scholarly journals Zinc Administration and Improved Serum Markers of Hepatic Fibrosis in Patients with Autoimmune Hepatitis

2021 ◽  
Vol 10 (11) ◽  
pp. 2465
Author(s):  
Kei Moriya ◽  
Norihisa Nishimura ◽  
Tadashi Namisaki ◽  
Hiroaki Takaya ◽  
Yasuhiko Sawada ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Serum Markers ◽  
Term Treatment ◽  
Regular Treatment ◽  
Procollagen Type ◽  
Long Term Treatment ◽  
Significant Difference ◽  
Molecularly Targeted Agents ◽  
Before And After

Aim: The aim of the present study is to investigate the effect of long-term zinc supplementation, which is important for the activation of various enzymes that contribute to antioxidant and antifibrotic activities, on the improvement of serum fibrotic markers in patients with autoimmune hepatitis (AIH). Methods: A total of 38 patients with AIH under regular treatment at our hospital who provided their consent for being treated with polaprezinc (75 mg twice daily) were included and classified into 2 groups: the patients with zinc elevation (n = 27) and the patients without zinc elevation (n = 11). Serum biomarker of fibrosis, protein expression levels of matrix metalloproteinases (MMPs), and their inhibitors (TIMPs) were evaluated. Results: A significant difference was found between the variability of serum procollagen type Ⅲ and collagen type Ⅳ-7S between the 2 groups before and after zinc administration for more than 24 months (p = 0.043 and p = 0.049). In the patients with zinc elevation, no significant changes were found in collagenase (MMP-1 and MMP-13) before and after zinc administration, whereas a significant increase in the expression of gelatinase (MMP-2 and MMP-9) was found after administration (p = 0.021 and p = 0.005). As for the relative ratio of MMPs to TIMPs, only MMP-9 to TIMP-1 showed a significant increase (p = 0.004). Conclusions: Long-term treatment with polaprezinc has been demonstrated to safely improve serum fibrosis indices through increases in MMP-2/-9 and MMP-9/TIMP-1 and is expected to be well combined with direct antifibrotic therapies such as molecularly targeted agents.

Long-term treatment reduction and steroids withdrawal in children with autoimmune hepatitis: a single centre experience on 55 children

2009 ◽  
Vol 21 (12) ◽  
pp. 1413-1418 ◽  
Author(s):  
Jérôme Dumortier ◽  
Carlos Torres Arita ◽  
Christine Rivet ◽  
Catherine LeGall ◽  
Raymonde Bouvier ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Hepatitis A ◽  
Term Treatment ◽  
Single Centre ◽  
Single Centre Experience ◽  
Long Term Treatment

Evaluation of antidiuretic hormone before and after long-term treatment with desmopressin in a group of enuretic children

1998 ◽  
Vol 81 (s3) ◽  
pp. 53-55 ◽  
Author(s):  
M.L. Chiozza ◽  
M. Plebani ◽  
C. Scaccianoce ◽  
M. Biraghi ◽  
G. Zacchello
Keyword(s):  
Antidiuretic Hormone ◽  
Term Treatment ◽  
Long Term Treatment ◽  
Before And After

scholarly journals Administration of ziprasidone for 10 days increases cocaine toxicity in mice

2008 ◽  
Vol 27 (6) ◽  
pp. 499-503 ◽  
Author(s):  
K Heard ◽  
S Krier ◽  
NR Zahniser
Keyword(s):  
Atypical Antipsychotic ◽  
Term Treatment ◽  
Toxic Effects ◽  
Neurotransmitter Receptors ◽  
Control Group ◽  
Long Term Treatment ◽  
Significant Difference ◽  
Group Survival ◽  
Cocaine Toxicity

