scholarly journals Human Nonmercaptalbumin Is a New Biomarker of Motor Function

2021 ◽  
Vol 10 (11) ◽  
pp. 2464
Author(s):  
Sadayuki Ito ◽  
Hiroaki Nakashima ◽  
Kei Ando ◽  
Kazuyoshi Kobayashi ◽  
Masaaki Machino ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Grip Strength ◽  
Motor Function ◽  
Walking Speed ◽  
The Elderly ◽  
Elderly Subjects ◽  
Locomotive Syndrome ◽  
Reduced Mobility

The ratio of human nonmercaptalbumin (HNA) and reduced albumin (HMA) may be a new marker for oxidative stress. Locomotive syndrome (LS) is reduced mobility due to impairment of locomotive organs. We investigated whether the HNA/HMA ratio could be a new biomarker of LS. This study included 306 subjects (mean age 64.24 ± 10.4 years) who underwent LS tests, grip strength, walking speed, and tests for HNA and HMA. Oxidative stress was measured by the ratio of HMA (f(HMA) = (HMA/(HMA + HNA) × 100)), and the subjects were divided into normal (N group; f[HMA] ≥ 70%) and low (L group; f[HMA] < 70%) groups. There were 124 non-elderly (<65 years) and 182 elderly subjects (≥65 years). There were no significant differences in LS, grip strength, and walking speed between the L and N groups in the non-elderly subjects. However, significant differences were found in the elderly subjects. In logistic regression analysis, there was an association between f(HMA) and the LS severity at older ages. LS in the elderly is associated with a decline in HMA and, thus, an increase in oxidative stress. Thus, f(HMA) is a new biomarker of LS.

Relationship Between the Accumulation of Metabolic Syndrome Components and Orthostatic Hypotension

2021 ◽  
Vol 34 (7) ◽  
pp. 775-776
Author(s):  
Xiao-qi Cai ◽  
Xin-lei Gao ◽  
Ting-jun Wang ◽  
Yi-hua Shen ◽  
Guo-yan Xu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Orthostatic Hypotension ◽  
Logistic Regression Analysis ◽  
Middle Age ◽  
Binary Logistic Regression ◽  
The Elderly ◽  
Elderly Subjects ◽  
Binary Logistic Regression Analysis

Abstract Background To investigate the relationship between the accumulation of metabolic syndrome (MS) components and orthostatic hypotension (OH). Methods A total of 2,201 subjects were enrolled and divided into 0 component (n = 199), 1–2 components (n = 1,003), and 3–4 components (n = 999) groups based on the number of MS components according to the criteria of 2018 Chinese Guidelines for Prevention and Management of Hypertension. Stratified analyses and binary logistic regression analysis were performed. Results The incidence of OH was significantly increased with the number of MS components (5.0% in 0 component group, 13.5% in 1–2 components group, and 17.9% in 3–4 components group, P &lt; 0.05). Compared with subjects without OH, the incidence of MS in those with OH was significantly elevated (55.2% vs. 43.7%, P &lt; 0.05). The incidence of OH in the elderly subjects was significantly higher than that in the young and middle-aged subjects (22.3% vs. 10.9%, P &lt; 0.01). Binary logistic regression analysis showed that the number of MS components was associated with OH in all subjects, and the risk of OH was increased with the increment of MS components. Compared with the subjects without any MS component, the risk of OH increased by 2.3 times in the subjects with 4 MS components (odds ratio = 3.274, 95% confidence interval 1.626–6.594, P &lt; 0.05). Stratified analyses found that the number of MS components was independently associated with OH in young to middle-age, female and non-MS subjects. Conclusions The incidence of OH is elevated with accumulations of MS components, especially in young to middle-age, female and non-MS subjects.

scholarly journals Cross-Sectional Association between Hypercholesterolemia and Knee Pain in the Elderly with Radiographic Knee Osteoarthritis: Data from the Korean National Health and Nutritional Examination Survey

2021 ◽  
Vol 10 (5) ◽  
pp. 933
Author(s):  
Byung Woo Cho ◽  
Du Seong Kim ◽  
Hyuck Min Kwon ◽  
Ick Hwan Yang ◽  
Woo-Suk Lee ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Knee Pain ◽  
Logistic Regression Analysis ◽  
National Health ◽  
Large Scale ◽  
Metabolic Diseases ◽  
The Elderly ◽  
Cross Sectional ◽  
Ordinal Logistic Regression Analysis

