scholarly journals Portal Vein Thrombosis Is Associated with an Increased Incidence of Depression and Anxiety Disorders

2021 ◽  
Vol 10 (23) ◽  
pp. 5689
Author(s):  
Simon Johannes Gairing ◽  
Peter Robert Galle ◽  
Jörn M. Schattenberg ◽  
Karel Kostev ◽  
Christian Labenz
Keyword(s):  
Anxiety Disorders ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Cox Regression ◽  
Severe Disease ◽  
Well Being ◽  
Depression And Anxiety ◽  
Vein Thrombosis ◽  
The Impact ◽  
The Relationship

Portal vein thrombosis (PVT) is a severe disease that adversely affects patients’ well-being. Data on the influence of PVT on the occurrence of depression or anxiety disorders are lacking. This study aimed to explore the impact of PVT on the incidence of depression and anxiety disorders diagnoses in a large German primary care cohort over a ten-year period. Patients with PVT were matched to non-PVT individuals by age, sex, yearly consultation frequency, index year and comorbidities in a 1:5 ratio. The primary outcome of the study was the incidence of depression and anxiety disorders. The relationship between PVT and both depression and anxiety disorders was investigated using Cox regression models. We compared 547 patients with PVT with 2735 matched individuals without PVT. Within 5 years of the index date, 17.4% of patients with PVT and 9.3% of non-PVT individuals were diagnosed with depression (p < 0.001). Anxiety disorders were diagnosed in 5.5% and 3.0% of patients with PVT and non-PVT individuals, respectively (p = 0.002). On regression analyses, PVT was positively associated with incident depression (HR 2.01, 95% CI 1.53–2.64, p < 0.001) as well as anxiety disorders (HR 2.16, 95% CI 1.35–3.46, p = 0.001). Regarding depression, this association remained significant in women as well as in men. There was no association between PVT and the incidence of anxiety disorders in women. In conclusion, PVT is associated with the development of depression and anxiety disorders. However, further prospective studies are needed to confirm our findings before definitive recommendations can be made.

The impact of portal vein thrombosis on the prognosis and liver function of nonmalignant cirrhotic patients

2018 ◽  
Vol 53 (10-11) ◽  
pp. 1340-1346 ◽  
Author(s):  
Kei Endo ◽  
Takayoshi Oikawa ◽  
Keisuke Kakisaka ◽  
Akio Tamura ◽  
Shigeru Ehara ◽  
...  
Keyword(s):  
Liver Function ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Vein Thrombosis ◽  
Cirrhotic Patients ◽  
The Impact

scholarly journals Dynamic 4D-CT Angiography for Guiding Transarterial Chemoembolization: Impact on the Reduction of Contrast Material, Operator Radiation Exposure, Catheter Consumption, and Diagnostic Confidence

2018 ◽  
Vol 190 (06) ◽  
pp. 513-520
Author(s):  
Moritz Albrecht ◽  
Thomas Vogl ◽  
Julian Wichmann ◽  
Simon Martin ◽  
Jan-Erik Scholtz ◽  
...  
Keyword(s):  
Portal Vein ◽  
Contrast Media ◽  
Radiation Exposure ◽  
Portal Vein Thrombosis ◽  
Ct Angiography ◽  
Transarterial Chemoembolization ◽  
Contrast Material ◽  
Diagnostic Confidence ◽  
Vein Thrombosis ◽  
The Impact