Long-term treatment with antipsychotic medications alters the regional density of several of the neurotransmitter receptors that mediate cocaine toxicity. However, the effect of either up- or down-regulation of the neurotransmitter receptors on cocaine toxicity is unknown. In this study, we determined if subacute administration of the atypical antipsychotic ziprasidone altered the toxic effects of cocaine in mice. Ziprasidone (4 mg/kg) or placebo was administered to the first two groups of CF-1 mice for 10 days and, then on day 10, an estimated LD50 dose of cocaine (102 mg/kg) was given to these mice. In a third group, in order to produce a ziprasidone withdrawal state, we administered ziprasidone for 10 days, followed by no treatment for 2 days before cocaine administration. There was no significant difference among the three groups in overall survival: 63% in the treatment group, 60% in the withdrawal group, and 80% in the placebo group. Survival time was significantly shorter for the withdrawal group than for the control group. Our study may have been limited by lower than expected serum ziprasidone concentrations and lower than expected lethality from cocaine. However, our findings suggest that administration of an atypical antipsychotic for 10 days may increase the toxic effects of cocaine.

scholarly journals Bone histomorphometry before and after long-term treatment with cinacalcet in dialysis patients with secondary hyperparathyroidism

2015 ◽  
Vol 87 (4) ◽  
pp. 846-856 ◽  
Author(s):  
Geert J. Behets ◽  
Goce Spasovski ◽  
Lulu R. Sterling ◽  
William G. Goodman ◽  
David M. Spiegel ◽  
...  
Keyword(s):  
Secondary Hyperparathyroidism ◽  
Bone Histomorphometry ◽  
Term Treatment ◽  
Dialysis Patients ◽  
Long Term Treatment ◽  
Before And After

Relationship Among Serum and Urine Neopterin, Fibrinogen, and Other Serum Analytes in Atherosclerotic Patients and the Long-term Effect of H.E.L.P. Therapy

Pteridines ◽  
1999 ◽  
Vol 10 (4) ◽  
pp. 190-196
Author(s):  
Karoline Vrecko ◽  
Manfred Walz ◽  
Erwin Tafeit ◽  
G. Reibnegger
Keyword(s):  
Term Treatment ◽  
Term Effect ◽  
Long Term Effect ◽  
Long Term Treatment ◽  
Cellular Immune System ◽  
Before And After ◽  
Immune Activation Marker ◽  
Cellular Immune ◽  
Serum And Urine

Summary In 30 atherosclerotic patients different serum analytes and neopterin concentrations in serum and urine were determined before and after Heparin-Induced Extracorporeal LDL and Fibrinogen Precipitation therapy. Neopterin concentrations in serum of all 30 patients were increased (mean=9.18 nmol/l, SD=3.23) compared to age matched healthy people (mean=5.34 nmol/l, SD=2.70) and were significantly lowered after H.E.L.P therapy (mean=S.22 nmol/l; SD=3.22, p=0.002, t-test) . These results suggest the involvement of the cellular immune system in the occurrence of atherosclerosis. Further neopterin, the macrophagederived immune activation marker, is significantly correlated with fibrinogen (linear correlation coefficient r=0.36, p=0.05). Long-term neopterin concentrations in serum of 4 patients (three with coronary heart disease and one with Papilla edema), from the first up to the 9th, respectively 12th therapy decreased, in contrast to fibrinogen which stayed stable or even increased during long-term treatment.

scholarly journals Predictability decomposition detects the impairment of brain–heart dynamical networks during sleep disorders and their recovery with treatment

2016 ◽  
Vol 374 (2067) ◽  
pp. 20150177 ◽  
Author(s):  
Luca Faes ◽  
Daniele Marinazzo ◽  
Sebastiano Stramaglia ◽  
Fabrice Jurysta ◽  
Alberto Porta ◽  
...  
Keyword(s):  
Sleep Disorders ◽  
Linear Models ◽  
Sleep Apnoea ◽  
Term Treatment ◽  
Long Term Treatment ◽  
Before And After ◽  
Multivariate Linear Models ◽  
Predictability Analysis ◽  
Physiological Complexity

