scholarly journals The Assessment of Muscle Mass and Function in Patients with Long-Standing Rheumatoid Arthritis

2021 ◽  
Vol 10 (16) ◽  
pp. 3458
Author(s):  
Hye-Won Yun ◽  
Chun-Ja Kim ◽  
Ji-Won Kim ◽  
Hyoun-Ah Kim ◽  
Chang-Hee Suh ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Old Age ◽  
Muscle Mass ◽  
Tnf Inhibitors ◽  
Muscular Dysfunction ◽  
Low Body Mass Index ◽  
Low Bmi ◽  
Male Sex ◽  
And Function

Muscular dysfunction in rheumatoid arthritis (RA) can affect the quality of life and comorbidities. We enrolled 320 patients with RA, and evaluated their muscle mass, grip strength, and physical performance. Seven (2.2%) and 21 RA patients (6.6%) had sarcopenia, as defined by the European and Asian Working Group for Sarcopenia (EWGS and AWGS), respectively; 54 patients (16.9%) were determined to have low muscle mass with normal muscle function, as defined by the EWGS; 38 patients (11.9%) reported sarcopenia by SARC-F questionnaire. Male sex (odds ratio (OR) 140.65), low body mass index (BMI) (OR 0.41), and use of tumor necrosis factor (TNF) inhibitors (OR 4.84) were associated with a low muscle mass as defined by the EWGS, while male sex, old age, and low BMI were associated with sarcopenia as defined by the AWGS. Old age (OR 1.11), high BMI (OR 1.13), and a high Disease Activity Score 28 (OR 1.95) were associated with sarcopenia as reported on the SARC-F. Male, low BMI, and use of TNF inhibitors were associated with a low muscle mass, while male sex, old age, and low BMI were associated with sarcopenia in patients with long-standing RA.

scholarly journals POS0514 IMPORTANCE OF BODY MASS MEASUREMENT AND THE GRIP STRENGTH TEST TO PREDICT FALLS IN PATIENTS WITH RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 491.2-491
Author(s):  
M. Tada ◽  
Y. Yamada ◽  
K. Mandai ◽  
N. Hidaka
Keyword(s):  
Rheumatoid Arthritis ◽  
Survival Rate ◽  
Grip Strength ◽  
Muscle Mass ◽  
Curve Analysis ◽  
Roc Curve Analysis ◽  
Free Survival ◽  
Leg Muscle ◽  
And Function

Background:We previously reported that the prevalence of sarcopenia was 28% in patients with rheumatoid arthritis (RA) in a cohort study 1. RA patients have a high risk of falls and fractures 2. However, the predictors of falls and fractures in RA patients are not known.Objectives:Whether evaluation of muscle mass and function at baseline could predict falls and fractures during four-year follow-up was investigated.Methods:The four-year follow-up data from a prospective, observational study (CHIKARA study: Correlation researcH of sarcopenIa, sKeletal muscle and disease Activity in Rheumatoid Arthritis) were used. Muscle mass was measured by a body impedance analyzer, and leg muscle mass was calculated. The leg muscle score (max: 100, min: 0) reflected the ratio of leg muscle mass to overall weight. Grip strength as an indicator of muscle function was evaluated using a digital, hand-held, isokinetic dynamometer. The correlations between muscle mass or function and falls or fractures were analyzed by survival rates and Cox hazard ratios. Leg muscle mass and grip strength were investigated by receiver operating characteristic (ROC) curve analysis for correlations with falls or fractures.Results:A total of 100 RA patients (female: 78%, mean age: 66.1 years) were enrolled; 35 patients had falls, and 19 patients had fractures during the four-year follow-up. The leg muscle score, grip strength, age, and fractures at baseline were significantly correlated with falls. The cut-off values of the leg muscle score and grip strength were calculated to be 84.5 points (sensitivity: 0.79, specificity: 0.43) and 15.9 kg (sensitivity: 0.56, specificity: 0.70), respectively, by ROC curve analysis. The patients were divided into four groups by their leg muscle scores and grip strength; the numbers of falls and fractures are shown in Table 1 for each group. The fall-free survival rate was significantly lower in the group with low leg muscle score and low grip strength (35.3%) than in the other groups (P=0.002) (Figure 1). The hazard ratio for the both low group was significantly increased, 3.6-fold (95%CI: 1.1-11.5), compared to that in the both high group.Table 1.Numbers of falls and fractures by category of leg muscle score and grip strengthLG + GS+(n=34)LG - GS+(n=12)LG + GS-(n=37)LG - GS-(n=17)P value*Falls, N6515110.010Fractures, N34660.072LG+: leg muscle score >84.5 points, GS+: grip strength >15.9kg, LG-: leg muscle score ≤84.5 points, GS+: grip strength ≤15.9kg*: compared in four groups by Kruskal-Walls test.Figure 1.Fall-free survival rate in the four groupsConclusion:RA patients with both low leg muscle score and low grip strength at baseline were at high risk for falls during the four-year follow-up period. Evaluation of muscle mass and function can predict falls in RA patients.References:[1]Tada, M., Yamada, Y., Mandai, K. & Hidaka, N. Matrix metalloprotease 3 is associated with sarcopenia in rheumatoid arthritis - results from the CHIKARA study. Int J Rheum Dis21, 1962-1969, doi:10.1111/1756-185X.13335 (2018).[2]van Staa, T. P., Geusens, P., Bijlsma, J. W., Leufkens, H. G. & Cooper, C. Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis. Arthritis Rheum54, 3104-3112, doi:10.1002/art.22117 (2006).Disclosure of Interests:None declared

