scholarly journals Management of Pleural Effusion Secondary to Malignant Mesothelioma

2021 ◽  
Vol 10 (18) ◽  
pp. 4247
Author(s):  
Valeria Musso ◽  
Cristina Diotti ◽  
Alessandro Palleschi ◽  
Davide Tosi ◽  
Alberto Aiolfi ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Occupational Exposure ◽  
Malignant Pleural Mesothelioma ◽  
Malignant Mesothelioma ◽  
Therapeutic Options ◽  
Pleural Mesothelioma ◽  
Common Cause ◽  
Comprehensive View ◽  
Clinical Challenge

Malignant pleural mesothelioma (MPM) is a highly aggressive pleural tumour which has been epidemiologically linked to occupational exposure to asbestos. MPM is often associated with pleural effusion, which is a common cause of morbidity and whose management remains a clinical challenge. In this review, we analysed the literature regarding the diagnosis and therapeutic options of pleural effusion secondary to mesothelioma. Our aim was to provide a comprehensive view on this subject, and a new algorithm was proposed as a practical aid to clinicians dealing with patients suffering from pleural effusion.

scholarly journals Multiplex Soluble Biomarker Analysis from Pleural Effusion

Biomolecules ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1113
Author(s):  
Joman Javadi ◽  
Katalin Dobra ◽  
Anders Hjerpe
Keyword(s):  
Pleural Effusion ◽  
Malignant Pleural Mesothelioma ◽  
Malignant Mesothelioma ◽  
Prognostic Markers ◽  
Pleural Cavity ◽  
Asbestos Exposure ◽  
Pleural Mesothelioma ◽  
Diagnostic Biomarkers ◽  
Biomarker Analysis ◽  
Angiopoietin 1

Malignant pleural mesothelioma (MPM) is a highly aggressive and therapy resistant pleural malignancy that is caused by asbestos exposure. MPM is associated with poor prognosis and a short patient survival. The survival time is strongly influenced by the subtype of the tumor. Dyspnea and accumulation of pleural effusion in the pleural cavity are common symptoms of MPM. The diagnostic distinction from other malignancies and reactive conditions is done using histopathology or cytopathology, always supported by immunohistochemistry, and sometimes also by analyses of soluble biomarkers in effusion supernatant. We evaluated the soluble angiogenesis related molecules as possible prognostic and diagnostic biomarkers for MPM by Luminex multiplex assay. Pleural effusion from 42 patients with malignant pleural mesothelioma (MPM), 36 patients with adenocarcinoma (AD) and 40 benign (BE) effusions were analyzed for 10 different analytes that, in previous studies, were associated with angiogenesis, consisting of Angiopoietin-1, HGF, MMP-7, Osteopontin, TIMP-1, Galectin, Mesothelin, NRG1-b1, Syndecan-1 (SDC-1) and VEGF by a Human Premixed Multi-Analyte Luminex kit. We found that shed SDC-1 and MMP-7 levels were significantly lower, whereas Mesothelin and Galectin-1 levels were significantly higher in malignant mesothelioma effusions, compared to adenocarcinoma. Galectin-1, HGF, Mesothelin, MMP-7, Osteopontin, shed SDC-1, NRG1-β1, VEGF and TIMP-1 were significantly higher in malignant pleural mesothelioma effusions compared to benign samples. Moreover, there is a negative correlation between Mesothelin and shed SDC-1 and positive correlation between VEGF, Angiopoietin-1 and shed SDC-1 level in the pleural effusion from malignant cases. Shed SDC-1 and VEGF have a prognostic value in malignant mesothelioma patients. Collectively, our data suggest that MMP-7, shed SDC-1, Mesothelin and Galectin-1 can be diagnostic and VEGF and SDC-1 prognostic markers in MPM patients. Additionally, Galectin-1, HGF, Mesothelin, MMP-7, Osteopontin, shed SDC-1 and TIMP-1 can be diagnostic for malignant cases.

scholarly journals Survival of Korean Patients with Malignant Pleural Mesothelioma Compensated for the Asbestos Injury Relief

2021 ◽  
Vol 11 (20) ◽  
pp. 9713
Author(s):  
Min-Sung Kang ◽  
Sung-Soo Lee ◽  
Soon-Chan Kwon ◽  
Da-An Huh ◽  
Yong-Jin Lee
Keyword(s):  
Prognostic Factors ◽  
Occupational Exposure ◽  
Malignant Pleural Mesothelioma ◽  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Performance Status ◽  
Smoking History ◽  
Pleural Mesothelioma ◽  
Histological Subtype ◽  
Epidemiologic Characteristics