Purpose This study was carried out to investigate the impact of abdominal dynamic four-dimensional CT angiography (4D-CTA) for guiding transarterial chemoembolization (TACE) on the amount of contrast material used, operator radiation exposure, catheter consumption, and diagnostic confidence. Materials and Methods Written consent was waived for this IRB-approved retrospective study. 29 patients (20 men; mean age: 65.7 ± 11.5 years) with malignant liver lesions underwent 4D-CTA, prior to initial TACE. Time-resolved volume-rendering technique (VRT), maximum-intensity projection (MIP), and multiplanar reconstruction (MPR) series were reconstructed, enabling a direct selective catheterization of the tumor-supplying artery without prior conventional digital subtraction angiography (DSA). 29 patients (16 men; mean age: 69.4 ± 13.9) who underwent traditional TACE served as the control group. The amount of administered contrast media, operator radiation exposure, and catheter consumption during TACE were compared. Two radiologists assessed diagnostic confidence in the exclusion of portal vein thrombosis. Results 4D-CTA TACE resulted in a significant reduction in the amount of contrast media used, compared to traditional TACE (–61.0 ml/ –66.3 % intra-arterial, –12.8 ml/ –13.8 % overall; P < 0.001). The dose-area product indicating operator radiation exposure during intervention was reduced by 50.5 % (P < 0.001), and 0.7 fewer catheters on average were used (P = 0.063), while 4D-CTA data was available to guide TACE. Diagnostic confidence in the exclusion of portal vein thrombosis was significantly enhanced by 4D-CTA, compared to traditional DSA images (scores, 3.9 and 2.4, respectively; P < 0.001). Conclusion Dynamic 4D-CTA enables TACE with a substantially reduced amount of contrast material, decreases operator radiation exposure, and increases diagnostic confidence in the exclusion of portal vein thrombosis. Key points  Citation Format

scholarly journals The Impact of Portal Vein Thrombosis on the Prognosis of Patients With Cirrhosis: A Retrospective Propensity-Score Matched Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Zhiji Chen ◽  
Tao Ran ◽  
Haiyan Cao ◽  
Feng Xu ◽  
Zhi-hang Zhou ◽  
...  
Keyword(s):  
Propensity Score ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Serum Sodium Level ◽  
Meld Score ◽  
Group 14 ◽  
Vein Thrombosis ◽  
Matched Study ◽  
The Impact

Objectives: To investigate the impact of portal vein thrombosis (PVT) on cirrhosis decompensation and survival of cirrhosis.Methods: In this retrospective observational study between January 2012 and August 2020, 117 patients with cirrhotic PVT and 125 patients with cirrhosis were included. Propensity score matching (PSM) was applied to reduce the bias. The clinical characteristics of non-tumoral PVT in cirrhosis and its influence on cirrhosis decompensation and survival were analyzed.Results: The median follow-up for the PVT group was 15 (8.0–23.0) months and for the non-thrombosis group 14 (8.0–23.5) months. The presence of PVT was related with esophageal varices, higher Child-Pugh score and MELD score (P &lt; 0.05). Most PVTs were partial (106/117). Non-occlusive PVT disappeared on later examinations in 32/106 patients (30.19%), of which six patients reappeared. All the 11 patients with occlusive PVT remained occlusive, among which five patients (45.45%) developed portal cavernoma. There was no significant correlation between PVT and decompensation or survival before or after PSM. Multivariate analysis identified only Child-Pugh score (HR = 2.210, 95% CI: 1.332–3.667) and serum sodium level (HR = 0.818, 95% CI: 0.717–0.933) as independent factors for death.Conclusion: Though PVT is associated with greater Child-Pugh score and MELD score, it has no significant impact on the progression of cirrhosis.

Non tumoral portal vein thrombosis during cirrhosis: Should anticoagulation be proposed?

2018 ◽  
Keyword(s):  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Anticoagulant Therapy ◽  
Control Group ◽  
Case Group ◽  
Early Introduction ◽  
Vein Thrombosis ◽  
History Of ◽  
One Year ◽  
The Impact

