journals Analysis of Consumer Purchasing Decisions through Product Quality and Promotion on Pam Pam Fried Chicken Products in the District of Pamulang, South Tangerang City

2020 ◽  
Vol 10 (1) ◽  
pp. 91
Author(s):  
Udin Ahidin
Keyword(s):  
Linear Regression ◽  
Product Quality ◽  
Regression Coefficient ◽  
Hypothesis Test ◽  
Test Reliability ◽  
Coefficient Of Determination ◽  
Simple Linear Regression ◽  
Purchasing Decisions ◽  
Linear Regression Coefficient ◽  
Regression Test

This study is to determine the effect of product quality partially on consumer purchasing decisions on Pam Pam Fried Chicken in Pamulang Subdistrict Area, to determine the effect of partial promotion on consumer purchasing decisions on Pam Pam Fried Chicken in Pamulang Subdistrict Area, to determine the effect of product quality and promotion together with consumer purchasing decisions on Pam Pam Fried Chicken in the Pamulang District Area, and to find out the company's efforts to improve consumer purchasing decisions on Pam Pam Fried Chicken in the Pamulang District Region .Quantitative associative research methods with a verification approach. The population in this study Pam-Pam Fried Chicken consumers amounted to 7,108 consumers in the District of Pamulang, while the sample taken was 100 respondents using the slovin formula, then a proportional random sampling was done because the research object contained 4 (four) branches. Collecting observational data, questionnaires and literature studies. The data analysis method uses validity test, reliability test, classic assumption test, simple linear regression test, multiple linear regression test, correlation coefficient test (product moment), determination coefficient test, hypothesis test (t-test and f-test) . The results showed that there was a positive and significant effect between product quality partially on purchasing decisions. It can be seen from the simple linear regression coefficient of 0.65. The coefficient of determination is 0.6%, t count 2.719> t table 1.984. There is a positive and significant influence between promotion partially on purchasing decisions. It can be seen from the simple linear regression coefficient of 0.32. The coefficient value of determination is 0.2, t count 2.112> t table 1.984.

scholarly journals Two-Way Fixed Effects Estimators with Heterogeneous Treatment Effects

2020 ◽  
Vol 110 (9) ◽  
pp. 2964-2996 ◽  
Author(s):  
Clément de Chaisemartin ◽  
Xavier D’Haultfœuille
Keyword(s):  
Linear Regression ◽  
Fixed Effects ◽  
Treatment Effects ◽  
Regression Coefficient ◽  
Weighted Sums ◽  
Linear Regression Coefficient ◽  
Heterogeneous Treatment Effects ◽  
Average Treatment Effects ◽  
Linear Regression Estimator ◽  
Linear Regressions

Linear regressions with period and group fixed effects are widely used to estimate treatment effects. We show that they estimate weighted sums of the average treatment effects (ATE ) in each group and period, with weights that may be negative. Due to the negative weights, the linear regression coefficient may for instance be negative while all the ATEs are positive. We propose another estimator that solves this issue. In the two applications we revisit, it is significantly different from the linear regression estimator. (JEL C21, C23, D72, J31, J51, L82)

scholarly journals Pengaruh Kreativitas dan Inovasi terhadap Kinerja Karyawan pada PT. Tohpati Grafika Utama Denpasar

Widya Amrita ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 1-13
Author(s):  
I Komang Indrajita ◽  
A.A Ngr. Gede Sadiartha ◽  
I Gede Aryana Mahayasa
Keyword(s):  
Data Analysis ◽  
Linear Regression ◽  
Human Resources ◽  
Regression Coefficient ◽  
Employee Performance ◽  
Coefficient Of Determination ◽  
Company Performance ◽  
Linear Regression Coefficient ◽  
Analysis Techniques ◽  
Creativity And Innovation

Employee performance is needed by the company to improve company performance. Therefore, to make it happen, it requires skilled and reliable human resources in their fields. This study aims to determine the effect of creativity and innovation partially and simultaneously on the performance of employees of PT. Tohpati Grafika Utama Denpasar. This research was conducted at PT. Tohpati Grafika Utama Denpasar. The sample used is the employees of PT. Tohpati Grafika Utama as many as 40 respondents. The data analysis techniques used in this study were validity, reliability, classical assumptions, multiple linear regression, coefficient of determination, t-test, and F-test. The results of the analysis show that creativity and innovation have a positive and significant effect partially and simultaneously on the performance of the employees of PT. Tohpati Grafika Utama Denpasar.

