scholarly journals Ocular Comorbidities in Rosacea: A Case-Control Study Based on Seven Institutions

2021 ◽  
Vol 10 (13) ◽  
pp. 2897
Author(s):  
Yu Ri Woo ◽  
Minah Cho ◽  
Hyun Jeong Ju ◽  
Jung Min Bae ◽  
Sang Hyun Cho ◽  
...  
Keyword(s):  
Dry Eye ◽  
Case Control Study ◽  
Matched Control ◽  
Case Control ◽  
Dry Eye Syndrome ◽  
Data Set ◽  
Ocular Symptoms ◽  
Inflammatory Dermatosis ◽  
Control Study ◽  
Surface Changes

Rosacea is a facial inflammatory dermatosis that is linked with various systemic illnesses. With regards to the eye, rosacea patients have been described to manifest ocular surface changes, such as blepharitis and conjunctivitis. However, studies that examine the association of rosacea with a wider array of ocular diseases are limited. Thus, our aim was to identify the range of ocular comorbidities in the Korean patient population and create a reference data set. A multi-institutional, case-control study was conducted, where 12,936 rosacea patients and an equal number of sex- and age-matched control subjects were extracted over a 12-year period. We were able to discover a notable association between rosacea and blepharitis (adjusted odds ratio (aOR) 3.44; 95% confidence interval, 2.71–4.36, p < 0.001), conjunctivitis (aOR 1.65; 95% CI, 1.50–1.82, p < 0.001), glaucoma (aOR 1.93; 95% CI, 1.70–2.20, p < 0.001), dry eye syndrome (aOR 1.89; 95% CI, 1.70–2.09, p < 0.001), and chalazion (aOR 3.26; 95% CI, 1.41–7.57, p = 0.006) from logistic regression analysis. Female subjects and individuals younger than 50 exclusively showed higher odds for chalazion. Our study suggests that ocular comorbidities (i.e., glaucoma, dry eye syndrome, and chalazion as well as blepharitis and conjunctivitis) are more prevalent among Koreans with rosacea. Clinicians should proactively check ocular symptoms in rosacea and employ joint care with an ophthalmologist in cases of need.

scholarly journals Herpes Zoster Does Not Increase the Risk of Neurodegenerative Dementia: A Case-Control Study

2021 ◽  
Vol 36 ◽  
pp. 153331752110065
Author(s):  
Hyo Geun Choi ◽  
Bum Jung Park ◽  
Jae Sung Lim ◽  
Song Yong Sim ◽  
Yoon Jung Jung ◽  
...  
Keyword(s):  
Herpes Zoster ◽  
Case Control Study ◽  
Matched Control ◽  
National Sample ◽  
Case Control ◽  
Herpes Zoster Infection ◽  
Neurodegenerative Dementia ◽  
National Cohort ◽  
Korean National Health Insurance ◽  
Control Study

Objective: This study was conducted to evaluate the association between neurodegenerative dementia and herpes zoster infection (HZI) using a national sample cohort. Methods: From the national cohort study conducted by the Korean National Health Insurance Service, we extracted data for patients with neurodegenerative dementia and for 1:4 matched control participants and searched the patient histories for HZI. Results: The adjusted odds ratio (OR) for HZI was 0.90 (95% CI = 0.84-0.97) in the dementia group. According to the subgroup analysis, the adjusted OR for HZI was 0.91 (95% confidence interval [CI] = 0.83 -1.00) in the < 80 years old group, 0.88 (95% CI = 0.78 -1.00) in the ≥ 80 years old group, 0.77 (95% CI = 0.66-0.89) in men and 0.96 (95% CI = 0.88 -1.05) in women. Conclusions: We concluded that HZI does not increase the risk of neurodegenerative dementia in individuals of any age or of either sex.

scholarly journals Mental Health Status in Dry Eye Disease – a Case Control Study