Background: The purpose of this study was to identify the epidemiologic characteristics and prognostic factors for malignant pleural mesothelioma in Korea, which are currently insufficient. The data were derived from malignant mesothelioma patients who registered under the Asbestos Injury Relief Act; Methods: A total of 728 patients received compensation from the Asbestos Injury Relief Act due to malignant mesothelioma between 2011 and 2015. Of these, 313 patients (43.0%) with malignant pleural mesothelioma were included in the study. The study variables were sex (male, female), age at diagnosis (<59, 60–69, ≥70), smoking history (yes, no), surgery (yes, no), chemotherapy (yes, no), occupational exposure to asbestos (yes, no), and histological subtype (epithelioid, nonepithelioid); Results: Median survival of mesothelioma was 8.0 months (95% confidence interval: 6.2 to 9.8). The 1-year, 2-year, and 5-year survival rates (%) were 43.5%, 23.6%, and 12.5%, respectively. In multivariate analysis of Cox’s proportional hazards model; sex, age, smoking history, occupational asbestos exposure, and histological subtype were not significant prognostic factors, but surgery and chemotherapy combined was a significant predictor; Conclusions: Although the representativeness of these data is limited, our study estimates the epidemiologic characteristics of malignant pleural mesothelioma. Non-occupational exposure had a similar prognosis to occupational asbestos exposure, and there was no sex difference. In addition, it was found that receiving a combination of surgery and chemotherapy affects the survival rate, but there is a limitation in that factors such as performance status, comorbidities, and stage that contribute to survival are not considered.

scholarly journals A Case of Pulmonary Embolism with Sarcomatoid Malignant Pleural Mesothelioma with Long-Term Pleural Effusion

2021 ◽  
Vol Volume 14 ◽  
pp. 4231-4237
Author(s):  
Rumeng Gu ◽  
Luxi Jiang ◽  
Ting Duan ◽  
Chun Chen ◽  
Shengchang Wu ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Pleural Effusion ◽  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma

scholarly journals Pleural effusion TGF-beta is highly diagnostic and prognostic in malignant pleural mesothelioma

2019 ◽  
Vol 30 ◽  
pp. v750-v751
Author(s):  
P. Stockhammer ◽  
T. Ploenes ◽  
M. Schuler ◽  
S. Langer ◽  
C. Aigner ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma ◽  
Tgf Beta

scholarly journals Diagnostic value of soluble mesothelin-related peptides in pleural effusion for malignant pleural mesothelioma

Medicine ◽  
2019 ◽  
Vol 98 (14) ◽  
pp. e14979 ◽  
Author(s):  
Ruiyue Gao ◽  
Feng Wang ◽  
Zhen Wang ◽  
Yanbing Wu ◽  
Lili Xu ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Malignant Pleural Mesothelioma ◽  
Diagnostic Value ◽  
Pleural Mesothelioma

scholarly journals Mesothelium and Malignant Mesothelioma

2019 ◽  
Vol 7 (2) ◽  
pp. 7 ◽  
Author(s):  
Emilye Hiriart ◽  
Raymond Deepe ◽  
Andy Wessels
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Malignant Mesothelioma ◽  
Pleural Cavity ◽  
Pleural Mesothelioma ◽  
Primary Cancer ◽  
Epithelial Structure

The mesothelium is an epithelial structure derived from the embryonic mesoderm. It plays an important role in the development of a number of different organs, including the heart, lungs, and intestines. In this publication, we discuss aspects of the development of the mesothelium, where mesothelial structures can be found, and review molecular and cellular characteristics associated with the mesothelium. Furthermore, we discuss the involvement of the mesothelium in a number of disease conditions, in particular in the pathogenesis of mesotheliomas with an emphasis on malignant pleural mesothelioma (MPM)—a primary cancer developing in the pleural cavity.

scholarly journals Endoscopic diagnosis and management of pleural effusion in malignant pleural mesothelioma

2018 ◽  
Vol 10 (S2) ◽  
pp. S269-S275 ◽  
Author(s):  
Paolo Ceruti ◽  
Sara Lonni ◽  
Francesca Baglivo ◽  
Giampietro Marchetti
Keyword(s):  
Pleural Effusion ◽  
Malignant Pleural Mesothelioma ◽  
Endoscopic Diagnosis ◽  
Pleural Mesothelioma ◽  
Diagnosis And Management

scholarly journals Value of plasma and pleural effusion fibulin-3 levels in the diagnosis of malignant pleural mesothelioma effusions

2014 ◽  
Vol 63 (4) ◽  
pp. 883-888 ◽  
Author(s):  
Alaa eldin M. Elgazzar ◽  
Sameh Embarak ◽  
Ali M. Refat ◽  
Ahmed Bakry ◽  
Ahmed Mokhtar
Keyword(s):  
Pleural Effusion ◽  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma
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