scholarly journals Association of Physical Activity, Muscle Mass, Strength, and Function to Quality of Life in Older Adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 185-186
Author(s):  
Murad Taani ◽  
Chi Cho ◽  
Julie Ellis
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Older Adults ◽  
Muscle Mass ◽  
Handgrip Strength ◽  
Community Dwelling ◽  
Steps Per Day ◽  
Mental Hrqol ◽  
And Function

Abstract Physical inactivity and loss of muscle mass, strength, and function are associated with negative outcomes including disability and a decline in health-related quality of life (HRQoL) among older adults. Older adults living in continuing care retirement communities (CCRCs) are at greater risk for declining physical activity and muscle outcomes compared to community-dwelling older adults. Few researchers studying the association of muscle and physical activity have examined the distinction between physical and mental HRQoL. Understanding the differential association of physical and mental HRQoL to physical activity and muscle outcomes can inform the development of useful interventions. The aim of this study was to examine the relationships between physical activity, muscle mass, strength, function and physical and mental HRQoL. Using a descriptive, correlational design, 105 older adults living in CCRCs were recruited. Light physical activity (LPA), moderate physical activity (MPA), sedentary behavior, and steps per day were assessed using ActiGraph GT3X. Appendicular skeletal muscle mass (ASMM) was assessed with bioelectrical impedance spectroscopy, handgrip strength with JAMAR Smart Hand Dynamometer, muscle function with the Short Physical Performance Battery (SPPB) test, and physical and mental HRQoL with the SF-36 questionnaire. The mean age of participants was 83 (SD=7.4). Using multiple regression models adjusted for sex and age, steps per day and SPPB score explained 38.4 % of the variance in physical HRQoL. Handgrip strength explained 8 % of the variance in mental HRQoL. These findings suggest that QoL improvement programs should include components to improve physical activity, muscle strength and function.

scholarly journals Myopenia and Musculoskeletal Aging in Rheumatoid Arthritis

2020 ◽  
Author(s):  
Dan Xu ◽  
Jiake Xu ◽  
Lei Dai
Keyword(s):  
Rheumatoid Arthritis ◽  
Muscle Function ◽  
Inflammatory Arthritis ◽  
Muscle Wasting ◽  
Management Strategies ◽  
Chronic Inflammatory Disease ◽  
Muscular Dysfunction ◽  
Younger Age ◽  
High Prevalence

Rheumatoid arthritis (RA), the commonest inflammatory arthritis, is a debilitating disease leading to decreased functional capacity, social disability and reduced quality of life. RA affects multisystems with chronic inflammatory disease characterized by destructive synovitis and muscular dysfunction leading to premature musculoskeletal aging, which has been coined with many terms including myopenia, sarcopenia, cachexia, muscle failure and muscle wasting. Myopenia is described as the presence of clinically relevant muscle wasting due to any illness at any age, associated with impaired muscle function, increased morbidity and mortality. RA myopenia has significantly less muscle mass compared to the general population muscle loss showing preservation or slight increase in fat mass. RA myopenia is unique compared to chronic disease-related myopenia in cancer, chronic heart failure, kidney disease and chronic infection as it is rarely accompanied by a net weight loss. RA myopenia has younger-age onset compared to elderly primary sarcopenia, while higher-grade inflammation has been considered as the pathophysiology of muscle wasting. Research, however, indicates that inflammation itself cannot fully explain the high prevalence of muscle wasting in RA. This chapter aims to review the literature on the casual relationships among RA myopenia, premature musculoskeletal aging and management strategies to delay musculoskeletal aging.