Background: Portal vein thrombosis (PVT) is considered as infrequent and pejorative event in cirrhosis. Up to date, many questions remain about therapeutic management. Aim: The objectives of this study were to assess the impact of the PVT on the progression of liver disease, to review the indications for anticoagulation and its repercussions. Materials and methods: A case-control study was conducted over a period of 12 years (2002-2013). It included 484 cases of cirrhosis. Among these patients, 41 had non tumoral portal vein thrombosis (case group). The control group included the remaining 443 patients. Results: In our study, there was no impact of PVT on the natural history of cirrhosis both in terms of complications or survival. Only the early introduction of anticoagulant therapy was associated with a re-permeabilization of portal vein at one year (OR1.6; 95% CI [1.10-2.01]). Prolonged anticoagulation was inversely correlated with recurrent PVT after treatment. However, obtaining a portal vein re-permeabilization was not correlated to a significant gain in terms of prevention of complication related to cirrhosis and survival. Conclusions: results suggest that portal vein thrombosis in patients with cirrhosis is not a formal indication for anticoagulant therapy. It should be reserved for candidates of liver transplantation, those with an extension of the PVT to mesenteric vessels or with severe prothrombotic status. Key words: portal vein thrombosis, cirrhosis, anticoagulation.

The Impact of Portal Vein Thrombosis on Liver Transplant Outcomes

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Michael D. Rizzari ◽  
Mohamed Safwan ◽  
Michael Sobolic ◽  
Toshihiro Kitajima ◽  
Kelly Collins ◽  
...  
Keyword(s):  
Portal Vein ◽  
Liver Transplant ◽  
Portal Vein Thrombosis ◽  
Transplant Outcomes ◽  
Vein Thrombosis ◽  
The Impact

923 THE IMPACT OF TREATMENT WITH ANTICOAGULATION FOR IN CIRRHOTIC PATIENTS DIAGNOSED WITH PORTAL VEIN THROMBOSIS AT TIME OF TRANS-JUGULAR INTRAHEPATIC PORTOSYSTEMIC STENT PLACEMENT

2020 ◽  
Vol 158 (6) ◽  
pp. S-1299
Author(s):  
Mohanad T. Al-Qaisi ◽  
Roy Bisht ◽  
Gurbir S. Sehmbey ◽  
Jenna E. Koblinski ◽  
Faruq Pradhan ◽  
...  
Keyword(s):  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Stent Placement ◽  
Vein Thrombosis ◽  
Cirrhotic Patients ◽  
The Impact

scholarly journals Folate levels in hepatocellular carcinoma patients with portal vein thrombosis

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Giulia Malaguarnera ◽  
Vito Emanuele Catania ◽  
Saverio Latteri ◽  
Antonio Maria Borzì ◽  
Gaetano Bertino ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Serum Folate ◽  
Red Cell ◽  
Patient Evaluation ◽  
Average Difference ◽  
Vein Thrombosis ◽  
And Control ◽  
The Relationship

Abstract Background Portal vein thrombosis (PVT) occurs frequently in hepatocellular carcinoma (HCC) and is often diagnosed in the course of a routine patient evaluation and surveillance for liver cancer. The purpose of this study is to investigate the relationship between folate status and portal vein thrombosis. Methods HCC with PVT patients were 78, HCC without PVT were 60 and control subjects were 70 randomly selected. We evaluate serum and red blood cellular folate, homocysteine, alpha fetal protein cholesterol, triglycerides, prothrombin time. Results HCC patients with PVT showed lower levels of serum folate, respect HCC patients without PVT, with an average difference of 1.6 nmol/l p < 0.01 (95% CI − 2.54 to − 0.66), red cell folate 33.6 nmol/l p < 0.001 (95% CI − 43.64 to − 23.55) and albumin 0.29 g/dl p < 0.001 (95% CI − 0.42 to − 0.15); PVT patients displayed higher levels of bilirubin 0.53 mg/dl p < 0.001 (95% CI 0.23 to 0.78), INR 0.91 p < 0.001 (95% CI 0.72 to 1.09), γGT 7.9 IU/l (95% CI 4.14 to 11.65) and homocysteine 4.6 μmol/l p < 0.05 (95% CI 0.32 to 8.87) Conclusion The low folate concentration and higher levels of homocysteine are associated with the loss of antithrombotic function, and with a more aggressive course of HCC and with a higher change of complications related to portal vein thrombosis

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