scholarly journals Physicochemical Properties of Lipoproteins Assessed by Nuclear Magnetic Resonance as a Predictor of Premature Cardiovascular Disease. PRESARV-SEA Study

2021 ◽  
Vol 10 (7) ◽  
pp. 1379
Author(s):  
Bárbara Fernández-Cidón ◽  
Beatriz Candás-Estébanez ◽  
Miriam Gil-Serret ◽  
Núria Amigó ◽  
Emili Corbella ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Physicochemical Properties ◽  
Lipid Profile ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Ldl Particles ◽  
Premature Cardiovascular Disease ◽  
Nuclear Magnetic

Some lipoprotein disorders related to the residual risk of premature cardiovascular disease (PCVD) are not detected by the conventional lipid profile. In this case-control study, the predictive power of PCVD of serum sdLDL-C, measured using a lipoprotein precipitation method, and of the physicochemical properties of serum lipoproteins, analyzed by nuclear magnetic resonance (NMR) techniques, were evaluated. We studied a group of patients with a first PCVD event (n = 125) and a group of control subjects (n = 190). Conventional lipid profile, the size and number of Very Low Density Lipoproteins (VLDL), Low Density Lipoproteins (LDL), High Density Lipoproteins (HDL) particles, and the number of particles of their subclasses (large, medium, and small) were measured. Compared to controls, PCVD patients had lower concentrations of all LDL particles, and smaller and larger diameter of LDL and HDL particles, respectively. PCVD patients also showed higher concentrations of small dense LDL-cholesterol (sdLDL), and triglycerides (Tg) in LDL and HDL particles (HDL-Tg), and higher concentrations of large VLDL particles. Multivariate logistic regression showed that sdLDL-C, HDL-Tg, and large concentrations of LDL particles were the most powerful predictors of PCVD. A strong relationship was observed between increased HDL-Tg concentrations and PCVD. This study demonstrates that beyond the conventional lipid profile, PCVD patients have other atherogenic lipoprotein alterations that are detected by magnetic resonance imaging (MRI) analysis.

Temperature-dependent carbon-13 nuclear magnetic resonance studies of human serum low density lipoproteins

Biochemistry ◽  
1976 ◽  
Vol 15 (19) ◽  
pp. 4151-4157 ◽  
Author(s):  
Barry Sears ◽  
Richard J. Deckelbaum ◽  
Martin J. Janiak ◽  
G. Graham Shipley ◽  
Donald M. Small
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Human Serum ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Temperature Dependent ◽  
Magnetic Resonance Studies ◽  
Nuclear Magnetic

scholarly journals Establishing reference intervals for triglyceride-containing lipoprotein subfraction metabolites measured using nuclear magnetic resonance spectroscopy in a UK population

2020 ◽  
pp. 000456322096175
Author(s):  
Roshni Joshi ◽  
Goya Wannamethee ◽  
Jorgen Engmann ◽  
Tom Gaunt ◽  
Deborah A Lawlor ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Reference Interval ◽  
Reference Intervals ◽  
Low Density ◽  
Lipoprotein Subfractions ◽  
Nuclear Magnetic

Background Nuclear magnetic resonance (NMR) spectroscopy allows triglycerides to be subclassified into 14 different classes based on particle size and lipid content. We recently showed that these subfractions have differential associations with cardiovascular disease events. Here we report the distributions and define reference interval ranges for 14 triglyceride-containing lipoprotein subfraction metabolites. Methods Lipoprotein subfractions using the Nightingale NMR platform were measured in 9073 participants from four cohort studies contributing to the UCL-Edinburgh-Bristol consortium. The distribution of each metabolite was assessed, and reference interval ranges were calculated for a disease-free population, by sex and age group (<55, 55–65, >65 years), and in a subgroup population of participants with cardiovascular disease or type 2 diabetes. We also determined the distribution across body mass index and smoking status. Results The largest reference interval range was observed in the medium very-low density lipoprotein subclass (2.5th 97.5th percentile; 0.08 to 0.68 mmol/L). The reference intervals were comparable among male and female participants, with the exception of triglyceride in high-density lipoprotein. Triglyceride subfraction concentrations in very-low density lipoprotein, intermediate-density lipoprotein, low-density lipoprotein and high-density lipoprotein subclasses increased with increasing age and increasing body mass index. Triglyceride subfraction concentrations were significantly higher in ever smokers compared to never smokers, among those with clinical chemistry measured total triglyceride greater than 1.7 mmol/L, and in those with cardiovascular disease, and type 2 diabetes as compared to disease-free subjects. Conclusion This is the first study to establish reference interval ranges for 14 triglyceride-containing lipoprotein subfractions in samples from the general population measured using the nuclear magnetic resonance platform. The utility of nuclear magnetic resonance lipid measures may lead to greater insights for the role of triglyceride in cardiovascular disease, emphasizing the importance of appropriate reference interval ranges for future clinical decision making.

Solid-state nuclear magnetic resonance study of linear low-density polyethylenes: 1. Ethylene-1-butene copolymers

Polymer ◽  
1989 ◽  
Vol 30 (8) ◽  
pp. 1508-1512 ◽  
Author(s):  
E. Pérez ◽  
A. Bello ◽  
J.M. Pereña ◽  
R. Benavente ◽  
M.C. Martínez ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Solid State ◽  
Magnetic Resonance ◽  
Nuclear Magnetic Resonance Study ◽  
Low Density ◽  
Magnetic Resonance Study ◽  
Nuclear Magnetic
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