Few studies have reported the relationship between knee pain and hypercholesterolemia in the elderly population with osteoarthritis (OA), independent of other variables. The aim of this study was to reveal the association between knee pain and metabolic diseases including hypercholesterolemia using a large-scale cohort. A cross-sectional study was conducted using data from the Korea National Health and the Nutrition Examination Survey (KNHANES-V, VI-1; 2010–2013). Among the subjects aged ≥60 years, 7438 subjects (weighted number estimate = 35,524,307) who replied knee pain item and performed the simple radiographs of knee were enrolled. Using multivariable ordinal logistic regression analysis, variables affecting knee pain were identified, and the odds ratio (OR) was calculated. Of the 35,524,307 subjects, 10,630,836 (29.9%) subjects experienced knee pain. Overall, 20,290,421 subjects (56.3%) had radiographic OA, and 8,119,372 (40.0%) of them complained of knee pain. Multivariable ordinal logistic regression analysis showed that among the metabolic diseases, only hypercholesterolemia was positively correlated with knee pain in the OA group (OR 1.24; 95% Confidence Interval 1.02–1.52, p = 0.033). There were no metabolic diseases correlated with knee pain in the non-OA group. This large-scale study revealed that in the elderly, hypercholesterolemia was positively associated with knee pain independent of body mass index and other metabolic diseases in the OA group, but not in the non-OA group. These results will help in understanding the nature of arthritic pain, and may support the need for exploring the longitudinal associations.

scholarly journals Association between inflammatory mediators, grip strength and mobility in community-dwelling elderly

2018 ◽  
Vol 31 (0) ◽  
Author(s):  
Barbara Gazolla de Macedo ◽  
Hanna Sette Câmara de Oliveira ◽  
Marielle Viotti de Paula ◽  
Gisele de Cássia Gomes ◽  
Carlos Maurício de Figueiredo Antunes
Keyword(s):  
Grip Strength ◽  
Muscle Mass ◽  
Functional Capacity ◽  
Inflammatory Mediators ◽  
Interleukin 6 ◽  
The Elderly ◽  
Community Dwelling ◽  
Elderly Subjects ◽  
C Reactive Protein ◽  
Reactive Protein

Abstract Introduction: Aging is associated with loss of muscle mass, immunosenescence and increased production of inflammatory mediators, high levels being predictors of a decline in functional capacity in the elderly. Objective: To assess the association between inflammatory mediators, interleukin 6 (IL-6) and C-reactive protein (CRP) and functional capacity in the elderly. Methods: Cross-sectional study with 308 community-dwelling elderly. The study was approved by the Research Ethics Committee, under protocol number 067/2010. Grip strength (GS) was measured using a JAMAR® dynamometer and functional capacity by the Timed Up and Go (TUG) test. Blood tests were performed and serum levels of C-reactive protein and interleukin 6 assessed. Spearman’s coefficient was applied to analyze the correlation between variables and the Mann-Whitney for intergroup comparison. Significance was set at 0.05. Results: There was no significant correlation between GS, the TUG and inflammatory mediators (CRP and IL-6). However, by adjusting for variables such as age, sex and muscle mass, a significant and inverse correlation (p = 0.023) was observed between GS and CPR. Conclusion: Elderly subjects with low C-reactive protein levels performed better in the grip strength test. It is important to investigate the adverse effects on functional capacity that can be influenced by inflammatory cytokines in the elderly during aging.

scholarly journals Ferula asafoetida Linn. is effective for early functional recovery following mechanically induced insult to the sciatic nerve of a mouse model

2020 ◽  
Vol 19 (9) ◽  
pp. 1903-1910
Author(s):  
Syed Kashif Shahid Kamran ◽  
Azhar Rasul ◽  
Haseeb Anwar ◽  
Shahzad Irfan ◽  
Khizar Sami Ullah ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sciatic Nerve ◽  
Antioxidant Capacity ◽  
Grip Strength ◽  
Nerve Injury ◽  
Muscle Mass ◽  
Motor Function ◽  
Sciatic Nerve Injury ◽  
Sensory Function ◽  
Ferula Asafoetida