Patients with Rheumatoid Arthritis Are More Likely to Have Pain and Poor Function After Total Hip Replacements than Patients with Osteoarthritis

2014 ◽  
Vol 41 (9) ◽  
pp. 1774-1780 ◽  
Author(s):  
Susan M. Goodman ◽  
Danielle N. Ramsden-Stein ◽  
Wei-Ti Huang ◽  
Rebecca Zhu ◽  
Mark P. Figgie ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Womac Pain ◽  
Postoperative Function ◽  
Total Hip ◽  
Disease Modifying Therapy ◽  
Total Hip Replacements ◽  
Hip Replacements ◽  
Disease Modifying ◽  
And Function

Objective.Total hip replacement (THR) outcomes have been worse for patients with rheumatoid arthritis (RA) compared with those who have osteoarthritis (OA). Whether this remains true in contemporary patients with RA with a high use of disease-modifying and biologic therapy is unknown. The purpose of our study is to assess pain, function, and quality of life 2 years after primary THR, comparing patients with RA and patients with OA.Methods.Baseline and 2-year data were compared between validated patients with RA and patients with OA who were enrolled in a single-center THR registry between May 1, 2007, and February 25, 2011.Results.There were 5666 eligible primary THR identified, of which 193 were for RA. RA THR had worse baseline Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain (44.8 vs 53.2, p < 0.001) and function (38.7 vs 49.9, p < 0.001) compared with OA. These differences remained after surgery: pain (88.4 vs 94.0, p < 0.001) and function (82.9 vs 91.8, p < 0.001). Patients with RA were as likely to have a significant improvement as patients with OA (Δ WOMAC > 10) in pain (94% vs 96%, p = 0.35) and function (95% vs 94%, p = 0.69), but were 4 times as likely to have worse function (WOMAC ≤ 60; 19% vs 4%, p < 0.001) and pain (12% vs 3%, p < 0.001). In multivariate logistic regression controlling for multiple potential confounders, RA increased the odds of poor postoperative function (OR 4.32, 95% CI 1.57–11.9), and in patients without a previous primary THR, worse postoperative pain (OR 3.17, 95% CI 1.06–9.53).Conclusion.Contemporary patients with RA have significant improvements in pain and function after THR, but higher proportions have worse 2-year pain and function. In addition, RA is an independent predictor of 2-year pain and poor function after THR, despite high use of disease-modifying therapy.

Low body mass index is associated with impaired quality of life in patients with rheumatoid arthritis

2013 ◽  
Vol 16 (3) ◽  
pp. 297-302 ◽  
Author(s):  
Wataru Fukuda ◽  
Atsushi Omoto ◽  
Tamaki Ohta ◽  
Saori Majima ◽  
Toshihiro Kimura ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Body Mass Index ◽  
Body Mass ◽  
Low Body Mass Index ◽  
Impaired Quality

Sarcopenia

2017 ◽  
pp. 421-428
Author(s):  
Luis Miguel F. Gutiérrez Robledo ◽  
Mario Ulises Pérez-Zepeda
Keyword(s):  
Muscle Mass ◽  
Physical Performance ◽  
Protein Supplementation ◽  
High Quality Protein ◽  
Vitamin D Levels ◽  
Reduce Risk ◽  
Performance Ability ◽  
25 Oh Vitamin D ◽  
And Function

Sarcopenia is a muscle wasting condition that develops gradually during ageing and results in a loss of muscle mass and strength, leading to impairment in physical performance ability with loss of mobility and function, falls, and mortality. Diagnostic criteria include measurements of physical performance, muscle strength, and body composition. Sarcopenia is a treatable malady of ageing. It is clear that both aerobic and resistance exercise can improve muscle function. Furthermore, there is increasing evidence that high-quality protein supplementation can enhance muscle mass and function. Also, low 25(OH) vitamin D levels requires replacement therapy. Aside from exercise and nutritional supplementation, the pharmaceutical approach to sarcopenia is still under development. A specific well-directed programme of lifelong training could preserve body balance, muscle structure, and contractile properties up to old age, which in turn would improve quality of life and reduce risk of undue functional impairment.

Quality of Life of Patients With Rheumatoid Arthritis Undergoing Out-Patient Treatment With TNF Inhibitors

2008 ◽  
Vol 32 (3) ◽  
pp. 178-181
Author(s):  
L.C. Fernández Lisón ◽  
B. Vázquez Domínguez ◽  
J. Luis Fernández ◽  
P. Moreno Álvarez ◽  
I. Fruns Giménez ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Tnf Inhibitors ◽  
Patient Treatment
Sign in / Sign up

Export Citation Format

Share Document