2018 ◽  
Vol 12 (1) ◽  
pp. 56 ◽  
Author(s):  
Luxmi Singh ◽  
Vijay Pratap Singh ◽  
Swati Yadav ◽  
Pragati Garg ◽  
◽  
...  
Keyword(s):  
Mental Health ◽  
Health Status ◽  
Dry Eye ◽  
Case Control Study ◽  
Case Control ◽  
Dry Eye Disease ◽  
Mental Health Status ◽  
Eye Disease ◽  
Control Study

scholarly journals Case Control Study of Cerebrovascular Damage Defined by Magnetic Resonance Imaging in Patients with OSA and Normal Matched Control Subjects

SLEEP ◽  
2001 ◽  
Vol 24 (6) ◽  
pp. 715-720 ◽  
Author(s):  
Christopher W.H. Davies ◽  
Joy H. Crosby ◽  
Rebecca L. Mullins ◽  
Zoë C. Traill ◽  
Philip Anslow ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Case Control Study ◽  
Matched Control ◽  
Case Control ◽  
Resonance Imaging ◽  
Control Subjects ◽  
Control Study

scholarly journals Is Gout Associated with Pyoderma Gangrenosum? A Population-Based Case-Control Study

2020 ◽  
Vol 9 (6) ◽  
pp. 1626 ◽  
Author(s):  
Khalaf Kridin ◽  
Ralf J. Ludwig ◽  
Dana Tzur Bitan ◽  
Mouhammad Kridin ◽  
Giovanni Damiani ◽  
...  
Keyword(s):  
Pyoderma Gangrenosum ◽  
Regression Models ◽  
Case Control Study ◽  
Matched Control ◽  
Population Based ◽  
Case Control ◽  
Significant Independent Predictor ◽  
Logistic Regression Models ◽  
Control Subjects ◽  
Control Study

The coexistence of pyoderma gangrenosum (PG) and gout has been reported in individual patients; however, the association between these conditions has not been investigated. We aimed to assess the association between PG and gout and to examine whether the presence of gout predisposes to the development of PG. A population-based case-control study was conducted comparing PG patients (n = 302) with age-, sex-, and ethnicity-matched control subjects (n = 1497) with respect to the presence of preceding gout. Logistic regression models were utilized for univariate and multivariate analyses. The prevalence of preceding gout was greater in patients with PG than in control subjects (3.7% vs. 0.7%, respectively; p < 0.001). Gout was associated with a more than fivefold increase in the risk of PG (OR, 5.15; 95% CI, 2.21–11.98). After adjusting for confounding factors, gout emerged as a significant independent predictor of PG (adjusted OR, 4.08; 95% CI, 1.69–9.80). Gout preceded the diagnosis of PG by a median latency of 4.6 years. Patients with gout-associated PG were older, predominantly male, and had a higher prevalence of metabolic syndrome than other patients with PG. In conclusion, gout increases the risk of developing PG by more than fivefold. Physicians managing patients with gout and PG should be aware of this emerging association.

Migraine and Left-Handedness are not Associated. A New Case—Control Study and Meta-Analysis

Cephalalgia ◽  
2008 ◽  
Vol 28 (5) ◽  
pp. 553-557 ◽  
Author(s):  
K Biehl ◽  
A Frese ◽  
M Marziniak ◽  
I-W Husstedt ◽  
S Evers
Keyword(s):  
Diagnostic Criteria ◽  
Case Control Study ◽  
Matched Control ◽  
International Headache Society ◽  
Meta Analysis ◽  
Case Control ◽  
Left Handedness ◽  
Significant Difference ◽  
Control Study ◽  
Age And Sex

To investigate the possible association between migraine and left-handedness, we enrolled 100 patients with a diagnosis of migraine according to the International Headache Society diagnostic criteria and 100 age- and sex-matched control subjects into a case—control study. Handedness was determined by the Edinburgh Handedness Inventory. There was no significant difference in the frequency or grade of left-handedness between the two groups. Additionally, we pooled our data with those from five similar studies, which did not alter the result. Thus, neither our study nor the meta-analysis support Geschwind and Behan's hypothesis of an association between migraine and left-handedness.

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