scholarly journals ABG Assistant—Towards an Understanding of Complex Acid-Base Disorders

2021 ◽  
Vol 10 (7) ◽  
pp. 1516
Author(s):  
Łukasz Gutowski ◽  
Kaja Gutowska ◽  
Alicja Brożek ◽  
Marcin Nowicki ◽  
Dorota Formanowicz
Keyword(s):  
Healthcare Workers ◽  
Blood Gases ◽  
Blood Gas Analysis ◽  
Gas Analysis ◽  
Acid Base ◽  
Arterial Blood Gas ◽  
Arterial Blood ◽  
Multiple Data ◽  
Base Disorder ◽  
Definitive Statement

The ability to diagnose acid-base imbalances correctly is essential for physicians and other healthcare workers. Despite its importance, it is often considered too complex and confusing. Although most people dealing with arterial blood gases (ABGs) do not usually have problems with acid-base disorder assessment, such an analysis is also carried out by other healthcare workers for whom this can be a challenging task. Many aspects may be problematic, partly due to multiple data analysis methods and no definitive statement on which one is better. According to our survey, the correctness of arterial blood gas analysis is unsatisfactory, especially in mixed disorders, which do not always manifest an obvious set of symptoms. Therefore, ABG parameters can be used as an established biomarker panel, which is considered to be a powerful tool for personalized medicine. Moreover, using different approaches to analyze acid-base disorders can lead to varying diagnoses in some cases. Because of these problems, we developed a mobile application that can spot diagnostic differences by taking into account physiological and chemical approaches, including their variants, with a corrected anion gap. The proposed application is characterized by a high percentage of correct analyses and can be an essential aid for diagnosing acid-base disturbances.

Exercise-induced hypoxemia in older athletes

1994 ◽  
Vol 76 (1) ◽  
pp. 120-126 ◽  
Author(s):  
C. Prefaut ◽  
F. Anselme ◽  
C. Caillaud ◽  
J. Masse-Biron
Keyword(s):  
Blood Gases ◽  
Blood Gas Analysis ◽  
Gas Analysis ◽  
Lung Water ◽  
Arterial Blood Gas ◽  
Arterial Blood ◽  
Older Athletes ◽  
Level Of Training ◽  
Exercise Induced ◽  
Arterial Po2

To determine whether exercise induces hypoxemia in highly trained older “master” athletes (MA), as it does in certain elite endurance-trained young athletes (YA), 10 MA (65.3 +/- 2.6 yr), 10 control subjects (CS; 68.3 +/- 2.2 yr), and 10 endurance-trained YA (23.3 +/- 1.1 yr) performed an incremental exercise test. During testing, blood samples for arterial blood gas analysis were drawn during the last 20 s of each load. Lung exchanges were measured using a breath-by-breath automated exercise device. Exercise-induced hypoxemia (EIH) appeared in all MA and 8 of 10 YA, whereas there were no changes in the blood gases of CS. In MA, arterial PO2 decreased significantly from 40% of maximal O2 uptake onward and was associated with a significant increase in the ideal alveolar-arterial O2 difference from 60% onward. The MA also showed a lower ventilation for a given absolute load compared with CS. In all subjects arterial PCO2 rose slightly but significantly during the work, but this increase was most marked in MA. The EIH differed between MA and YA in the following ways: 1) all MA showed a drop in arterial PO2 during exercise, 2) this drop appeared earlier and was significantly greater for a given load in MA, and 3) EIH appeared at a lower level of training regimen in MA. This hypoxemia was at first isolated, probably at least partially due to relative hypoventilation, and then was associated with a widened ideal alveolar-arterial O2 difference, which may have been due to an increase in extravascular lung water.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Arterial Blood Gas Analysis: Selecting the Clinically Appropriate Option for Calculating Base Excess

2002 ◽  
Vol 39 (6) ◽  
pp. 614-615 ◽  
Author(s):  
Michael J Peake ◽  
Graham H White
Keyword(s):  
Base Excess ◽  
Extracellular Fluid ◽  
Blood Gas Analysis ◽  
Gas Analysis ◽  
Blood Gas ◽  
Acid Base ◽  
Arterial Blood Gas ◽  
Arterial Blood ◽  
Arterial Blood Gas Analysis ◽  
Acid Base Disturbance

As part of arterial blood gas analysis, base excess is often reported as a measure of non-respiratory acid-base disturbance. Most blood gas analysers offer the option of calculating either the base excess of the blood sample or the base excess of the extracellular fluid (ECF). We report a case that illustrates that selecting the physiologically appropriate parameter avoids the potential for misinterpretation of acid-base data. We recommend that the base excess of the ECF is the appropriate metabolic blood gas parameter for clinical use.

scholarly journals Arterialised Capillary Blood Gases in Accident and Emergency Department Patients - a Reliable Alternative to Arterial Sampling?