Purpose: To evaluate the effect of Ferula asafoetida (oleo gum resin powder) on sensory and motor functions retrieval on an induced sciatic nerve injury in a mouse model.Methods: A mechanical crush was inserted in the sciatic nerve of all the experimental mice after acclimatization. The mice were allocated to four groups; one normal chow group (control, n = 7) and three Ferula asafoetida chow groups (each n = 7) of different doses (50, 100 and 200 mg/kg). Muscle grip strength, muscle mass, and sciatic functional index were measured to evaluate the motor function regain, while sensory function regain was assessed by hot plate test. Oxidative stress and glycemic levels were measured by biochemical assays.Results: The findings of this study indicate that Ferula asafoetida 200 mg/kg has a highly significant (p≤ 0.001) ameliorating effect in terms of improved grip strength (77.7 ± 5.4 % for 200 mg/kg vs. 46 ± 5.1 % for control), reversal of SFI towards normal ( -34 ± 8.1 for 200 mg/kg group vs. –61 ± 6.1 for control), decrease in paw withdrawal latency (7.10 ± 0.06 s for 200 mg/kg group vs. 15 ± 0.5 s for control) on day 12 post-injury, as well as restoration of skeletal muscle mass towards normal. Interestingly, F. asafoetida chow 50 mg/kg and 100 mg/kg groups also impacted significant (p < 0.01) improvement in the ameliorative effect. However, the differences among all treatment groups in ameliorating recovery were not significant (p > 0.05). Moreover, comparatively improved (p < 0.0001) total antioxidant capacity along with reduced total oxidant status (p = 0.01) in the Ferula asafoetida chow (200 mg/kg) group, indicate the antioxidative effect of this plant. Furthermore, the treated mice (200 mg/kg) also expressedan improved glycemic level (p = 0.0005).Conclusion: Ferula asafoetida supplementation helps to accelerate both sensory and motor function retrieval following sciatic nerve injury. This  improvement is thought to be correlated with the antioxidant capacity of the plant. However, further investigations are required to identify the therapeutic principles responsible for the observed actions. Keywords: Sciatic nerve injury, Ferula asafoetida, Function recovery, Oxidative stress, Biochemical analysis

scholarly journals Oral Functions Are Associated with Muscle Strength and Physical Performance in Old-Old Japanese

2021 ◽  
Vol 18 (24) ◽  
pp. 13199
Author(s):  
Yuki Murotani ◽  
Kodai Hatta ◽  
Toshihito Takahashi ◽  
Yasuyuki Gondo ◽  
Kei Kamide ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Grip Strength ◽  
Physical Performance ◽  
Motor Function ◽  
Walking Speed ◽  
Tongue Pressure ◽  
Masticatory Performance ◽  
Physical Frailty ◽  
Swallowing Function ◽  
Occlusal Force

Grip strength and walking speed are considered to be important indicators of physical frailty. However, no study has contemporaneously examined any association of multiple oral functions with grip strength and walking speed. The purpose of this study was to examine which oral functions are associated with muscle strength (grip strength), physical performance (walking speed) or both. The study participants were 511 community-dwelling people (254 men and 257 women) aged 77–81 years old. Six oral functions—oral wetness, occlusal force, tongue-lip motor function, tongue pressure, masticatory performance and swallowing function—were measured. Grip strength and walking speed were also measured. A partial correlation analysis, adjusted for gender, showed that occlusal force, tongue-lip motor function, masticatory performance and swallowing function were significantly associated with both grip strength and walking speed. In addition, tongue pressure was significantly associated with grip strength. A general linear model showed that tongue pressure and occlusal force were significantly associated with grip strength. Swallowing function and tongue-lip motor function were significantly associated with walking speed. It is suggested that there are different oral function measures for muscle strength and physical performance, and these oral function measures could be a useful proxy for physical frailty.

scholarly journals Awareness of Locomotive Syndrome and Factors Associated with Awareness: A Community-Based Cross-Sectional Study

2020 ◽  
Vol 17 (19) ◽  
pp. 7272
Author(s):  
Keiko Sugai ◽  
Haruhiko Imamura ◽  
Takehiro Michikawa ◽  
Keiko Asakura ◽  
Yuji Nishiwaki
Keyword(s):  
The Elderly ◽  
Cross Sectional Study ◽  
Locomotive Syndrome ◽  
Musculoskeletal Health ◽  
Community Based ◽  
Cross Sectional ◽  
Social Settings ◽  
One Year ◽  
Reduced Mobility ◽  
Prevalence Ratios