scholarly journals AGE DISTRIBUTION OF WRESTLERS PARTICIPATING IN THE WORLD CHAMPIONSHIPS

2021 ◽  
pp. 138-143
Author(s):  
Mykola Latyshev ◽  
Victor Shandrygos ◽  
Yrui Tropin ◽  
Olena Polianychko ◽  
Alfiia Deineko ◽  
...  
Keyword(s):  
Linear Regression ◽  
Regression Coefficient ◽  
Age Distribution ◽  
Competitive Performance ◽  
Linear Regression Coefficient ◽  
Weight Group ◽  
The World ◽  
And Gender

The age of peak competitive performance is particularly important as the entire sports career in each sport is planned on its basis. Depending on the sport and gender of the athlete, the age of peak competitive performance varies considerably. The objective of the study - to determine the age indicators of the wrestlers who participated in the World Championships, depending on the place taken and the weight group. We have studied 332 sports careers of the freestyle and Greko-Roman male wrestlers from 1st to 8th ranks who participated in the World Championships 2017, 2018 and 2019. The following indicators are analyzed: the average age, the average age of the international career start, the average age of first success and the proportion of athletes who achieved success at junior level. Results. The average age of the wrestlers is 26.5 ± 3.6 years: the medalists are slightly younger – 26.3 ± 3.4 years, and non-medalists are older than 26.7 ± 3.8 years. The analysis of the distribution of the age of peak competitive performance of athletes-medalists has shown the following results: there are 67.7 % of medalist among the athletes who are 22-28 years old, 11.8% among those who are younger than 23 years old and only 26.6% among those who are older than 28 years. More than half (53.4%) of medalists achieved success being juniors, while for non-medalists this proportion is only 38.2%. The linear regression coefficient between the age and the weight of athletes is positive and is equal to 0.47 kg per year. The results obtained on the medalists show that the period for achieving the peak competitive performance is limited and quite a few athletes can succeed beyond a certain period of age.

Analysis of the association of MPO and MMP-9 with stroke severity and outcome

Neurology ◽  
2020 ◽  
Vol 95 (1) ◽  
pp. e97-e108 ◽  
Author(s):  
Ilaria Maestrini ◽  
Madjid Tagzirt ◽  
Sophie Gautier ◽  
Annabelle Dupont ◽  
Anne-Marie Mendyk ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Ex Vivo ◽  
Plasma Concentrations ◽  
Recombinant Tissue Plasminogen Activator ◽  
Hemorrhagic Transformation ◽  
Stroke Severity ◽  
Excellent Outcome ◽  
Symptomatic Intracerebral Hemorrhage ◽  
Acute Cerebral Ischemia ◽  
Neutrophil Degranulation

ObjectiveIn acute cerebral ischemia, circulating neutrophil count and neutrophil-to-lymphocyte ratio (NLR) are positively associated with stroke severity and worse outcomes. Mediators of this effect are unknown. We aimed to investigate (1) the relationship between plasma matrix metalloproteinase-9 (MMP-9) and myeloperoxidase (MPO) concentrations with stroke severity and outcome and (2) MMP-9 and MPO release after ex vivo stimulation of neutrophils by recombinant tissue plasminogen activator (rtPA).MethodsWe analyzed data collected in 255 patients with supratentorial cerebral infarcts recruited within 48 hours of symptoms onset irrespective of rtPA treatment. The endpoints were excellent outcome (modified Rankin Scale score 0–1), symptomatic intracerebral hemorrhage (European Cooperative Acute Stroke Study–II definition), and death at 3 months. The role of rtPA treatment on peripheral neutrophil degranulation was investigated in 18 patients within 4.5 hours and after 72 hours.ResultsNeutrophil counts, NLR, and MPO plasma concentrations, but not MMP-9, were positively correlated with stroke severity. Higher neutrophil counts and NLR were independently associated with worse outcomes and higher mortality rates at month 3. Higher MPO plasma concentrations, but not MMP-9, were associated with worse outcome. Neutrophil-derived MMP-9, after ex vivo rtPA stimulation, but not MPO, were higher after 72 hours in patients treated by IV rtPA but not associated with hemorrhagic transformation.ConclusionsNeutrophil counts, NLR, and MPO plasma concentrations are associated with worse outcome in patients with acute cerebral ischemia, in contrast to MMP-9. Further investigations are needed to deepen our knowledge on MPO’s role in the deleterious effect of neutrophils because it could represent a potential therapeutic target.

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