scholarly journals Non-Invasive Biomarkers of Musculoskeletal Health with High Discriminant Ability for Age and Gender

2021 ◽  
Vol 10 (7) ◽  
pp. 1352
Author(s):  
Sandra Agyapong-Badu ◽  
Martin B. Warner ◽  
Dinesh Samuel ◽  
Vasiliki Koutra ◽  
Maria Stokes
Keyword(s):  
Physical Function ◽  
Peak Flow ◽  
Community Dwelling ◽  
Thigh Muscle ◽  
Musculoskeletal Health ◽  
Timed Up And Go ◽  
Age And Gender ◽  
Linear Discriminant ◽  
Anterior Thigh ◽  
And Gender

A novel approach to ageing studies assessed the discriminatory ability of a combination of routine physical function tests and novel measures, notably muscle mechanical properties and thigh composition (ultrasound imaging) to classify healthy individuals according to age and gender. The cross-sectional study included 138 community-dwelling, self-reported healthy males and females (65 young, mean age ± SD = 25.7 ± 4.8 years; 73 older, 74.9 ± 5.9 years). Handgrip strength; quadriceps strength; respiratory peak flow; timed up and go; stair climbing time; anterior thigh tissue thickness; muscle stiffness, tone, elasticity (Myoton technology), and self-reported health related quality of life (SF36) were assessed. Stepwise feature selection using cross-validation with linear discriminant analysis was used to classify cases based on criterion variable derived from known effects of age on physical function. A model was trained and features selected using 126 cases with 0.92 accuracy (95% CI = 0.86–0.96; Kappa = 0.89). The final model included five features (peak flow, timed up and go, biceps brachii elasticity, anterior thigh muscle thickness, and percentage thigh muscle) with high sensitivity (0.82–0.96) and specificity (0.94–0.99). The most sensitive novel biomarkers require no volition, highlighting potentially useful tests for screening and monitoring effects of interventions on musculoskeletal health for vulnerable older people with pain or cognitive impairment.

Age- and Gender-Related Changes in Physical Function in Community-Dwelling Brazilian Adults Aged 50 to 102 Years

2019 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Hélio J. Coelho-Junior ◽  
Marco C. Uchida ◽  
Ivan O. Gonçalves ◽  
Riccardo Calvani ◽  
Bruno Rodrigues ◽  
...  
Keyword(s):  
Physical Function ◽  
Community Dwelling ◽  
Age And Gender ◽  
And Gender

scholarly journals Circumstances of fall-related injuries by age and gender among community-dwelling adults in the United States

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0176561 ◽  
Author(s):  
Lava R. Timsina ◽  
Joanna L. Willetts ◽  
Melanye J. Brennan ◽  
Helen Marucci-Wellman ◽  
David A. Lombardi ◽  
...  
Keyword(s):  
United States ◽  
The United States ◽  
Community Dwelling ◽  
Age And Gender ◽  
And Gender

The Subjective Experience of Aging: Correlates of Divergent Views

1989 ◽  
Vol 8 (1) ◽  
pp. 7-18 ◽  
Author(s):  
Ingrid Connidis
Keyword(s):  
Older Persons ◽  
Subjective Experience ◽  
Subjective Health ◽  
Community Dwelling ◽  
Age And Gender ◽  
Positive View ◽  
Significant Relationships ◽  
Age Related ◽  
Dependent Variables ◽  
And Gender

ABSTRACTA stratified random sample of 400 community-dwelling older persons were asked whether they like or dislike anything about being their age and if they have any worries about growing older. The results of multivariate analysis show significant relationships between the dependent variables and several respondent charaderistics including age, subjective health, expectations of older age, and gender. A negative view of aging appears to be associated with experiencing age-related declines. Overall, despite some diversity, the respondents tend to hold a positive view of old age that is coupled with a realistic appreciation of the shortcomings this stage of life may bring.

scholarly journals Dietary habits are major determinants of the plasma antioxidant status in healthy elderly subjects

2005 ◽  
Vol 94 (5) ◽  
pp. 639-642 ◽  
Author(s):  
Timur Anlasik ◽  
Helmut Sies ◽  
Helen R. Griffiths ◽  
Patrizia Mecocci ◽  
Wilhelm Stahl ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Healthy Subjects ◽  
Antioxidant Status ◽  
Fruits And Vegetables ◽  
Community Dwelling ◽  
Protein Carbonyls ◽  
Elderly Subjects ◽  
Age And Gender ◽  
Age Related ◽  
And Gender

Previous studies indicate that regular consumption of a diet rich in fruits and vegetables is associated with a lower risk for age-related diseases. The aim of the present study was to evaluate whether the often-reported age-related decrease of plasma antioxidants in man depends on differences in dietary intake or on other age- and gender-related factors. In this observational case-control study, thirty-nine community-dwelling healthy subjects aged 65 years and older consuming high intakes of fruits and vegetables daily (HI) and forty-eight healthy subjects aged 65 and older consuming low intakes of fruit and vegetables daily (LI) were enrolled. Plasma levels of retinol, tocopherols, carotenoids and malondialdehyde (MDA) as well as content of protein carbonyls in Ig G were measured. Plasma levels of retinol, tocopherols and carotenoids were significantly higher in group HI than in group LI subjects independent of age and gender. MDA levels were inversely correlated with vitamin A and α-carotene. Protein carbonyls were inversely correlated with γ-tocopherol. In the elderly, a higher daily intake of fruits and vegetables is associated with an improved antioxidant status in comparison to subjects consuming diets poor in fruits and vegetables. Modification of nutritional habits among other lifestyle changes should be encouraged to lower prevalence of disease risk factors in later life.