Locomotive syndrome is a condition of reduced mobility, and patients have a high risk of requiring nursing care. In order to investigate the level of awareness of the term “locomotive syndrome” and the factors relating to awareness in a community, awareness of locomotive syndrome was included in a questionnaire survey on health and daily life conducted in Koumi Town (Japan), which was distributed to 3181 eligible residents aged 40 years or older. Information on age, sex, marital status, educational attainment, lifestyle, and social environment was also collected, and the association of awareness with various factors was analyzed with two multivariable Poisson regression models. As a result, awareness among respondents was 44.6%. Awareness was significantly higher among women, those who were 60–79 years old, married, and had received higher education. Additionally, awareness was significantly associated with social factors, especially attendance at regional events within the last one year, in both women and men: the adjusted prevalence ratios (95% confidence intervals) were 1.26 (1.10–1.43) and 1.48 (1.19–1.83), respectively. In conclusion, in addition to strengthen awareness rising campaigns targeting men and for younger people, providing health education at social settings such as regional events may help improve future musculoskeletal health in the elderly.

scholarly journals Changes in Cognitive Function and Risk Factors for Cognitive Impairment of the Elderly in China: 2005–2014

2019 ◽  
Vol 16 (16) ◽  
pp. 2847 ◽  
Author(s):  
Qilin Zhang ◽  
Yanli Wu ◽  
Tiankuo Han ◽  
Erpeng Liu
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Logistic Regression Analysis ◽  
Binary Logistic Regression ◽  
The Elderly ◽  
Binary Logistic Regression Analysis ◽  
Chinese Elderly

Background: The cognitive function of the elderly has become a focus of public health research. Little is known about the changes of cognitive function and the risk factors for cognitive impairment in the Chinese elderly; thus, the purposes of this study are as follows: (1) to describe changes in cognitive function in the Chinese elderly from 2005–2014 and (2) to explore risk factors for cognitive impairment of the Chinese elderly. Design and setting: A total of 2603 participants aged 64 years and above participated in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) and were followed up from 2005 to 2014. Cognitive function and cognitive impairment were assessed using the Chinese version of the Mini-Mental State Examination (MMSE). Binary logistic regression analysis was used to estimate the odds ratio (OR) and 95% confidence intervals (CI) of cognitive impairment. Results: Results revealed that the cognitive function of the Chinese elderly shows diversified changes: deterioration (55.09%), unchanged (17.21%) and improvement (27.70%). In addition, there are significant demographic differences in gender, age, education, marriage and other aspects when it comes to the changes of cognitive function in Chinese elderly. In the binary logistic regression analysis, female, increased age, lower education level, no spouse, less income, worse PWB (psychological well-being), less fresh fruit and vegetable intake, more activities of daily living (ADL) limitations, lower social engagement were significantly associated with higher odds for cognitive impairment. Conclusions: Various interventions should be implemented to maintain cognitive function in Chinese elderly.

Gender Roles in a Geriatric Therapeutic Community

1993 ◽  
Vol 5 (1) ◽  
pp. 79-90 ◽  
Author(s):  
Matti Isohanni
Keyword(s):  
Gender Differences ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Gender Roles ◽  
Functional Activity ◽  
Intervention Study ◽  
Therapeutic Community ◽  
The Elderly ◽  
Explanatory Variables ◽  
Aged People

During the years 1983–1989 an action research/intervention study in a 40-bed Finnish home for the elderly had as its goal the development of a modified therapeutic community. This paper focuses on the gender roles. Logistic regression analysis indicated that males (N=17) were best differentiated from females (N=38) by extramural functional activity, extramural social passivity, religious neutrality, passivity in contacts with a personal nurse, and better education. These five explanatory variables correctly predicted gender in 84% of the cases. These mild gender differences reflect the traditional sex roles of an agrarian Finnish village and were seen mainly as a positive phenomenon. The findings and some other gender identity themes in the elderly, also were illustrated by qualitative case material. These data suggested that the therapeutic community of aged people should permit active preservation of even conservative and stereotyped gender roles, thereby aiding in the defense and continuity of their often frail identity. The search for new role elements should be supported as well, however, because some elderly continue to develop their gender roles during their final years.

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