This work introduces a framework to study the network formed by the autonomic component of heart rate variability (cardiac process η ) and the amplitude of the different electroencephalographic waves (brain processes δ , θ , α , σ , β ) during sleep. The framework exploits multivariate linear models to decompose the predictability of any given target process into measures of self-, causal and interaction predictability reflecting respectively the information retained in the process and related to its physiological complexity, the information transferred from the other source processes, and the information modified during the transfer according to redundant or synergistic interaction between the sources. The framework is here applied to the η , δ , θ , α , σ , β time series measured from the sleep recordings of eight severe sleep apnoea–hypopnoea syndrome (SAHS) patients studied before and after long-term treatment with continuous positive airway pressure (CPAP) therapy, and 14 healthy controls. Results show that the full and self-predictability of η , δ and θ decreased significantly in SAHS compared with controls, and were restored with CPAP for δ and θ but not for η . The causal predictability of η and δ occurred through significantly redundant source interaction during healthy sleep, which was lost in SAHS and recovered after CPAP. These results indicate that predictability analysis is a viable tool to assess the modifications of complexity and causality of the cerebral and cardiac processes induced by sleep disorders, and to monitor the restoration of the neuroautonomic control of these processes during long-term treatment.

scholarly journals The voiding dysfunctions in patients with non-Hunner-type interstitial cystitis/bladder pain syndrome do not affect long-term treatment outcome

2021 ◽  
Author(s):  
Wan-Ru Yu ◽  
Wei-Chuan Chang ◽  
Hann-Chorng Kuo
Keyword(s):  
Treatment Outcome ◽  
Interstitial Cystitis ◽  
Pain Syndrome ◽  
Bladder Pain Syndrome ◽  
Term Treatment ◽  
Bladder Pain ◽  
Long Term Treatment ◽  
Significant Difference ◽  
Voiding Dysfunctions

Aims: The role of urodynamic studies in the diagnosis and prognosis of interstitial cystitis/bladder pain syndrome (IC/BPS) remains controversial. We evaluated the correlation of baseline voiding dysfunctions with long-term treatment outcome in a large cohort of patients with IC/BPS. Methods: We studied 211 patients with nonulcerative IC/BPS. All patients underwent video urodynamic examination at baseline to identify their voiding conditions and they received subsequent treatments. The primary endpoint was the global response assessment (GRA) at the current interview. Secondary endpoints included O’Leary-Sant score (OSS), Visual Analog Scale (VAS) for pain, and the rate of IC symptom flare-up. Results: Mean patient age was 56.8 ± 12.8 years and mean IC symptom duration was 16.0 ± 9.9 years. At baseline, 83 (39.3%) patients had a voiding problem and 62.7% had one to three comorbidities. The duration, comorbidity, treatments, changes in OSS and VAS, maximum bladder capacity (MBC), glomerulations, GRA, and flare-up rate were not significantly different among the different voiding subtypes. When we divided the patients by their voiding conditions of normal (n = 32) and hypersensitive bladder with (n = 76) and without (n = 103) voiding dysfunctions, only MBC (P = 0.002) and glomerulation (P = 0.021) demonstrated a significant difference. When we analyzed subgroups by GRA, patients with a GRA ≥ 2 had a significantly shorter disease duration. There also were significant associations between GRA and the changes in OSS and VAS (P < 0.001). Conclusions: Voiding dysfunctions in patients with non-Hunner IC/BPS do not affect long-term treatment outcome.

scholarly journals Oxaliplatin for Metastatic Colon Cancer in a Patient with Renal Failure

2008 ◽  
Vol 2 ◽  
pp. CMO.S412
Author(s):  
Kenji Katsumata ◽  
Tetsuo Sumi ◽  
Tatehiko Wada ◽  
Yasuharu Mori ◽  
Masayuki Hisada ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Renal Failure ◽  
Term Treatment ◽  
Pharmacokinetic Data ◽  
Metastatic Colon Cancer ◽  
Standard Regimen ◽  
Long Term Treatment ◽  
Before And After ◽  
Cecal Cancer