scholarly journals Vitamin D, muscle strength and physical function in UK South Asian older women

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Sabeen Zahra ◽  
Bernard Corfe ◽  
Elizabeth Williams
Keyword(s):  
Vitamin D ◽  
Muscle Strength ◽  
Physical Function ◽  
Older Women ◽  
South Asian ◽  
Handgrip Strength ◽  
Community Dwelling ◽  
Vitamin D Status ◽  
Timed Up And Go ◽  
Chair Stand

AbstractA positive association has been reported between vitamin D status, muscle strength and physical function in older Caucasian women. However, little is known about this relationship in UK South Asian older women. This cross-sectional study aimed to explore the association between vitamin D status, muscle strength and physical function in UK South Asian (Pakistani and Indian) older women.One hundred and twenty community-dwelling women were recruited via visiting community centres, mosques, Indian temples (Gurdwara) and by word of mouth (between January to May 2018). Inclusion criteria were: community-dwelling, South Asian women, age 60 years and above, able to communicate effectively and able to give written or verbal consent. A general interview (demographic, anthropometric, self-reported exhaustion, health history, supplementation use/duration/dose), handgrip strength (kg), short physical performance battery (single chair stand, repeated chair stands, balance, timed up-and-go test), and blood 25 hydroxyvitamin D (25(OH)D, nmol/l) concentration were performed. Dietary intake and self-reported physical activity was also assessed using multiple-pass 24-hour diet recall method and International Physical Activity Questionnaire (IPAQ) short form respectively.Overall, 47% of participants had insufficient blood 25(OH)D concentration (< 50nmol/L) and 53% had sufficient blood 25(OH)D (≥ 50nmol/L) using the IOM classification. As expected 86% of current vitamin D supplement users had adequate vitamin D status and only 14% of women who reported current vitamin D supplement use had insufficient vitamin D status. Amongst supplement non-users 68% had insufficient vitamin D status and only 32% had adequate levels. An inverse correlation (Spearman's analysis) was found between vitamin D status and single chair stand test (sec) (r = -0.25, p = 0.006); repeated chair stand test (sec) (r = -0.29, p = 0.002) and timed up-and-go test (sec) (r = -0.20, p = 0.02). No correlation was observed between vitamin D status and handgrip strength (r = 0.09, p = 0.30).The prevalence of vitamin D insufficiency is high in post-menopausal South Asian women not taking vitamin D supplements. Significant association was observed between vitamin D status and some aspects of muscle strength and physical function. We are now conducting a randomized control trial to investigate whether vitamin D supplementation may restore muscle strength and function in this population.

scholarly journals The Application of 'Timed Up and Go' Test in Fall Screening of Elderly People in Shanghai: A Cross-Sectional Study

2021 ◽  
Author(s):  
Jian Wang ◽  
Xiuqin Chen ◽  
Xiaoming Sun ◽  
Huifen Ma ◽  
Yan Yu ◽  
...  
Keyword(s):  
Elderly People ◽  
Predictive Value ◽  
Fall Risk ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Cluster Sampling ◽  
Timed Up And Go ◽  
Cross Sectional ◽  
And Gender

Background: We aimed to evaluate the predictive value of the 'Timed Up and Go' test (TUGT) for identifying fall risk in community-dwelling elderly. Methods: From Aug 2016 to Feb 2017, cluster sampling was conducted among residents aged over 60 from 15 communities in Songjiang district, Shanghai. Face-to-face questionnaire interviews and TUGT measures were conducted to collect data. Results: 6,014 participants were enrolled, with an average age 72.7±7.0 years. 637 (10.6%) elderly people had a fall experience in the past year. TUGT for the non-fall group, one-fall group and recurrent-fall group was 9.02±4.39, 10.00±5.26 and 10.78±4.51 seconds respectively (P<0.001). ROC analysis showed that the TUGT cut-off point for the elderly was 12.5 seconds and AUC was 0.573 for any-fall group and 0.613 for recurrent-fall group respectively. After adjusting for age and gender, the predictive value was not high for any-fall group (AUC=0.614) and recurrent-fall group (AUC=0.648). The TUGT cut-off point for the elderly aged below 65, 65-74, 75-84 and 85 and above was 13.52s, 12.51s, 12.51s, 12.00s, respectively. After adjustment of the confounding factors, the OR values for the risk of fall for the elderly men and women who completed TUGT longer than the cut-off point was 2.404 and 2.075 times higher than those who completed TUGT shorter than the cut-off point, respectively. Conclusion: TUGT with the cut-off score of 12.5s has limited capability in predicting fall risk in community-dwelling elderly.

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