2020 ◽  
Vol 7 (2) ◽  
Author(s):  
Faheem Shakur ◽  
Suzanne Mason
Keyword(s):  
Blood Gases ◽  
Blood Gas Analysis ◽  
Gas Analysis ◽  
Capillary Blood ◽  
Blood Gas ◽  
Arterial Blood Gas ◽  
Arterial Blood ◽  
Arterial Blood Gas Analysis ◽  
Significant Difference ◽  
Emergency Department Patients

OBJECTIVES: Many patients with respiratory complaints who present to the Accident & Emergency (A & E) department have an arterial blood gas analysis performed at some point. It is our belief that there is no difference between arterial and capillary blood gas values in patients presenting to the A & E department. It is also anticipated that body temperature and blood pressure may play a part, so these will also be reported and associations will be investigated. METHODS: Patients who require arterial blood gas analysis at any stage during their stay in the A & E department at the Northern General hospital of Sheffield are eligible for inclusion in the study. In total there were 32 patients. PROCEDURE:Transvasin cream was applied to the ear lobe to improve local blood flow by dilating the capillaries. When ten minutes have elapsed after the application of the Transvasin cream, a capillary sample is taken from the ear lobe by the researchers. CONCLUSION: From the t-tests conducted, no significant difference was seen between the arterial and capillary blood gas samples for the parameters pO2 and O2 saturation. However, for pCO2, pH and [HCO3] there were significant differences observed. This result seems to disagree with the findings of most other studies that have so far shown stronger correlations generally for pH, pCO2 and bicarbonate, than for oxygen measuring parameters.

scholarly journals Effects of buspirone on posthypoxic ventilatory behavior in the C57BL/6J and A/J mouse strains

2008 ◽  
Vol 105 (2) ◽  
pp. 518-526 ◽  
Author(s):  
Motoo Yamauchi ◽  
Jesse Dostal ◽  
Hiroshi Kimura ◽  
Kingman P. Strohl
Keyword(s):  
Partial Agonist ◽  
Blood Gases ◽  
Blood Gas Analysis ◽  
Periodic Breathing ◽  
Gas Analysis ◽  
Mouse Strains ◽  
Arterial Blood Gas ◽  
Arterial Blood ◽  
Arterial Blood Gas Analysis ◽  
Brain Stem Injury

Buspirone, a partial agonist of the serotonergic 5-HT1A receptor, improves breathing irregularities in humans with Rett syndrome or brain stem injury. The purpose of this study was to examine whether buspirone alters posthypoxic ventilatory behavior in C57BL/6J (B6) and A/J mouse strains. Measurements of ventilatory behavior were collected from unanesthetized adult male mice ( n = 6 for each strain) using the plethysmographic method. Mice were given intraperitoneal injections of vehicle or several doses of buspirone and exposed to 2 min of hypoxia (10% O2) followed by rapid reoxygenation (100% O2). Twenty minutes later, mice were tested for hypercapnic response (8% CO2-92% O2). On a separate day, mice were injected with the 5-HT1A receptor antagonist 4-iodo- N-{2-[4-(methoxyphenyl)-1-piperazinyl] ethyl}- N-2-pyridinylbenzamide ( p-MPPI) before the injection of buspirone, and measurements were repeated. In separate studies, arterial blood-gas analysis was performed for each strain ( n = 12 in B6 and 10 in A/J) with buspirone or vehicle. In both strains, buspirone stimulated ventilation at rest. In the B6 mice, the hypoxic response was unchanged, but the response to hypercapnia was reduced with buspirone (5 mg/kg; P < 0.05). With reoxygenation, vehicle-treated B6 exhibited periodic breathing and greater variation in ventilation compared with A/J ( P < 0.01). In B6 animals, ≥3 mg/kg of buspirone reduced variation and prevented the occurrence of posthypoxic periodic breathing. Both effects were reversed by p-MPPI. Treatment effect of buspirone was not explained by a difference in resting arterial blood gases. We conclude that buspirone improves posthypoxic ventilatory irregularities in the B6 mouse through its agonist effects on the 5-HT1A receptor.

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