Objective Oxaliplatin, a key part of the standard regimen for colorectal cancer in Western countries, has become available in Japan. In a hemodialysis patient with cecal cancer, we investigated the efficacy, safety, pharmacokinetics, and dialysability of oxaliplatin. Methods A 65-year-old man who had cecal cancer was treated with oxaliplatin (40 mg/m2) and l-leucovorin(l-LV) (200 mg/m2), which were administered simultaneously over 120 min via the side and main arms of a Y-tube, respectively. Then 5-FU (400 mg/m2) was administered rapidly via the side tube, followed by 5-FU (2,000 mg/m2) over 46 hours via the main tube. The patient had chronic renal failure due to diabetic nephropathy and hemodialysis was performed 3 times a week. Blood samples were collected from the dialyzer before and after each hemodialysis session to examine platinum clearance. Results The patient received 3 courses of oxaliplatin before he died of cancer. During hemodialysis, the platinum level fell from 0.32 μg/mL to 0.15 μg/mL. Conclusion Since patients with renal failure have various associated disorders and oxaliplatin has a long half-life, it is necessary to obtain more pharmacokinetic data to investigate its accumulation and dialysability during long-term treatment. Such data will assist in treating the rapidly increasing number of hemodialysis patients with colorectal cancer.

Compared Incidence of First Myocardial Infarction in Hypertensive Patients under Treatment Containing Propranolol or excluding β-Receptor Blockade

1976 ◽  
Vol 51 (s3) ◽  
pp. 509s-511s ◽  
Author(s):  
I. McD. G. Stewart
Keyword(s):  
Myocardial Infarction ◽  
Term Treatment ◽  
Receptor Blocker ◽  
Receptor Blockade ◽  
Hypertensive Patients ◽  
Long Term Treatment ◽  
Significant Difference ◽  
Group A ◽  
Β Receptor

1. After some exclusions, 169 severe uncomplicated essential hypertensive patients presenting consecutively were divided into two groups according to their treatment. Of these, 121 had been given long-term treatment containing propranolol (PC group) and forty-eight had been treated with hypotensive agents excluding any β-receptor-blocker group, the non-β-receptor-blocker (NBB) group. 2. There were no significant differences in myocardial infarction risk factors between the two groups. 3. After a mean follow-up of 5·25 years, nine of the 121 subjects (7·5%) in the PC group had suffered first infarctions and fifteen of the forty-eight subjects (31%) in the NBB group, a significant difference (P < 0·01). 4. It was concluded that the presence of propranolol had prevented more or caused fewer infarctions, perhaps a combination of both, than had the older hypotensive agents unsupported by β-receptor blockade.

Long-term treatment for hyperphenylalaninemia and phenylketonuria: a risk for nutritional vitamin B12 deficiency?

2015 ◽  
Vol 28 (11-12) ◽  
Author(s):  
Dagmar Procházková ◽  
Jiří Jarkovský ◽  
Zdena Haňková ◽  
Petra Konečná ◽  
Hana Benáková ◽  
...  
Keyword(s):  
Vitamin B12 Deficiency ◽  
Term Treatment ◽  
Plasma Homocysteine ◽  
Serum Folate ◽  
Vitamin B ◽  
Long Term Treatment ◽  
Significant Difference ◽  
B12 Deficiency ◽  
Nutritional Vitamin

AbstractThe objective of the study was to determine the incidence of vitamin BThe group consisted of 51 PKU (n=29) and HPA (n=22) patients aged 3–48 years (28 children, 23 adults).A significant difference in serum folate levels was discovered between adult HPA patients and PKU patients (p=0.004, Mann-Whitney U-test). A significant difference in plasma homocysteine concentrations within the normal levels (p=0.032, χWe have proven that adult patients with PKU and HPA are at risk of vitamin B

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